CARLA IACOBINI

Carla Iacobini, PhD
Curriculum Vitae

E-mail: carla.iacobini@uniroma1.it

Studi:
2004 Ph.D., dottorato di Ricerca in Endocrinologia e Medicina Molecolare, Università La Sapienza Roma
1995 Specializzazione in Patologia Clinica Università La Sapienza Roma;
1991 Laurea Magistrale in Scienze Biologiche Università La Sapienza Roma

Impiego attuale:

Professore Associato SSD MEDS-08/C (Scienza dell'alimentazione e delle tecniche dietetiche applicate) Dipartimento di medicina Clinica e Molecolare, Facoltà di Medicina e Psicologia, Università “La Sapienza”, Roma.

Impieghi precedenti:

2021-2024 Ricercatore a tempo determinato Tipo b, MED/49 Scienze Tecniche Dietetiche Applicate, Dipartimento di Medicina Clinica e Molecolare, Facoltà di Medicina e Psicologia, Università “La Sapienza”, Roma.

2009-2021 Assegnista di Ricerca/Contrattista MED/13 Endocrinologia, MED/49 Scienze tecniche dietetiche applicate, Dipartimento di Medicina Clinica e Molecolare, Facoltà di Medicina e Psicologia, Università “La Sapienza”, Roma.
1998-2009 Contrattista di Ricerca, MED/13 Endocrinologia, MED/14 Nefrologia, Dipartimento di Scienze Cliniche Università “La Sapienza”, Roma; Contrattista di Ricerca presso il Laboratorio di Biochimica Patologica Istituto Superiore di Sanità Roma (2000-2004)
1991-1998 Contrattista di Ricerca Centro di Ricerche Sperimentali Istituto Regina Elena Roma

Attività didattica:
2016-2020 Attività didattica nell’ambito del Dottorato di Ricerca in Scienze Endocrinologiche Università “La Sapienza” Roma
2021- Insegnamento: corso integrato “Malattie del Sistema Endocrino e Metabolico” Cds: Medicina e Chirurgia; Facoltà di Medicina e Psicologia, Università La Sapienza Roma
2024- Insegnamento: “Fisiologia della Nutrizione” Cds: Dietistica Roma Azienda Policlinico Umberto I
2024- Insegnamento: “Scienza dell’Alimentazione” Cds: Scienze, culture e politiche gastronomiche per il benessere L/GASTR

Attività di ricerca ed editoriale:

1991-98 Ricerca traslazionale sugli effetti delle terapie antiblastiche sul metabolismo delle cellule tumorali
1999- Ricerca nel campo del diabete dell’obesità e dell’invecchiamento. In particolare, sono indagati i meccanismi molecolari alla base dell’insorgenza del diabete tipo 2 delle complicanze vascolari (nefropatia e aterosclerosi) e metaboliche (steatoepatite non alcolica– NASH), nonché dell’aumento del rischio di adenocarcinoma pancreatico associato al diabete;
2002- Attività di “peer review” per numerose riviste scientifiche internazionali: Diabetologia, Atherosclerosis, ACTA Diabetologica, Diabetes, PLOS ONE, Life Sciences, Journal of the American Society of Nephrologyl etc.;

2019- Academic Editor della rivista “Journal of Diabetes Research”

2020- Membro del Board Editoriale della rivista “Acta Diabetologica”

