Notizie
a.a. 2024-2025
Insegnamento di Biologia e Genetica I (Corso di laurea in Medicina e Chirurgia "C"):
- le lezioni si svolgeranno in presenza a partire dal 9 ottobre 2024
- il programma delle lezioni e il materiale didattico saranno disponibili sulla piattaforma Moodle Sapienza (https://elearning.uniroma1.it/course/view.php?id=1365)
Insegnamento di Biologia e Genetica II (Corso di laurea in Medicina e Chirurgia "C"):
- le lezioni si svolgeranno in presenza a partire dal 3 marzo 2025
- il programma delle lezioni e il materiale didattico saranno disponibili sulla piattaforma Moodle Sapienza (https://elearning.uniroma1.it/course/view.php?id=741)
Insegnamento di Basi Molecolari delle Funzioni Cellulari (CLM in Biotecnologie Mediche):
- le lezioni si svolgeranno in presenza a partire dal 4 novembre 2024
- il programma delle lezioni e il materiale didattico saranno disponibili sulla piattaforma Moodle Sapienza (https://elearning.uniroma1.it/course/view.php?id=713)
Orari di ricevimento
Su appuntamento tramite email
Al II piano della V Clinica Medica (Policlinico Umberto I)
Curriculum
EDUCATION AND TRAINING
2001-2002 Fogarty International Fellow - National Cancer Institute NIH, Frederick, MD, USA
1999 Specialty in Clinical Pathology - Sapienza University, Rome
1994 CNR fellow - CNR (National Council of Research)
1991-1993 AIRC fellow - AIRC (Italian Association for Cancer Research)
1990 Degree cum Laude in Biological Science, University Sapienza
RESEARCH EXPERIENCE
Current position and research projects:
Associate Professor (BIO/13) - Sapienza University, Rome
- Role of ERK5/MAPK in the regulation of the mechano-transducer YAP and analysis of the molecular mechanisms involved; identification of new transcriptional partners of YAP involved in the regulation of gene expression in EMT and cancer
2008-2022
Researcher (BIO/13) - Sapienza University, Rome
- Role of microenvironment in hepatocyte differentiation and liver carcinogenesis; signal transduction pathways controlling EMT/MET dynamics; new molecular tools for gene therapy of hepatocellular carcinomas
2003-2008
Post-doctoral fellow - Department of Cellular Biotechnologies and Hematology, Sapienza University, Rome, with Prof. Marco Tripodi.
- Role of Snail in the epithelial-to-mesenchymal transition (EMT) induced by TGFbeta in hepatocytes; dissection of signal transduction pathways in TGFbeta-induced EMT.
2001-2002
Visiting Fellow - Regulation of Cell Growth Laboratory, National Cancer Institute, NIH, Frederick, MD, USA, with Dr Karen H. Vousden.
- Role of ERK5/MAPK in the p53-induced apoptosis
1995-2001
Pre- and Post- doctoral Fellow - Molecular Oncogenesis Laboratory, Regina Elena Cancer Institute, Rome, with Dr Silvia Soddu
- Role of p53 in muscle differentiation, growth arrest and apoptosis; functional effects induced by wild-type p53 overexpression in normal and in transformed muscle cells and mechanisms involved
1991-1994
Research Fellow - Nucleic Acid Center, University Sapienza, Rome, with Dr Sergio Nasi
- Interactions between helix-loop-helix domains of transcriptional factors involved in cellular proliferation and differentiation
SCIENTIFIC PUBLICATIONS (last 15 years):
- Bontempi G, Terri M, Garbo S, Montaldo C, Mariotti D, Bordoni V, Valente S, Zwergel C, Mai A, Marchetti A, Domenici A, Menè P, Battistelli C, Tripodi M, Strippoli R."Restoration of WT1/miR-769-5p axis by HDAC1 inhibition promotes MMT reversal in mesenchymal-like mesothelial cells". Cell Death Dis. 2022, 13:965.
- Amicone L, Marchetti A, Cicchini C. Exosome-Associated circRNAs as Key Regulators of EMT in Cancer. Cells 2022 ; 11 : 1716
- Riccioni V, Trionfetti F, Montaldo C, Garbo S, Marocco F, Battistelli C, Marchetti A, Strippoli R, Amicone L, Cicchini C, Tripodi M. "SYNCRIP Modulates the Epithelial-Mesenchymal Transition in Hepatocytes and HCC Cells". Int J Mol Sci. 2022; 23:913.
