Curriculum
Mattia La Torre
Curriculum Vitae
Part I – General Information
Full Name Mattia La Torre
E-mail mattia.latorre@uniroma1.it, mattia.latorre@pec.it
Spoken Languages Italian (native), English (fluent)
Part II – Education and training
Postdoctoral training 2019 CNR - Istituto di Genetica Molecolare Luigi Luca Cavalli-Sforza (IGM-CNR Bologna Unit) Postdoctoral training and collaboration at the Istituto di Genetica Molecolare Luigi Luca Cavalli-Sforza (IGM-CNR Bologna Unit). Tutor Dr Cristina Capanni. Head of the Unit Dr Giovanna Lattanzi. Training and collaboration coordinator Professor Isabella Saggio.
PhD 2016 PhD in Pasteurian Sciences / Life Sciences PhD, classification: excellent. Supervisor: Professor Isabella Saggio. Project: Production and characterization of a mouse line knock-out for Ft1, a lamin interacting protein involved in telomere metabolism.
2014 Scuola Romana di fotografia Assigned with a scholarship for the photography course from Scuola Romana di Fotografia
Master degree 2012 Sapienza University of Rome, Rome (Italy) Master degree summa cum laude (110 e lode/110). Thesis title: "Production of a mouse line knock-out for Ft1 gene, a lamin interactor with effect on telomere metabolism". Thesis project coordinator: Professor Isabella Saggio, Department of Biology and Biotechnologies "Charles Darwin", Sapienza University of Rome
Student training 2011-2012 Sapienza University of Rome, Rome (Italy) Student training, Department of Biology and Biotechnologies "Charles Darwin", Sapienza University of Rome. Training coordinator Professor Isabella Saggio
University graduation 2010 University of Pisa, Pisa (Italy) Bachelor degree summa cum laude (110 e lode/110). Thesis title: "Modulation of Cytochromes P450 4A and 2E in organs of control and fed with high-fat diet pigs". Thesis project coordinators: Dr Vincenzo Longo, Institute of Biology and Agrarian Biotechnology, CNR; Professor Marcella Camici, University of Pisa
Student training 2010 University of Pisa, Pisa (Italy) Student training, Institute of Biology and Agrarian Biotechnology, CNR, Pisa. Training coordinator Dr. Vincenzo Longo
High school graduation 2007 Liceo Scientifico Statale “Amantea” High school graduation 100/100
Part III – Appointments
IIIA – Academic Appointments
2023 ongoing Dept. of Biology and Biotechnology "Charles Darwin", Sapienza University of Rome (Italy) RTD-A. Supervisor: Professor Isabella Saggio. Project: CN5-PNRR
2022 2023 Dept. of Biology and Biotechnology "Charles Darwin", Sapienza University of Rome (Italy) Postdoctoral Fellow. Supervisor: Professor Isabella Saggio. Project: Telomere Biology Disorders and Nuclear Boundaries
2021 2022 Dept. of Biology and Biotechnology "Charles Darwin", Sapienza University of Rome (Italy) Postdoctoral Fellow. Assigned with a research fellowship from Sapienza BeForERC. Project: When Borders Lose integrity: study of the impact of Nuclear Envelope and Telomere fragility in lymphomagenesis (BLiNET)
2020 2020 Dept. of Biology and Biotechnology "Charles Darwin", Sapienza University of Rome (Italy) Postdoctoral Fellow. Supervisor: Professor Isabella Saggio. Project: AKTIP in envelopathies and cancer
2019 2020 Dept. of Biology and Biotechnology "Charles Darwin", Sapienza University of Rome (Italy) Postdoctoral Fellow. Assigned with a research fellowship from FIRC – Fondazione Italiana per la Ricerca sul Cancro – AIRC. Supervisor: Professor Isabella Saggio. Project: Nuclear envelope organization and genome instability in cancer diffusion
2019 2019 Dept. of Biology and Biotechnology "Charles Darwin", Sapienza University of Rome (Italy) Postdoctoral Fellow. Assigned with a scholarship from Fondazione Adriano Buzzati-Traverso. Supervisor: Professor Isabella Saggio. Project: Biology and pharmacology of DNA replication stress upstream and downstream pathways in HGPS
2018 2018 Dept. of Biology and Biotechnology "Charles Darwin", Sapienza University of Rome (Italy) Postdoctoral Fellow. Supervisor: Professor Isabella Saggio, funds holder (Progeria Foundation). Project: Analysis of the biochemical and functional role of the telomeric accessory protein AKTIP/Ft1
2017 2018 Institute of Molecular Biology and Pathology (IBPM) - National Research Council (CNR) and at the Dept. of Biology and Biotechnology "Charles Darwin", Sapienza University of Rome (Italia) Postdoctoral Fellow. Supervisors: Professor Isabella Saggio, Professor Maurizio Gatti, funds holder (AIRC). Project: In vivo study of the protein AKTIP/Ft1 (SSD BIO/11 – Biologia Molecolare updated to BIOS-08/A)
2016 2017 Nanyang Technological University, Singapore (Singapore) Visiting Fellow in the laboratory directed by Professor Daniela Rhodes at the Institute of Structural Biology, Nanyang Technological University, Singapore. Project: Analysis of the biochemical properties of the telomeric accessory protein AKTIP/Ft1
2016 2017 Dept. of Biology and Biotechnology "Charles Darwin", Sapienza University of Rome (Italy) Postdoctoral Fellow. Supervisor: Professor Isabella Saggio, funds holder (Telethon). Project: Analysis of genes involved in DNA metabolism
2015 2015 Dept. of Biology and Biotechnology "Charles Darwin", Sapienza University of Rome (Italy) Research Fellow. Assigned with a scholarship from Fondazione Adriano Buzzati-Traverso. Supervisor: Professor Isabella Saggio. Scholarship n. 772
2015 2015 Nanyang Technological University, Singapore (Singapore) Visiting Graduate Student in the laboratory directed by Professor Daniela Rhodes at the Institute of Structural Biology, Nanyang Technological University, Singapore. Supervisors: Professor Isabella Saggio and Professor Daniela Rhodes. Project: Interaction of AKTIP with binding partners
IIIB – Other Appointments
2022 Ongoing National Research Council (CNR)-Eligible in the ranking for a Level III Researcher position (Call Code 367.226 – Prot. AMMCEN n. 0012732/2022
2022 2022 Dept. of Biology and Biotechnology "Charles Darwin", Sapienza University of Rome (Italy) Lecturer for the Sapienza University Master "La Scienza nella Pratica Giornalistica": Fundamental elements for an informative website
