DOMENICO ALVARO

Patologia Integrata III CLMMC "A" Professore D. Alvaro Coordinatore 

Malattie dell'Apparato Digerente Docenti: D Alvaro - N Pallotta - F Maccioni - S Pontone - A Lamazza - G Cavallaro

Malattie del Sistema Endocrino e del Metabolismo Docenti: R Buzzetti - P Gargiulo - D Gianfrilli -

_________________

Applied Pathology III CLMMC "F" Professor D. Alvaro _ 

Applied Pathology III CLMMC "F" Professor D. Alvaro _ 

ALVARO DOMENICO
SSD = MED/12 (Gastroenterologia), Settore Concorsuale= 06/D4: Malattie cutanee, malattie infettive e malattie dell’apparato digerente.
2005-presente Professore ordinario di Gastroenterologia, Univ. Sapienza, Roma
2002-2005 Professore associato di Gastroenterologia, Univ. Sapienza, Roma
2001-2002 Ricercatore, Gastroenterologia, Univ. Sapienza, Roma
1988-2001 "Funzionario Tecnico”, Univ. Sapienza, Roma
1990-1992, Ricercatore associato "Digestive Diseases”, YALE Univ. USA.

Attuale:
Professore Ordinario di Gastroenterologia, Direttore UOC Gastroenterologia, Direttore Dipartimento di Medicina Interna e Specialità Mediche, Policlinico Umberto I°.
Preside della Facoltà di Medicina e Odontoiatria, Sapienza (dal 22-12-2020). Compreso tra il 2% dei top scientists mondiali di tutte le discipline secondo la recente ricerca della Stanford University. Autore di N. 342 pubblicazioni internazionali (PEER REVIEWED PAPERS; H.I. = 83) e di N. 4 BREVETTI INTERNAZIONALI.
Dipartimento di Medicina Traslazionale e di Precisione, Università Sapienza Roma Italy, Viale dell’Università, 37, 00185 Roma.

- 2003-2017, Coordinatore Patologia Integrata III, CCLE
- 2003-oggi, membro del collegio dei docenti della Scuola di Specializzazione Gastroenterologia, Sapienza Roma
- 2004-presente, coordinatore insegnamento Patologia Integrata III, CCLA Sapienza Univ. di Roma.
- 2005-presente, membro del Collegio dei decenti del dottorato in epato-gastroenterologia sperimentale e clinica.
- 2008-Presente, Comitato editoriale Digestive and Liver Diseases
- 2008-2010, Presidente Società Italiana di Gastroenterologia (Sezione Lazio)
- 2008-2016, Responsabile -Editore della rivista Digestive and Liver Disease
- 2010-presente, Membro della Medical Academy di Roma
- 2010-2017, responsabile Centro Regionale Latina per Celiachia
- 2011-presente, Membro dell'Editorial Board della rivista Hepatology
- 2011-2012, Membro del gruppo di lavoro, Agenzia italiana del farmaco (AIFA)
- 2011-2016, membro del comitato direttivo Dipartimento di Scienze e Biotecnologie Medico-Chirurgiche, Università degli Studi di Roma “Sapienza”.
- 2014-2017 Responsabile del Centro Malattie Rare, ASL Latina
- 2015-presente, Membro del Comitato di Facoltà per la nomina del Professore Emerito
- 2015-presente, Rappresentante dell'Università Sapienza nel consorzio per il trapianto di organi
- 2016-presente, Membro del comitato Direttivo Società Italiana di Gastroenterologia
- 2017-presente, Direttore UOC Gastroenterologia, AOU Policlinco Umberto 1°
- 2018-2019, Coordinatore Scuola di Specializzazione in Malattie Apparato Digerente
- 2018-2020, Presidente della Società Italiana di Gastroenterologia
- 2018-2020, Direttore del Dipartimento di Medicina Traslazionale e di Precisione, Sapienza
- 2018-attuale, Direttore di STITCH (Sapienza Information-Based Technology Innovation Center for Health)
- 2017-2020, componente del Comitato Ateneo per la valutazione dei brevetti.
- 2019 –presente, componente Comitato indirizzo Scuola Superiore Studi Avanzati, Sapienza.
- 2019-2020, Senatore Accademico, Rappresentante PO, Senato Accademico Sapienza, macroarea C.
- 2019-presente Direttore DAI Medicina Interna e Specialità Mediche, Policlinico Umberto Primo, Roma.
- 2020-2024; Presidente COLMAD (Collegio dei docenti Malattie Apparato Digerente)
- 2020-presente; Preside della Facoltà di Medicina e Odontoiatria, Sapienza.
- 1980 Laurea specialistica in Medicina e Chirurgia, 'Università di Roma "La Sapienza" con il massimo dei voti
-1981 vincitore Borsa di Studio istituto Superiore di Sanità, Roma
-1985 Specializzazione Medicina interna, Univ. Sapienza Roma
-1986 vincitore Borsa di Studio istituto Superiore di Sanità, Roma
-1987 vincitore Borsa di Studio istituto Superiore di Sanità, Roma
-1988 Specializzazione Gastroenterologia Univ. Sapienza Roma
-1988 vincitore Borsa di Studio istituto Superiore di Sanità, Roma

