FABIO DI DOMENICO

PERSONAL DATA
Fabio Di Domenico
Department of Biochemical Sciences,
Sapienza University of Rome
Office ph. +39 06.49910900
fabio.didomenico@uniroma1.it
www.LRBN.it
Pubmed

SUMMARY OF SCIENTIFIC ACHIEVEMENTS
(October 2017)

Papers: 73 (from Scopus)
Total Impact factor: 300
Total Citations: 2642
Average Citations per Product: 35
H-index: 32

EDUCATION

2009. PhD in Biochemical Sciences from Sapienza University of Rome
2005. University graduation in Biological Sciences from Sapienza University of Rome

APPOINTMENTS

2015 – present. Associate Professor position at the Department of Biochemical Sciences of Sapienza University of Rome
2010 – 2015. Researcher (Assistant Professor) position at the Department of Biochemical Sciences of Sapienza University of Rome
2009 – 2010. Post-doctoral fellows (from Istituto Pasteur – Fondazione Cenci Bolognetti) at the Department of Chemistry of the University of Kentucky
2007 – 2008. PhD foreign student at the Department of Chemistry of the University of Kentucky
2005 – 2008. PhD student at the Department of Biochemical Sciences of Sapienza University of Rome

TEACHING EXPERIENCE

2016 – present. Teacher of Biochemistry for Medicine School course “A” at faculty of Pharmacy and Medicine of Sapienza University of Rome
2016 – present Teacher of Biochemistry for TNPEE course at faculty of Pharmacy and Medicine of Sapienza University of Rome
2015 – present Teacher of Biochemistry for Nursing school course “J” at faculty of Pharmacy and Medicine of Sapienza University of Rome
2015 – present Teacher of Biochemistry for Nursing school course of “Forlanini” Hospital
2015 – present Teacher of Biochemistry for Nursing school course of “Spallanzani” Hospital
2014 - present Teacher of Biology and Genetics for Obstetrics degree at faculty of Pharmacy and Medicine of Sapienza University of Rome
2011 – 2014. Teacher of Biochemistry for Nursing school course “Y” at faculty of Pharmacy and Medicine of Sapienza University of Rome
2011 – 2014. Teacher of Biochemistry for Physical therapist school course “B” ” at faculty of Pharmacy and Medicine of Sapienza University of Rome

SOCIETY MEMBERBERSHIPS, AWARDS AND HONORS

2015. Junior faculty award at 12th International Conference on Alzheimer’s Disease and Parkinson’s Disease (APDP 2015)
2013 – present. Member of Trisomy 21 research society T21RS
2012 - present . Member of Society of Free Radical Research – Europe (SFRRE)
2013. Associate editor of Journal of Alzheimer Disease – IOS press
2012. Selected among the best young “under 40” researcher of faculty of pharmacy and medicine of Sapienza University of Rome
2008 – present. Member of the Italian Society of Biochemistry and Molecular Biology (SIB)

