Curriculum
Brief curriculum vitae of Daniela Carnevale
EDUCATION AND TRAINING
2010 PhD in Neuroscience – Faculty of Medicine and Surgery, Catholic University of the Sacred Heart in Rome.
2007 Selected for the Third International Course of Neuroscience (European Programme) Attendance to the course “Neuron-glia interactions in health and disease” held in Dubrovnik, Croatia, in October 2007.
2006 Professional qualification in Biology, “Sapienza” University of Rome.
2005 Degree in Biological Sciences, “Sapienza” University of Rome, final mark 110/110 cum laude.
2003-2005 Internship at the Department of Cellular Biology and Neuroscience, Istituto Superiore di Sanità, Rome.
PROFESSIONAL EMPLOYMENT AND POST-LAUREAM RESEARCH EXPERIENCE
2016 – Director of the Laboratory of Neuro and Cardiovascular Immunology, Department of Molecular Medicine, “Sapienza” University of Rome, based in the Molise Section at IRCCS Neuromed, Pozzilli (IS), Department of Angio-Cardio-Neurology and Translational Medicine.
March 2012- Assistant Professor/Researcher with a permanent position at the Department of Molecular Medicine of “Sapienza” University of Rome.
2010-2011 Post Doctoral appointment at the Department of Angio-Cardio-Neurology, IRCCS Neuromed, Pozzilli (IS), directed by Professor Giuseppe Lembo.
July 2009 Research fellowship (6 months) in the project “Therapeutic innovation and prognostic stratification: clinical and experimental models” at the Department of Experimental Medicine, “Sapienza” University of Rome, disciplinary group MED/50, under the responsibility of Professor Giuseppe Lembo.
July 2007 Research fellowship (1 year) - Unit of Experimental Neurology (Department of Cellular Biology and Neuroscience, Istituto Superiore di Sanità, Rome).
2006-2009 Guest Researcher at the Department of Angio-Cardio-Neurology, IRCCS Neuromed, Pozzilli (IS), Italy, in collaboration with Professor Giuseppe Lembo.
2005-2007 Guest Researcher at the Unit of Experimental Neurology (Department of Cellular Biology and Neuroscience, Istituto Superiore di Sanità, Rome).
TEACHING ACTIVITY
2012- Professor of “Psychology and Social Nursing” in the “U” Degree Course in Nursing Sciences of “Sapienza” University of Rome.
2012- Professor of “Evidence Based Nursing” in the “U” Degree Course in Nursing Sciences of “Sapienza” University of Rome.
2012-2014 Professor of “Molecular and Cellular Basis of Life” in the “U” Degree Course in Nursing Sciences of “Sapienza” University of Rome.
2012-2015 Professor of Scientific English III in the “U” Degree Course in Nursing Sciences of “Sapienza” University of Rome.
2011-2012 Professor of Infectious Diseases and Hygiene in the “U” Degree Course in Nursing Sciences of “Sapienza” University of Rome.
2011-2012 Professor of Biology, Biochemistry, Medical Genetics and Applied Physics in the “U” Degree Course in Nursing Sciences of “Sapienza” University of Rome.
2010-2011 Professor of Biology, Biochemistry and Medical Genetics in the “U” Degree Course in Nursing Sciences of “Sapienza” University of Rome.
2009-2010 Appointed Professor of Biology, Biochemistry, Medical Genetics and Applied Physics in the “U” Degree Course in Nursing Sciences of “Sapienza” University of Rome.
INSTITUTIONAL RESPONSIBILITIES
2014- Dean of the “U” Degree Course in Nursing Sciences of “Sapienza” University of Rome.
2014- Faculty member of the PhD School in Translational Medicine, Faculty of Medicine, University of Molise (Unimol).
HONOURS, AWARDS, PATENTS
2016 Awarded as Fellow of the American Heart Association (FAHA) for scientific merits at the Council on Hypertension 2016 – Orlando (FL) USA.
2014 Eligibility as Associate Professor in Technical and Medical Sciences - (National Program of Qualification for Associate Professorships).
2010 International Patent in the technological field applied to medicine. Date of deposit: 12 May 2010. Number of deposit: TO2010A000397. Inventors: Accornero Federica, Brancaccio Mara, Tarone Guido, Lembo Giuseppe, Carnevale Daniela “Recombinant melusin fusion protein as pharmacological agent in the treatment of heart pathologies and compositions thereof”.
2010 Winner of a Poster Award at the XXVII National Congress of the Italian Society of Arterial Hypertension.
2009 Winner of a Research Award from the Italian Society of Arterial Hypertension
2009 Winner of a Research Award from the Foundation “Roberto Cornelli” for excellent studies presented at the Ninth International Conference on Alzheimer “AD/PD” held in Prague, Czech Republic, 11-15 March 2009.
2007 Winner of a Research Award from the “Istituto Giuseppe Toniolo di Studi Superiori” for studies led under the supervision of Prof. Pierluigi Navarra (Catholic University of Sacred Heart) and Dr Luisa Minghetti (Istituto Superiore di Sanità).
