GUIDO CARPINO

CV - 2025

Part I – General Information
Guido Carpino
E-mail guido.carpino@uniroma1.it
Spoken Languages Italian (native speaker), English

Part II – Education
2017 MUR Abilitazione Scientifica Nazionale a Professore Universitario di I Fascia (SC 05/H1 - ANATOMIA UMANA)
2014 MUR Abilitazione Scientifica Nazionale a Professore Universitario di II Fascia (SC 05/H1 - ANATOMIA UMANA)
2007 Doctoral Degree (Ph.D.) in Experimental and Clinical Hepatology, Sapienza University of Rome, Rome, Italy
2004 License to practice medicine, Sapienza University of Rome, Rome, Italy
2003 Master’s Degree in Medicine and Surgery (110/110 cum laude), Sapienza University of Rome, Rome, Italy
1997 High School graduation, Liceo Classico (60/60),Istituto San Giovanni Evangelista, Rome, Italy

Part III – Appointments
Academic Appointments
2024-Current: Full Professor in Human Anatomy. SSD BIOS-12/A – Anatomia Umana (ex BIO/16). Department of Anatomical, Histological, Forensic Medicine and Orthopedic Sciences. Sapienza University of Rome, Rome, Italy
2022-2024: Associate Professor in Human Anatomy. SSD BIOS-12/A – Anatomia Umana (ex BIO/16). Department of Anatomical, Histological, Forensic Medicine and Orthopedic Sciences. Sapienza University of Rome, Rome, Italy
2015-2022: Associate Professor in Human Anatomy (SSD BIO/16 – Anatomia Umana). Department of Motor, Human and Health Sciences, University of Rome “Foro Italico”, Rome, Italy.
2007 – 2015: Ricercatore a tempo indeterminato (RU) in Human Anatomy (SSD BIO/16 – Anatomia Umana). Department of Motor, Human and Health Sciences, University of Rome “Foro Italico”, Rome, Italy.
Jan 2007 – Sept 2007: Research Fellow. Department of Morphology and Molecular Pathology, Catholic University of Leuven, Belgium.
2003 – 2007: PhD student in Experimental and Clinical Hepatology. Sapienza University of Rome, Italy.Department of Human Anatomy. Sapienza University of Rome, Rome, Italy.
2002 – 2003: Graduate student and thesis internship. Department of Human Anatomy. Sapienza University of Rome, Rome, Italy.

Other Appointments
2025-present: Coordinator of the PhD Course in "Epato-Gastroenterologia Sperimentale e Clinica". Sapienza University of Rome, Rome, Italy
2024-present: Referente per la VQR 2020-2024, Department of Anatomical, Histological, Forensic Medicine and Orthopedic Sciences. Sapienza University of Rome, Rome, Italy
2023-present: Working Group Co-Leader and Management committee Member for Italy, COST Action Precision medicine in biliary tract cancer (CA22125)
2023-present: Componente del Nucleo di Valutazione dipartimentaleDepartment of Anatomical, Histological, Forensic Medicine and Orthopedic Sciences. Sapienza University of Rome, Rome, Italy
2022-present: Referente del Centro per la Dissezione in Anatomia Umana, Department of Anatomical, Histological, Forensic Medicine and Orthopedic Sciences. Sapienza University of Rome, Rome, Italy
2022- present: Steering Committee Member (elected), Collegio dei Docenti di Anatomia Umana
2022- present: Research Committee MemberItalian Society of Anatomy and Histology
2020- present: Steering Committee Member, STITCH: Sapienza Information-Based Technology InnovaTion Center for Health
2019- present: Member of the “Collegio dei Docenti“ of the PhD Course in "Epato-Gastroenterologia Sperimentale e Clinica"Sapienza University of Rome, Rome, Italy
2018-2024: Steering Committee Member, European Network for the Study of Cholangiocarcinoma (ENSCCA)
2019-2023: Working Group Leader and Management committee Member for Italy, COST Action Euro-Cholangionet (CA18122)
2015-2022: Academic Tutor for the Erasmus Plus Project for Corso di Laurea Triennale di Scienze Motorie e Sportive. University of Rome “Foro Italico”, Rome, Italy
2016-2022: Componente della Commissione per la consultazione con le organizzazioni rappresentative – a livello nazionale ed internazionale – della produzione di bene e servizi, delle professioni del CdCdLM68. University of Rome “Foro Italico”, Rome, Italy
2017-2018: Componente del Gruppo Qualità del CdCdLM67. University of Rome “Foro Italico”, Rome, Italy
2013–2015: Member of the Disciplinary Committee. Sapienza University of Rome, Rome, Italy

