GLORIA RIITANO

Pubblicazioni:

Longo A, Manganelli V, Misasi R, Riitano G, Caglar TR, Fasciolo E, Recalchi S, Sorice M, Garofalo T. Extracellular Vesicles in the Crosstalk of Autophagy and Apoptosis: A Role for Lipid Rafts. Cells. 2025 May 20;14(10):749. doi: 10.3390/cells14100749.

Mancuso S, Caliste M, Petretto A, Corsiero E, Grinovero N, Capozzi A, Riitano G, Barbati C, Truglia S, Alessandri C, Sorice M, Bombardieri M, Conti F. Anti-β2glycoprotein I-induced neutrophil extracellular TRAPS cause endothelial activation. Rheumatology (Oxford). 2025 Apr 16:keaf204. doi: 10.1093/rheumatology/keaf204.

Buttari B°, Recalchi S°, Riitano G°, Capozzi A, Ucci FM, Manganelli V, Fratini F, Profumo E, Garofalo T, Alessandri C, Misasi R, Conti F, Longo A, Sorice M. Extracellular microvesicles from patients with Rheumatoid arthritis promote dendritic cell activation in vitro. Front Immunol. 2025 Mar 5;16:1532114. doi: 10.3389/fimmu.2025.1532114.

Riitano G, Spinelli F, Manganelli V, Caissutti D, Capozzi A, Garufi C, Garofalo T, Misasi R, Sorice M, Conti F, Longo A, Alessandri C. Wnt signaling as a translational target in rheumatoid and psoriatic arthritis. J Transl Med. 2025 Feb 4;23(1):158. doi: 10.1186/s12967-025-06174-2.

Marconi M, Riitano G, Fisher AD, Cocchetti C, Pagano MT, Capozzi A, Longo A, D'Arienzo S, Vignozzi L, Sorice M, Ortona E, Pierdominici M. Gender-affirming hormone therapy and autoimmunity: new insights from a three-year follow-up study. Clin Exp Immunol. 2025 Jan 21;219(1): uxad122. doi: 10.1093/cei/uxad122. PMID: 37962550; PMCID: PMC11771183.

Truglia S°, Riitano G°, Mancuso S, Recalchi S, Rapino L, Garufi C, Manganelli V, Garofalo T, Misasi R, Alessandri C, Sorice M, Longo A, Conti F, Capozzi A. Antibody profiles in the mosaic of "seronegative" APS syndrome. Clin Exp Immunol. 2024 Aug 28:uxae079. doi: 10.1093/cei/uxae079. Epub ahead of print. PMID: 39192704.

Manganelli V, Dini L, Tacconi S, Dinarelli S, Capozzi A, Riitano G, Recalchi S, Caglar TR, Fratini F, Misasi R, Sorice M, Garofalo T. Autophagy Promotes Enrichment of Raft Components within Extracellular Vesicles Secreted by Human 2FTGH Cells. Int J Mol Sci. 2024 Jun 4;25(11):6175. doi: 10.3390/ijms25116175. PMID: 38892363; PMCID: PMC11172899.

Riitano G, Capozzi A, Recalchi S, Augusto M, Conti F, Misasi R, Garofalo T, Sorice M, Manganelli V. Role of Lipid Rafts on LRP8 Signaling Triggered by Anti-β2-GPI Antibodies in Endothelial Cells. Biomedicines. 2023 Nov 24;11(12):3135. doi: 10.3390/biomedicines11123135. PMID: 38137358; PMCID: PMC10740635.

Riitano G, Recalchi S, Capozzi A, Manganelli V, Misasi R, Garofalo T, Sorice M, Longo A. The Role of Autophagy as a Trigger of Post-Translational Modifications of Proteins and Extracellular Vesicles in the Pathogenesis of Rheumatoid Arthritis. Int J Mol Sci. 2023 Aug 14;24(16):12764. doi: 10.3390/ijms241612764. PMID: 37628944; PMCID: PMC10454292.

Sorice M, Profumo E, Capozzi A, Recalchi S, Riitano G, Di Veroli B, Saso L, Buttari B. Oxidative Stress as a Regulatory Checkpoint in the Production of Antiphospholipid Autoantibodies: The Protective Role of NRF2 Pathway. Biomolecules. 2023 Aug 5;13(8):1221. doi: 10.3390/biom13081221. PMID: 37627286; PMCID: PMC10452087.