2020 2021 Dept. of Biology and Biotechnology "Charles Darwin", Sapienza University of Rome (Italy) Collaboration for didactic laboratory for master’s degree course "Stem cells and genome editing (u-stem). In memoriam of Paolo Bianco"
Part IV – Teaching and tutoring experiences
2025 PhD school in Genetics and Molecular Biology, Sapienza University of Rome Course: 2D and 3D Image post production and video animation
2025 Dept. of Matematica Guido Castelnuovo, Sapienza University of Rome (Italy) Teaching, student supervision and educational project organization for master’s degree course "Science communication" Sapienza University of Rome
2025 Dept. of Biology and Biotechnologies "Charles Darwin", Sapienza University of Rome (Italy) Member of the Sapienza University master’s degree Thesis commission "La Scienza nella Pratica Giornalistica" (academic year 2024/2025)
2024 PhD school in Genetics and Molecular Biology, Sapienza University of Rome 2D and 3D Image post production and video animation
2024 Superior School of Advanced Studies, Sapienza University of Rome (Italy) – National Biodiversity Future Center (NBFC) Support in the educational programme of One Health master’s degree course
2023 Dept. of Biology and Biotechnologies "Charles Darwin", Sapienza University of Rome (Italy) Member of the master’s degree thesis commission "La Scienza nella Pratica Giornalistica" (academic year 2022/2023)
2022 Dept. of Biology and Biotechnologies "Charles Darwin", Sapienza University of Rome (Italy) Member of the master’s degree thesis commission "La Scienza nella Pratica Giornalistica" (academic year 2021/2022)
2022 Dept. of Biology and Biotechnologies "Charles Darwin", Sapienza University of Rome (Italy) Lecturer for the master’s degree "La Scienza nella Pratica Giornalistica": Fundamental elements for an informative website
2021 Dept. of Biology and Biotechnologies "Charles Darwin", Sapienza University of Rome (Italy) Member of the master’s degree thesis commission "La Scienza nella Pratica Giornalistica" (academic year 2020/2021)
2021-ongoing Dept. of Scienze Anatomiche, Istologiche, Medico-legali e dell'Apparato Locomotore, Sapienza University of Rome (Italy) Teaching, student supervision and educational project organization for master’s degree course "Communication, science and medicine"
2018-2021 Dept. of Biology and Biotechnologies "Charles Darwin", Sapienza University of Rome (Italy) Seminars on 'Crispr applications', teaching, student supervision and educational project organization for the master’s degree "Stem cells and genome editing (u-stem). In memoriam of Paolo Bianco"
2018-2020 Dept. of Biology and Biotechnologies "Charles Darwin", Sapienza University of Rome (Italy) Seminars on 'Crispr applications', teaching, student supervision and educational project organization of the master’s degree courses "Gene Therapy", "Stem cell biology and applications", "Gene therapy and neuroscience"
2016 – ongoing Dept. of Biology and Biotechnologies "Charles Darwin", Sapienza University of Rome (Italy) Supervisor of students in their PhD projects >10, PI Professor Isabella Saggio
2014-2025 Dept. of Biology and Biotechnologies "Charles Darwin", Sapienza University of Rome (Italy) Teaching, student supervision and educational project organization of the master’s degree course "La Scienza nella Pratica Giornalistica". Director: Isabella Saggio
2014-2023 Dept. of Biology and Biotechnologies "Charles Darwin", Sapienza University of Rome (Italy) Student supervision and educational project organization of the master’s degree course "Gene Therapy"
2012 – ongoing Dept. of Biology and Biotechnology "Charles Darwin", Sapienza University of Rome (Italy) Supervisor of students in their undergraduate projects >10, PI Professor Isabella Saggio
2009-2010 USID studentship, University of Pisa, Pisa (Italy) Scholarship for educational and academic support and tutoring for a person with a physical disability, University of Pisa
date Examination report n Teaching Activity
15/12/2023 866987 Member of the examination committee for the courses: “Gene Therapy” (6 CFU), Master’s Degree in Genetics and Molecular Biology [code: 28700, class: LM-6], Sapienza University of Rome; “Le nuove frontiere della biomedicina nella genetica e nelle neuroscienze” (6 CFU), Master’s Degree in Neurobiology [code: 14560, ordinance 2010 and code: 28701, ordinance 2017, class: LM-6], Sapienza University of Rome; “Terapia genica e neuroscienze” (6 CFU), Master’s Degree in Neurobiology [code: 28701, class: LM-6], Sapienza University of Rome.
08/02/2024 866988, 894945 Member of the examination committee for the courses: “Gene Therapy” (6 CFU), Master’s Degree in Genetics and Molecular Biology [code: 28700, class: LM-6], Sapienza University of Rome; “Le nuove frontiere della biomedicina nella genetica e nelle neuroscienze” (6 CFU), Master’s Degree in Neurobiology [code: 14560, ordinance 2010 and code: 28701, ordinance 2017, class: LM-6], Sapienza University of Rome; “Terapia genica e neuroscienze” (6 CFU), Master’s Degree in Neurobiology [code: 28701, class: LM-6], Sapienza University of Rome.
23/02/2024 894946, 894947 Member of the examination committee for the courses: “Gene Therapy” (6 CFU), Master’s Degree in Genetics and Molecular Biology [code: 28700, class: LM-6], Sapienza University of Rome; “Le nuove frontiere della biomedicina nella genetica e nelle neuroscienze” (6 CFU), Master’s Degree in Neurobiology [code: 14560, ordinance 2010 and code: 28701, ordinance 2017, class: LM-6], Sapienza University of Rome; “Terapia genica e neuroscienze” (6 CFU), Master’s Degree in Neurobiology [code: 28701, class: LM-6], Sapienza University of Rome.
14/06/2024 894951, 894948 Member of the examination committee for the courses: “Gene Therapy” (6 CFU), Master’s Degree in Genetics and Molecular Biology [code: 28700, class: LM-6], Sapienza University of Rome; “Le nuove frontiere della biomedicina nella genetica e nelle neuroscienze” (6 CFU), Master’s Degree in Neurobiology [code: 14560, ordinance 2010 and code: 28701, ordinance 2017, class: LM-6], Sapienza University of Rome; “Terapia genica e neuroscienze” (6 CFU), Master’s Degree in Neurobiology [code: 28701, class: LM-6], Sapienza University of Rome.