Part IV – Teaching experience
2022–present Sapienza University of Rome, Rome, Italy Anatomia Umana I (BIO/16, 1 CFU). Corso integrato di Anatomia Umana. Corso di Laurea Magistrale a ciclo unico in Medicina e Chirurgia "A" (abilitante all'esercizio della professione di Medico Chirurgo) - Roma Azienda Policlinico Umberto I (LM-41)
2022–present Sapienza University of Rome, Rome, Italy Anatomia Umana II (BIO/16, 1 CFU). Corso integrato di Anatomia Umana. Corso di Laurea Magistrale a ciclo unico in Medicina e chirurgia "A" (abilitante all'esercizio della professione di Medico Chirurgo) - Roma Azienda Policlinico Umberto I (LM-41)
2022–present Sapienza University of Rome, Rome, Italy Anatomia Umana III (BIO/16, 1 CFU). Corso integrato di Anatomia Umana. Corso di Laurea Magistrale a ciclo unico in Medicina e chirurgia "A" (abilitante all'esercizio della professione di Medico Chirurgo) - Roma Azienda Policlinico Umberto I (LM-41)
2022-present Sapienza University of Rome, Rome, Italy Anatomia Umana (BIO/16, 3 CFU). Corso Integrato di Anatomia e Fisiologia Generale. Corso di Laurea in Biotecnologie (L-2)
2022-present Sapienza University of Rome, Rome, Italy Anatomia umana (BIO/16, 3 CFU). Corso Integrato di Basi Morfologiche e Funzionali del Corpo Umano. Corso di Laurea in Tecniche di Laboratorio Biomedico (abilitante alla professione sanitaria di tecnico di laboratorio biomedico) - Sede di Roma Azienda Policlinico Umberto I (L/SNT3)
2022-present Sapienza University of Rome, Rome, Italy Anatomia umana (BIO/16, 3 CFU). Corso Integrato di Basi Anatomo-fisiologiche del Corpo Umano. Infermieristica (abilitante alla professione sanitaria di Infermiere) - Corso di Laurea A - Roma Azienda Policlinico Umberto I (L/SNT1)
2022-present Sapienza University of Rome, Rome, Italy Anatomia umana (BIO/16, 3 CFU). Corso Integrato di Fisiologia ed Anatomia. Corso di Laurea Magistrale in Biotecnologie Farmaceutiche (LM-9)
2022-present Sapienza University of Rome, Rome, Italy Istologia e Fisiologia Umana (BIO/17, 1 CFU - BIO/09, 2 CFU). Corso Integrato di Basi Morfologiche e Funzionali del Corpo Umano. Corso di Laurea in Tecniche di Fisiopatologia Cardiocircolatoria e Perfusione Cardiovascolare (abilitante alla professione sanitaria di tecnico di fisiopatologia cardiocircolatoria e perfusione cardiovascolare) - Sede di Roma Azienda Policlinico Umberto I (L/SNT3)
2022–present Sapienza University of Rome, Rome, Italy Organizzazione e supervisione di attività didattica dissettiva per studenti del Corso di Laurea Magistrale a ciclo unico in Medicina e Chirurgia e delle Scuole di Specializzazione in area medica
2022–present Sapienza University of Rome, Rome, Italy Anatomia Umana. Scuola di Specializzazione in Ortopedia e Traumatologia
2022–present Sapienza University of Rome, Rome, Italy Anatomia Umana. Scuola di Specializzazione in Medicina dello Sport
2019- present Sapienza University of Rome, Rome, Italy Seminari nell’ambito del Corso di Dottorato in "Epato-Gastroenterologia Sperimentale e Clinica"
2022-2024 Sapienza University of Rome, Rome, Italy Anatomia Umana (BIO/16, 3 CFU). Corso di Laurea in Scienze Farmaceutiche Applicate (L-29)
2014-2022 University of Rome, “Foro Italico”, Rome, Italy Anatomia Applicata (BIO/16). Corso di Laurea Triennale di Scienze Motorie e Sportive (L22-02)
2012-2022 University of Rome, “Foro Italico”, Rome, Italy Anatomia Umana (BIO/16, 3 CFU). Corso integrato di Posturologia, Traumatologia e Rieducazione. Corso di Laurea Magistrale in Attività Motorie Preventive e Adattate (LM-67)
2012-2022 University of Rome, “Foro Italico”, Rome, Italy Anatomia Umana (BIO/16, 3 CFU). Corso integrato di Anatomia Funzionale e Traumatologia dello sport. Corso di Laurea Magistrale in Scienze e Tecniche dello Sport (LM-68)
2008-2022 University of Rome, “Foro Italico”, Rome, Italy Anatomia Umana applicata all’attività motorie ed antropometria (BIO/16, 12 CFU). Corso di Laurea Triennale di Scienze Motorie e Sportive (L-22)
2017-2021 Sapienza University of Rome, Rome, Italy Insegnamento su “Anatomia e fisiologia del sistema venoso” in Master di I livello in “Accessi vascolari: management ed impianti in ambito ospedaliero e domiciliare”