Manganelli V, Misasi R, Riitano G, Capozzi A, Mattei V, Caglar TR, Ialongo D, Madia VN, Messore A, Costi R, Di Santo R, Sorice M, Garofalo T. Role of a Novel Heparanase Inhibitor on the Balance between Apoptosis and Autophagy in U87 Human Glioblastoma Cells. Cells. 2023 Jul 19;12(14):1891. doi: 10.3390/cells12141891. PMID: 37508554; PMCID: PMC10378526.

Capozzi A, Riitano G, Recalchi S, Manganelli V, Longo A, Falcou A, De Michele M, Garofalo T, Pulcinelli FM, Sorice M, Misasi R. Antiphospholipid antibodies in patients with stroke during COVID-19: A role in the signaling pathway leading to platelet activation. Front Immunol. 2023 Mar 2;14:1129201. doi: 10.3389/fimmu.2023.1129201. PMID: 36936925; PMCID: PMC10017527.

Capozzi A, Manganelli V, Riitano G, Caissutti D, Longo A, Garofalo T, Sorice M, Misasi R. Advances in the Pathophysiology of Thrombosis in Antiphospholipid Syndrome: Molecular Mechanisms and Signaling through Lipid Rafts. J Clin Med. 2023 Jan 23;12(3):891. doi: 10.3390/jcm12030891. PMID: 36769539; PMCID: PMC9917860.

Ucci FM, Recalchi S, Barbati C, Manganelli V, Capozzi A, Riitano G, Buoncuore G, Garofalo T, Ceccarelli F, Spinelli FR, Balbinot E, Celia AI, Longo A, Alessandri C, Misasi R, Sorice M, Conti F. Citrullinated and carbamylated proteins in extracellular microvesicles from plasma of patients with rheumatoid arthritis. Rheumatology (Oxford). 2023 Jun 1;62(6):2312-2319. doi: 10.1093/rheumatology/keac598. PMID: 36255236.

Truglia S, Capozzi A, Mancuso S, Manganelli V, Rapino L, Riitano G, Recalchi S, Colafrancesco S, Ceccarelli F, Garofalo T, Alessandri C, Longo A, Misasi R, Conti F, Sorice M. Relationship Between Gender Differences and Clinical Outcome in Patients With the antiphospholipid syndrome. Front Immunol. 2022 Jul 4;13:932181. doi: 10.3389/fimmu.2022.932181. PMID: 35860235; PMCID: PMC9289158.

Riitano G, Capozzi A, Recalchi S, Caissutti D, Longo A, Mattei V, Conti F, Misasi R, Garofalo T, Sorice M, Manganelli V. Anti-β2-GPI Antibodies Induce Endothelial Cell Expression of Tissue Factor by LRP6 Signal Transduction Pathway Involving Lipid Rafts. Cells. 2022 Apr 11;11(8):1288. doi: 10.3390/cells11081288. PMID: 35455968; PMCID: PMC9025633.

Capozzi A, Truglia S, Buttari B, Recalchi S, Riitano G, Manganelli V, Mancuso S, Alessandri C, Longo A, Mattei V, Profumo E, Garofalo T, Misasi R, Conti F, Sorice M. Carbamylation of β2-GPI generates new autoantigens for antiphospholipid syndrome: a new tool for diagnosis of "seronegative" patients. Rheumatology (Oxford). 2022 Feb 2: keac045. doi: 10.1093/rheumatology/keac045. Epub ahead of print. PMID: 35108369.

Ferlito C, Visco V, Biselli R, Cattaruzza MS, Carreras G, Salerno G, Lista F, Capobianchi MR, Castilletti C, Lapa D, Antonelli G, Gentile M, Sorice M, Riitano G, Lucania G, Riccieri V, Mainiero F, Angeloni A, Lucarelli M, Ferraguti G, Autore A, Lastilla M, Salemi S, Biondo MI, Picchianti-Diamanti A, Caporuscio S, Teloni R, Mariotti S, Nisini R, D'Amelio R. Safety of Multiple Vaccinations and Durability of Vaccine-Induced Antibodies in an Italian Military Cohort 5 Years after Immunization. Biomedicines. 2021 Dec 21;10(1):6. doi: 10.3390/biomedicines10010006. PMID: 35052686; PMCID: PMC8773007.

