EMANUELE CACCI

Full Name: Emanuele Cacci
Current position: Assistant Professor
Current address: Sapienza, University of Rome Department of Biology and
Biotechnology “Charles Darwin”, Piazzale Aldo Moro n. 5, 00185, Roma, Italia
Tel./Fax: +39 06 4991 2206/ +39 06 4991 2351
e-mail: emanuele.cacci@uniroma1.it

Education
- 2003 Ph.D. in Cell and Developmental Biology University of Rome “La
Sapienza”
- 1999 B.Sc. in Biology cum laude University of Rome “La Sapienza”

Employment and research experience
1997‐1999 undergraduate student Dept. Of Cell and Developmental Biology,
University of Rome “La Sapienza”
1999-2003 graduate research student Dept. Of Cell and Developmental Biology,
University of Rome “La Sapienza”
2003-2006 Post Doctoral position in the group headed by Professors Olle
Lindvall and Zaal kokaia at University Hospital of Lund (Sweden) at Stem Cell
Center.
July-August 2015: Visiting scientist at Stem Cell Center, hosted by Prof Zaal
Kokaia, at Stem Cell Center, University hospital, Lund (Sweden)
June-July: Visiting scientist at Istitute of di Scienze e Technology (IST) of
Klosterneuburg (Austria) hosted by Prof Gaia Novarino,
Present: permanent researcher (ricercatore) at Department of Biology and
Biotechnology ‘Charles Darwin’, Sapienza, University of Rome.

Teaching experience
- 2007-2008/2008-2009 lecture in “Methodologies to study the nervouse system”
- 2012- present: lecturer in “Stem cells in the nervouse system”

Research field
Dr.Cacci research is mainly focused on studying: 1) the contribution of specific
extrinsic and intrinsic factors controlling neural stem cell (NSCs) properties 2) the
effects of neuroinflammation, mainly mediated by microglia and astrocytes, on
neural stem cells (NSCs) maintenance, differentiation and neuronal survival 3)
the properties of NSCs and their neurogenic potential in the brain of adult mice
under pathological conditions (e.g. autism spectrum disorders) and during aging.

Selected publication (last 15 years)
1. Poiana G, Gioia R, Sineri S, Cardarelli S, Lupo G, Cacci E. Transcriptional
regulation of adult neural stem/progenitor cells: tales from the
subventricular zone. Neural Regen Res. 2020 Oct;15(10):1773-1783. doi:
10.4103/1673-5374.280301. Review.

2. Eleonora Stronati, Roberta Conti, Emanuele Cacci, Silvia Cardarelli,
Stefano Biagioni, Giancarlo Poiana (2019). Exosome-induced
differentiation of neural stem progenitor cells. INTERNATIONAL
JOURNAL OF MOLECULAR SCIENCES, Jul 27;20(15). pii: E3691. doi:
10.3390/ijms20153691

3. Maria Antonietta Ajmone-Cat, Angela Onori, Camilla Toselli, Eleonora
Stronati, Mariangela Morlando, Irene Bozzoni, Emanuela Monni, Zaal
Kokaia, Giuseppe Lupo, Luisa Minghetti, Stefano Biagioni, Emanuele
Cacci (2019). Increased FUS levels in astrocytes leads to astrocyte and
microglia activation and neuronal death. SCIENTIFIC REPORTS, vol. 9, p.
1-15, ISSN: 2045-2322, doi: 10.1038/s41598-019-41040-4.

4. Giuseppe Lupo, Roberta Gioia, Paola Serena Nisi, Stefano Biagioni,
Emanuele Cacci (2019). Molecular mechanisms of neurogenic aging in
the adult mouse subventricular zone. JOURNAL OF EXPERIMENTAL
NEUROSCIENCE, vol. 13, p. 1-10, ISSN: 1179-0695

5. Giuseppe Lupo, Silvana Gaetani, Emanuele Cacci, Stefano Biagioni,
Rodolfo Negri (2019). Molecular signatures of the aging brain: finding the
links between genes and phenotypes. NEUROTHERAPEUTICS, ISSN:
1933-7213, doi: 10.1007/s13311-019-00743-2.

6. Cera Arcangela Anna, Cacci Emanuele, Toselli Camilla, Cardarelli Silvia,
Bernardi Alessandra, Gioia Roberta, Giorgi Mauro, Poiana Giancarlo,
Biagioni Stefano (2018). Egr1 maintains NSC proliferation and its
overexpression counteracts cell cycle exit triggered by the withdrawal of
Epidermal Growth Factor. DEVELOPMENTAL NEUROSCIENCE, vol. 40,
p. 223-233, ISSN: 0378-5866, doi: 10.1159/000489699.

7. Lupo Giuseppe, Nisi Paola S, Esteve Pilar, Paul Yu-Lee, Novo Clara
Lopes, Sidders Ben, Khan, Muhammad A, Biagioni Stefano, Liu Hai-Kun,
Bovolenta Paola, Cacci Emanuele*, Rugg-Gunn, Peter J (2018).
Molecular profiling of aged neural progenitors identifies Dbx2 as a
candidate regulator of age-associated neurogenic decline. AGING CELL,
vol. 17, p. 1-15, ISSN: 1474-9718, doi: 10.1111/acel.12745.
*corresponding author.