Part V - Society memberships, Awards and Honors

Society memberships
2023–present COST Action Precision medicine in biliary tract cancer (CA22125)
2017–present Collegio dei Docenti di Anatomia Umana
2016–present European Network for the Study of Cholangiocarcinoma (ENS-CCA)
2007–present Società Italiana di Anatomia e Istologia (SIAI)
2019–2023 COST Action Euro-Cholangionet (CA18122)
2011 Associazione Italiana per lo Studio del Fegato (AISF)

Participation to Expert Committees or Consortia
2024 EASL Clinical Practice Guidelines for Extrahepatic Cholangiocarcinoma.
2021 HPB – Organoid Consortium
2020 Italian Clinical Practice Guidelines for Cholangiocarcinoma.
2018 The Cancer Genome Atlas (TGCA) research network

Awards and Honors
2014 Distinguished PhD for the Solemn Ceremony for the 30th year of Doctorate at Sapienza University.
2013 Best Under 40 Researcher Award received from Italian Society of Anatomy and Histology.
2010 Best oral communication – Monothematic Conference: “The Pathologies of the Intra and Extra-Hepatic Biliary Tree” di A.I.S.F. Italian Association for the Study of the Liver.
2010 Best oral communication – XI meeting of Italian Societies of Gastroenterology and Endoscopy, Rome, Italy

Editorial board membership
2024-present Gastroenterology Report Editorial Board
2021–present Frontiers in Medicine Review editor
2022 Frontiers in Cell and Developmental Biology Topic Editor for a special issue
2020 Cells Guest Editor for a special issue
Present Reviewer for several scientific journal such as Gastroenterology, Journal of Hepatology, Hepatology, Liver International, Gut, Antioxidants & Redox Signaling, PlOS One, Digestive and Liver Diseases. Reviewer

Part VII – Research Activities

Research Activities
- Characterization of hepatic stem/progenitor cells (HpSCs) and their niche in liver diseases and in cholangiopathies
- Identification of a niche of stem/progenitor cells within the biliary tree.
- Characterization of anatomical and histological subtypes of cholangiocarcinoma and their relationship with duct of origin.

Patents
2019 Stem/progenitor cells from duodenal brunner's glands and methods of isolating and using them. US patent application 20190300849
2018 Cryopreservation method. US patent application. 20180295834
2014 Method of treating pancreatic and liver conditions by endoscopic-mediated (or laparoscopic-mediated) transplantation of stem cells into/onto bile duct walls of particular regions of the biliary tree. Patent #20140301985.
2011 Multipotent Stem Cells from the Extrahepatic Biliary Tree and Methods of Isolating Same. Patent #20110135610.

Research experience in International Research Institutions
2017 Visiting researcher (25/6/17-1/7/2017), Department of Cell Biology and Physiology. University of North Carolina at Chapel Hill, Chapel Hill, NC, USA (Prof. Lola Reid).
2007 Research Fellow (07/1/07-31/8/2007), Department of Morphology and Molecular Pathology, (Prof. Tania Roskams), Katholieke Universiteit Leuven (KU Leuven), Belgio.

Summary of Scientific Achievements
Research output was calculated based on Scopus database. Impact factor was obtained from Journal Citation Reports (JCR) – Clarivate based on the year of publication of each paper. Latest JCR update: 2023.

Bibliometric Indexes – Past 10 years (2014-2024)
Total Publications: 134
Total Impact factor (IF): 1449.8
Average IF: 10.81
Total IF as prominent author*: 292.5 (n=36)
Average IF as first/co-first author: 8.124
Total Citations: 25719
Average Citations per Product: 190
Hirsch (H) index: 54
*first, last, corresponding author

Bibliometric Indexes – Career (2004-2025)
Papers: 194 (Scopus)
Total Impact Factor: 1713.1
H-Index: 66 (Scopus)
Total Citations: 31767 (Scopus)

Part IX–Publications

List of the selected publications (n= 10)

1. Cardinale V, Carpino G*, Overi D, Safarikia S, Zhang W, Kanke M, Franchitto A, Costantini D, Riccioni O, Nevi L, Chiappetta M, Onori P, Franchitto M, Bini S, Hung YH, Lai Q, Zizzari I, Nuti M, Nicoletti C, Checquolo S, Di Magno L, Giuli MV, Rossi M, Sethupathy P, Reid LM, Alvaro D, Gaudio E. *corresponding author and co-first author.
Human duodenal submucosal glands contain a defined stem/progenitor subpopulation with liver-specific regenerative potential.
Journal of Hepatology. 2023 Jan;78(1):165-179.