Rigenerazione epatica, danno da farmaci, trasportatori di farmaci nel fegato, apoptosi delle cellule epatiche, colestasi, patofisiologia e trattamento delle malattie del fegato, cellule staminali epatiche, medicina rigenerativa del fegato e del pancreas, colangiocarcinoma.
LIVER STEM CELLS
- COORDINATOR OF SAPIENZA NETWORK FOR THE CELL THERAPY OF LIVER DISEASES
- RECIPIENT OF THE FIRB, ACCORDI DI PROGRAMMA 2010, GRANT
- N. 4 INTERNATIONAL PATENTS ON BILIARY STEM CELLS
D. ALVARO WAS THE FIRST TO DISCOVER STEM CELLS IN THE HUMAN BILIARY TREE AND TO USE THEM FOR THE CELL THERAPY OF CIRRHOSIS.
CHOLANGIOCARCINOMA
- COORDINATOR OF THE AISF GROUP ON CHOLANGIOCARCINOMA WITH PUBLICATION OF A POSITION PAPER OF THE ITALIAN LIVER ASSOCIATION.
- COORDINATOR OF THE AISF COMMITTEE ON CHOLANGIOCARCINOA WITH PUBLICATION OF THE ITALIAN GUIDELINES
- COORDINATOR OF THE EUROPEAN NETWORK FOR THE STUDY OF CHOLANGIOCARCINOMA (ENS-CCA)
- INVITED LECTURE ON CHOLANGIOCARCINOMA AT THE ASCO GI MEETING, SAN FRANCISCO, 2012.
- COORDINATOR OF THE ITALIAN GUIDELINES ON CHOLANGIOCARCINOMA (PUBLISHED ON DIG. LIVER DIS. 2020. PART I AND II)
- CO-CHAIRS OF THE INTERNATIONAL GUIDELINES ON CHOLANGIOCARCINOMA (EASL+ILCA)
- RECIPIENT OF EUROPEA N COST-ACTION GRANT FOR COORDINATION OF THE EUROPEAN NETWORK FOR THE STUDY OGF CHOLANGIOCARCINOMA
D. ALVARO WAS THE FIRST TO DEMONSTRATE THAT CHOLANGIOCARCINOMA IS A STEM-CELL BASED DISEASE AND TO DEFINE THE PROFILE OF CANCER STEM CELLS IN THIS CANCER.
CHOLESTATIC DISEASES
-MEMBER OF THE AISF COMMITTEE ON CHOLESTATIC LIVER DISEASES WITH THE PUBLICATION OF THE ITALIAN GUIDELINES
-RECIPIENT OF N. 10 GRANTS FROM PRIN, ATENEO, FACULTY.
D. ALVARO WAS THE FIRST TO IDENTIFY THE CRUCIAL ROLE OF CHOLANGIOCYTES IN THE BILE PATHOPHYSIOLOGY AND TO DEMONSTRATE HOW THEY REPRESENT A NEUROENDOCRINE COMPARTMENT IN DISEASED LIVER, DRIVING REPAIR PROCESSES. D. ALVARO DISCOVERED THE ISOLATED BILE DUCT UNIT.

