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Lunedi Mercoledi H 14.00 in via dei Sardi 70 III piano Laboratorio C2

Sabrina Sabatini
Associate Professor in Molecular Biology at the University of Rome Sapienza, Rome, Italy.
E-mail: sabrina.sabatini@uniroma1.it

The research work of Sabrina Sabatini is focused on the Arabidopsis root meristem as a model system and aims to clarify the fundamental processes that govern the division and differentiation processes of stem cells.

Education:
- 1993: M.Sc. degree in Biology cum laude, Sapienza University of Rome.
- 1998: Ph.D. in Genetics and Molecular Biology, Sapienza University of Rome.

Research Experience:
- 1998-2003: Post-Doctoral Fellow, University of Utrecht (NL), Dpt. of Genetics and Cell Biology.
- 2003-2006, 2008: Contract professor at Mathematical, Physical and Natural Sciences faculty, Sapienza University of Rome.
- 2008-2012: Researcher at the Dpt. of Genetics and Molecular Biology, Sapienza University of Rome.
- 2012-present: Associate Professor at the Dpt. of Biology and Biotechnology, Sapienza University of Rome.

Scientific activities:

-1993-1998: Ph.D. in Genetics and Molecular Biology, Sapienza University of Rome.
-1998-2003: Research work as PostDoc in the laboratory of Prof. Ben Scheres, University of Utrecht (NL). EMBO long term fellowship.
Dal 2003: Career Development Award of the Giovanni Armenise-Harvard Foundation of Harvard University (USA), Dpt. of Genetics and Molecular Biology, Sapienza University of Rome.
Teaching activities abroad:
2016 - present Lesson/seminars for the PhD school in PLANT DEVELOPMENTAL BIOLOGY, Retzbach, Germany.

2016 - present Lesson/seminars for the PhD school in MOLECULAR BIOLOGY OF PLANT DEVELOPMENT, Ghent University, Belgium.

2018 Invited to organize and deliver a course in ADVANCE TOPICS IN PLANT GENETICS at the University of San Paulo (USP), Brazil.

Editorial Activities:
Editor - Plant Development for "Cell Reports" http://www.cell.com/cell-reports/editorial-board
Senior Editor - Plant Science for "Cogent Biology" https://www.cogentoa.com/journal/biology/editors
Advisory Editor for "Plant & Cell Phisiology" https://academic.oup.com/pcp/pages/Editorial_Board

Projects funded:

2003-2009: Rientro dei Cervelli , MIUR, D.M. 13 of 26.1.2001. Coordinator: 90.000 . Project title: Ruolo dell'ormone auxina e citochininina durante lo sviluppo del meristema radicale di Arabidopsis. http://cervelli.cineca.it/index.php?pag=RC_FI

2003-2008: Career Development Award of the Giovanni Armenise-Harvard Foundation. Coordinator: 750 .000 US $. Project title: Role of the hormone Cytokinin during Arabidopsis root development. http://www.armeniseharvard.org/cda/?lang=it

2009-2012: Grant Istituto Pasteur - Fondazione Cenci Bolognetti. Coordinator: 60.000 . Project title: To the root of organ growth: the control of root meristem activity in Arabidopsis.

Consolidator Grant, European Research Council (ERC) LS3 panel. Grant agreement no.: 260368. Coordinator: 1.500.000 . Project title: To The Root Of Organ Growth: The Control Of Root Meristem Activity In Arabidopsis. Project acronym: ROMA.
https://erc.europa.eu/sites/default/files/document/file/erc_2010_stg_res...

2013-2015: Grant Istituto Pasteur- Fondazione Cenci Bolognetti. Coordinator: 60.000 . Project title: Size matters: the molecular mechanisms maintaining meristem size during root growth http://www.istitutopasteur.it/ricercatori

Fellowship and Awards:
- AccademiaNet member (http://www.academia-net.org/selection-criteria/) Outstanding women academics and scientists are nominated for the portal by our partners. Our scientific partner organisations have appointed high-ranking persons to the steering committee, which then agreed on a set of standards for all of the partners to use when nominating candidates for AcademiaNet.
- Europen Molecular Biology Organization (EMBO) member
- Selected among the 100 most influential women for the economic and social development of our country. https://100esperte.it/search?id=140.

