ALESSANDRA ZINGONI

In the last 10 years, Alessandra Zingoni’s research activity has been mainly focused on tumor immunology and pointed to understand the complex interactions between immune NK cells and Multiple Myeloma cancer cells in order to design more tailored and effective immunotherapies and these studies have been mostly performed using ex vivo multiple myeloma patient’s samples. In particular She has been studying the mechanisms responsible of anti-tumor NK cell activity in response to chemotherapy. Furthermore, She is currently investigating the immunomodulatory action of multiple myeloma-derived exosomes and their potential role as biomarkers associated to multiple myeloma progression. She is collaborating with several groups in order to study the immunoregulatory role of exosome and microvesicles in different pathological conditions including autoimmunity, infections and allergic reactions. She is also studying the role of artificial liposome nanoparticle as vectors to deliver DNA/RNA or drugs in cancer patients and their impact on immune cells.
Some of the activities were done in collaboration with many groups in Italy and abroad: M.T. Petrucci ( University of Rome “Sapienza”), G. Caracciolo (University of Rome “Sapienza”,); L. Masuelli (University of Rome “Sapienza”); D.Fuerst (University of Ulm, Germany); A. Ludwig (University of Ulm, Germany); L.L. Lanier (University of San Francisco, CA); M.Tripodi (University of Rome, Sapienza); M. Ardolino (University of Ottawa, Canada); A. Achour (Karolinska Institutet, Stockholm, Sweden).

Summary of Scientific Achievements

H index: 41 (Scopus)
Total Published articles: 85 (Scopus)

Selected Publications

1.Zingoni A, Antonangeli F, Sozzani S, Santoni A, Cippitelli M, Soriani A. The senescence journey in cancer immunoediting. Molecular Cancer, 2024; 23(1):68. doi:10.1186/s12943-024-01973-5. IF: 27.7

2.Renzi S, Digiacomo L, Pozzi D, Quagliarini E, Vulpis E, Giuli MV, Mancusi A, Natiello B, Pignataro MG, Canettieri G, Di Magno L, Pesce L, De Lorenzi V, Ghignoli S, Loconte L, Montone CM, Laura Capriotti A, Laganà A, Nicoletti C, Amenitsch H, Rossi M, Mura F, Parisi G, Cardarelli F, Zingoni A*, Checquolo S*, Caracciolo G*. Nat Commun. 2024 doi: 10.1038/s41467-024-53569-8

3.Vulpis, E., Loconte, L., Cassone, C., Antonangeli F, Caracciolo G, Masuelli L, Fazio F, Petrucci MT, Fionda C, Soriani A, Cerboni C, Cippitelli M, Santoni, A., Zingoni, A. Cross-Dressing of Multiple Myeloma Cells Mediated by Extracellular Vesicles Conveying MIC and ULBP Ligands Promotes NK Cell Killing. International Journal of Molecular Sciences, 2023; 24(11):9467. doi: 10.3390/ijms24119467

4.Vulpis E, Loconte L, Peri A, Molfetta R, Caracciolo G, Masuelli L, Tomaipitinca L, Peruzzi G, Petillo S, Petrucci MT, Fazio F., Simonelli L, Fionda C, Soriani A, Cerboni C, Cippitelli M, Paolini R, Bernardini G, Palmieri G, Santoni A, Zingoni A. Impact on NK cell functions of acute versus chronic exposure to extracellular vesicle-associated MICA: Dual role in cancer immunosurveillance. Journal of Extracellular Vesicles, 2022; e12176. doi: 10.1002/jev2.12176. IF: 16

5.Zingoni A., Banales J. PIGR-enriched circulating vesicles contributes to hepatocellular carcinoma aggressiveness. Journal of Hepatology, 2022; 76:768-770. doi:10.1016/j.ihep.2022.02.001; IF: 25.7

6.Hasim MS, Marotel M, Hodgins JJ, Vulpis E, Makinson OJ, Asif S, Shih HY, Scheer AK, MacMillan O, Alonso FG, Burke KP, Cook DP, Li R, Petrucci MT, Santoni A, Fallon PG, Sharpe AH, Sciumè G, Veillette A, Zingoni A, Gray DA, McCurdy A, Ardolino M. When killers become thieves: Trogocytosed PD-1 inhibits NK cells in cancer. Science Advance, 2022; 8(15):eabj3286. doi: 10.1126/sciadv.abj3286

7.Soriani A, Vulpis E, Cuollo L, Santoni A, Zingoni A. Cancer extracellular vesicles as novel regulators of NK cell response. Cytokine Growth Factor Rev. 2020;51:19-26. doi: 10.1016/j.cytogfr.2019.11.007