Catalogo dei Corsi di studio

Silvia Chichiarelli, Ph.D.
Dipartimento di Scienze Biochimiche A. Rossi Fanelli
Università di Roma La Sapienza -, n°5 , P.le Aldo Moro, 00185, Roma, Italy
Ricercatore Universitario (SSD BIO/10)
silvia.chichiarelli@uniroma1.it

Link:
http://dsb.uniroma1.it/users/chichiarelli-silvia

Link:
https://www.ncbi.nlm.nih.gov/pubmed/?term=Chichiarelli+S

EDUCATION:
2001 PhD in Biochemistry
University of Rome La Sapienza - Department of Biochemical Sciences A. Rossi Fanelli , - Università degli Studi di Roma "Tor Vergata" - Research in Biochemistry
2000 Research Fellowship

1997 Qualified as a Professional Biologist
( Abilitazione alla professione di Biologo )

1995 Degree in Biological Sciences, Molecular Biology area (110/110 cum laude).
Faculty of Mathematics, Physics and Natural Sciences, Università di Roma La Sapienza .

Professional EXPERIENCE
2006 to date: Assistant Professor
University of Rome La Sapienza - Department of Biochemical Sciences A. Rossi Fanelli , P.le Aldo Moro, n°5 - 00185, Roma, Italy
Research Sector: Biochemistry

2005 - 2006 Post-Doc Research Fellowship in Biochemistry (Assegno di ricerca)
University of Rome La Sapienza - Department of Biochemical Sciences A. Rossi Fanelli ,

2004 - 2005 Fellowship (Collaborazione Coordinata e Continuativa) University of Rome La Sapienza - Department of Biochemical Sciences A. Rossi Fanelli ,

2002 2003 Post-Doc Research Fellowship in Biochemistry
University of Rome La Sapienza - Department of Biochemical Sciences A. Rossi Fanelli - Research in Biochemistry

2001 Research Fellowship
Pasteur Institute - Cenci-Bolognetti Foundation
Research in Biochemistry

2000 Research Fellowship
Pasteur Institute - Cenci-Bolognetti Foundation
Research in Biochemistry

TEACHING EXPERIENCE
Faculty of Pharmacy and Medicine, Università di Roma La Sapienza .:
2022-2023
Lecturer of BIOCHEMICAL BIOTECHNOLOGIES II (PHARMACEUTICAL BIOTECHNOLOGIES) into the degree course of Biochemistry

2018/2019 to date
Lecturer of MOLECULAR BIOLOGY into the degree course of Chemistry and Pharmaceutical Technologies

2013/2014 to date Lecturer of APPLIED BIOCHEMISTRY and BIOTECHNOLOGY into the degree course of Chemistry and Pharmaceutical Technologies

2012/2013 Lecturer of APPLIED BIOCHEMISTRY into the degree course of Pharmacy

2011 to 2013 Lecturer of INDUSTRIAL BIOCHEMISTRY into the degree course of Chemistry and Pharmaceutical Technologies

2007 to 2012 Lecturer of ENZYMOLOGY into the degree course of Chemistry and Pharmaceutical Technologies

PERSONAL SKILLS
Mother tongue: Italian
Other languages: English (limited working proficiency), French (Basic)

Organisational / managerial skills:
Component of Quality Assurance Management Group of the degree in Chemistry and Pharmaceutical Technologies

From 2017 to 2019, Coordinator of the Quality Control Committee for Internal Quality Assurance Processes in accordance with European standards by the ENQA Guidelines. (degree in Chemistry and Pharmaceutical Technologies)

Until 2020 Component of the Educational Committee (degree in Chemistry and Pharmaceutical Technologies), involved in issues pertaining to the organization and harmonization of teaching activities related to the degree course.

Component of the Educational Committee (Dipt. Biochemical Sciences A Rossi Fanelli SAPIENZA. (involved in issues pertaining to the organization of teaching activities).