FUNDING INFORMATION

2016. Co-PI of project entitled Intranasal rapamycin administration to prevent Alzheimer-like dementia in Down Syndrome”, funded by Jerome Lejeune foundation with 26.000,00 euro.
2016. PI of “progetti di Ateneo” from Sapienza University of Rome financed with 34.000,00 euro with the project Brain insulin resistance in age-related cognitive decline: molecular mechanisms and novel therapeutic approaches”
2015. PI of Programma "SIR" from Ministero dell’Istruzione dell’Università e della Ricerca, Protocollo: RBSI144MTL financed with 169.938,00 euro with the project “Cross-talk between insulin signalling and oxidative stress in Alzheimer disease: A new paradigm”
2015. PI of “progetti di Ateneo” from Sapienza University of Rome financed with 4000,00 Euro with the project “Aberrant serine/glycine one-carbon metabolism in cancer cells: role of oxidative stress”
2015. Supervisor of “Avvio alla ricerca” grant from Sapienza University of Rome financed with 2000,00 euro with the project “Unravelling the impairment of the HO-1/BVR-A system during the progression of Alzheimer disease: new insights for the role of heme”
2014. Co-PI of a Multidisciplinary project from Sapienza University of Rome financed with 15.000,00 euro with the project “Alternative methods to animal testing: legal and social, scientific and technological aspects”
2014. Supervisor of “Avvio alla ricerca” grant from Sapienza University of Rome financed with 3.000,00 euro with the title “The Heme oxygenase 1/ Biliverdin reductase A system as novel therapeutic target for simvastatin treatment in Alzheimer disease”
2013. PI of “progetti di Ateneo” from Sapienza University of Rome financed with 7.500,00 Euro with the project “Analysis of autoantibodies in CSF and serum of Alzheimer Disease and Mild Cognitive Impairment subjects: Involvement in pathology progression and biomarker discovery”
2013. Co-PI of Marie Curie action grant to Eugenio Barone financed with 180.000,00 euro with the project “Biliverdin Reductase-A in brain insulin signaling and oxidative stress-mediated neurodegeneration”
2012 PI of “FARI” from Sapienza University of Rome financed with 7.000,00 euro with the project “Analysis of autoantibody in CSF and serum of AD and MCI subjects: immunoproteomics approach for biomarker discovery”
2012. PI of a 1 year fellowship to hire a collaborator as one of the best young “under 40” researcher of faculty of pharmacy and medicine of Sapienza University of Rome finaced with 22.800,00 Euro with the project “Ruolo dello stress ossidativo nei meccanismi molecolari della neurodegenerazione per lo studio di nuovi bersagli farmacologici”