• 1990-2018: N. 28 Grants di Ateneo o Facoltà;
• 2010-2017. FIRB, accordi di programma, scientific responsability local Research Unit, RBAP10Z7FS_004.Cellule staminali multipotenti isolate dall'albero biliare umano extraepatico e loro differenziazione in cellule epatiche e pancreatiche: studi pre-clinici e potenziali applicazioni cliniche.
• 2017-present: Grant Sapienza "Progetti H2020”; Cell Therapies of Untreatable Liver Diseases using Human Biliary Tree Stem Cells. n. prot.PH11715C6.
• 2018-present: Cost-Action European grant (280,000 Euros) for management of the ENSCCA network, cod. CA18122.
• 2020-present: come direttore di STITCH ha coordinato i “Progetti Strategici Regione Lazio”bando POR FESR LAZIO. Progetto T0002E0001 (Area di Spec.ne SCIENZE DELLA VITA). Sono stati finanziati N. 16 progetti con determina del n. G12528 del 28.10.2020 (budget 4800K
• 2020 Grant ECO4CO (35k) – Earth Cognitive system 4 COvid-19”, presentato da Telespazio, Bando ESA ITT AO10314 – “Space in response to COVID-19 outbreak”
• call for tender” (Ref: ESA AO/1-10314/20/NL/AF)

-AUTORE DI N. 343 PEER REVIEWED PAPERS; H.I. = 83,
-CITAZIONI TOTALI = 16.042, N. 4 BREVETTI INTERNAZIONALI.
-2% top scientist secondo la recente ricerca della Stanford Univ. (PLOS Biology |

https://doi.org/10.1371/journal.pbio.3000918)
Nel ruolo di presidente della Società Italiana di Gastroenterologia è stato autore di N. 23 articoli apparsi sui principali quotidiani nazionali riguardanti le malattie gastroenterologiche.

Direttore di Dipartimento universitario, Direttore DAI, Senatore Accademico, coordinatore di insegnamenti per corsi di laurea e dottorati, Direttore del centro di ricerche interdisciplinari STITCH
Componente comitato editoriale di riviste scientifiche internazionali (HEPATOLGY, DIGESTIVE AND LIVER DISEASE, FRONTIERS IN MEDICINE, J. HEPATOLOGY, WORLD J. GASTROENTEROLOGY)
- YALE UNIVERSITY, LIVER CENTER (BOYER JB)
- TEXAS A&M UNIVERSITY (ALPINI G, GLASER S.)
- DIABETES RESEARCH INSTITUTE AND CELL TRANSPLANT PROGRAM, UNIVERSITY OF MIAMI (RICORDI C., INVERARDI L., LANZONI G.)
- DIVISION OF DIABETES, UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO (FOLLI F.)
- LIVER AND GASTROINTESTINAL DISEASES, UNIV.BASQUE COUNTRY, SAN SEBASTIÁN, SPAIN (BANALES J)
- DEPART. CELL BIOLOGY AND PHYSIOLOGY, CHAPEL HILL, NORTH CAROLINA UNC UNIVERSITY (REID L.)