Component of the Orientation group which deals specifically with incoming orientation (meeting days with the students of the high schools of Lazio, participation in "Open Doors at the Sapienza"), in itinere orientation (days of presentation of the optional and complementary courses), and outbound orientation ("Career day")

Component of the Faculty Council (Faculty of Pharmacy and Medicine), Academic year 2011/12, from September 2016 to July 2017 and from Academic year 2020/21 to date

Academic International Mobility Manager (RAM for the degree Course of Chemistry and Pharmaceutical Technologies) from Academic year 2020/21 to date

Academic Coordinator for International Mobility - Faculty of Medicine and Pharmacy - Pharmaceutical Area - from 03/2022. to date.

ADDITIONAL INFORMATION
Memberships Member of the Italian Society of Biochemistry and Molecular Biology (SIB)
[SIB is a Member of the following International Associations: FEBS: Federation of European Biochemical Societies; IUBMB: International Union of Biochemistry and Molecular Biology]

Member of Reviewer board of the International Journal of Molecular Sciences (IJMS) to date https://www.mdpi.com/journal/ijms/submission_reviewers

Projects Research grants: I have been the recipient of some Italian grants from Sapienza University and MIUR, also I participated to projects funded by the Italian Ministero dell Istruzione e dell Università (PRIN)

LIST OF PUBLICATIONS
1. Temaj G, Telkoparan-Akillilar P, Nuhii N, Chichiarelli S, Saha S, Saso L. Recoding of Nonsense Mutation as a Pharmacological Strategy. Biomedicines. 2023 Feb 22;11(3):659. doi: 10.3390/biomedicines11030659
2. Méndez-Valdés G, Pérez-Carreño V, Bragato MC, Hundahl M, Chichiarelli S, Saso L, Rodrigo R. Cardioprotective Mechanisms against Reperfusion Injury in Acute Myocardial Infarction: Targeting Angiotensin II Receptors. Biomedicines. 2023; 11(1):17. doi: 10.3390/biomedicines11010017
3. Abelli J, Méndez-Valdés G, Gómez-Hevia F, Bragato MC, Chichiarelli S, Saso L, Rodrigo R. Potential Antioxidant Multitherapy against Complications Occurring in Sepsis. Biomedicines. 2022 Dec 1;10(12):3088. doi: 10.3390/biomedicines10123088.
4. Temaj G, Chichiarelli S, Eufemi M, Altieri F, Hadziselimovic R, Farooqi AA, Yaylim I, Saso L. Ribosome-Directed Therapies in Cancer. Biomedicines. 2022 Aug 26;10(9):2088. doi: 10.3390/biomedicines10092088.
5. González-Montero J, Chichiarelli S, Eufemi M, Altieri F, Saso L, Rodrigo R.
Ascorbate as a Bioactive Compound in Cancer Therapy: The Old Classic Strikes Back. Molecules. 2022 Jun 14;27(12):3818. doi: 10.3390/molecules27123818.
6. Chichiarelli S, Altieri F, Paglia G, Rubini E, Minacori M, Eufemi M.
ERp57/PDIA3: new insight. Cell Mol Biol Lett. 2022 Feb 2;27(1):12. doi: 10.1186/s11658-022-00315-x
7. Rubini E, Minacori M, Paglia G, Macone A, Chichiarelli S, Altieri F, Eufemi M.
Tomato and Olive Bioactive Compounds: A Natural Shield against the Cellular Effects Induced by -Hexachlorocyclohexane-Activated Signaling Pathways.Molecules. 2021 Nov 25;26(23):7135. doi: 10.3390/molecules26237135