PUBBLICATIONS

[1] Di Domenico F, Tramutola A, Foppoli C, Head E, Perluigi M, Butterfield DA (2017) mTOR in Down syndrome: Role in Abeta and tau neuropathology and transition to Alzheimer disease-like dementia. Free Radic Biol Med.
[2] Fontaine SN, Ingram A, Cloyd RA, Meier SE, Miller E, Lyons D, Nation GK, Mechas E, Weiss B, Lanzillotta C, Di Domenico F, Schmitt F, Powell DK, Vandsburger M, Abisambra JF (2017) Identification of changes in neuronal function as a consequence of aging and tauopathic neurodegeneration using a novel and sensitive magnetic resonance imaging approach. Neurobiol Aging 56, 78-86.
[3] Spadaccio C, Nappi F, Al-Attar N, Coccia R, Perluigi M, Di Domenico F (2016) CURRENT DEVELOPMENTS IN DRUG ELUTING DEVICES: Introductory Editorial: Drug-Eluting Stents or Drug-Eluting Grafts? Insights from Proteomic Analysis. Drug Target Insights 10, 15-19.
[4] Di Domenico F, Tramutola A, Perluigi M (2016) Cathepsin D as a therapeutic target in Alzheimer's disease. Expert Opin Ther Targets 20, 1393-1395.
[5] Di Domenico F, Tramutola A, Butterfield DA (2017) Role of 4-hydroxy-2-nonenal (HNE) in the pathogenesis of alzheimer disease and other selected age-related neurodegenerative disorders. Free Radic Biol Med 111, 253-261.
[6] Di Domenico F, Barone E, Perluigi M, Butterfield DA (2017) The Triangle of Death in Alzheimer's Disease Brain: The Aberrant Cross-Talk Among Energy Metabolism, Mammalian Target of Rapamycin Signaling, and Protein Homeostasis Revealed by Redox Proteomics. Antioxid Redox Signal 26, 364-387.
[7] Tramutola A, Lanzillotta C, Di Domenico F (2017) Targeting mTOR to reduce Alzheimer-related cognitive decline: from current hits to future therapies. Expert Rev Neurother 17, 33-45.
[8] Tramutola A, Di Domenico F, Barone E, Arena A, Giorgi A, di Francesco L, Schinina ME, Coccia R, Head E, Butterfield DA, Perluigi M (2017) Polyubiquitinylation Profile in Down Syndrome Brain Before and After the Development of Alzheimer Neuropathology. Antioxid Redox Signal 26, 280-298.
[9] Perluigi M, Barone E, Di Domenico F, Butterfield DA (2016) Aberrant protein phosphorylation in Alzheimer disease brain disturbs pro-survival and cell death pathways. Biochim Biophys Acta 1862, 1871-1882.
[10] Spadaccio C, Coccia R, Perluigi M, Pupo G, Schinina ME, Giorgi A, Blarzino C, Nappi F, Sutherland FW, Chello M, Di Domenico F (2016) Redox proteomic analysis of serum from aortic anerurysm patients: insights on oxidation of specific protein target. Mol Biosyst 12, 2168-2177.
[11] Tramutola A, Pupo G, Di Domenico F, Barone E, Arena A, Lanzillotta C, Brokeaart D, Blarzino C, Head E, Butterfield DA, Perluigi M (2016) Activation of p53 in Down Syndrome and in the Ts65Dn Mouse Brain is Associated with a Pro-Apoptotic Phenotype. J Alzheimers Dis 52, 359-371.
[12] Tramutola A, Di Domenico F, Barone E, Perluigi M, Butterfield DA (2016) It Is All about (U)biquitin: Role of Altered Ubiquitin-Proteasome System and UCHL1 in Alzheimer Disease. Oxid Med Cell Longev 2016, 2756068.
[13] Klionsky DJ, et al. (2016) Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy 12, 1-222.
[14] Barone E, Di Domenico F, Cassano T, Arena A, Tramutola A, Lavecchia MA, Coccia R, Butterfield DA, Perluigi M (2016) Impairment of biliverdin reductase-A promotes brain insulin resistance in Alzheimer disease: A new paradigm. Free Radic Biol Med 91, 127-142.
[15] Di Domenico F, Pupo G, Giraldo E, Lloret A, Badia MC, Schinina ME, Giorgi A, Butterfield DA, Vina J, Perluigi M (2016) Autoantibodies Profile in Matching CSF and Serum from AD and aMCI patients: Potential Pathogenic Role and Link to Oxidative Damage. Curr Alzheimer Res 13, 112-122.
[16] Di Domenico F, Pupo G, Giraldo E, Badia MC, Monllor P, Lloret A, Schinina ME, Giorgi A, Cini C, Tramutola A, Butterfield DA, Vina J, Perluigi M (2016) Oxidative signature of cerebrospinal fluid from mild cognitive impairment and Alzheimer disease patients. Free Radic Biol Med 91, 1-9.