12/07/2024 894953, 894952 Member of the examination committee for the courses: “Gene Therapy” (6 CFU), Master’s Degree in Genetics and Molecular Biology [code: 28700, class: LM-6], Sapienza University of Rome; “Le nuove frontiere della biomedicina nella genetica e nelle neuroscienze” (6 CFU), Master’s Degree in Neurobiology [code: 14560, ordinance 2010 and code: 28701, ordinance 2017, class: LM-6], Sapienza University of Rome; “Terapia genica e neuroscienze” (6 CFU), Master’s Degree in Neurobiology [code: 28701, class: LM-6], Sapienza University of Rome.
22/09/2024 894955 Member of the examination committee for the courses: “Gene Therapy” (6 CFU), Master’s Degree in Genetics and Molecular Biology [code: 28700, class: LM-6], Sapienza University of Rome; “Le nuove frontiere della biomedicina nella genetica e nelle neuroscienze” (6 CFU), Master’s Degree in Neurobiology [code: 14560, ordinance 2010 and code: 28701, ordinance 2017, class: LM-6], Sapienza University of Rome; “Terapia genica e neuroscienze” (6 CFU), Master’s Degree in Neurobiology [code: 28701, class: LM-6], Sapienza University of Rome.
17/12/2024 935554 Member of the examination committee for the courses: “Gene Therapy” (6 CFU), Master’s Degree in Genetics and Molecular Biology [code: 28700, class: LM-6], Sapienza University of Rome; “Le nuove frontiere della biomedicina nella genetica e nelle neuroscienze” (6 CFU), Master’s Degree in Neurobiology [code: 14560, ordinance 2010 and code: 28701, ordinance 2017, class: LM-6], Sapienza University of Rome; “Terapia genica e neuroscienze” (6 CFU), Master’s Degree in Neurobiology [code: 28701, class: LM-6], Sapienza University of Rome.
20/01/2025 935556 Member of the examination committee for the courses: “Gene Therapy” (6 CFU), Master’s Degree in Genetics and Molecular Biology [code: 28700, class: LM-6], Sapienza University of Rome; “Le nuove frontiere della biomedicina nella genetica e nelle neuroscienze” (6 CFU), Master’s Degree in Neurobiology [code: 14560, ordinance 2010 and code: 28701, ordinance 2017, class: LM-6], Sapienza University of Rome; “Terapia genica e neuroscienze” (6 CFU), Master’s Degree in Neurobiology [code: 28701, class: LM-6], Sapienza University of Rome.
12/02/2025 935557, 935558 Member of the examination committee for the courses: “Gene Therapy” (6 CFU), Master’s Degree in Genetics and Molecular Biology [code: 28700, class: LM-6], Sapienza University of Rome; “Le nuove frontiere della biomedicina nella genetica e nelle neuroscienze” (6 CFU), Master’s Degree in Neurobiology [code: 14560, ordinance 2010 and code: 28701, ordinance 2017, class: LM-6], Sapienza University of Rome; “Terapia genica e neuroscienze” (6 CFU), Master’s Degree in Neurobiology [code: 28701, class: LM-6], Sapienza University of Rome.
25/02/2025 935559, 935560 Member of the examination committee for the courses: “Gene Therapy” (6 CFU), Master’s Degree in Genetics and Molecular Biology [code: 28700, class: LM-6], Sapienza University of Rome; “Le nuove frontiere della biomedicina nella genetica e nelle neuroscienze” (6 CFU), Master’s Degree in Neurobiology [code: 14560, ordinance 2010 and code: 28701, ordinance 2017, class: LM-6], Sapienza University of Rome; “Terapia genica e neuroscienze” (6 CFU), Master’s Degree in Neurobiology [code: 28701, class: LM-6], Sapienza University of Rome.
22/04/2025 935562, 935561 Member of the examination committee for the courses: “Gene Therapy” (6 CFU), Master’s Degree in Genetics and Molecular Biology [code: 28700, class: LM-6], Sapienza University of Rome; “Le nuove frontiere della biomedicina nella genetica e nelle neuroscienze” (6 CFU), Master’s Degree in Neurobiology [code: 14560, ordinance 2010 and code: 28701, ordinance 2017, class: LM-6], Sapienza University of Rome; “Terapia genica e neuroscienze” (6 CFU), Master’s Degree in Neurobiology [code: 28701, class: LM-6], Sapienza University of Rome.
20/05/2025 985985 Member of the examination committee for the course: “Comunicazione Scientifica” (Scientific Communication), 3 CFU, Master’s Degree in Mathematical Sciences for Artificial Intelligence [code: 31778, class: L-35], Sapienza University of Rome
26/06/2025 935563 Member of the examination committee for the courses: “Comunicazione Scientifica” (Scientific Communication), 3 CFU, Master’s Degree in Mathematical Sciences for Artificial Intelligence [code: 31778, class: L-35], Sapienza University of Rome; “Gene Therapy” (6 CFU), Master’s Degree in Genetics and Molecular Biology [code: 28700, class: LM-6], Sapienza University of Rome; “Le nuove frontiere della biomedicina nella genetica e nelle neuroscienze” (6 CFU), Master’s Degree in Neurobiology [code: 14560, ordinance 2010 and code: 28701, ordinance 2017, class: LM-6], Sapienza University of Rome; “Terapia genica e neuroscienze” (6 CFU), Master’s Degree in Neurobiology [code: 28701, class: LM-6], Sapienza University of Rome.