Best High Impact Publications:
1. Sabatini S., Beis D., Wolkenfelt H., Murfett J., Guilfoyle T., Malamy J., Benfey P., Leyser O., Bechtold N., Weisbeek, P. and Scheres, B. An Auxin-dependent distal organizer of pattern and polarity in the Arabidopsis root. Cell 99, 463-472, 1999. IF 36.6

2. Papi, M.*, Sabatini, S.*, Bouchez D., Camilleri C., Costantino P. and Vittorioso P. Identification and disruption of an Arabidopsis zinc finger gene controlling seed germination. Genes & Development 14, 28-33, 2000. *First co-authors. IF 12.6

3. Sabatini S., Heidstra R. and Scheres, B. Scarecrow is involved in positioning the stem cell niche in the Arabidopsis root meristem. Genes & Development 17, 354-358, 2003. IF 12.6

4. Dello Ioio R., Scaglia Linhares F., Scacchi E., Casamitjana-Martinez E., Heisdra R., Costantino P. and Sabatini S. Cytokinins determine Arabidopsis root-meristem size by controlling cell differentiation. Current Biology 17, 678-682, 2007. IF 9.5

5. Dello Ioio R., Nakamura K., Moubayidin L., Perilli S., Taniguchi M., Morita M.T., Aoyama T., Costantino P. and Sabatini S. A genetic framework for the control of cell division and differentiation in the root meristem. Science 322, 1380-84, 2008 IF 41.06

6. Moubayidin L, Di Mambro R, Sabatini S. Cytokinin-auxin crosstalk. Trends in Plant Science 14, 557-62, 2009. IF 12.3

7. Moubayidin, L., Perilli, S., Dello Ioio, R., Di Mambro, R., Costantino, P. and Sabatini, S. The rate of cell differentiation controls the Arabidopsis root meristem growth phase. Current Biology, 20, 1138 1143, 2010. IF 9.5

8. Aichinger E, Villar CB, Di Mambro R, Sabatini S, Köhler C. The CHD3 chromatin remodeler PICKLE and polycomb group proteins antagonistically regulate meristem activity in the Arabidopsis root. Plant Cell. 23, 1047-60, 2011. IF 8.6

9. Perilli S., Di Mambro R., Sabatini S. Growth and development of the root apical meristem. Current Opinion in Plant Biology 5, 17-23, 2012. IF 8.5;

10. Dello Ioio R, Galinha C, Fletcher AG, Grigg SP, Molnar A, Willemsen V, Scheres B, Sabatini S, Baulcombe D, Maini PK, Tsiantis M. A PHABULOSA/cytokinin feedback loop controls root growth in Arabidopsis. Current Biology 22, 1699-704, 2012. IF 9.5

11. Moubayidin L, Di Mambro R, Sozzani R, Pacifici E, Salvi E, Terpstra I, Bao D, van Dijken A, Dello Ioio R, Perilli S, Ljung K, Benfey PN, Heidstra R, Costantino P, Sabatini S. Spatial coordination between stem cell activity and cell differentiation in the root meristem. Developmental Cell. 26, 405-15, 2013. IF 10.4;

12. Del Bianco M, Giustini L, Sabatini S. Spatiotemporal changes in the role of cytokinin during root development. New Phytologist, 199, 324-338, 2013. IF 7.4;

13. Perilli S, Perez-Perez JM, Di Mambro R, Peris CL, Díaz-Triviño S, Del Bianco M, Pierdonati E, Moubayidin L, Cruz-Ramírez A, Costantino P, Scheres B, Sabatini S. RETINOBLASTOMA-RELATED protein stimulates cell differentiation in the Arabidopsis root meristem by interacting with cytokinin signaling. Plant Cell 25, 4469-78, 2013. IF 9.6;