[17] Tramutola A, Lanzillotta C, Arena A, Barone E, Perluigi M, Di Domenico F (2016) Increased Mammalian Target of Rapamycin Signaling Contributes to the Accumulation of Protein Oxidative Damage in a Mouse Model of Down's Syndrome. Neurodegener Dis 16, 62-68.
[18] Nenna A, Nappi F, Avtaar Singh SS, Sutherland FW, Di Domenico F, Chello M, Spadaccio C (2015) Pharmacologic Approaches Against Advanced Glycation End Products (AGEs) in Diabetic Cardiovascular Disease. Res Cardiovasc Med 4, e26949.
[19] Barone E, Cenini G, Di Domenico F, Noel T, Wang C, Perluigi M, St Clair DK, Butterfield DA (2015) Basal brain oxidative and nitrative stress levels are finely regulated by the interplay between superoxide dismutase 2 and p53. J Neurosci Res 93, 1728-1739.
[20] Di Domenico F, Perluigi M, Butterfield DA (2016) Redox Proteomics in Human Biofluids: Sample Preparation, Separation and Immunochemical Tagging for Analysis of Protein Oxidation. Methods Mol Biol 1303, 391-403.
[21] Bedse G, Di Domenico F, Serviddio G, Cassano T (2015) Aberrant insulin signaling in Alzheimer's disease: current knowledge. Front Neurosci 9, 204.
[22] Perluigi M, Di Domenico F, Butterfield DA (2015) mTOR signaling in aging and neurodegeneration: At the crossroad between metabolism dysfunction and impairment of autophagy. Neurobiol Dis 84, 39-49.
[23] Tramutola A, Triplett JC, Di Domenico F, Niedowicz DM, Murphy MP, Coccia R, Perluigi M, Butterfield DA (2015) Alteration of mTOR signaling occurs early in the progression of Alzheimer disease (AD): analysis of brain from subjects with pre-clinical AD, amnestic mild cognitive impairment and late-stage AD. J Neurochem 133, 739-749.
[24] Di Domenico F, Pupo G, Mancuso C, Barone E, Paolini F, Arena A, Blarzino C, Schmitt FA, Head E, Butterfield DA, Perluigi M (2015) Bach1 overexpression in Down syndrome correlates with the alteration of the HO-1/BVR-a system: insights for transition to Alzheimer's disease. J Alzheimers Dis 44, 1107-1120.
[25] Di Domenico F, Barone E, Perluigi M, Butterfield DA (2015) Strategy to reduce free radical species in Alzheimer's disease: an update of selected antioxidants. Expert Rev Neurother 15, 19-40.
[26] Butterfield DA, Di Domenico F, Swomley AM, Head E, Perluigi M (2014) Redox proteomics analysis to decipher the neurobiology of Alzheimer-like neurodegeneration: overlaps in Down's syndrome and Alzheimer's disease brain. Biochem J 463, 177-189.
[27] Butterfield DA, Di Domenico F, Barone E (2014) Elevated risk of type 2 diabetes for development of Alzheimer disease: a key role for oxidative stress in brain. Biochim Biophys Acta 1842, 1693-1706.
[28] Butterfield DA, Gu L, Di Domenico F, Robinson RA (2014) Mass spectrometry and redox proteomics: applications in disease. Mass Spectrom Rev 33, 277-301.
[29] Perluigi M, Pupo G, Tramutola A, Cini C, Coccia R, Barone E, Head E, Butterfield DA, Di Domenico F (2014) Neuropathological role of PI3K/Akt/mTOR axis in Down syndrome brain. Biochim Biophys Acta 1842, 1144-1153.
[30] Di Domenico F, Pupo G, Tramutola A, Giorgi A, Schinina ME, Coccia R, Head E, Butterfield DA, Perluigi M (2014) Redox proteomics analysis of HNE-modified proteins in Down syndrome brain: clues for understanding the development of Alzheimer disease. Free Radic Biol Med 71, 270-280.
[31] Spadaccio C, De Marco F, Di Domenico F, Coccia R, Lusini M, Barbato R, Covino E, Chello M (2014) Simvastatin attenuates the endothelial pro-thrombotic shift in saphenous vein grafts induced by Advanced glycation endproducts. Thromb Res 133, 418-425.
[32] Perluigi M, Di Domenico F, Buttterfield DA (2014) Unraveling the complexity of neurodegeneration in brains of subjects with Down syndrome: insights from proteomics. Proteomics Clin Appl 8, 73-85.