Part V - Society memberships, Awards and Honors
2021 Awarded with a research fellowship from SapiExcellence BeForERC with BLiNET project. Dept. of Biology and Biotechnology "Charles Darwin", Sapienza University of Rome (Italy) Supervisor: Professor Isabella Saggio. Project: BLiNET When Borders Lose integrity: study of the impact of Nuclear Envelope and telomere fragility in lymphomagenesis
2019 Awarded with a research fellowship from FIRC – Fondazione Italiana per la Ricerca sul Cancro – AIRC. Supervisor: Professor Isabella Saggio. Project: Nuclear envelope organization and genome instability in cancer diffusion. Dept. of Biology and Biotechnology "Charles Darwin", Sapienza University of Rome (Italy)
2019 Awarded with a research fellowship from Fondazione Adriano Buzzati-Traverso. Supervisor: Professor Isabella Saggio. Project: Biology and pharmacology of DNA replication stress upstream and downstream pathways in HGPS. Dept. of Biology and Biotechnology "Charles Darwin", Sapienza University of Rome (Italy)
2019-ongoing Member of the Council of the Dept. of Biology and Biotechnology "Charles Darwin", Sapienza University of Rome (Italy)
2018 Awarded with a fellowship for training activities in national or foreign laboratories from Consorzio Interuniversitario Biotecnologie (CIB)
2018-ongoing Member of the AGI (Associazione Genetica Italiana)
2014 Awarded with a fellowship for participation in the EMBO Conference – Telomeres, telomerase and disease", Bruxelles, April 30 - May 4 2014, from Consorzio Interuniversitario Biotecnologie (CIB)
2012 Awarded with a scholar fellowship from The John R. Mott Scholarship Foundation
2010 Awarded with a scholar fellowship from Sapienza University of Rome, "Wanted the Best 2010/11"
Part VI - Funding Information [grants as PI-principal investigator or I-investigator]
2022 Modulating Nuclear Envelope stability as an anti-cancer strategy I-Progetti di Ricerca (Piccoli, Medi) - Progetti Piccoli, Sapienza University of Rome (Italy) 3000€
2022 Role of DNA damage, inflammation in the ageing heart PI-Progetti per Avvio alla Ricerca - Tipo 2, Sapienza University of Rome (Italy) 2800€
2021 BliNeT-When Borders Lose integrity: study of the impact of Nuclear Envelope and Telomere fragility in lymphomagenesis PI-Sapienza SapiExcellence BeForERC, Sapienza University of Rome 50000€
2021 L'etica della sperimentazione animale nella pratica. Percezione del beneficio, trasparenza e comunicazione. I- Progetti di Ricerca (Piccoli, Medi) - Progetti Medi, Sapienza University of Rome (Italy) 11400€
2021 Telomere Biology Disorders and Nuclear Boundaries: focus on the role of the ESCRT machinery PI-Progetti per Avvio alla Ricerca - Tipo 2, Sapienza University of Rome (Italy) 3200€
2019 Control of nuclear fragility PI-Progetti per Avvio alla Ricerca - Tipo 2, Sapienza University of Rome (Italy) 2400€
2016 Analysis of the hematopoietic and stromal BM subsets in mouse models of premature aging PI-Progetti per Avvio alla Ricerca - Tipo 2, Sapienza University of Rome (Italy) 2800€
Part VII – Research Activities
M. La Torre contributed to identifying a new human telomere-associated factor linked with the nuclear envelope. M. La Torre contributed to the genetics dissection of its roles in telomere and genome stability maintenance (Burla et al. Plos Genetics 2015; Burla et al. Open Biology 2016; Merigliano, Burla et al. Plos genetics 2021; La Torre, Merigliano, J Exp Clin Cancer Res 2022). M. La Torre also contributed to the dissection of the ESCRTI AKTIP human protein role in the biology of cancer and aging by producing and characterizing the first animal model with its reduced gene expression (La Torre et al. Aging cell 2018). Currently, M. La Torre is involved in projects that aim to unravel the link between telomeres and the nuclear factors acting at the nuclear envelope in the context of cancer and aging (PI Isabella Saggio).
During her PhD and her postdoctoral experience in the laboratory of Professor Isabella Saggio, M. La Torre used molecular biology and genetic tools (included vectors for gene transfer and gene silencing) for the dissection of the role of genes involved in genome stability (Burla et al. Plos Genetics 2015; Burla et al. Open Biology 2016; Merigliano, Burla et al. Plos genetics 2021; La Torre, Merigliano, J Exp Clin Cancer Res 2022) and in cellular models of inherited diseases to find new possible therapeutic targets (Raimondo et al. Plos one 2020, Piersanti et al. Plos One, 2015, La Torre, Merigliano, J Exp Clin Cancer Res 2022). M. La Torre contributed to the analysis of the role of vitamin B6 in a D. melanogaster model of type 2 diabetes and its role in genome stability (Merigliano et al. Scientific reports 2018). M. La Torre contributed to the study of the genetic and molecular basis of the human Fibrous dysplasia of bone disease caused by dominant activating gene mutations of the GNAS locus (Raimondo et al. Plos one 2020). M. La Torre also contributed to studying the role of telomeres and DNA damage in a mouse model of premature aging (La Torre et al. Aging cell 2018) and the specific contribution of DNA damage and genome stability in the hypertrophic heart (La Torre et al., Aging cell 2023).