14. Heidstra R, Sabatini S. Plant and animal stem cells: similar yet different. Nature Reviews Molecular Cell Biology. 15, 301-12, 2014. IF 37.8;

15. Pacifici E, Polverari L, Sabatini S. Plant hormone cross-talk: the pivot of root growth. Journal of Experimental Botany 66, 1113-21, 2015. IF 5.7;

16. Franciosini A, Moubayidin L, Du K, Matari NH, Boccaccini A, Butera S, Vittorioso P, Sabatini S, Jenik PD, Costantino P, Serino G. The COP9 SIGNALOSOME is required for postembryonic meristem maintenance in Arabidopsis thaliana. Molecular Plant 8, 1623-34, 2015. IF 7.1;

17. Di Mambro R., de Ruvo M., Pacifici E., Salvi E., Sozzani R., Benfey P., Bush W., Ljung K., Di Paola L, Maree L., Grieneisen V., Costantino P., Sabatini S. An auxin minimum triggers the developmental switch from cell division to cell differentiation in the Arabidopsis root. Proc Natl Acad Sci U S A. 2017;114:E7641-E7649 IF 9.7;

18. Di Ruocco G, Bertolotti G, Pacifici E, Polverari L, Tsiantis M, Sabatini S, Costantino P, Dello Ioio R. Differential spatial distribution of miR165/6 determines variability in plant root anatomy. Development. 2018;145(1). doi:10.1242/dev.153858. IF 6.3;

19. Pacifici E, Di Mambro R, Dello Ioio R, Costantino P, Sabatini S. Acidic cell elongation drives cell differentiation in the Arabidopsis root. EMBO J. 2018 15;37(16). pii: e99134. doi: 10.15252/embj.201899134. IF 10.6;

20. Di Mambro R, Svolacchia N, Dello Ioio R, Pierdonati E, Salvi E, Pedrazzini E, Vitale A, Perilli S, Sozzani R, Benfey PN, Busch W, Costantino P, Sabatini S. The Lateral Root Cap Acts as an Auxin Sink that Controls Meristem Size. Curr Biol. 2019;29(7):1199-1205.e4. doi: 10.1016/j.cub.2019.02.022. IF 9.2;

21. Barrera-Rojas CH, Rocha GHB, Polverari L, Brito DAP, Batista DS, Notini MM, da Cruz ACF, Morea EGO, Sabatini S, Otoni WC, Nogueira FTS. miR156-targeted SPL10 controls root meristem activity and root-derived de novo shoot regeneration via cytokinin responses. J Exp Bot. 2019 Oct 23. pii: erz475. doi: 10.1093/jxb/erz475. IF 6.3.

Books Chapters

Serino G., Costantino P. and Sabatini S. Piante transgeniche . In Biologia Molecolare . G. Melino, G. Ciliberto editors. SEU, Roma. 2006

Perilli S. and Sabatini S., Analysis of root meristem size development in Methods Mol Biol. . 2010;655:177-87.

Perilli S., Moubayidin L. and Sabatini S. (2011) Molecular basis of cytokinin action during root development" in Plant Roots: The Hidden Half 4th Edition. 2016

Di Mambro R, Sabatini S. Developmental Analysis of Arabidopsis Root Meristem. Methods Mol Biol. 2018;1761:33-45. doi: 10.1007/978-1-4939-7747-5_3.