Roma 07/04/2025

DOMENICO ALVARO
Sapienza University of Rome, Viale Università 37, 00185, Rome, Italy
domenico.alvaro@uniroma1.it
Research activity (since 1980) in the field of liver damage, liver regeneration, drug-induced liver damage, drug-transporters in the liver, hepatic cell proliferation and apoptosis, cholestasis, liver disease pathophysiology and treatment, Hepatic Stem-cells, regenerative medicine of liver and pancreas, cholangiocarcinoma and liver cancer, network and precision medicine, Liver Stem cells. Coordinator of Sapienza Network for the cell therapy of liver diseases; D. Alvaro was the first to discover stem cells in the human biliary tree and to use them for the cell therapy of cirrhosis; coordinator of the AISF Group on cholangiocarcinoma (Italian Liver Association); coordinator of the AISF-SIGE committee on cholangiocarcinoma with publication of the Italian Guidelines; Coordinator of the European Network for the Study of Cholangiocarcinoma (ENS-CCA); -Coordinator of the Italian guidelines on Cholangiocarcinoma (published on Dig. Liver Dis. 2020. Part I and II); Chairs of the International guidelines on Cholangiocarcinoma (EASL+ILCA); D. Alvaro was the first to demonstrate that cholangiocarcinoma is a stem-cell based disease and to define the profile of cancer stem cells in this cancer. D. Alvaro was the first to identify the crucial role of cholangiocytes in the bile pathophysiology and to demonstrate how they represent a neuroendocrine compartment in diseased liver, driving repair processes. D. Alvaro discovered the isolated bile duct unit. D. Alvaro founded the first italian university department on Translational and Precision Medicine. Prof. D. Alvaro was one of the founders of a start-up (Biosensing srl) engaged in the development of medical devices aimed at real-time diagnostics of changes in intestinal permeability or intestinal inflammation or markers of systemic inflammation. The Co-PI is the owner of four international patents on the identification, preparation and therapeutic use of stem cells for the treatment of terminal hepatic and biliary tract diseases. The Co-PI is the director of STITCH - Sapienza information-based Technology InnovaTion Center for Health which is the first Sapienza research center that combines medicine with the most innovative information technologies, such as network medicine, big data, virtual reality, artificial intelligence, robotics and sensors at the service of medicine. STITCH's activities are focused on the promotion and coordination of transdisciplinary research projects whose competitive advantage is given by the integration between the IT departments, engineering and medical, or from the common management of skills, instruments and laboratories, for the development of innovative solutions in the health sector.
H-index= 78
No. publications:= 329
No. citations: 22315
1990-92 Assciate Researcher at YALE Uinv., Liver center
1988 Bursary National Health Institute, Rome
1987 Bursary National Health Institute, Rome
1986 Bursary National Health Institute, Rome
1988 Specialization Gastroenterology Univ. Sapienza Rome
1985 Specialization Internal Medicine, Univ. Sapienza Rome
1981Bursary Health Ministry, Rome
1980 Master’s degree in medicine at the University of Rome “La Sapienza” with honours
2005-present Full Professor of Gastroenterology, Univ. Sapienza, Rome
2002-2005 Associate Professor of Gastroenterology, Univ. Sapienza, Rome
2001-2002 Researcher, Gastroenterology, Univ. Sapienza, Rome
1988-2001 Funzionario Tecnico, Univ. Sapienza, Rome