[33] Barone E, Di Domenico F, Butterfield DA (2014) Statins more than cholesterol lowering agents in Alzheimer disease: their pleiotropic functions as potential therapeutic targets. Biochem Pharmacol 88, 605-616.
[34] Di Domenico F, De Marco F, Perluigi M (2013) Proteomics strategies to analyze HPV-transformed cells: relevance to cervical cancer. Expert Rev Proteomics 10, 461-472.
[35] Barone E, Di Domenico F, Mancuso C, Butterfield DA (2014) The Janus face of the heme oxygenase/biliverdin reductase system in Alzheimer disease: it's time for reconciliation. Neurobiol Dis 62, 144-159.
[36] Di Domenico F, Perluigi M, Barone E (2013) Biliverdin Reductase-A correlates with inducible nitric oxide synthasein in atorvastatin treated aged canine brain. Neural Regen Res 8, 1925-1937.
[37] Fiorini A, Koudriavtseva T, Bucaj E, Coccia R, Foppoli C, Giorgi A, Schinina ME, Di Domenico F, De Marco F, Perluigi M (2013) Involvement of oxidative stress in occurrence of relapses in multiple sclerosis: the spectrum of oxidatively modified serum proteins detected by proteomics and redox proteomics analysis. PLoS One 8, e65184.
[38] Di Domenico F, Coccia R, Cocciolo A, Murphy MP, Cenini G, Head E, Butterfield DA, Giorgi A, Schinina ME, Mancuso C, Cini C, Perluigi M (2013) Impairment of proteostasis network in Down syndrome prior to the development of Alzheimer's disease neuropathology: redox proteomics analysis of human brain. Biochim Biophys Acta 1832, 1249-1259.
[39] Spadaccio C, Patti G, De Marco F, Coccia R, Di Domenico F, Pollari F, Zanzonico R, Pettinari M, Lusini M, Di Sciascio G, Covino E, Chello M (2013) Usefulness of preprocedural levels of advanced glycation end products to predict restenosis in patients with controlled diabetes mellitus undergoing drug-eluting stent implantation for stable angina pectoris (from the Prospective ARMYDA-AGEs Study). Am J Cardiol 112, 21-26.
[40] Cocciolo A, Di Domenico F, Coccia R, Fiorini A, Cai J, Pierce WM, Mecocci P, Butterfield DA, Perluigi M (2012) Decreased expression and increased oxidation of plasma haptoglobin in Alzheimer disease: Insights from redox proteomics. Free Radic Biol Med 53, 1868-1876.
[41] Di Domenico F, Barone E, Mancuso C, Perluigi M, Cocciolo A, Mecocci P, Butterfield DA, Coccia R (2012) HO-1/BVR-a system analysis in plasma from probable Alzheimer's disease and mild cognitive impairment subjects: a potential biochemical marker for the prediction of the disease. J Alzheimers Dis 32, 277-289.
[42] Mancuso C, Barone E, Guido P, Miceli F, Di Domenico F, Perluigi M, Santangelo R, Preziosi P (2012) Inhibition of lipid peroxidation and protein oxidation by endogenous and exogenous antioxidants in rat brain microsomes in vitro. Neurosci Lett 518, 101-105.
[43] Barone E, Di Domenico F, Sultana R, Coccia R, Mancuso C, Perluigi M, Butterfield DA (2012) Heme oxygenase-1 posttranslational modifications in the brain of subjects with Alzheimer disease and mild cognitive impairment. Free Radic Biol Med 52, 2292-2301.
[44] De Marco F, Bucaj E, Foppoli C, Fiorini A, Blarzino C, Filipi K, Giorgi A, Schinina ME, Di Domenico F, Coccia R, Butterfield DA, Perluigi M (2012) Oxidative stress in HPV-driven viral carcinogenesis: redox proteomics analysis of HPV-16 dysplastic and neoplastic tissues. PLoS One 7, e34366.
[45] Di Domenico F, Casalena G, Jia J, Sultana R, Barone E, Cai J, Pierce WM, Cini C, Mancuso C, Perluigi M, Davis CM, Alkayed NJ, Butterfield DA (2012) Sex differences in brain proteomes of neuron-specific STAT3-null mice after cerebral ischemia/reperfusion. J Neurochem 121, 680-692.
[46] Di Domenico F, Sultana R, Ferree A, Smith K, Barone E, Perluigi M, Coccia R, Pierce W, Cai J, Mancuso C, Squillace R, Wiengele M, Dalle-Donne I, Wolozin B, Butterfield DA (2012) Redox proteomics analyses of the influence of co-expression of wild-type or mutated LRRK2 and Tau on C. elegans protein expression and oxidative modification: relevance to Parkinson disease. Antioxid Redox Signal 17, 1490-1506.