2. Calvisi DF, Boulter L, Vaquero J, Saborowski A, Fabris L, Rodrigues PM, Coulouarn C, Castro RE, Segatto O, Raggi C, van der Laan LJW, Carpino G, Goeppert B, Roessler S, Kendall TJ, Evert M, Gonzalez-Sanchez E, Valle JW, Vogel A, Bridgewater J, Borad MJ, Gores GJ, Roberts LR, Marin JJG, Andersen JB, Alvaro D, Forner A, Banales JM, Cardinale V, Macias RIR, Vicent S, Chen X, Braconi C, Verstegen MMA, Fouassier L; CCA Model Consortium.
Criteria for preclinical models of cholangiocarcinoma: scientific and medical relevance.
Nat Rev Gastroenterol Hepatol. 2023 Jul;20(7):462-480.

3. Macias RIR, Cardinale V, Kendall TJ, Avila MA, Guido M, Coulouarn C, Braconi C, Frampton AE, Bridgewater J, Overi D, Pereira SP, Rengo M, Kather JN, Lamarca A, Pedica F, Forner A, Valle JW, Gaudio E, Alvaro D, Banales JM, Carpino G.
Clinical relevance of biomarkers in cholangiocarcinoma: critical revision and future directions.
Gut. 2022 Aug;71(8):1669-1683.

4. Carpino G, Cardinale V, Di Giamberardino A, Overi D, Donsante S, Colasanti T, Amato G, Mennini G, Franchitto M, Conti F, Rossi M, Riminucci M, Gaudio E, Alvaro D, Mancone C.
Thrombospondin 1 and 2 along with PEDF inhibit angiogenesis and promote lymphangiogenesis in intrahepatic cholangiocarcinoma.
Journal of Hepatology. 2021 Dec;75(6):1377-1386.

5. Carpino G, Del Ben M, Pastori D, Carnevale R, Baratta F, Overi D, Francis H, Cardinale V, Onori P, Safarikia S, Cammisotto V, Alvaro D, Svegliati-Baroni G, Angelico F, Gaudio E, Violi F.
Increased liver localization of lipopolysaccharides in human and experimental non-alcoholic fatty liver disease.
Hepatology. 2020 Aug 72(2):470-485.

6. Banales JM, Marin JJG, Lamarca A, Rodrigues PM, Khan SA, Roberts LR, Cardinale V, Carpino G, Andersen JB, Braconi C, Calvisi DF, Perugorria MJ, Fabris L, Boulter L, Macias RIR, Gaudio E, Alvaro D, Gradilone SA, Strazzabosco M, Marzioni M, Coulouarn C, Fouassier L, Raggi C, Invernizzi P, Mertens JC, Moncsek A, Ilyas SI, Heimbach J, Koerkamp BG, Bruix J, Forner A, Bridgewater J, Valle JW, Gores GJ.
Cholangiocarcinoma 2020: the next horizon in mechanisms and management.
Nat Rev Gastroenterol Hepatol. 2020 Sep;17(9):557-588.

7. Carpino G, Nevi L, Overi D, Cardinale V, Lu WY, Di Matteo S, Safarikia S, Berloco PB, Venere R, Onori P, Franchitto A, Forbes SJ, Alvaro D, Gaudio E.
Peribiliary gland niche participates in biliary tree regeneration in mouse and in human primary sclerosing cholangitis.
Hepatology. 2020 Mar;71(3):972-989. 43

8. Carpino G, Cardinale V, Folseraas T, Overi D, Grzyb K, Costantini D, Berloco PB, Di Matteo S, Karlsen TH, Alvaro D, Gaudio E.
Neoplastic transformation of peribiliary stem cell niche in cholangiocarcinoma arisen in primary sclerosing cholangitis.
Hepatology. 2019 Feb;69(2):622-638.

9. Banales JM, Cardinale V, Carpino G, Marzioni M, Andersen JB, Invernizzi P, Lind GE, Folseraas T, Forbes SJ, Fouassier L, Geier A, Calvisi DF, Mertens JC, Trauner M, Benedetti A, Maroni L, Vaquero J, Macias RI, Raggi C, Perugorria MJ, Gaudio E, Boberg KM, Marin JJ, Alvaro D.
Expert consensus document: Cholangiocarcinoma: current knowledge and future perspectives consensus statement from the European Network for the Study of Cholangiocarcinoma (ENS-CCA).
Nat Rev Gastroenterol Hepatol. 2016 May;13(5):261-80.

10. Carpino G, Cardinale V, Renzi A, Hov JR, Berloco PB, Rossi M, Karlsen TH, Alvaro D, Gaudio E.
Activation of biliary tree stem cells within peribiliary glands in primary sclerosing cholangitis
J Hepatol. 2015 Nov;63(5):1220-8.