FUNDING INFORMATION [grants as PI-principal investigator]
2015- “Cellular and molecular insights into the role of immunity in the onset and maintenance of hypertension.” - Grant for scientific research “Sapienza” University of Rome. PI - € 30.000,00
2014 “Use of a MRI scan of new generation, of great accessibility and application ease for preclinical research in arterial hypertension models, for the definition of organ damage”. Scientific Research – Year 2014. Granted for the acquistition of “7Tesla MRI” for small animals (Bruker), for the development of a facility for preclinical imaging in murine models of arterial hypertension. Grant for the acquisition of medium and large scientific equipments – “Sapienza” University of Rome. PI - € 200.000,00
2014- “Characterization of immune reservoirs involved in the adaptive cardiac remodeling to pressure overload”. Istituto Pasteur – Foundation Cenci Bolognetti. PI - € 90.000,00
2013- “Characterization of novel molecular targets in the human vascular wall”, Italian Ministry of Health, Regione Molise. PI UNIT - € 150.000,00
2012 “Characterization of novel molecular targets in a mouse model of vascular Alzheimer's Disease.” Ricerche Universitarie 2012 – “Sapienza” University of Rome. PI - € 40.000,00
SCIENTIFIC SOCIETIES
Member of the “American Heart Association (AHA)”
Member of the “Italian Society of Hypertension (SIIA)”
SUPERVISION OF STUDENTS
2014 – Supervision of 4 PhD Students - PhD program in Translational Medicine, Faculty of Medicine, Unimol University
2013 – 2015 Supervision of 2 Post-Doctoral Fellows - Department of Molecular Medicine - Faculty of Medicine and Pharmacy, Sapienza University of Rome
2009 – 2015 Supervision of 5 BSc Students – Degree Course in Biomedical Laboratory Techniques, “Sapienza” University of Rome
2011 Supervision of 1 BSc Student – Degree Course in Nursing Sciences, “Sapienza” University of Rome
2009 Supervision of 1 MSc Student - Degree Course in Medical Biotechnology, “Tor Vergata” University of Rome
EDITORIAL BOARD ACTIVITY
Frontiers in Physiology
REVIEWER ACTIVITY
Circulation Research; Hypertension; Arteriosclerosis Thrombosis and Vascular Biology; Cardiovascular Research; Cell Death & Disease; International Journal of Cardiology; British Journal of Clinical Pharmacology; Nutrition, Metabolism and Cardiovascular Disease; Plos One; Journal of the Neurological Sciences; Journal of Cardiovascular Medicine; etc.
ADVISOR FOR INTERNATIONAL SCIENTIFIC BODIES
French National Research Agency; Alzheimer’s Association
INVITED LECTURES
1) “Cholinergic-sympathetic pathway primes immunity in hypertension and mediates brain to-spleen communication.” Annual meeting of the Working Groups on “Myocardial Function” and “Cellular Biology of the Heart” - 25-28 May, 2017, Villa Monastero, Varenna (LC), Italy.
2) “Neuroimmune mechanisms in hypertension.” Invited Seminar for the Center for Thrombosis and Hemostasis (CTH), University Medical Center - 26 April, 2017, Mainz, Germany.
3) “Neuroimmune interactions contribute to hypertension.” American Society of Nephrology - 17-20 November, 2016, Chicago, IL, USA.
4) “Phenotyping cardiovascular and immune systems with ultrasound imaging.” XX Annual Meeting of the European Council for Cardiovascular Research (ECCR) - 14-16 October, 2016, Garda (VR), Italy.
5) “The immune response in the pathogenesis and target organ damage of hypertension.” Capri Cardiovascular Conference 2.0 - 15-16 April, 2016, Capri (NA), Italy.
6) “Neuroimmune Interactions in Hypertension.” Angiotensin: From Cell Biology and Signaling Networks to Novel Physiological Paradigms and Therapeutics. Gordon Research Conference - 21-26 February, 2016, Barga (LU), Italy.
7) “Role of the Immune System in Arterial Hypertension.” Accademia Medica di Roma (L’Accademia Medica e i Giovani Ricercatori “Immunometabolismo e malattie croniche”) - 5 June, 2014, Rome, Italy.
8) “Molecular mechanisms of hypertension-induced target organ damage.” CERM - Centro Europeo di Risonanze Magnetiche - 21 February, 2012, Florence, Italy.
9) “Alzheimer-like pathology in a murine model of arterial hypertension.” Models of dementia; the good, the bad and the future. - 15-17 December, 2010, Cambridge, UK.
10) “Role of neuroinflammation in hypertension-induced β-amyloid deposition.” Bis10 (Brain Ischemia and Stroke) - 6-9 October, 2010, Rome, Italy.
11) “Hypertension and β-amyloid deposition.” SINS, Annual Congress of the Italian Society of Neurosciences - 2-5 October, 2009, Milan, Italy.
ORAL PRESENTATIONS AT INTERNATIONAL AND NATIONAL CONGRESSES
1) Carnevale D. “Targeting IL-1β Protects from Aortic Aneurysms Induced by Disrupted TGFβ signaling in SMCs”. ATVB|PVD 2017 Scientific Sessions, May 4-6 2017, Minneapolis, MN.