[47] Barone E, Cenini G, Sultana R, Di Domenico F, Fiorini A, Perluigi M, Noel T, Wang C, Mancuso C, St Clair DK, Butterfield DA (2012) Lack of p53 decreases basal oxidative stress levels in the brain through upregulation of thioredoxin-1, biliverdin reductase-A, manganese superoxide dismutase, and nuclear factor kappa-B. Antioxid Redox Signal 16, 1407-1420.
[48] Spadaccio C, Di Domenico F, Perluigi M, Lusini M, Giorgi A, Schinina ME, Blarzino C, Covino E, Chello M, Coccia R (2012) Serum proteomics in patients with diagnosis of abdominal aortic aneurysm. Cardiovasc Pathol 21, 283-290.
[49] Di Domenico F, Foppoli C, Coccia R, Perluigi M (2012) Antioxidants in cervical cancer: chemopreventive and chemotherapeutic effects of polyphenols. Biochim Biophys Acta 1822, 737-747.
[50] Di Domenico F, Coccia R, Butterfield DA, Perluigi M (2011) Circulating biomarkers of protein oxidation for Alzheimer disease: expectations within limits. Biochim Biophys Acta 1814, 1785-1795.
[51] Barone E, Mancuso C, Di Domenico F, Sultana R, Murphy MP, Head E, Butterfield DA (2012) Biliverdin reductase-A: a novel drug target for atorvastatin in a dog pre-clinical model of Alzheimer disease. J Neurochem 120, 135-146.
[52] Butterfield DA, Barone E, Di Domenico F, Cenini G, Sultana R, Murphy MP, Mancuso C, Head E (2012) Atorvastatin treatment in a dog preclinical model of Alzheimer's disease leads to up-regulation of haem oxygenase-1 and is associated with reduced oxidative stress in brain. Int J Neuropsychopharmacol 15, 981-987.
[53] Sultana R, Robinson RA, Di Domenico F, Abdul HM, St Clair DK, Markesbery WR, Cai J, Pierce WM, Butterfield DA (2011) Proteomic identification of specifically carbonylated brain proteins in APP(NLh)/APP(NLh) x PS-1(P264L)/PS-1(P264L) human double mutant knock-in mice model of Alzheimer disease as a function of age. J Proteomics 74, 2430-2440.
[54] Di Domenico F, Sultana R, Barone E, Perluigi M, Cini C, Mancuso C, Cai J, Pierce WM, Butterfield DA (2011) Quantitative proteomics analysis of phosphorylated proteins in the hippocampus of Alzheimer's disease subjects. J Proteomics 74, 1091-1103.
[55] Barone E, Di Domenico F, Cenini G, Sultana R, Coccia R, Preziosi P, Perluigi M, Mancuso C, Butterfield DA (2011) Oxidative and nitrosative modifications of biliverdin reductase-A in the brain of subjects with Alzheimer's disease and amnestic mild cognitive impairment. J Alzheimers Dis 25, 623-633.
[56] Perluigi M, di Domenico F, Fiorini A, Cocciolo A, Giorgi A, Foppoli C, Butterfield DA, Giorlandino M, Giorlandino C, Schinina ME, Coccia R (2011) Oxidative stress occurs early in Down syndrome pregnancy: A redox proteomics analysis of amniotic fluid. Proteomics Clin Appl 5, 167-178.
[57] Barone E, Di Domenico F, Cenini G, Sultana R, Cini C, Preziosi P, Perluigi M, Mancuso C, Butterfield DA (2011) Biliverdin reductase--a protein levels and activity in the brains of subjects with Alzheimer disease and mild cognitive impairment. Biochim Biophys Acta 1812, 480-487.
[58] Barone E, Cenini G, Di Domenico F, Martin S, Sultana R, Mancuso C, Murphy MP, Head E, Butterfield DA (2011) Long-term high-dose atorvastatin decreases brain oxidative and nitrosative stress in a preclinical model of Alzheimer disease: a novel mechanism of action. Pharmacol Res 63, 172-180.
[59] Di Domenico F, Perluigi M, Butterfield DA, Cornelius C, Calabrese V (2010) Oxidative damage in rat brain during aging: interplay between energy and metabolic key target proteins. Neurochem Res 35, 2184-2192.
[60] Sultana R, Di Domenico F, Tseng M, Cai J, Noel T, Chelvarajan RL, Pierce WD, Cini C, Bondada S, St Clair DK, Butterfield DA (2010) Doxorubicin-induced thymus senescence. J Proteome Res 9, 6232-6241.