8. Rubini E, Minacori M, Paglia G, Altieri F, Chichiarelli S, Romaniello D, Eufemi M.
-Hexachlorocyclohexane Drives Carcinogenesis in the Human Normal Bronchial Epithelium Cell Line BEAS-2B. Int J Mol Sci. 2021 May 29;22(11):5834. doi: 10.3390/ijms22115834.
9. Marrocco I, Altieri F, Rubini E, Paglia G, Chichiarelli S, Giamogante F,Macone A, Perugia G, Magliocca FM, Gurtner A, Maras B, Ragno R, Patsilinakos A,Manganaro R, Eufemi M. Shmt2: A Stat3 Signaling New Player in Prostate Cancer Energy Metabolism. Cells. 2019 Sep 6;8(9). pii: E1048. doi: 10.3390/cells8091048
10. Miele AE, Badaoui S, Maugliani L, Salza R, Boumis G, Chichiarelli S, Duclos B, Ricard-Blum S. A comparative analysis of secreted protein disulfide isomerases from the tropical co-endemic parasites Schistosoma mansoni and Leishmania major. Sci Rep. 2019 Jul 2;9(1):9568. doi: 10.1038/s41598-019-45709-8
11. Cocchiola R, Rubini E, Altieri F, Chichiarelli S, Paglia G, Romaniello D, Carissimi S, Giorgi A, Giamogante F, Macone A, Perugia G, Gurtner A, Eufemi M. STAT3 Post-Translational Modifications Drive Cellular Signaling Pathways in Prostate Cancer Cells. Int J Mol Sci. 2019 Apr 12;20(8). pii: E1815. doi: 10.3390/ijms20081815
12. Altieri F, Cairone F, Giamogante F, Carradori S, Locatelli M, Chichiarelli S, Cesa S. Influence of Ellagitannins Extracted by Pomegranate Fruit on DisulfideIsomerase PDIA3 Activity. Nutrients. 2019 Jan 17;11(1). pii: E186. doi:10.3390/nu11010186
13. Rubini E, Altieri F, Chichiarelli S, Giamogante F, Carissimi S, Paglia G,Macone A, Eufemi M. STAT3, a Hub Protein of Cellular Signaling Pathways, Is Triggered by -Hexaclorocyclohexane. Int J Mol Sci. 2018 Jul 20;19(7). pii:E2108. doi: 10.3390/ijms19072108.
14. Giamogante F, Marrocco I, Cervoni L, Eufemi M, Chichiarelli S, Altieri F. Punicalagin, an active pomegranate component, is a new inhibitor of PDIA3 reductase activity. Biochimie. 2018 Feb 6. pii: S0300-9084(18)30034-8. doi:10.1016/j.biochi.2018.01.008.
15. Cocchiola R, Romaniello D, Grillo C, Altieri F, Liberti M, Magliocca FM, Chichiarelli S, Marrocco I, Borgoni G, Perugia G, Eufemi M. Analysis of STAT3 post-translational modifications (PTMs) in human prostate cancer with different Gleason Score. Oncotarget. 2017 Jun 27;8(26):42560-42570. doi:10.18632/oncotarget.17245
16. Gaucci E, Raimondo D, Grillo C, Cervoni L, Altieri F, Nittari G, Eufemi M, Chichiarelli S. Analysis of the interaction of calcitriol with the disulfide isomerase ERp57.
Sci Rep. 2016 Nov 29;6:37957. doi: 10.1038/srep37957
17. Giamogante F, Marrocco I, Romaniello D, Eufemi M, Chichiarelli S, Altieri F. Comparative Analysis of the Interaction between Different Flavonoids and PDIA3Oxidative Medicine and Cellular Longevity - Volume 2016 (2016), Article ID 4518281, 12 pages
http://dx.doi.org/10.1155/2016/4518281
18. Cocchiola R, Grillo C, Altieri F, Chichiarelli S, Turano C, Eufemi M. Upregulation of TPX2 by STAT3: Identification of a Novel STAT3 Binding Site. PLoS One. 2014; 9(11):e113096.
doi: 10.1371/journal.pone.0113096. eCollection 2014
