GRAZIA DANIELA RAFFA

PERSONAL DATA

Date of birth 04 July 1976
Cityzenship Italian
Languages Italian, English
Actual Address Dipartimento di Genetica
e Biologia molecolare
Universita’ di Roma “La Sapienza”
Piazzale Aldo Moro, 5
00185 Roma, Italy
Tel: 39-06-4419843
Fax: 39-06-4456866
e-mail Address graziadaniela.raffa@uniroma1.it

ORCID ID https://orcid.org/0000-0002-5072-5240

PROFESSIONAL EXPERIENCE AND RESEARCH

2010-present
Researcher-Assistant Professor of Genetics
Sapienza, University of Rome
Department of Biology and Biotechnology

2017
National Scientific Qualification as Associate Professor
(Settore Concorsuale: 05/I1, Fascia: 2)

2016-2017
Invited Assistant Professor at Stanford University Medical Center
Division of Hematology, Stanford, CA, USA
Research in collaboration with Prof. Steven Artandi (18 months)
(Investigating the role of TGS1 in telomere homeostasis)

2006/2010
Postdoctoral associate in the laboratory of Prof. Maurizio Gatti
(Drosophila telomere biology)
Sapienza, University of Rome-Department of Biology and Biotechnology

FELLOWSHIPS
(2006/2007) Fellowship from Fondazione “Adriano Buzzati Traverso”
(2007/2009) Fellowship from Fondazione “Cenci Bolognetti”
(2009/2010) Fellowship from Italian Association for Cancer Research (AIRC)

2004/2006
Research associate in the laboratory of Prof. Michael N. Boddy
(Control of genome stability and DNA damage checkpoint in
Schizosaccharomyces pombe).
The Scripps Research Institute La Jolla, CA, USA

2003
Postdoctoral associate in the laboratory
of Prof. Maurizio Gatti
(Drosophila telomere biology)
Sapienza, University of Rome
Department of Biology and Biotechnology

1999/2002 PhD in Genetics and Molecular Biology
Sapienza, University of Rome
Research under direction of Prof. Maurizio Gatti
(Genetic and molecular analysis of
telomere capping in Drosophila melanogaster)

In this period I spent 12 months in the laboratory of
Prof. Michael L. Goldberg at Cornell University

1999 Fellowship “Luca Barone” from Accademia Nazionale Dei Lincei
1999 Laurea (bachelor degree) in Biological Sciences
110/110 cum laude
Sapienza, University of Rome
Research under direction of Prof. Maurizio Gatti
(Genetic analysis of spermatogenesis in Drosophila melanogaster)

PUBLICATIONS
PUBLICATIONS

1. Di Giorgio ML, Esposito A, Maccallini P, Micheli E, Bavasso F, Gallotta I, . . . Raffa GD. (2017) WDR79/TCAB1 plays a conserved role in the control of locomotion and ameliorates phenotypic defects in SMA models. Neurobiology of disease, 105, 42-50.

2. Cicconi A, Micheli E, Verni F, Jackson A, Gradilla AC, Cipressa F, . . . Raffa GD. (2017) The Drosophila telomere-capping protein Verrocchio binds single-stranded DNA and protects telomeres from DNA damage response. Nucleic acids research, 45, 3068-3085.

3. Cipressa F, Morciano P, Bosso G, Mannini L, Galati A, Raffa GD, . . . Cenci G. (2016) A role for Separase in telomere protection. Nature communications, 7, 10405.

4. Burla R, Carcuro M, Torre ML, Fratini F, Crescenzi M, D'Apice MR, Spitalieri P,
Raffa, GD. . . . Saggio I. (2016) The telomeric protein AKTIP interacts with A- and B-type lamins and is involved in regulation of cellular senescence. Open biology, 6.

5. Cenci G, Ciapponi L, Marzullo M, Raffa GD, Morciano P, Raimondo D, . . . Gatti M. (2015) The Analysis of Pendolino (peo) Mutants Reveals Differences in the Fusigenic Potential among Drosophila Telomeres. PLoS genetics, 11, e1005260.

6. Burla R, Carcuro M, Raffa GD, Galati A, Raimondo D, Rizzo A, . . . Saggio I. (2015) AKTIP/Ft1, a New Shelterin-Interacting Factor Required for Telomere Maintenance. PLoS genetics, 11, e1005167.

7. Sechi S, Colotti G, Belloni G, Mattei V, Frappaolo A, Raffa GD, . . . Giansanti MG. (2014) GOLPH3 is essential for contractile ring formation and Rab11 localization to the cleavage site during cytokinesis in Drosophila melanogaster. PLoS genetics, 10, e1004305.

8. Raffa GD, Cenci G, Ciapponi L and Gatti M. (2013) Organization and Evolution of Drosophila Terminin: Similarities and Differences between Drosophila and Human Telomeres. Frontiers in oncology, 3, 112.

9. Raffa GD, Cenci G, Ciapponi L and Gatti M. (2013) Organization and maintenance of Drosophila telomeres: the roles of terminin and non-terminin proteins. Tsitologiia, 55, 204-208.

10. Raffa GD, Ciapponi L, Cenci G and Gatti M. (2011) Terminin: a protein complex that mediates epigenetic maintenance of Drosophila telomeres. Nucleus, 2, 383-391.

11. Raffa GD, Raimondo D, Sorino C, Cugusi S, Cenci G, Cacchione S, . . . Ciapponi L. (2010) Verrocchio, a Drosophila OB fold-containing protein, is a component of the terminin telomere-capping complex. Genes & development, 24, 1596-1601.

12. Raffa GD, Siriaco G, Cugusi S, Ciapponi L, Cenci G, Wojcik E and Gatti M. (2009) The Drosophila modigliani (moi) gene encodes a HOAP-interacting protein required for telomere protection. Proceedings of the National Academy of Sciences of the United States of America, 106, 2271-2276.

13. Abel J, Eskeland R, Raffa GD, Kremmer E and Imhof A. (2009) Drosophila HP1c is regulated by an auto-regulatory feedback loop through its binding partner Woc. PloS one, 4, e5089.

14. Ceprani F, Raffa GD, Petrucci R and Piergentili R. (2008) Autosomal mutations affecting Y chromosome loops in Drosophila melanogaster. BMC genetics, 9, 32.

15. Prudden J, Pebernard S, Raffa GD, Slavin DA, Perry JJ, Tainer JA, . . . Boddy MN. (2007) SUMO-targeted ubiquitin ligases in genome stability. The EMBO journal, 26, 4089-4101.

16. Raffa GD, Wohlschlegel J, Yates JR, 3rd and Boddy MN. (2006) SUMO-binding motifs mediate the Rad60-dependent response to replicative stress and self-association. The Journal of Biological Chemistry, 281, 27973-27981.

17. Raffa GD, Cenci G, Siriaco G, Goldberg ML and Gatti M. (2005) The putative Drosophila transcription factor woc is required to prevent telomeric fusions. Molecular Cell, 20, 821-831.

18. Piergentili R, Bonaccorsi S, Raffa GD, Pisano C, Hackstein JH and Mencarelli C. (2004) Autosomal control of the Y-chromosome kl-3 loop of Drosophila melanogaster. Chromosoma, 113, 188-196.

19. Cenci G, Siriaco G, Raffa GD, Kellum R and Gatti M. (2003) The Drosophila HOAP protein is required for telomere capping. Nature cell biology, 5, 82-84.