Part VIII – Summary of Scientific Achievements
Papers [international] 16 Scopus 2015 2025
Publications [science communication] 36 Google – STAR ISSN 2785-5058 2021 2025
Publications [photography] 48 Google 2017 2020
Total publications 2015-2025 14
Total Impact factor 2015-2025 82.174
Total Citations 2015-2025 269
Average Citations per Product 16.4
Average Impact factor per Product 5.13
Total Hirsch (H) index 11
Normalized H index* 1.1
Normalized H index** 0.8
*H index divided by the academic seniority (from the first published paper)
** H index divided by the academic seniority (from Master Degree)
Total Impact and Average Citations per Product have been calculated in relation to the year of publication
National scientific qualification (ASN)
Hirsch (H) index last 10 years 11 above the threshold 05/F1 - BIOLOGIA APPLICATA, 8
publications last 5 years 8 equal to the threshold 05/F1 - BIOLOGIA APPLICATA, 8
citations last 10 years 282 below to the threshold 05/F1 - BIOLOGIA APPLICATA, 307
Part IX– Publications*
1 Edison Di Pietro, Romina Burla, Mattia La Torre, Mary-Paz González-García, Raffaele Dello Ioio, Isabella Saggio, Telomeres: an organized string linking plants and mammals, Biology Direct, 19:119, (2024). https://doi.org/10.1186/s13062-024-00558-y 2024 5.7 1
2 *Mattia La Torre, Romina Burla, Isabella Saggio, Preserving Genome Integrity: Unveiling the Roles of ESCRT Machinery, Cells, 13(15), 1307. https://doi.org/10.3390/cells13151307 2024 5.1 2
3 *Mattia La Torre, Eleonora Centofante, Carmine Nicoletti, Romina Burla, Alessandro Giampietro, Federica Cannistrà, Leonardo Schirone, Valentina Valenti, Sebastiano Sciarretta, Antonio Musarò, Isabella Saggio, Impact of diffused versus vasculature targeted DNA damage on the heart of mice depleted of telomeric factor Ft1. Aging Cell, 22, e14022 (2023). https://doi.org/10.1111/acel.14022 2023 8 1
4 *Mattia La Torre, Chiara Merigliano, Klizia Maccaroni, Alexandre Chojnowski, Wah Ing Goh, Maria Giubettini, Fiammetta Vernì, Cristina Capanni, Daniela Rhodes, Graham Wright, Brian Burke, Silvia Soddu, Romina Burla and Isabella Saggio. Combined alteration of lamin and nuclear morphology influences the localization of the tumor-associated factor AKTIP. J Exp Clin Cancer Res 41, 273 (2022). https://doi.org/10.1186/s13046-022-02480-5 2022 11.3 6
5 Klizia Maccaroni, Mattia La Torre, Romina Burla, Isabella Saggio. Phase Separation in the Nucleus and at the Nuclear Periphery during Post-Mitotic Nuclear Envelope Reformation. Cells, 11(11):1749 (2022) https://doi.org/10.3390/cells11111749 2022 6 6
6 Chiara Merigliano, Romina Burla, Mattia La Torre , Simona Del Giudice, Hsiang Ling Teo , Chong Wai Liew, Wah Ing Goh, Alexandre Chojnowski, Yolanda Olmos, Irene Chiolo, Jeremy G Carlton, Domenico Raimondo, Fiammetta Vernì, Colin Stewart, Daniela Rhodes, Graham D Wright, Brian Burke, Isabella Saggio. AKTIP interacts with ESCRT I and is needed for the recruitment of ESCRT III subunits to the midbody. PLOS Genetics (2021) 17(8): e1009757. https://doi.org/10.1371/journal.pgen.1009757 2021 6.02 13
7 Domenico Raimondo, Cristina Remoli, Letizia Astrologo, Romina Burla, Mattia La Torre, Fiammetta Vernì, Enrico Tagliafico, Alessandro Corsi, Simona Del Giudice, Agnese Persichetti, Giuseppe Giannicola, Pamela G Robey, Mara Riminucci, Isabella Saggio. Changes in gene expression in human skeletal stem cells transduced with constitutively active Gsα correlates with hallmark histopathological changes seen in fibrous dysplastic bone. PLOS ONE (2020) 15(1): e0227279. https://doi.org/10.1371/journal.pone.0227279 2020 3.24 11
8 Romina Burla, Mattia La Torre, Klizia Maccaroni, Fiammetta Vernì, Simona Giunta, Isabella Saggio. Interplay of the nuclear envelope with chromatin in physiology and pathology. Nucleus (2020) 11(1), 205–218. https://doi.org/10.1080/19491034.2020.1806661 2020 4.197 19
9 *Mattia La Torre, Chiara Merigliano, Romina Burla, Carla Mottini, Giorgia Zanetti, Simona Del Giudice, Mariateresa Carcuro, Ilaria Virdia, Elisabetta Bucciarelli, Isabella Manni, Gianluca Rampioni Vinciguerra, Giulia Piaggio, Mara Riminucci, Ana Cumano, Armando Bartolazzi, Fiammetta Verni, Silvia Soddu, Maurizio Gatti, Isabella Saggio. Mice with reduced expression of the telomere-associated protein Ft1 develop p53-sensitive progeroid traits. Aging Cell. (2018) 17:e12730. https://doi.org/10.1111/acel.12730 2018 7.346 15
10 Romina Burla†, *Mattia La Torre†, Giorgia Zanetti, Alex Bastianelli, Chiara Merigliano, Simona del Giudice, Alessandro Vercelli, Ferdinando Di Cunto, Marina Boido, Fiammetta Vernì and Isabella Saggio. p53-sensitive epileptic behavior and inflammation in Ft1 hypomorphic mice. Frontiers in Genetics (2018) Vol. 9 DOI: 10.3389/fgene.2018.00581 († co-first authorship) 2018 3.517 14
11 Romina Burla, Mattia La Torre, Chiara Merigliano, Fiammetta Vernì and Isabella Saggio. Genomic instability and DNA replication defects in progeroid syndromes. Nucleus (2018), 9(1), 368–379. https://doi.org/10.1080/19491034.2018.1476793 2018 2.157 40
12 Chiara Merigliano, Elisa Mascolo, Mattia La Torre, Isabella Saggio, Fiammetta Vernì. Protective role of vitamin B6 (PLP) against DNA damage in Drosophila models of type 2 diabetes, Sci Rep (2018) 8, 11432. https://doi.org/10.1038/s41598-018-29801-z 2018 4.011 33
13 Romina Burla, Mariateresa Carcuro, Mattia La Torre, Federica Fratini, Marco Crescenzi, Maria Rosaria D’Apice, Paola Spitalieri, GraziaDaniela Raffa, Letizia Astrologo, Giovanna Lattanzi, Enrico Cundari, Domenico Raimondo, Maurizio Gatti, Isabella Saggio. The telomeric protein AKTIP interacts with A- and B-type lamins and is involved in regulation of cellular senescence. Open Biol. (2016) 6160103 http://doi.org/10.1098/rsob.160103 2016 3.481 26