- Noce V, Battistelli C, Cozzolino AM, Consalvi V, Cicchini C, Strippoli R, Tripodi M, Marchetti A and Amicone L "YAP integrates the regulatory Snail/HNF4α circuitry controlling epithelial/hepatocyte differentiation” Cell Death Disease, 2019; 10: 768
- Bisceglia F, Battistelli C, Noce V, Montaldo C, Zammataro A, Strippoli R, Tripodi M, Amicone L and Marchetti A “TGFβ impairs HNF1α functional activity in Epithelial-to-Mesenchymal Transition interfering with the recruitment of CBP/p300 acetyltransferases”, Front Pharmacol. 2019 July vol.10: 1-12 (article number 942)
- Stazi G, Battistelli C, Piano V, Mazzone R, Marrocco B, Marchese S, Louie SM, Zwergel C, Antonini L, Patsilinakos A, Ragno R, Viviano M, Sbardella G, Ciogli A, Fabrizi G, Cirilli R, Strippoli R, Marchetti A, Tripodi M, Nomura DK, Mattevi A, Mai A, and Valente S “Development of Alkyl Glycerone Phosphate Synthase Inhibitors: Structure Activity Relationship and Effects on Ether Lipids and Epithelial-Mesenchymal Transition in Cancer Cells” Eur J Med Chem 2018; 163: 722-735
- Amicone L, Marchetti A “Microenvironment and tumor cells: two targets for new molecular therapies of hepatocellular carcinoma. Transl Gastroenterol Hepatol 2018; 3:24.
- De Santis Puzzonia M, Cozzolino AM, Grassi G, Bisceglia F, Strippoli R, Guarguaglini G, Citarella F, Sacchetti B, Tripodi M, Marchetti A and Amicone L “TGFbeta induces binucleation/polyploidization in hepatocytes through a Src-dependent cytokinesis failure” PLoS ONE 11: e0167158 (2016)
- Strippoli R, Moreno-Vicente R, Battistelli C, Cicchini C, Noce V, Amicone L, Marchetti A, del Pozo MA, and Tripodi M “ Molecular mechanisms underlying peritoneal EMT and fibrosis” Stem Cells International , vol. 2016
- Cozzolino AM, Noce V, Battistelli C, Marchetti A, Grassi G, Cicchini C, Tripodi M and Amicone L “Modulating the substrate stiffness to manipulate differentiation of Resident Liver Stem Cells and to improve the differentiation state of hepatocytes” Stem Cells International, vol. 2016, Article ID 5481493, 12 pages, 2016.
- Marchetti A, Bisceglia F, Cozzolino AM, Tripodi M “New Tools for Molecular Therapy of Hepatocellular Carcinoma” Diseases 3: 325-340 (2015)
- Cicchini C, Amicone L, Alonzi T, Marchetti A, Mancone C and Tripodi M “Molecular mechanisms controlling the phenotype and the EMT/MET dynamics of hepatocyte” Liver Int. 35: 302-10 (2015)
- Marchetti A, Cicchini C, Santangelo L, Cozzolino AM, Costa V, Tripodi M and Amicone L. “Signaling networks controlling HCC onset and progression: influence of microenvironment and implications for cancer gene therapy” J. Cancer Ther. 4: 353-358
- Cozzolino AM, Alonzi T, Santangelo L, Mancone C, Conti B, Steindler C, Musone M, Cicchini C, Tripodi M and Marchetti A. “TGFβ overrides HNF4α tumor suppressing activity through GSK-3β inactivation: implication for hepatocellular carcinoma gene therapy” J. Hepatol. 58: 65-72 (2013)
- Garibaldi F, Cicchini C, Conigliaro A, Santangelo L, Cozzolino AM, Grassi G, Marchetti A, Tripodi M and Amicone L. “An epistatic mini-circuitry between the transcription factors Snail and HNF4α controls liver stem cell and hepatocyte features exhorting opposite regulation on stemness-inhibiting microRNAs” Cell Death Differ. 19: 937-946 (2012)
- Santangelo L, Marchetti A, Cicchini C, Conigliaro A, Conti B, Mancone C, Bonzo JA, Gonzalez FJ, Alonzi T, Amicone L, Tripodi M. “The stable repression of mesenchymal program is required for hepatocyte identity: a novel role for hepatocyte nuclear factor 4a” Hepatology 53: 2063-2074 (2011)
- Marchetti A, Colletti M, Cozzolino AM, Steindler C, Lunadei M, Mancone C, Tripodi M. “ERK5/MAPK is activated by TGFbeta in hepatocytes and required for the GSK-3beta-mediated Snail protein stabilization” Cell Signal 20: 2113-2118 (2008)
- Cicchini C., Filippini D., Coen S., Marchetti A., Cavallari C., Laudadio I., Spagnoli F.M., Alonzi T. and Tripodi M. "Snail controls differentiation of hepatocytes by repressing HNF4α expression” J. Cell. Physiol. 209: 230-238 (2006)
- Marchetti A., Cecchinelli B., D’Angelo M., D’Orazi G.,.Crescenzi M., Sacchi A., and Soddu S. “p53 can inhibit cell proliferation through caspase-mediated cleavage of ERK2/MAPK” Cell Death Differ. 11: 596-607 (2004)