8. Roberto Sacco, Emanuele Cacci, Gaia Novarino (2018). Neural stem
cells in neuropsychiatric disorders. CURRENT OPINION IN
NEUROBIOLOGY, vol. 48, p. 131-138, ISSN: 0959-4388, doi:
10.1016/j.conb.2017.12.005.

9. Cacci Emanuele, Negri, Rodolfo, Biagioni, Stefano, Lupo, Giuseppe
(2017). Histone methylation and microRNA-dependent regulation of
epigenetic activities in neural progenitor self-renewal and differentiation.
CURRENT TOPICS IN MEDICINAL CHEMISTRY, vol. 17, p. 794-807,
ISSN: 1568-0266, doi: 10.2174/1568026616666160414124456.

10. Guglielmi L, Nardella M, Musa C, Iannetti I, Arisi I, D'Onofrio M, Storti A,
Valentini A, Cacci Emanuele, Biagioni, S, Augusti Tocco G, D'Agnano I,
Felsani A. (2017). Lamin A/C Is Required for ChAT-Dependent
Neuroblastoma Differentiation. MOLECULAR NEUROBIOLOGY, vol. 5, p.
3729-3744, ISSN: 0893-7648, doi: 10.1007/s12035-016-9902-6.

11. Guadagno Noemi Antonella, Moriconi Claudia, Licursi Valerio, D'acunto
Emanuela, Nisi Paola Serena, Carucci, Nicoletta, De Jaco Antonella,
Cacci Emanuele, Negri Rodolfo, Lupo Giuseppe, Miranda Banos Maria
Elena (2017). Neuroserpin polymers cause oxidative stress in a neuronal
model of the dementia FENIB. NEUROBIOLOGY OF DISEASE, vol. 103,
p. 32-44, ISSN: 0969-9961, doi: 10.1016/j.nbd.2017.03.010.

12. Carucci Nicoletta, Cacci Emanuele, Nisi Paola Serena, Licursi Valerio,
Paul, Yu Lee, Biagioni Stefano, Negri Rodolfo, Rugg Gunn, Peter J., Lupo,
Giuseppe (2017). Transcriptional response of Hoxb genes to retinoid
signalling is regionally restricted along the neural tube rostrocaudal axis.
ROYAL SOCIETY OPEN SCIENCE, vol. 4, ISSN: 2054-5703, doi:
10.1098/rsos.160913.

13. Soldati C, Caramanica P, Burney MJ, Toselli C, Bithell A, Augusti Tocco G,
Stanton LW, Biagioni, S, Buckley NJ, Cacci Emanuele (2015). RE1
silencing transcription factor/neuron-restrictive silencing factor regulates
expansion of adult mouse subventricular zone-derived neural
stem/progenitor cells in vitro. JOURNAL OF NEUROSCIENCE
RESEARCH, vol. 8, p. 1203-1214, ISSN: 1097-4547, doi:
10.1002/jnr.23572.

14. Gioia Ubaldo, Valerio Di Carlo, Pasquale Caramanica, Camilla Toselli,
Antonella Cinquino, Marcella Marchioni, Pietro Laneve, Stefano Biagioni,
Irene Bozzoni, Emanuele Cacci*, Elisa Caffarelli (2014). miR-23a and
miR-125b regulate neural stem/progenitor cell proliferation by targeting
Musashi1. RNA BIOLOGY, vol. 11, p. 1105-1112, ISSN: 1547-6286, doi:
10.4161/rna.35508. *corresponding author.

15. Gabriele De Luca, Ilenia Ventura, Valentina Sanghez, Maria Teresa Russo,
Maria Antonietta Ajmone Cat, Cacci, Emanuele, Alberto Martire, Patrizia
Popoli, Germana Falcone, Flavia Michelini, Marco Crescenzi, Paolo
Degan, Luisa Minghetti, Margherita Bignami, Gemma Calamandrei (2013).
Prolonged lifespan with enhanced exploratory behavior in mice
overexpressing the oxidized nucleoside triphosphatase hMTH1. AGING
CELL, vol. 12, p. 695-705, ISSN: 1474-9718, doi: 10.1111/acel.12094.

16. Maddalena Sinno, Stefano Biagioni, Maria Antonietta Ajmone-Cat, Irene
Pafumi, Pasquale Caramanica, Virginia Medda, Gaetana Tonti, Luisa
Minghetti, Ferdinando Mannello, Emanuele Cacci (2013). The Matrix
Metalloproteinase Inhibitor Marimastat Promotes Neural Progenitor Cell
Differentiation into Neurons by Gelatinase-Independent TIMP-2-
Dependent Mechanisms. STEM CELLS AND DEVELOPMENT, vol. 22, p.
345-358, ISSN: 1547-3287, doi: 10.1089/scd.2012.0299.