14 Romina Burla; Mattia La Torre; Isabella Saggio. Mammalian telomeres and their partnership with lamins, Nucleus, (2016) 7(2), 187–202. https://doi.org/10.1080/19491034.2016.1179409 2016 2.387 32
15 Stefania Piersanti, Romina Burla, Valerio Licursi, Catarina Brito, Mattia La Torre, Paula Alves, Daniel Simao, Carla Mottini, Sara Salinas, Rodolfo Negri, Enrico Tagliafico, Eric J Kremer, and Isabella Saggio, Transcriptional response of human neurospheres to helper-dependent CAV-2 vectors: activation of DNA damage response, modulation of microtubule motors and centromeric proteins, PLOS ONE (2015) 10(7): e0133607. https://doi.org/10.1371/journal.pone.0133607 2015 3.057 11
16 Romina Burla, Mariateresa Carcuro, Grazia Raffa, Alessandra Galati, Domenico Raimondo, Angela Rizzo, Mattia La Torre, Emanuela Micheli, Laura Ciapponi, Giovanni Cenci, Enrico Cundari, Antonio Musio, Annamaria Biroccio, Stefano Cacchione, Maurizio Gatti, Isabella Saggio, AKTIP/Ft1, a new shelterin-interacting factor required for telomere maintenance, PLOS Genetics (2015) 11(6): e1005167. https://doi.org/10.1371/journal.pgen.1005167 2015 6.661 39
* first or co-first papers
Source Scopus, Web of Science
Part X– Publications submitted/in preparation
Mattia La Torre*#, Federica Cannistrà#, Romina Burla, Wenting Zhao, Oliver Dreesen, Isabella Saggio*, ESCRT-III-dependent Nuclear Envelope Reformation Requires the ESCRT-I-like AKTIP. In preparation
#co-first, *co-corresponding
Mattia La Torre#, Federica Cannistrà, Romina Burla, Isabella Saggio* The dynamics of the ESCRT machinery in open mitosis from physiology to pathology. In preparation
*co-corresponding
Part XI – Books
2025 Isabella Saggio e Mattia La Torre, One Health, Carocci
2024 Isabella Saggio, Fabrizio Rufo Elogio della diversità (In Praise of Diversity). Mattia La Torre - photographic contents Sillabe (Li) ISBN 978-88-3340-495-0, SBN RMB0826510
Part XII – Participation to National and International Research Projects
2023-2025 National Biodiversity Future Center Science and society. PI Isabella Saggio
2022-2023 Pasteur Cenci Bolognetti Nuclear Envelope and Cancer. PI Isabella Saggio
2021-ongoing AIRC charity project Nuclear envelope and telomere instability in lymphomagenesis. PI Isabella Saggio
2016 Telethon charity EG project AKTIP and laminopathies. PI Isabella Saggio
2016 Progeria Research Foundation The lamin-interacting telomeric protein AKTIP in HGPS. PI Isabella Saggio
2015-2018 AIRC charity project Telomeric genes from Drosophila to man. I Isabella Saggio
Part XIII – Participation to National and International Conferences [selection]
2025 Mattia La Torre, Romina Burla, Federica Cannistrà, Wenting Zhao, Isabella Saggio, BAF-Dependent Localization of AKTIP at Chromatin Discs affects ESCRT- III Recruitment and Nuclear Envelope Reassembly. Selected talk at EMBO Workshop ESCRT function, evolutionary diversity and mechanism of action, 23 – 27 June 2025, Caux, Switzerland
2025 Expo 2025 moderator of the meeting One health – From food to longevity. Approaches to Health and Sustainability, 22 June 2025 Osaka Japan
2022 Romina Burla, Mattia La Torre, Klizia Maccaroni, Isabella Saggio, The nuclear envelope-associated ESCRT factor CHMP7 is needed for telomere integrity. Poster and micro talk selection at EMBO Workshop Telomere function and evolution in health and disease, 26 September-01 October 2022, Tróia, Portugal
2022 Mattia La Torre, Romina Burla, Alessandro Giampietro, Martina Meucci, Carmine Nicoletti, Antonio Musarò, Isabella Saggio, Ft1 deficiency induces DNA damage and cardiac defects. Poster at XVI FISV Congress, September 14-16, 2022 Portici, Napoli
2018 Mattia La Torre, Romina Burla, Chiara Merigliano, Teo Hsiang Ling, Liew Chong Wai, Fiammetta Vernì, Daniela Rhodes, Isabella Saggio, AKTIP a telomeric and ESCRT complex associated factor. Poster at EMBO Workshop, Telomere biology in health and human disease, May 01-06, 2018, Tróia, Portugal
2017 Romina Burla, Mattia La Torre, Giorgia Zanetti, Simona Del Giudice, Chiara Merigliano, Teo Hsiang Ling, Liew Chong Wai, Daniela Rhodes, Maurizio Gatti, Fiammetta Vernì, and Isabella Saggio Triangle connection of the E2 variant protein AKTIP with lamins and telomeres in generating a p53-sensitive progeroid phenotype. Poster at Cold Spring Harbor Laboratory, Telomeres and Telomerase, May 02-06, 2017, Cold Spring Harbour, NY, USA
2017 Romina Burla, Mattia La Torre, Giorgia Zanetti, Simona Del Giudice, Fiammetta Vernì and Isabella Saggio, The lamin-interacting protein AKTIP in progeroid syndromes. Poster at 3rd Skeleton Meeting, March 12-13, 2017, Riva del Garda, Italy
2016 Giorgia Zanetti, Romina Burla, Mattia La Torre, Carla Mottini, Simona Del Giudice, Domenico Raimondo, Maurizio Gatti, Isabella Saggio. AKTIP (Ft1), a protein that interacts with lamins, is required for telomere maintenance and mouse development. Selected Oral presentation at FISV 2016, September 20-23, Sapienza University of Rome, Italy
2015 Romina Burla, Mattia La Torre, Maria Teresa Carcuro, Grazia Daniela Raffa, Maurizio Gatti, Isabella Saggio. AKTIP (Ft1), a telomeric protein that interacts with lamin, is required for mouse survival and development. Non-presenting participant at Cold Spring Harbor Laboratory conference, Telomeres and Telomerase, April 28 – May 2, 2015, Cold Spring Harbour, NY, USA
2015 Mattia La Torre, Romina Burla, Mariateresa Carcuro, Grazia Raffa, Alessandra Galati, Domenico Raimondo, Angela Rizzo, Emanuela Micheli, Laura Ciapponi, Giovanni Cenci, Enrico Cundari, Antonio Musio, Annamaria Biroccio, Stefano Cacchione, Maurizio Gatti, Isabella Saggio. Selected Oral presentation at BeMM symposium 2015, PhD cycle XXVII. The telomeric protein Ft1 (AKTIP) plays a role in mouse physiology, January 23 23, Sapienza University of Rome, Italy