2) Carnevale D. “Adoptive Transfer of CD8 T Cells With 2 Constitutively Active PI3Kγ Induces Hypertension in Mice.” AHA Council on Hypertension, Sept 14-17, Orlando, FL, USA, 2016.
3) Carnevale D, Perrotta M, Pallante F, Fardella V, Iacobucci R, Cutrone A, Lembo G. “Selective splenic denervation inhibits the egression of T cell from spleen, induced by angiotensinII, and protects from hypertension.” AHA Council on Hypertension, Sept. 15-19, Washington DC, USA, 2015.
4) Carnevale D, Casaburo M, De Lucia M, Pallante F, Fardella V, Bressan GM, Lembo G. “The myogenic tone of resistance arteries is controlled by a molecular pathway driven by TGFβ through Emilin1 and converging on the regulation of TRP channels.” HBPR 2014 American Heart Association, Hilton San Francisco Union Square, Sept 9-12, San Francisco, CA, USA, 2014.
5) Carnevale D, Casaburo M, Pallante F, Iacobucci R, De Lucia M, Bressan GM, Lembo G. “Splenic PIGF Checks T-Cell Costimulation Allowing the Onset of Hypertension.” Arteriosclerosis, Thrombosis, and Vascular Biology 2014 Scientific Sessions, scheduled for May 1-3, Toronto, Ontario, Canada, 2014.
6) Carnevale D, Casaburo M, De Lucia M, Pallante F, Fardella V, Bressan GM, Lembo G. “L’ablazione inducibile di emilina1 nelle cellule muscolari lisce induce ipertensione, aumentando il tono miogenico attraverso un pathway TGFβ/ALK5.” XXX National Congress of the Italian Society of Arterial Hypertension, Oct 3-5, Rome, Italy, 2013.
7) Carnevale D, Pallante F, Fardella V, De Lucia M, Fardella S, Iacobucci R, Lembo G. “PlGF, fattore di crescita placentare, ha un ruolo cruciale nella risposta ipertensiva ad angiotensinaII e nell’infiltrato linfocitario negli organi bersaglio.” XXX National Congress of the Italian Society of Arterial Hypertension, Oct 3-5, Rome, Italy, 2013.
8) Carnevale D, Damato A, Cifelli G, Bressan GM, Lembo G. “Emilina1 espressa nelle cellule muscolari lisce è un regolatore della risposta miogenica dei vasi di resistenza e della pressione arteriosa.” XXIX National Congress of the Italian Society of Arterial Hypertension, Oct 4-6, Rome, Italy, 2012.
9) Carnevale D, Mascio G, D’Andrea I, Fardella V, Fardella S, Pallante F, Lembo G. “L’ipertensione arteriosa induce deposizione di β-amiloide e deficit cognitivo, attraverso l’attivazione del recettore RAGE nell’endotelio dei vasi cerebrali.” XXIX National Congress of the Italian Society of Arterial Hypertension, Oct 4-6, Rome, Italy, 2012.
10) Carnevale D, Mascio G, D’Andrea I, Yan SD, Lembo G. “Hypertension triggers vascular related Alzheimer by activation of RAGE.” Alzheimer’s Association International Conference on Alzheimer’s Disease (AAICAD), Jul 16-21, Paris, France, 2011.
11) Carnevale D, Vecchione C, Mascio G, Cifelli G, Lembo G. “L’inibizione farmacologica di PI3K riduce la pressione interferendo con il pathway Akt/canali del calcio L-type: una nuova possibilità terapeutica per l’ipertensione.” National Congress of the Italian Society of Arterial Hypertension, Sept 30 - Oct 3, Rome, Italy, 2010.
COLLABORATIONS
- Prof. Matthias Nahrendorf, Harvard University, Boston, MA, USA
Neuroimmune mechanisms in cardiovascular diseases
- Prof. David Harrison, University of Vanderbilt, Nashville, USA
Immune mechanisms in hypertension
- Prof. Tomasz Guzik, University of Glasgow, UK
Immune mechanisms in hypertension
- Prof. Andreas Habenicht, University of Munich, DE
Neuroimmune mechanisms in atherosclerosis
- Prof. Giorgio Maria Bressan, University of Padova, Italy
Role of extracellular matrix proteins in vascular pathophysiology
SUMMARY OF SCIENTIFIC ACHIEVEMENTS
[Impact Factor=IF 2015 JCR Science Edition]
Total Papers 32 - Database Google Scholar – Start date 2005 to End date 2017
Total Impact Factor: 191.307
Mean IF: 5.978
H index 14
H index normalized 6
Total Citations 806
Average Citations per Product 25
ORCID ID 0000-0002-5016-3161
Research interests: biotechnologies and translational approaches applied to cardiovascular disease, neuroscience and immunity.
Keywords: hypertension, heart failure, neurovascular diseases, neuroimmune mechanisms, murine models of cardio- and neurovascular diseases.