Elenco Pubblicazioni
1- Iacobini C, Vitale M, Haxhi J, Menini S, Pugliese G. Impaired Remodeling of White Adipose Tissue in Obesity and Aging: From Defective Adipogenesis to Adipose Organ Dysfunction. Cells. 2024 Apr 30;13(9):763.
2- Haxhi J, Vitale M, Mattia L, Giuliani C, Sacchetti M, Orlando G, Iacobini C, Menini S, Zanuso S, Nicolucci A, Balducci S, Pugliese G. Effect of sustained decreases in sedentary time and increases in physical activity on liver enzymes and indices in type 2 diabetesFront Endocrinol (Lausanne). 2024 May 24;15:1393859
3- Iacobini C, Vitale M, Sentinelli F, Haxhi J, Pugliese G, Menini S. Renal Expression and Localization of the Receptor for (Pro)renin and Its Ligands in Rodent Models of Diabetes, Metabolic Syndrome, and Age-Dependent Focal and Segmental Glomerulosclerosis. Int J Mol Sci. 2024 Feb 12;25(4):2217
4- Iacobini C, Fassino V, Mazzaferro S, Tartaglione L. In vitro evaluation of the calcification inhibitory properties of Policosanol, Genistein and Vitamin D (Reduplaxin®) either alone or in combination. Kidney Blood Press Res. 2024 Jan 24
5- Balducci S, Haxhi J, Vitale M, Mattia L, Sacchetti M, Orlando G, Cardelli P, Iacobini C, Bollanti L, Conti F, Zanuso S, Nicolucci A, Pugliese G; Italian Diabetes and Exercise Study 2 (IDES_2) Investigators Diabetes. Sustained increase in physical fitness independently predicts improvements in cardiometabolic risk profile in type 2 diabetes. Diabetes Metab Res Rev. 2023 Sep;39(6): e3671
6- Iacobini C, Vitale M, Pugliese G, Menini S The "sweet" path to cancer: focus on cellular glucose metabolism. Front Oncol. 2023 May 25;13:1202093.
7- Iacobini C, Vitale M, Haxhi J, Pesce C, Pugliese G, Menini S. Mutual Regulation between Redox and Hypoxia-Inducible Factors in Cardiovascular and Renal Complications of Diabetes Antioxidants (Basel) 2022 Nov 4;11(11):2183
8- Iacobini C, Vitale M, Haxhi J, Pesce C, Pugliese G, Menini S. Food-Related Carbonyl Stress in Cardiometabolic and Cancer Risk Linked to Unhealthy Modern Diet. Nutrients 2022; 14(5):1061
9- Balducci S, Haxhi J, Sacchetti M, Orlando G, Cardelli P, Vitale M, Mattia L, Iacobini C, Bollanti L, Conti F, Zanuso S, Nicolucci A, Pugliese G; Italian Diabetes and Exercise Study 2 (IDES_2) Investigators. Relationships of Changes in Physical Activity and Sedentary Behavior With Changes in Physical Fitness and Cardiometabolic Risk Profile in Individuals With Type 2 Diabetes: The Italian Diabetes and Exercise Study 2 (IDES_2) Diabetes Care. 2022 Jan 1;45(1):213-221
10- Iacobini C, Vitale M, Pugliese G, Menini S. Normalizing HIF-1α Signaling Improves Cellular Glucose Metabolism and Blocks the Pathological Pathways of Hyperglycemic Damage. Biomedicines 2021;9(9):1139
11- Iacobini C, Vitale M, Pesce C, Pugliese G, Menini S. Diabetic Complications and Oxidative Stress: A 20-Year Voyage Back in Time and Back to the Future. Antioxidants (Basel). 2021;10(5):727.
12- Menini S, Iacobini C, Vitale M, Pesce C, Pugliese G. Diabetes and Pancreatic Cancer-A Dangerous Liaison Relying on Carbonyl Stress. Cancers (Basel). 2021;13(2):313.
13- Blasetti Fantauzzi C, Iacobini C, Menini S, Vitale M, Sorice GP, Mezza T, Cinti S, Giaccari A, Pugliese G. Galectin-3 gene deletion results in defective adipose tissue maturation and impaired insulin sensitivity and glucose homeostasis. Sci Rep. 2020;10:20070.