Capozzi A, Caissutti D, Mattei V, Gado F, Martellucci S, Longo A, Recalchi S, Manganelli V, Riitano G, Garofalo T, Sorice M, Manera C, Misasi R. Anti-Inflammatory Activity of a CB2 Selective Cannabinoid Receptor Agonist: Signaling and Cytokines Release in Blood Mononuclear Cells. Molecules. 2021 Dec 23;27(1):64. doi: 10.3390/molecules27010064. PMID: 35011295; PMCID: PMC8746368.

Capozzi A, Riitano G, Recalchi S, Manganelli V, Pulcinelli F, Garofalo T, Misasi R, Longo A, Sorice M. Effect of heparanase inhibitor on tissue factor overexpression in platelets and endothelial cells induced by anti-β2-GPI antibodies: Reply to comment from Mackman et al. J Thromb Haemost. 2022 Jan;20(1):261-262. doi: 10.1111/jth.15558. PMID: 34954878

Muley A, Kim Uh M, Salazar-De Simone G, Swaminathan B, James JM, Murtomaki A, Youn SW, McCarron JD, Kitajewski C, Gnarra Buethe M, Riitano G, Mukouyama YS, Kitajewski J, Shawber CJ. Unique functions for Notch4 in murine embryonic lymphangiogenesis. Angiogenesis. 2022 May;25(2):205-224. doi: 10.1007/s10456-021-09822-5. Epub 2021 Oct 19. PMID: 34665379; PMCID: PMC9054879.

Misasi R, Capozzi A, Riitano G, Recalchi S, Manganelli V, Mattei V, Longo A, De Michele M, Garofalo T, Pulcinelli FM, Sorice M. Signal transduction pathway involved in platelet activation in immune thrombotic thrombocytopenia after COVID-19 vaccination. Haematologica. 2021 Oct 7. doi: 10.3324/haematol.2021.279729. Epub ahead of print. PMID: 34615340.

Manganelli V, Longo A, Mattei V, Recalchi S, Riitano G, Caissutti D, Capozzi A, Sorice M, Misasi R, Garofalo T. Role of ERLINs in the Control of Cell Fate through Lipid Rafts. Cells. 2021 Sep 13;10(9):2408. doi: 10.3390/cells10092408. PMID: 34572057; PMCID: PMC8470593.

Capozzi A, Riitano G, Recalchi S, Manganelli V, Costi R, Saccoliti F, Pulcinelli F, Garofalo T, Misasi R, Longo A, Di Santo R, Sorice M. Effect of heparanase inhibitor on tissue factor overexpression in platelets and endothelial cells induced by anti-β2-GPI antibodies. J Thromb Haemost. 2021 Sep;19(9):2302-2313. doi: 10.1111/jth.15417. Epub 2021 Jul 4. PMID: 34107171; PMCID: PMC8456873.

Capozzi A, Riitano G, Mancuso S, Recalchi S, Manganelli V, Garofalo T, Alessandri C, Longo A, Misasi R, Conti F, Truglia S, Sorice M. Anti-vimentin/cardiolipin IgA in the anti-phospholipid syndrome: A new tool for 'seronegative' diagnosis. Clin Exp Immunol. 2021 Sep;205(3):326-332. doi: 10.1111/cei.13633. Epub 2021 Jun 29. PMID: 34107056; PMCID: PMC8374216.

Panimolle F, Tiberti C, Spaziani M, Riitano G, Lucania G, Anzuini A, Lenzi A, Gianfrilli D, Sorice M, Radicioni AF. Non-organ-specific autoimmunity in adult 47,XXY Klinefelter patients and higher-grade X-chromosome aneuploidies. Clin Exp Immunol. 2021 Sep;205(3):316-325. doi: 10.1111/cei.13616. Epub 2021 Jun 10. PMID: 33978253; PMCID: PMC8374223.

Truglia S, Mancuso S, Capozzi A, Recalchi S, Riitano G, Longo A, De Carolis S, Spinelli FR, Alessandri C, Ceccarelli F, De Carolis C, Misasi R, Sorice M, Conti F. "Non-criteria antiphospholipid antibodies": bridging the gap between seropositive and seronegative antiphospholipid syndrome. Rheumatology (Oxford). 2021 May 10:keab414. doi: 10.1093/rheumatology/keab414. Epub ahead of print. PMID: 33970223.