1990-92 Associate Researcher “Digestive Diseases, YALE Univ. USA
CURRENT POSITIONS Full Professor of Gastroenterology (MED/12), Sapienza Univ. Rome
- 2020 Current Dean of the Faculty of Medicine and Dentistry (Academic Sector) Sapienza Uiniv. Rome, Rome Italy: Main duties/responsibilities: coordination of 11 Departments, 550 Teacgers and 11,00 students
- 2019 Current Member of Comitato indirizzo Scuola Superiore Studi Avanzati ((Academic Sector) Sapienza Univ. Rome, Rome Italy: Main duties/responsibilities: coordination of teaching course for studentss.
- 2022-current Coordinator of Advance Course of Network Medicine (HARVARD- SAPIENZA) (Academic Sector) Sapienza Univ. Rome, Rome Italy: Main duties/responsibilities: Coordinantion of educational activities in network medicine of N. 80 graduated students
- 2019-2020 Chief of the Department of Translation and Precision Medicine, Sapienza (Academic and Scientific Sector) Sapienza Univ. Rome, Rome Italy Main duties/responsibilities: coordination of N. 110 MD and employers.
- 2020 present President of the board of teachers of digestive system diseases COLMAD, Corso Francia Rome, Italy (Academic Sector): Main duties/responsibilities: coordination of N. 90 academic gastroenterologists
- 2019 present Director of STITCH (Sapienza Information-Based Technology InnovaTion Center for Health Sapienza Univ. Rome, Rome Italy: (Research sector)
- 2018 present Director of Department of Internal Medicine and Medical Specialties (DAI) (Health sector) Policlinico Umberto 1, University Hospital, Rome Italy Main duties/responsibilities: coordination of medical activities N. 290 medical doctors
- 2017 present Director of Divison of Gastroenterology (Health sector) Policlinico Umberto 1, University Hospital, Rome Italy Main duties/responsibilities: coordination of N. 11 gastroenterologists
- 2020-present -Coordination of N. 18 research projects “Regione Lazio Strategic Grant (5500K, cod. N. G125278): as director of STITCH.
- 2018 present As Director of STITCH (Sapienza Information-Based Technology InnovaTion Center for Health) coordination of research activities on network medicine and precision medicine.
- 2008-present Legal responsible of Digestive and Liver Diseasedministrator Editrice Gastroenterologica Italiana and liable responsible of Digestive and Liver Disease
- 2005 Coordinator for AISF of the “IL COLANGIOCARCINOMA”, recommendations
- 2020: Component of the International Board who developed the uidelines on IgG4 disaese
- 2021:Coordinator of the multlidisciplinary Practical National Guidelines on “Colangiocarcinoma intrapeatico e Peri-ilare) LINEE GUIDA NAZIONALI ISS_SNGL.
- 2022 Coordinator for EASL and ILCA of the International guidelines on “Intrahepatic Cholangiocarcinoma”
- 2008-2020 Editorial Board Digestive and Liver Diseases
- 2008-2010 President Italian Society Gastroenterology (Sezione Lazio)
- 2008-2016 Responsabile (law)-Editor of Digestive and Liver Disease
- 2010-present Member of Medical Academy Rome
- 2010-2017 Chief of the Latina Regional Center for Celiac Disease
- 2011-2020 Member of Editorial Board Hepatology
- 2011-2012 Member Working Team, Italian Drug Agency (AIFA)
- 2011-2016 Member of steering committee Department of “Scienze e Biotecnologie Medico-Chirurgiche”, University of Rome “Sapienza”.
- 2014-2017 Responsible of the Centre of Rare Disease, ASL Latina
- 2015-2018 Member of the Faculty Committee for the appointment of Professor Emeritus
- 2016-2020 Representative of the Sapienza University in the consortium for organ transplant