14- Menini S, Iacobini C, de Latouliere L, Manni I, Vitale M, Pilozzi E, Pesce C, Cappello P, Novelli F, Piaggio G, Pugliese G. Diabetes promotes invasive pancreatic cancer by increasing systemic and tumour carbonyl stress in Kras G12D/+ mice. J Exp Clin Cancer Res. 2020;39:152
15- Menini S, Iacobini C, Vitale M, Pugliese G. The Inflammasome in Chronic Complications of Diabetes and Related Metabolic Disorders. Cells 2020;9:1812
16- Menini S, Iacobini C, Fantauzzi CB, Pugliese G. L-carnosine and its Derivatives as New Therapeutic Agents for the Prevention and Treatment of Vascular Complications of Diabetes. Curr Med Chem. 2020;27:1744-1763.
17- Iacobini C, Pugliese G, Blasetti Fantauzzi C, Federici M, Menini S. Metabolically healthy versus metabolically unhealthy obesity, Metabolism 2019;92:51-60
18- Menini S, Iacobini C, Pugliese G, Pesce C. Dietary interventions to contrast the onset and progression of diabetic nephropathy: A critical survey of new data Crit Rev Food Sci Nutr. 2018 Jul 3;58(10):1671-1680
19- Menini S, Iacobini C, de Latouliere L, Manni I, Ionta V, Blasetti Fantauzzi C, Pesce C, Cappello P, Novelli F, Piaggio G, Pugliese G. The advanced glycation endproduct Nε -carboxymethyllysine promotes progression of pancreatic cancer: implications for diabetes-associated risk and its prevention. J Pathol. 2018;245:197-208
20- Iacobini C, Blasetti Fantauzzi C, Bedini R, Pecci R, Bartolazzi A, Amadio B, Pesce C, Pugliese C, Menini S. Galectin-3 is essential for proper bone cell differentiation and activity, bone remodeling and biomechanical competence in mice. Metabolism 2018;83:149-158
21- Iacobini C, Menini S, Blasetti Fantauzzi C, Pesce CM, Giaccari A, Salomone E, Lapolla A, Orioli M, Aldini G, Pugliese G. FL-926-16, a novel bioavailable carnosinase-resistant carnosine derivative, prevents onset and stops progression of diabetic nephropathy in db/db mice. Br J Pharmacol. 2018;175:53-66.
22- Menini S, Iacobini C, Pugliese G, Pesce C. Dietary Interventions To Contrast The Onset And Progression Of Diabetic Nephropathy: A Critical Survey of New Data. Crit Rev Food Sci Nutr. 2018;58:1671-1680
23- Iacobini C, Fantauzzi CB, Pugliese G, Menini S. Role of Galectin-3 in Bone Cell Differentiation, Bone Pathophysiology and Vascular Osteogenesis. Int J Mol Sci. 2017 21;18. pii: E2481.
24- Blasetti Fantauzzi C, Menini S, Iacobini C, Rossi C, Santini E, Solini A, Pugliese G. Deficiency of the Purinergic Receptor 2X7 Attenuates Nonalcoholic Steatohepatitis Induced by High-Fat Diet: Possible Role of the NLRP3 Inflammasome. Oxid Med Cell Longev. 2017;2017:8962458.
25- Conti F, Balducci S, Pugliese L, D’Errico V, Vitale M, Alessi E, Salerno G, Iacobini C, Menini S, Bollanti L, Nicolucci A, and Pugliese G. Correlates of calcaneal quantitative ultrasound parameters in patients with diabetes: the study on the assessment of determinants of muscle and bone strength abnormalities in diabetes. J Diab Res. 2017;2017:4749619