Sorice M, Misasi R, Riitano G, Manganelli V, Martellucci S, Longo A, Garofalo T, Mattei V. Targeting Lipid Rafts as a Strategy Against Coronavirus. Front Cell Dev Biol. 2021 Feb 4;8:618296. doi: 10.3389/fcell.2020.618296. PMID: 33614627; PMCID: PMC7890255.

Manganelli V, Capozzi A, Recalchi S, Riitano G, Mattei V, Longo A, Misasi R, Garofalo T, Sorice M. The Role of Cardiolipin as a Scaffold Mitochondrial Phospholipid in Autophagosome Formation: In Vitro Evidence. Biomolecules. 2021 Feb 5;11(2):222. doi: 10.3390/biom11020222. PMID: 33562550; PMCID: PMC7915802.

Misasi R, Longo A, Recalchi S, Caissutti D, Riitano G, Manganelli V, Garofalo T, Sorice M, Capozzi A. Molecular Mechanisms of "Antiphospholipid Antibodies" and Their Paradoxical Role in the Pathogenesis of "Seronegative APS". Int J Mol Sci. 2020 Nov 9;21(21):8411. doi: 10.3390/ijms21218411. PMID: 33182499; PMCID: PMC7665122.

Manganelli V, Matarrese P, Antonioli M, Gambardella L, Vescovo T, Gretzmeier C, Longo A, Capozzi A, Recalchi S, Riitano G, Misasi R, Dengjel J, Malorni W, Fimia GM, Sorice M, Garofalo T. Raft-like lipid microdomains drive autophagy initiation via AMBRA1-ERLIN1 molecular association within MAMs. Autophagy. 2021 Sep;17(9):2528-2548. doi: 10.1080/15548627.2020.1834207. Epub 2020 Oct 23. PMID: 33034545; PMCID: PMC8496542.

Riitano G, Manganelli V, Capozzi A, Mattei V, Recalchi S, Martellucci S, Longo A, Misasi R, Garofalo T, Sorice M. LRP6 mediated signal transduction pathway triggered by tissue plasminogen activator acts through lipid rafts in neuroblastoma cells. J Cell Commun Signal. 2020 Sep;14(3):315-323. doi: 10.1007/s12079-020-00551-w. Epub 2020 Feb 15. PMID: 32062833; PMCID: PMC7511500.

Manganelli V, Truglia S, Capozzi A, Alessandri C, Riitano G, Spinelli FR, Ceccarelli F, Mancuso S, Garofalo T, Longo A, Valesini G, Sorice M, Conti F, Misasi R. Alarmin HMGB1 and Soluble RAGE as New Tools to Evaluate the Risk Stratification in Patients with the antiphospholipid syndrome. Front Immunol. 2019 Mar 14; 10:460. doi: 10.3389/fimmu.2019.00460. PMID: 30923525; PMCID: PMC6426766.

Capozzi A, Manganelli V, Riitano G, Recalchi S, Truglia S, Alessandri C, Longo A, Garofalo T, Misasi R, Valesini G, Conti F, Sorice M. Tissue factor over-expression in platelets of patients with anti-phospholipid syndrome: induction role of anti-β2-GPI antibodies. Clin Exp Immunol. 2019 Apr;196(1):59-66. doi: 10.1111/cei.13248. Epub 2019 Jan 15. PMID: 30549270; PMCID: PMC6422660.

Truglia S, Capozzi A, Mancuso S, Recalchi S, Spinelli FR, Perricone C, De Carolis C, Manganelli V, Riitano G, Garofalo T, Longo A, De Carolis S, Alessandri C, Misasi R, Valesini G, Sorice M, Conti F. A Monocentric Cohort of Obstetric Seronegative Anti-Phospholipid Syndrome. Front Immunol. 2018 Jul 20; 9:1678. doi: 10.3389/fimmu.2018.01678. PMID: 30079071; PMCID: PMC6062588.

Manganelli V, Recalchi S, Capozzi A, Riitano G, Mattei V, Longo A, Di Franco M, Alessandri C, Bombardieri M, Valesini G, Misasi R, Garofalo T, Sorice M. Autophagy induces protein carbamylation in fibroblast-like synoviocytes from patients with rheumatoid arthritis. Rheumatology (Oxford). 2018 Nov 1;57(11):2032-2041. doi: 10.1093/rheumatology/key174. PMID: 29982776.