- 2016-2018 Member of the steering committee Italian Society of Gastroenterology
- 2018-2020 President of the Italian Society of Gastroenterology
- 2019-2020 Member of Comitato indirizzo Scuola Superiore Studi Avanzati
- 2019-2020 Member of Senato Accademico, Sapienza Università di Roma
- 2020 present President of the board of teachers of digestive system diseases (COLMAD)
- 2020-2021 Teaching Patologia Integrata III, CCLE Teaching at Scuola di Specializzazione Gastroenterologia , Sapienza Rome Appointed Coordinator of Patologia Integrata III, Medical School Faculty, CCLA Sapienza Univ. of Rome, Italy
- 2018-present Teaching Patologia Integrata III, CCLA and CCLC Teaching at Scuola di Specializzazione Gastroenterologia , Sapienza Rome Appointed Coordinator of Patologia Integrata III, Medical School Faculty, CCLA Sapienza Univ. of Rome, Italy
- 2014-2015 Teaching Patologia Integrata III, CCLE, Latina Teaching at Scuola di Specializzazione Gastroenterologia , Sapienza Rome Appointed Coordinator of Patologia Integrata III, Medical School Faculty, CCLE Sapienza Univ. of Rome, Italy
- 2011 Ricerca Universitaria (Ex Ateneo): "Inflammatory mediators and adipokines in Non Alcholic Fatty Liver Disease: their role in the modulation of Hepatic Progenitor Cell niche and liver damaging and correlations with systemic inflammation and atherosclerotic lesions."
- 2010-2017 - FIRB, accordi di programma 2010-2017, scientific responsability local Research Unit RBAP10Z7FS_004."Cellule staminali multipotenti isolate dall'albero biliare umano extraepatico e loro differenziazione in cellule epatiche e pancreatiche: studi pre-clinici e potenziali applicazioni cliniche.
- 2010 Ateneum grant for the conference:"The pathology of the biliary tree” "
- 2010-2018: private grants from VESTA Inc. (Usa) for a research program on biliary tree stem cells
- 2016-2019: private research grant from InterceptPharma for a research grant on “Effects of FXR modulators on experimental cholangiocarcinoma”.
- 2017: Grant ricerca Sapienza per II BIENNAL CONGRESS OF THE EUROPEAN NETWORK FOR THE STUDY OF CHOLANCIOCARCINOMA - n. Protocoll CC21715C6754EE97
- 2017-2020: Grant ricerca Sapienza "Progetti H2020 - H2020; Cell Therapies of Untreatable Liver Diseases using Human Biliary Tree Stem Cells. - n. Protocollo PH11715C6
- 2018-present: COST-ACTION european Grant on Cholangiocarcinoma Network
- 2020-present: Regione Lazio Strategic Grant (5500K, cod. N. G125278): as director of STITCH, Coordinator of a regional network managing N. 18 research grants (total 5,8 millions euros)=.
- 2020-present: Grant form European Space Agency: Title ECO4CO – Earth COgnitive system 4 COvid-19”, Telespazio S.p.A. Bando ESA ITT AO10314 “Space in response to COVID-19 outbreak” - call for tender” (Ref: ESA AO/1-10314/20/NL/AF), 35k.
- International Patent 2011 International patent on stem cells isolated from the biliary tree (U.S. Patent Application No.:61/256,846)
- International Patent 2014 International patent: Method of Treating Pancreatic and Liver Conditions by Endoscopic-Mediated Transplantation of Stem Cells into/onto Bile Duct Walls of Particular Regions of the Biliary Tree (U.S. Patent Application No.: 14/207,191).
- International Patent 2017 International Patent, U.S. Application 62/482644 date:_ 06.04.2017; titolo: Cryopreservation of biliary stem cells..
- International Patent 2019 International Patent US 2019/0300849 A1 Oct. 3, 2019 Titolo: Stem/progenitor cells from duodenal Brunner’s glands and methods of isolating and using them.