26- de Latouliere L, Manni I, Iacobini C, Pugliese G, Grazi GL, Perri P, Cappello P, Novelli F, Menini S, Piaggio G. A bioluminescent mouse model of proliferation to highlight early stages of pancreatic cancer: A suitable tool for preclinical studies. Ann Anat. 2016; 207:2-8
27- Menini S, Iacobini C, Blasetti Fantauzzi C, Pesce CM, Pugliese G. Role of Galectin-3 in Obesity and Impaired Glucose Homeostasis. Oxid Med Cell Longev. 2016; 2016:9618092
28- Balducci S, Cardelli P, Pugliese L, D'Errico V, Haxhi J, Alessi E, Iacobini C, Menini S, Bollanti L, Conti FG, Nicolucci A, Pugliese G; Italian Diabetes Exercise Study (IDES) Investigators. Volume-dependent effect of supervised exercise training on fatty liver and visceral adiposity index in subjects with type 2 diabetes The Italian Diabetes Exercise Study (IDES). Diabetes Res Clin Pract. 2015; 109:355-63
29- Pugliese G, Iacobini C, Fantauzzi CB, Menini S. The dark and bright side of atherosclerotic calcification. Atherosclerosis 2015; 238:220-230
30- Menini S, Iacobini C, Ricci C, Fantauzzi CB, Pugliese G. Protection from diabetes-induced atherosclerosis and renal disease by D-carnosine-octylester: effects of early vs late inhibition of advanced glycation end-products in Apoe-null mice. Diabetologia 2015; 58:845-53
31- Pugliese G, Iacobini C, Pesce CM, Menini S. Galectin-3: an emerging all-out player in metabolic disorders and their complications. Glycobiology. 2015: 25:136-50
32- Pugliese G, Iacobini C, Ricci C, Fantauzzi CB, Menini S. Galectin-3 in diabetic patients. Clin Chem Lab Med. 2014; 52:1413-23
33- Balducci S, Sacchetti M, Orlando G, Salvi L, Pugliese L, Salerno G, D'Errico V, Iacobini C, Conti FG, Zanuso S, Nicolucci A, Pugliese G; Correlates of muscle strength in diabetes: The study on the assessment of determinants of muscle and bone strength abnormalities in diabetes (SAMBA) Nutr Metab Cardiovasc Dis. 2014 Jan;24(1):18-26
34- Menini S, Iacobini C, Ricci C, Fantauzzi CB, Salvi L, Pesce CM, Relucenti M, Familiari G, Taurino M, Pugliese G. The galectin-3/RAGE dyad modulates vascular osteogenesis in atherosclerosis. Cardiovasc Res. 2013; 100:472-80
35- Solini A, Menini S, Rossi C, Ricci C, Santini E, BlasettiFantauzzi C, Iacobini C, and Pugliese G. The purinergic 2X7 receptor participates in renal inflammation and injury induced by high fat diet: possible role of NLRP3 inflammasome activation. J Pathol. 2013;231:342-53
36- Balducci S, Zanuso S, Cardelli P, Salvi L, Bazuro A, Pugliese L, Maccora C, Iacobini C, Conti FG, Nicolucci A, Pugliese G; Italian Diabetes Exercise Study (IDES) Investigators). Effect of high- versus low-intensity supervised aerobic and resistance training on modifiable cardiovascular risk factors in type 2 diabetes; the Italian Diabetes and Exercise Study (IDES). PLoS One. 2012;7(11):e49297
37- Balducci S, Zanuso S, Cardelli P, Salvi L, Mazzitelli, G, Bazuro A, Iacobini C, Nicolucci A, Pugliese G; Italian Diabetes Exercise Study Investigators. Changes in physical fitness predict improvements in modifiable cardiovascular risk factors independently of body weight loss in subjects with type 2 diabetes participating in the Italian Diabetes and Exercise Study (IDES). Diabetes Care. 2012; 35:1347-54