2014 Mattia La Torre, Romina Burla, Mariateresa Carcuro, Grazia Raffa, Alessandra Galati, Domenico Raimondo, Angela Rizzo, Emanuela Micheli, Laura Ciapponi, Giovanni Cenci, Enrico Cundari, Antonio Musio, Annamaria Biroccio, Stefano Cacchione, Maurizio Gatti, Isabella Saggio. Selected Oral presentation at EMBO Meeting, Telomeres, Telomerase and Disease, AKTIP, an E2 variant enzyme that interacts with lamin, is required for correct telomere maintenance, April 30 – May 4, 2014, Brussels, Belgium
Part XIV – Third Mission, communication and course/event organization experience
2023 Organizer of Nature and politics Advanced training course, Dept. of Biology and Biotechnologies "Charles Darwin", Sapienza University of Rome Director Isabella Saggio
2023 Organizer of Public Science and Empowerment Advanced training course, Dept. of Biology and Biotechnologies "Charles Darwin", Sapienza University of Rome Director Isabella Saggio
2023 Organizer of Writers' week – science and literature Advanced training course, Dept. of Biology and Biotechnologies "Charles Darwin", Sapienza University of Rome Director Isabella Saggio
2023 Organizer of Genome integrity and genome organization in physiology and pathology, International Winter School Sapienza University of Rome Director Isabella Saggio (5CFU; 2CFU)
2022 Organizer of La biodiversità dentro e fuori i musei Advanced training course, Sapienza University of Rome Director Isabella Saggio https://www.stoccolmaaroma.it/la-biodiversita-dentro-e-fuori-i-musei/
2022 Organizer of One-Health and Biodiversity - Governance and Geopolitical challenges 2CFU Advanced training course, Sapienza University Director Isabella Saggio https://www.stoccolmaaroma.it/one-health-and-biodiversity/
2022 Organizer of Scienza, Conoscenza, Democrazia e Processi Decisionali 3CFU Advanced training course, Sapienza University of Rome Director Isabella Saggio https://www.stoccolmaaroma.it/upskilling/scienza-democrazia-2022/
2021 Organizer round table and photo exhibition In and out – la comunicazione circolare della scienza per una società democratica for the European Researchers’ Night – ERN 2021 Sapienza University of Rome activities https://www.stoccolmaaroma.it/corsi-alta-formazione/european-researchers...
2021 Organizer of Public speaking 1CFU Advanced training course Sapienza University of Rome Director Isabella Saggio https://www.stoccolmaaroma.it/corsi-alta-formazione/science-communication/
2021 Organizer of Se come e perché creare un giornale 3CFU, Advanced training course Sapienza University of Rome Director Isabella Saggio https://www.stoccolmaaroma.it/upskilling/se-come-e-perche-creare-un-gior...
2021 Organizer of Scienza e democrazia 3CFU Advanced training course Sapienza University of Rome Director Isabella Saggio https://www.stoccolmaaroma.it/scienza-e-democrazia/
2021 Organizer of International Winter School – Stem cells and Molecular Medicine 5CFU Advanced training course Sapienza University of Rome Director Isabella Saggio https://www.stoccolmaaroma.it/upskilling/winter-school-stem-cells-and-mo...
2021-ongoing Graphic editor for the website of science communication www.stoccolmaaroma.it Director Isabella Saggio
2021-ongoing Editor and graphic editor for STAR, Sapienza Magazine di Cultura Scientifica ISSN 2785-5058 Director Isabella Saggio https://bbcd.bio.uniroma1.it/bbcd/star-magazine-scientifico
2020 – present Social media manager of the social platforms (Instagram, Facebook, LinkedIn) for the STAR, Sapienza Magazine di Cultura Scientifica www.stoccolmaaroma.it Director Isabella Saggio
Facebook https://www.facebook.com/stoccolmaaroma/
Instagram https://www.instagram.com/star_sapienza_/?hl=it
Linkedin https://www.linkedin.com/company/starsapienza/
2020 – present Digital content manager for STAR, Sapienza Magazine di Cultura Scientifica www.stoccolmaaroma.it Director Isabella Saggio
2019-2021 Organizer Hansel e Greta contest for high school students Coordinator Isabella Saggio https://www.stoccolmaaroma.it/hansel-e-greta-premio/
Part XV – Research-related skills
Biochemistry Bacterial Transformation, Protein expression in bacteria, Protein purification (size exclusion, ion exchange and affinity chromatography), Protein-protein interaction assays (GST-pull down, size exclusion chromatography), Protein DNA interactions (EMSA), Protein extraction from mammalian cells, Protein SDS page protein separation, Immunoprecipitation
Cell biology Mammalian cell-culture techniques: Transfection (plasmids, oligos), RNA-interference technique, 2nd and 3rd generation lentivectors production, Lentivectors mediated cells transduction, Mammalian cell culture, Immunofluorescence, Cell line derivation from mouse tumors biopsies, MEF (mouse embryonic fibroblast) derivation
Molecular biology PCR, RT-PCR, RNA extraction from cells and tissues, RNA-seq, Plasmid DNA Purification (Maxiprep, Midiprep, Miniprep), Restriction Map analysis, Genomic DNA isolation from cells and tissues, Immunofluorescence on mammalian cell
Computing
Software and online packages for DNA and protein sequence analysis, databases (protein and DNA), RNA-seq analysis
Microscopy
Fluorescence microscopy, 3DSIM super resolution microscopy for cells and tissue samples analysis
Imaging post production Advanced skills in image post-production using Imaris, including 3D visualization, surface and volume rendering, segmentation, and quantitative analysis for microscopy-based research.