Publications: MOST RELEVANT PUBBLICATIONS (last 10 years)
1: Izquierdo-Sanchez L, Lamarca A, La Casta A, Buettner S, Utpatel K, Klümpen HJ, Adeva J, Vogel A, Lleo A, Fabris L, Ponz-Sarvise M, Brustia R, Cardinale V, Braconi C, Vidili G, Jamieson NB, Macias RI, Jonas JP, Marzioni M, Hołówko W, Folseraas T, Kupčinskas J, Sparchez Z, Krawczyk M, Krupa Ł, Scripcariu V, Grazi GL, Landa- Magdalena A, Ijzermans JN, Evert K, Erdmann JI, López-López F, Saborowski A, Scheiter A, Santos-Laso A, Carpino G, Andersen JB, Marin JJ, Alvaro D, Bujanda L, Forner A, Valle JW, Koerkamp BG, Banales JM. Cholangiocarcinoma landscape in Europe: diagnostic, prognostic and therapeutic insights from the ENSCCA Registry. J Hepatol. 2021 Dec 21:S0168-8278(21)02252-2.doi: 10.1016/j.jhep.2021.12.010. Epub ahead of print. PMID: 35167909.
2: Gerussi A, Verda D, Bernasconi DP, Carbone M, Komori A, Abe M, Inao M, Namisaki T, Mochida S, Yoshiji H, Hirschfield G, Lindor K, Pares A, Corpechot C, Cazzagon N, Floreani A, Marzioni M, Alvaro D, Vespasiani-Gentilucci U, Cristoferi L, Valsecchi MG, Muselli M, Hansen BE, Tanaka A, Invernizzi P. Machine learning in primary biliary cholangitis: A novel approach for risk stratification. Liver Int. 2022 Mar;42(3):615-627. doi: 10.1111/liv.15141. Epub 2022 Jan 7. PMID: 34951722.
3: Casadio M, Biancaniello F, Overi D, Venere R, Carpino G, Gaudio E, Alvaro D, Cardinale V. Molecular Landscape and Therapeutic Strategies in Cholangiocarcinoma: An Integrated Translational Approach towards Precision Medicine. Int J Mol Sci. 2021 May 25;22(11):5613. doi: 10.3390/ijms22115613. PMID: 34070643; PMCID: PMC8199244.
4: Sato K, Zhang W, Safarikia S, Isidan A, Chen AM, Li P, Francis H, Kennedy L, Baiocchi L, Alvaro D, Glaser S, Ekser B, Alpini G. Organoids and Spheroids as Models for Studying Cholestatic Liver Injury and Cholangiocarcinoma. Hepatology. 2021 Jul;74(1):491-502. doi: 10.1002/hep.31653. Epub 2021 Jun 4. PMID: 33222247; PMCID: PMC8529583.
5: Banales JM, Cardinale V, Carpino G, Marzioni M, Andersen JB, Invernizzi P, Lind GE, Folseraas T, Forbes SJ, Fouassier L, Geier A, Calvisi DF, Mertens JC, Trauner M, Benedetti A, Maroni L, Vaquero J, Macias RI, Raggi C, Perugorria MJ, Gaudio E, Boberg Curriculum Vitae Replace with First name(s) Surname(s) © European Union, 2002-2012 | http://europass.cedefop.europa.eu Page 4 / 5 KM, Marin JJ, Alvaro D. Expert consensus document: Cholangiocarcinoma: current knowledge and future perspectives consensus statement from the European Network for the Study of Cholangiocarcinoma (ENS-CCA). Nat Rev Gastroenterol Hepatol. 2016 May;13(5):261-80.
6. Di Matteo S, Di Meo C, Carpino G, Zoratto N, Cardinale V, Nevi L, Overi D, Costantini D, Pinto C, Montanari E, Marzioni M, Maroni L, Benedetti A, Viola M, Coviello T, Matricardi P, Gaudio E, Alvaro D. Therapeutic effects of dexamethasone-loaded hyaluronan nanogels in the experimental cholestasis. Drug Deliv Transl Res. 2022 Feb 28. doi: 10.1007/s13346-022-01132-7.
7. Zhang W, Lanzoni G, Hani H, Overi D, Cardinale V, Simpson S, Pitman W, Allen A, Yi X, Wang X, Gerber D, Prestwich G, Lozoya O, Gaudio E, Alvaro D, Tokaz D, Dominguez- Bendala J, Adin C, Piedrahita J, Mathews K, Sethupathy P, Carpino G, He Z, Wauthier E, Reid LM. Patch grafting, strategies for transplantation of organoids into solid organs such as liver. Biomaterials. 2021 Oct;277:121067. doi: 10.1016/j.biomaterials.2021.121067.
8. Nevi L, Di Matteo S, Carpino G, Zizzari IG, Samira S, Ambrosino V, Costantini D, Overi D, Giancotti A, Monti M, Bosco D, De Peppo V, Oddi A, De Rose AM, Melandro F, Bragazzi MC, Faccioli J, Massironi S, Grazi GL, Panici PB, Berloco PB, Giuliante F, Cardinale V, Invernizzi P, Caretti G, Gaudio E, Alvaro D. DCLK1, a Putative Stem Cell Marker in Human Cholangiocarcinoma. Hepatology. 2021 Jan;73(1):144-159. doi: 10.1002/hep.31571.
9. Cardinale V, Renzi A, Carpino G, Torrice A, Bragazzi MC, Giuliante F, DeRose AM, Fraveto A, Onori P, Napoletano C, Franchitto A, Cantafora A, Grazi G, Caporaso N, D'Argenio G, Alpini G, Reid LM, Gaudio E, Alvaro D. Profiles of cancer stem cell subpopulations in cholangiocarcinomas. Am J Pathol. 2015 Jun;185(6):1724-39. doi:10.1016/j.ajpath.2015.02.010. Epub 2015 Apr 17
10. Cardinale V, Carpino G, Cantafora A, Reid LM, Gaudio E, Alvaro D. Metabolic oxidation controls the hepatic stem cells (HpSCs) fate and the hepatic lineage organization in physiologic and pathologic conditions.Hepatology. 2012 Nov;56(5):2006-7. doi: 10.1002/hep.25825.

Rome April 7.2025