38- Menini S, Iacobini C, Ricci C, Scipioni A, Fantauzzi CB, Giaccari A, Salomone E, Canevotti R, Lapolla A, Orioli M, Aldini G, Pugliese G. D-carnosine-octylester attenuates atherosclerosis and renal disease in ApoE null mice fed a Western diet through reduction of carbonyl stress and inflammation. Br J Pharmacol. 2012;166:1344-1356
39- Nicolucci A, Balducci S, Cardelli P, Cavallo S, Fallucca S, Bazuro A, Simonelli P, Iacobini C, Zanuso S, Pugliese G; Italian Diabetes Exercise Study Investigators Relationship of exercise volume to improvements of quality of life with supervised exercise training in patients with type 2 diabetes in a randomised controlled trial: the Italian Diabetes and Exercise Study (IDES). Diabetologia. 2012; 55:579-88
40- Balducci S, Zanuso S, Cardelli P, Salerno G, Fallucca S, Nicolucci A, Pugliese G; Italian Diabetes Exercise Study (IDES) Investigators (Iacobini C) Supervised exercise training counterbalances the adverse effects of insulin therapy in overweight/obese subjects with type 2 diabetes. Diabetes Care. 2012; 35:39-41
41- Nicolucci A, Balducci S, Cardelli P, Zanuso S, Pugliese G; Italian Diabetes Exercise Study (IDES) Investigators (Iacobini C). Improvement of quality of life with supervised exercise training in subjects with type 2 diabetes mellitus. Arch Intern Med. 2011; 171:1951-3
42- Iacobini C, Menini S, Ricci C, Blasetti Fantauzzi C, Scipioni A, Salvi L, Cordone S, Delucchi F, Serino M, Federici M, Pricci F, Pugliese P. Galectin-3 ablation protects mice from diet-induced nonalcoholic steatohepatitis. Major scavenging role of galectin-3 in liver. J Hepatol. 2011; 54:975-83.
43- Balducci S, Zanuso S, Nicolucci A, De Feo P, Cavallo S, Cardelli P, Fallucca S, Alessi E, Fallucca F, Pugliese G; for the Italian Diabetes Exercise Study (IDES) Investigators (Iacobini C). Effect of an intensive exercise intervention strategy on modifiable cardiovascular risk factors in subjects with type 2 diabetes mellitus: a randomized controlled trial: the Italian Diabetes and Exercise Study (IDES). Arch Intern Med. 2010; 170:1794-803
44- Iacobini C, Menini S, Ricci C, Scipioni A, Sansoni V, Cordone S, Taurino M, Serino M, Marano G, Federici M, Pricci F, Pugliese G. Accelerated Lipid-Induced Atherogenesis in Galectin-3-Deficient Mice. Role of Lipoxidation via Receptor- Mediated Mechanisms. Arterioscler Thromb Vasc Biol. 2009 ;29:831-6.
45- Iacobini C, Menini S, Ricci C, Scipioni A, Sansoni V, Mazzitelli G, Cordone S, Pesce C, Pugliese F, Pricci F, Pugliese G. Advanced lipoxidation end-products mediate lipid-induced glomerular injury: role of receptor-mediated mechanisms. J Pathol. 2009; 218:360-9
46- Menghini R, Menini S, Amoruso R, Fiorentino L, Casagrande V, Marzano V, Tornei F, Bertucci P, Iacobini C, Serino M, Porzio O, Hribal ML, Folli F, Khokha R, Urbani A, Lauro R, Pugliese G, Federici M. Tissue Inhibitor of Metalloproteinase 3 Deficiency Causes Hepatic Steatosis and Adipose Tissue Inflammation in Mice. Gastroenterology 2009; 136:663-72.
47- Balducci S, Zanuso S, Massarini M, Corigliano G, Nicolucci A, Missori S, Cavallo S, Cardelli P, Alessi E, Pugliese G, Fallucca F; Italian Diabetes Exercise Study (IDES) Group (Iacobini C) The Italian Diabetes and Exercise Study (IDES): design and methods for a prospective Italian multicentre trial of intensive lifestyle intervention in people with type 2 diabetes and the metabolic syndrome Nutr Metab Cardiovasc Dis. 2008 Nov;18(9):585-95.