Data analysis and visualization Adobe suite (Photoshop, Illustrator, Indesign, Camera Raw, Premiere, Lightroom), Imagej, Imagelab, Office package (Word, PowerPoint, Excel), macOS (Keynote, Numbers, Pages), iPadOS (Keynote, Numbers, Pages, Procreate, Paper, iMovie), Prism, Galaxylab, RawGraphs
Animal Models
Mouse animal model study and design, Colony and genetic crossing management, Manipulation, Genotyping by PCR analysis, Tissue collection for histology analysis, Preparation of paraffin and OCT-embedded tissues samples for histology analysis, Preparation of tissue slides for histology analysis, Tissue staining, Immunohistochemistry, Survival analysis, Body weight assessment, Macroscopic organ analysis
Ministerial Protocols for animal models used for cancer and aging studies Experience as a collaborator or responsible for experimental activity in approved ministerial protocols (Mouse model study and design, Mouse colony management, Mouse manipulation)
Collaborator and responsible for the experimental activity: Research protocol approved by Ministero della Salute, n. 162/2002A (2012-2017). Analysis of the phenotype induced by Ft1 in vivo downregulation and generation of a new transgenic mouse line knockout for Ft1
Responsible for the experimental activity: Research protocol approved by Ministero della Salute, n. 355/2017-PR (2017-2022). Analysis of the phenotype on in vivo depletion of the accessory telomeric protein AKTIP/Ft1 and its role in carcinogenesis
Responsible for the experimental activity: Research protocol approved by Ministero della Salute, n. 693/2022-PR (2022-2027). In vivo analysis of the impact of AKTIP/Ft1 and ESCRT proteins on aging and cancer processes
Part XVI – Digital skills
Digital skills for general activities
Windows and Mac Os X, Microsoft Office package suite, Adobe Package Suite, Web browsers: Safari, Firefox, Chrome, Internet Explorer, GeneAmp700, Quantity one, GraphPad Prism, Image J, Endnote X7, U-GOV platform, MEPA platform
Digital skills for specific graphic and communication activities: Adobe suite (Photoshop, Illustrator, Indesign, Camera Raw, Premiere, Lightroom), Imagej, Imagelab, Office package (Word, PowerPoint, Excel), macOS (Keynote, Numbers, Pages), iPadOS (Keynote, Numbers, Pages, Procreate, Paper, iMovie), Prism, Galaxylab, RawGraphs, Canva, Wordpress and WordPress plugins, Jimbdo
Part XVII – Foreign Language
2007 English Entry Level Certificate in English (ESOL) – Entry 3 (Preliminary English Test – PET) University of Cambridge ESOL Examinations
2002 English Spoken English for Speakers of Other Languages – Grade 4 Trinity, The International Examination Board
English publications >10, Participation to international conferences >5, International experience – English spoken > 6 months
Part XVII – Publications [science communication]
STAR magazine di cultura scientifica per Sapienza Università di Roma https://www.stoccolmaaroma.it/mattia-la-torre/
Sapienza STAR ISSUE: sistemi complessi, artificio intelligente, genere immortale, personalità, STAR STAR
Articoli:
Il futuro è Sapienza – STAR Issue II, Artificio Intelligente
Nuovi saperi – STAR, Issue II, Artificio Intelligente
Le sfide del PNRR – STAR Issue II, Artificio Intelligente
Resolution Revolution – STAR Issue II, Artificio Intelligente
StaR = Stoccolma a Roma – STAR Issue II, Artificio Intelligente
Le donne sono un’innovazione? – STAR Issue II, Artificio Intelligente
Visitare le scienze della Terra – STAR Issue II, Artificio Intelligente
Avanti master – STAR Issue II, Artificio Intelligente
La natura degli insetti alla Sapienza – STAR Issue III, Genere Immortale
La cultura fra Siti e Pasolini – STAR Issue III, Genere Immortale
Le sensazioni e il Nobel per la medicina ai recettori – Issue III, Genere Immortale
La scoperta scientifica Daniela Rhodes ci racconta come si fa – STAR Issue III, Genere Immortale
La bellezza nella transmedialità secondo Massimo Fusillo – STAR Issue III, Genere Immortale
Organizziamoci – STAR Issue IV-V, personalità
La scienza che vorremmo – STAR Issue IV-V, personalità
Cosa pensare di noi – STAR Issue IV-V, personalità
STAR cells – STAR Issue IV-V, personalità
Prati incantati – STAR Issue IV-V, personalità
Musica musica musica – STAR Issue IV-V, personalità
Eccellere – STAR Issue IV-V, personalità
Savoir faire – STAR Issue IV-V, personalità
Dentro la nostra testa – STAR Issue IV-V, personalità
Faire savoir – STAR Issue IV-V, personalità
zoooo – STAR Issue VI, STAR
pronti bio – STAR Issue VI, STAR
facoltà – STAR Issue VI, STAR
diagnosi e destino – STAR Issue VI, STAR
cambiarecostruire – STAR Issue VI, STAR
rientrare in Italia – STAR Issue VI, STAR
roma città di scienza – STAR Issue VI, STAR
ologramma – STAR Issue VI, STAR
l’uomo e il pianeta assieme – STAR Issue VI, STAR
dialogate – STAR Issue VI, STAR
sii una rita levi – STAR Issue VI, STAR
lab 11 – STAR Issue VI, STAR
i nuovi 100 deeeeel Cnr – STAR Issue VI, STAR
Part XVIII – Participation to national and international research groups
2024-ongoing Nanyang Technological University, Singapore (Singapore) Collaboration with the laboratory directed by Professor Wenting Zhao at the School of Chemistry, Chemical Engineering and Biotechnology, Nanyang Technological University, Singapore. Supervisor: Professor Isabella Saggio. The collaboration resulted in the following paper in preparation La Torre, et al., BAF-Dependent Localization of AKTIP at Chromatin discs affects ESCRT-III Recruitment and Nuclear Envelope Reassembly
2022-ongoing Scienze Anatomiche, Istologiche, Medico Legali e dell'Apparato Locomotore, Sapienza University of Rome Collaboration with the laboratory directed by Professor Antonio Musarò. Supervisor: Professor Isabella Saggio. The collaboration resulted in the following published paper Impact of diffused versus vasculature targeted DNA damage on the heart of mice depleted of telomeric factor Ft1 La Torre et al., Aging cell 2023
2019 CNR - Istituto di Genetica Molecolare Luigi Luca Cavalli-Sforza (IGM-CNR Bologna Unit) Collaboration with Dr Cristina Capanni at the Unit of IGM-CNR headed by Dr Giovanna Lattanzi. Collaborator coordinator Professor Isabella Saggio. The collaboration resulted in the following published paper Combined alteration of lamin and nuclear morphology influences the localization of the tumor-associated factor AKTIP La Torre et al., J Exp Clin Cancer Res, 2022
2015-2021 Nanyang Technological University, Singapore (Singapore) Collaboration with the laboratory directed by Professor Daniela Rhodes at the Institute of Structural Biology, Nanyang Technological University, Singapore. Supervisors: Professor Isabella Saggio and Professor Daniela Rhodes. The collaboration resulted in the following published papers La Torre, Merigliano et al., Combined alteration of lamin and nuclear morphology influences the localization of the tumor-associated factor AKTIP J Exp Clin Cancer Res, 2022 and Merigliano, Burla, La Torre et al., AKTIP interacts with ESCRT I and is needed for the recruitment of ESCRT III subunits to the midbody Plos Genetics, 2021