17. M.A. Ajmone-Cat, M.L. Salvatori, Roberta De Simone, Melissa Mancini,
Stefano Biagioni, Antonietta Bernardo, Emanuele Cacci, Luisa Minghetti
(2012). Docosahexaenoic acid modulates inflammatory and
antineurogenic functions of activated microglial cells. JOURNAL OF
NEUROSCIENCE RESEARCH, vol. 90, p. 575-587, ISSN: 0360-4012, doi:
10.1002/jnr.22783.

18. Chiara Soldati, Emanuele Cacci, Stefano Biagioni, Nicoletta Carucci,
Giuseppe Lupo, Carla Perrone-Capano, Isabella Saggio, Gabriella
Augusti-Tocco (2012). Restriction of Neural Precursor Ability to Respond
to Nurr1 by Early Regional Specification. PLOS ONE, vol. 7, p. e51798-,
ISSN: 1932-6203, doi: 10.1371/journal.pone.0051798.

19. Maria Antonietta Ajmone-Cat*, Emanuele Cacci*, Ylenia Ragazzoni,
Luisa Minghetti, Stefano Biagioni (2010). Pro-gliogenic effect of IL-1α in
the differentiation of embryonic neural precursor cells in vitro. JOURNAL
OF NEUROCHEMISTRY, vol. 113, p. 1060-1072, ISSN: 0022-3042, doi:
10.1111/j.1471-4159.2010.06670.x. * gli autori hanno ugualmente
contribuito al lavoro.

20. Maria Antonietta Ajmone-Cat, Emanuele Cacci, Luisa Minghetti (2010).
Brain inflammation and the neuronal fate: from neurogenesis to
neurodegeneration. In: Kenneth Maiese. Neurovascular Medicine:
Pursuing Cellular Longevity for Healthy Aging. p. 319-344, Oxford
University Press, ISBN: 978-019532669-7, doi:
10.1093/acprof:oso/9780195326697.003.0013

21. Emanuele Cacci, Biagioni Stefano (2009). Colture di cellule staminali
neurali come modello per lo studio di patologie del sistema nervoso, studi
farmacologici e di neurotossicità. BIOCHIMICA CLINICA, vol. 33, p. 129-
136, ISSN: 0393-0564

22. G. Martella, A. Tassone, G. Sciamanna, P. Platania, D. Cuomo, M.T.
Viscomi, P. Bonsi, Emanuele Cacci, Stefano Biagioni, A. Usiello, G.
Bernardi, N. Sharma, D.G. Standaert, A. Pisani (2009). Impairment of
bidirectional synaptic plasticity in the striatum of a mouse model of DYT1
dystonia: role of endogenous acetylcholine. BRAIN, vol. 132, p. 2336-2349,
ISSN: 0006-8950, doi: 10.1093/brain/awp194.

23. Gaetana A. Tonti, Ferdinando Mannello, Cacci Emanuele, Biagioni
Stefano (2009). Neural stem cells at the crossroads: MMPs may tell the
way. THE INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY,
vol. 53, p. 1-17, ISSN: 0214-6282, doi: 10.1387/ijdb.082573gt.

24. Emanuele Cacci, Maria Antonietta Ajmone-Cat, Tonino Anelli, Stefano
Biagioni, Luisa Minghetti (2008). In vitro neuronal and glial differentiation
from embryonic or adult neural precursor cells are differently affected by
chronic or acute activation of microglia. GLIA, vol. 56, p. 412-425, ISSN:
0894-1491, doi: 10.1002/glia.20616.

25. Maria Ajmone-Cat, Emanuele Cacci, Luisa Minghetti (2008). Non
steroidal anti-inflammatory drugs and neurogenesis in the adult
mammalian brain. CURRENT PHARMACEUTICAL DESIGN, vol. 14, p.
1435-1442, ISSN: 1381-6128, doi: 10.2174/138161208784480199.

26. Emanuele Cacci, A. Villa, M. Parmar, M. Cavallaro, N. Mandahl, O.
Lindvall, A. Martinez-Serrano, Z. Kokaia (2007). Generation of human
cortical neurons from a new immortal fetal neural stem cell line.
EXPERIMENTAL CELL RESEARCH, vol. 313, p. 588-601, ISSN: 0014-
4827, doi: 10.1016/j.yexcr.2006.11.001.

27. Pär Thored, Andreas Arvidsson, Emanuele Cacci, H. Alhenius, Therese
Kallur, K. Ekdal, Zaal Kokaia, Olle Lindvall (2006). Persistent production of
neurons from adult brain stem cells during recovery after stroke. STEM
CELLS, vol. 24, p. 739-747, ISSN: 1066-5099, doi:
10.1634/stemcells.2005-0281.

28. Emanuele Cacci, J.H. Claasen, K. Kokaia (2005). Microglia-derived tumor
necrosis factor a exaggerates death of newborn hippocampal progenitor
cells in vitro. JOURNAL OF NEUROSCIENCE RESEARCH, vol. 89, p.
789-797, ISSN: 0360-4012, doi: 10.1002/jnr.20531.

Publication metrics (source: Scopus; 2019)
ORCID ID 0000-003-0082-6999
- H-index: 14
- Total publication number: 30
- Total citations: 1291
- Average Citations per Product: 43