48- Menini S, Iacobini C, Oddi G, Ricci C, Simonelli P, Fallucca S, Grattarola M, Pugliese F,Pesce C, Pugliese G. Increased glomerular cell (podocyte) apoptosis in rats with streptozotocin-induced diabetes mellitus: role in the development of diabetic glomerular disease. Diabetologia 2007; 50:2591-9
49- Pugliese G, Ricci C, Iacobini C, Menini S, Fioretto P, Ferrandi M, Giardino A, Armelloni S, Mattinzoli D, Rastaldi M, Pugliese F. Glomerular barrier dysfunction in glomerulosclerosis- resistant Milan rats with experimental diabetes: the role of renal haemodynamics. J Pathol. 2007; 213:210-8
50- Menini S, Iacobini C, Ricci C, Oddi G, Pesce C, Pugliese F, Block K, Abboud HE, Giorgio M, Migliaccio E, Pelicci PG, Pugliese G. Ablation of the gene encoding p66(Shc) protects mice against AGE-induced glomerulopathy by preventing oxidant-dependent tissue injury and further AGE accumulation. Diabetologia 2007; 50:1997-2007
51- Menini S, Amadio L, Oddi G, Ricci C, Pesce C, Pugliese F, Giorgio M, Migliaccio E, Pelicci P, Iacobini C, Pugliese G. Deletion of p66Shc longevity gene protects against experimental diabetic glomerulopathy by preventing diabetes-induced oxidative stress. Diabetes. 2006;55:1642-1650
52- Ricci C, Iacobini C, Oddi G, Amadio L, Menini S, Rastaldi MP, Frasheri A, PricciF, Pugliese F, Pugliese G. Role of TGF-{beta}/GLUT1 axis in susceptibility vs resistance to diabetic glomerulopathy in the Milan rat model. Nephrol Dial Transplant. 2006; 21:1514-24.
53- Iacobini C, Oddi G, Menini S, Amadio L, Ricci C, Di Pippo C, Sorcini M, Pricci F, Pugliese F, Pugliese G. Developement of age-dependent glomerular lesions in galectin-3/AGE-receptor-3 knockout mice. Am J Physiol Renal Physiol. 2005; 289:F611-21
54- Pugliese G, Pricci F, Barsotti P, Iacobini C, Ricci C, Oddi G, Romeo G, Leto G, Marano G, Sorcini M, Sabbatini M, Fuiano G, Di Mario U, Pugliese F. Development of diabetic nephropathy in the Milan normotensive strain, but not in the Milan hypertensive strain: possible permissive role of hemodynamics Kidney Int. 2005 Apr;67(4):1440-52
55- Solini A, Iacobini C, Ricci C, Chiozzi P, Amadio L, Pricci F, Di Mario U, Di Virgilio F, Pugliese G. Purinergic modulation of mesangial extracellular matrix production: role in diabetic and other glomerular diseases Kidney Int. 2005 Mar;67(3):875-85
56- Iacobini C, Menini S, Oddi G, Ricci C, Amadio L, Pricci F, Olivieri A, Sorcini M, Di Mario U, Pesce C and Pugliese G. Galectin-3/AGE-receptor 3 Knockout mice show accelerated AGE-induced glomerular injury. Evidence for a protective role of galectin-3 as an AGE-receptor. FASEB J. 2004; 18:1773-5
57- Menini S, Ricci C, Iacobini C, Bianchi G, Pugliese G, Pesce C. Glomerular number and size in Milan hypertensive and normotensive rats: their relationship to susceptibility and resistance to hypertension and renal disease. J Hypertens. 2004; 22:2185-92
58- Pricci F, Leto G, Amadio L, Iacobini C, Cordone S, Catalano S, Zicari A, Sorcini M, Di Mario U, Pugliese G. Oxidative stress in diabetes-induced endothelial dysfunction involvement of nitric oxide and protein kinase C Free Radic Biol Med. 2003 Sep 15;35(6):683-94.