Insegnamento Codice Anno Corso - Frequentare
MOLECULAR BIOLOGY 1049375 2021/2022 Bioinformatics - Bioinformatica
BIOLOGIA MOLECOLARE 1011772 2021/2022 Scienze Biologiche
BIOLOGIA MOLECOLARE 1011772 2020/2021 Scienze Biologiche
BIOLOGIA MOLECOLARE E BIOTECNOLOGIE RICOMBINANTI 1034850 2020/2021 Biotecnologie Agro-Industriali
MOLECULAR BIOLOGY 1049375 2020/2021 Bioinformatics - Bioinformatica
BIOLOGIA MOLECOLARE 1011772 2019/2020 Scienze Biologiche
BIOLOGIA MOLECOLARE E BIOTECNOLOGIE RICOMBINANTI 1034850 2019/2020 Biotecnologie Agro-Industriali
MOLECULAR BIOLOGY 1049375 2019/2020 Bioinformatics
BIOLOGIA MOLECOLARE 1011772 2018/2019 Scienze Biologiche
CELL DIFFERENTIATION AND DEVELOPMENT 1051854 2018/2019 Genetica e Biologia Molecolare
MOLECULAR BIOLOGY 1049375 2018/2019 Bioinformatics
BIOLOGIA DELLE CELLULE STAMINALI E APPLICAZIONI 1056104 2018/2019 Biologia e Tecnologie Cellulari
BIOLOGIA MOLECOLARE 1011772 2017/2018 Scienze Biologiche
CELL DIFFERENTIATION AND DEVELOPMENT 1051854 2017/2018 Genetica e Biologia Molecolare
MIGLIORAMENTO E CONTROLLO DELLA PRODUZIONE 1046900 2017/2018 Scienze e tecnologie alimentari- interateneo
BIOLOGIA DELLE CELLULE STAMINALI E APPLICAZIONI 1056104 2017/2018 Biologia e Tecnologie Cellulari
MOLECULAR BIOLOGY 1049375 2017/2018 Bioinformatica
CELL DIFFERENTIATION AND DEVELOPMENT 1051854 2016/2017 Genetica e Biologia Molecolare
BIOLOGIA MOLECOLARE 1011772 2016/2017 Scienze Biologiche
MIGLIORAMENTO E CONTROLLO DELLA PRODUZIONE 1046900 2016/2017 Scienze e tecnologie alimentari
Titolo Rivista Anno
A PHABULOSA-controlled genetic pathway regulates ground tissue patterning in the Arabidopsis root CURRENT BIOLOGY 2020
Arabidopsis primary root growth: let it grow, can't hold it back anymore! CURRENT OPINION IN PLANT BIOLOGY 2020
A Self-Organized PLT/Auxin/ARR-B Network Controls the Dynamics of Root Zonation Development in Arabidopsis thaliana DEVELOPMENTAL CELL 2020
Dissecting mechanisms in root growth from the transition zone perspective JOURNAL OF EXPERIMENTAL BOTANY 2020
Patterning the axes: A lesson from the root PLANTS 2019
Cytokinin-Dependent Control of GH3 Group II Family Genes in the Arabidopsis Root PLANTS 2019
The Lateral Root Cap Acts as an Auxin Sink that Controls Meristem Size CURRENT BIOLOGY 2019
Inhibition of Polycomb Repressive Complex2 activity reduces trimethylation of H3K27 and affects development in Arabidopsis seedlings BMC PLANT BIOLOGY 2019
Differential spatial distribution of miR165/6 determines variability in plant root anatomy DEVELOPMENT 2018
SCARECROW and SHORTROOT control the auxin/cytokinin balance necessary for embryonic stem cell niche specification PLANT SIGNALING & BEHAVIOR 2018
Acidic cell elongation drives cell differentiation in the Arabidopsis root EMBO JOURNAL 2018
Auxin minimum triggers the developmental switch from cell division to cell differentiation in the Arabidopsis root PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 2017
A SCARECROW-based regulatory circuit controls Arabidopsis thaliana meristem size from the root endodermis PLANTA 2016
Proline modulates root meristem size and root growth in Arabidopsis 2016
Proline modulates root meristem size and root growth in Arabidopsis thaliana 2016
The COP9 SIGNALOSOME is required for postembryonic meristem maintenance in Arabidopsis thaliana MOLECULAR PLANT 2015
Proline affects the size of the root meristematic zone in Arabidopsis BMC PLANT BIOLOGY 2015
Plant hormone cross-talk: the pivot of root growth JOURNAL OF EXPERIMENTAL BOTANY 2015
Dipartimento
BIOLOGIA E BIOTECNOLOGIE "CHARLES DARWIN"
SSD

BIO/11