[61] Di Domenico F, Owen JB, Sultana R, Sowell RA, Perluigi M, Cini C, Cai J, Pierce WM, Butterfield DA (2010) The wheat germ agglutinin-fractionated proteome of subjects with Alzheimer's disease and mild cognitive impairment hippocampus and inferior parietal lobule: Implications for disease pathogenesis and progression. J Neurosci Res 88, 3566-3577.
[62] Perluigi M, Di Domenico F, Giorgi A, Schinina ME, Coccia R, Cini C, Bellia F, Cambria MT, Cornelius C, Butterfield DA, Calabrese V (2010) Redox proteomics in aging rat brain: involvement of mitochondrial reduced glutathione status and mitochondrial protein oxidation in the aging process. J Neurosci Res 88, 3498-3507.
[63] Di Domenico F, Casalena G, Sultana R, Cai J, Pierce WM, Perluigi M, Cini C, Baracca A, Solaini G, Lenaz G, Jia J, Dziennis S, Murphy SJ, Alkayed NJ, Butterfield DA (2010) Involvement of Stat3 in mouse brain development and sexual dimorphism: a proteomics approach. Brain Res 1362, 1-12.
[64] Di Domenico F, Sultana R, Tiu GF, Scheff NN, Perluigi M, Cini C, Butterfield DA (2010) Protein levels of heat shock proteins 27, 32, 60, 70, 90 and thioredoxin-1 in amnestic mild cognitive impairment: an investigation on the role of cellular stress response in the progression of Alzheimer disease. Brain Res 1333, 72-81.
[65] Perluigi M, Sultana R, Cenini G, Di Domenico F, Memo M, Pierce WM, Coccia R, Butterfield DA (2009) Redox proteomics identification of 4-hydroxynonenal-modified brain proteins in Alzheimer's disease: Role of lipid peroxidation in Alzheimer's disease pathogenesis. Proteomics Clin Appl 3, 682-693.
[66] Perluigi M, Di Domenico F, Blarzino C, Foppoli C, Cini C, Giorgi A, Grillo C, De Marco F, Butterfield DA, Schinina ME, Coccia R (2010) Effects of UVB-induced oxidative stress on protein expression and specific protein oxidation in normal human epithelial keratinocytes: a proteomic approach. Proteome Sci 8, 13.
[67] Perluigi M, Di Domenico F, Cini C, Coccia R, Giorlandino FR, Giorlandino M, Cignini P, Mesoraca A, Giorlandino C (2009) Proteomic analysis for the study of amniotic fluid protein composition. J Prenat Med 3, 39-41.
[68] Chello M, Spadaccio C, Lusini M, Covino E, Blarzino C, De Marco F, Di Domenico F, Coccia R (2009) Advanced glycation end products in diabetic patients with optimized glycaemic control and their effects on endothelial reactivity: possible implications in venous graft failure. Diabetes Metab Res Rev 25, 420-426.
[69] Di Domenico F, Perluigi M, Foppoli C, Blarzino C, Coccia R, De Marco F, Butterfield DA, Cini C (2009) Protective effect of ferulic acid ethyl ester against oxidative stress mediated by UVB irradiation in human epidermal melanocytes. Free Radic Res 43, 365-375.
[70] Perluigi M, Giorgi A, Blarzino C, De Marco F, Foppoli C, Di Domenico F, Butterfield DA, Schinina ME, Cini C, Coccia R (2009) Proteomics analysis of protein expression and specific protein oxidation in human papillomavirus transformed keratinocytes upon UVB irradiation. J Cell Mol Med 13, 1809-1822.
[71] Di Domenico F, Cenini G, Sultana R, Perluigi M, Uberti D, Memo M, Butterfield DA (2009) Glutathionylation of the pro-apoptotic protein p53 in Alzheimer's disease brain: implications for AD pathogenesis. Neurochem Res 34, 727-733.
[72] Di Domenico F, Foppoli C, Blarzino C, Perluigi M, Paolini F, Morici S, Coccia R, Cini C, De Marco F (2009) Expression of human papilloma virus type 16 E5 protein in amelanotic melanoma cells regulates endo-cellular pH and restores tyrosinase activity. J Exp Clin Cancer Res 28, 4.
[73] Owen JB, Di Domenico F, Sultana R, Perluigi M, Cini C, Pierce WM, Butterfield DA (2009) Proteomics-determined differences in the concanavalin-A-fractionated proteome of hippocampus and inferior parietal lobule in subjects with Alzheimer's disease and mild cognitive impairment: implications for progression of AD. J Proteome Res 8, 471-482.