59- Iacobini C, Amadio L, Oddi G, Ricci C, Barsotti P, Missori S, Sorcini M, Di Mario U, Pricci F, Pugliese G. Role of galectin-3 in diabetic nephropathy. J Am Soc Nephrol. 2003 Aug;14(8 Suppl 3):S264-70.
60- Leto G, Pricci F, Amadio L, Iacobini C, Cordone S, Diaz-Horta O, Romeo G, Barsotti P, Rotella CM, di Mario U, Pugliese G. Increased retinal endothelial cell monolayer permeability induced by the diabetic milieu: role of advanced non-enzymatic glycation and polyol pathway activation Diabetes Metab Res Rev. 2001 Nov-Dec;17(6):448-58.
61- Pugliese G, Pricci F, Iacobini C, Leto G, Amadio L, Barsotti P, Frigeri L, Hsu DK, Vlassara H, Liu FT, Di Mario U. Accelerated diabetic glomerulopathy in galectin-3/AGE receptor 3 knockout mice FASEB J. 2001 Nov;15(13):2471-9.
62- Pricci F, Leto G, Amadio L, Iacobini C, Romeo G, Cordone S, Gradini R, Barsotti P, Liu FT, Di Mario U, Pugliese G. Role of galectin-3 as a receptor for advanced glycosylation end products. Kidney Int Suppl. 2000 Sep;77:S31-9.
63- Pugliese G, Pricci F, Leto G, Amadio L, Iacobini C, Romeo G, Lenti L, Sale P, Gradini R, Liu FT, Di Mario U. The diabetic milieu modulates the advanced glycation end product-receptor complex in the mesangium by inducing or upregulating galectin-3 expression Diabetes. 2000 Jul;49(7):1249-57
64- Fanciulli M, Bruno T, Di Padova M, De Angelis R, Iezzi S, Iacobini C, Floridi A, Passananti C Identification of a novel partner of RNA polymerase II subunit 11, Che-1, which interacts with and affects the growth suppression function of Rb FASEB J. 2000 May;14(7):904-12
65- Pugliese G, Pricci F, Romeo G, Leto G, Amadio L, Iacobini C, Di Mario U. Autocrine and paracrine mechanisms in the early stages of diabetic nephropathy J Endocrinol Invest. 1999 Oct;22(9):708-35.
66- Bruno T, Leonetti C, Aloe S, Iacobini C, Floridi A, Di Tondo U, Punturieri A, Fanciulli M. Levels of expression of hRPB11, a core subassembly subunit of human RNA polymerase II, affect doxorubicin sensitivity and cellular differentiation FEBS Lett. 1998 May 8;427(2):241-6.
67- Fanciulli M, Bruno T, Cerboni C, Bonetto F, Iacobini C, Frati L, Piccoli M, Floridi A, Santoni A, Punturieri A. Cloning of a novel human RNA polymerase II subunit downregulated by doxorubicin: new potential mechanisms of drug related toxicity FEBS Lett. 1996 Apr ;384(1):48-52.
68- Martelli F, Iacobini C, Caruso M, Felsani A. Characterization of two novel YY1 binding sites in the polyomavirus late promoter J Virol. 1996 Mar;70(3):1433-8.
69- Floridi A, Gentile FP, Bruno T, Delpino A, Iacobini C, Paggi MG, Castiglione S, Benassi M. Thermal behavior of a human glioma cell line and its response to combinations of hyperthermia and lonidamine Oncol Res. 1993;5(1):1-10.
70- Floridi A, Gentile PF, Bruno T, Delpino A, Iacobini C, Benassi M Survival response of a human glioma cell line to hyperthermia associated with rhein Anticancer Drugs. 1992 Aug;3(4):407-11
71- Caruso M, Iacobini C, Passananti C, Felsani A, Amati P. Protein recognition sites in polyomavirus enhancer: formation of a novel site for NF-1 factor in an enhancer mutant and characterization of a site in the enhancer D domain EMBO J. 1990 Mar;9(3):947-55.