19. Grillo C, Chichiarelli S, Gaucci E, Altieri F, Turano C, Cervoni L, The Binding of Silibinin to ERp57 Chemico-Biological Interactions 2014;213:37-43.
20. Aureli C, Cassano T, Masci A, Francioso A, Martire S, Cocciolo A, Chichiarelli S, Romano A, Gaetani S, Mancini P, Fontana M, d'Erme M, Mosca L. 5-S-cysteinyldopamine neurotoxicity: Influence on the expression of -synuclein and ERp57 in cellular and animal models of Parkinson's disease. J Neurosci Res 2014; 92(3):347-58.
21. Gaucci E, Altieri F, Turano C, Chichiarelli S The protein ERp57 contributes to EGF receptor signaling and internalization in MDA-MB-468 breast cancer cells.
J Cell Biochem. 2013 Nov;114(11):2461-70.
22. Aureli C, Gaucci E, Arcangeli V, Grillo C, Eufemi M, Chichiarelli S. ERp57/PDIA3 binds specific DNA fragments in a melanoma cell line. Gene. 2013 Jul 25;524(2):390-5.
23. D'Arrigo G, Di Meo C, Gaucci E, Chichiarelli S, Coviello T, Capitani D, Alhaique F and Matricardi P. Self-assembled gellan-based nanohydrogels as a tool for prednisolone delivery.
Soft Matter. 2012 ;8:11557-11564.
24. Frasconi M, Chichiarelli S, Gaucci E, Mazzei F, Grillo C, Chinazzi A, Altieri F. Interaction of ERp57 with calreticulin: analysis of complex formation and effects of vancomycin.
Biophysical Chemistry 2012Jan;160(1):46-53.
25. Turano C, Gaucci E, Grillo C, Chichiarelli S. ERp57/GRP58: A protein with multiple functions.
Cell Mol Biol Lett. 2011 Dec;16(4):539-63.
26. Chichiarelli S, Gaucci E, Ferraro A, Grillo C, Altieri F, Cocchiola R, Arcangeli V, Turano C, Eufemi M. Role of ERp57 in the signaling and transcriptional activity of STAT3 in a melanoma cell line.
Arch Biochem Biophys. 2010;494(2):178-83.
27. Egistelli L, Chichiarelli S, Gaucci E, Eufemi M, Schininà ME, Giorgi A, Lascu I, Turano C, Giartosio A, Cervoni L. IFI16 and NM23 bind to a common DNA fragment both in the P53 and the cMYC gene promoters. J Cell Biochem. 2009;106(4):666-72.
28. Gaucci E, Chichiarelli S, Grillo C, Vecchio ED, Eufemi M, Turano C. The binding of antibiotics to ERp57/GRP58. J Antibiot (Tokyo). 2008;61(6):400-2.
29. Altieri F, Grillo C, Maceroni M, Chichiarelli S. DNA damage and repair: from molecular mechanisms to health implications. Antioxid Redox Signal. 2008;10(5):891-937. Review.
30. Chichiarelli S, Ferraro A, Altieri F, Eufemi M, Coppari S, Grillo C, ArcangeliV, Turano C. The stress protein ERp57/GRP58 binds specific DNA sequences in HeLa cells. J Cell Physiol. 2007;210(2):343-51.
31. Perrini B, Piacentini L, Fanti L, Altieri F, Chichiarelli S, Berloco M, Turano C, Ferraro A, Pimpinelli S. HP1 controls telomere capping, telomere elongation, and telomere silencing by two different mechanisms in Drosophila. Mol Cell. 2004;15(3):467-76.
32. Carbone M, Ascione G, Chichiarelli S, Garcia MI, Eufemi M, Amati P. Chromosome-protein interactions in polyomavirus virions. J Virol. 2004;78(1):513-9.
33. Mearini G, Chichiarelli S, Zampieri M, Masciarelli S, D'Erme M, Ferraro A, Mattia E. Interaction of EBV latent origin of replication with the nuclearmatrix: identification of S/MAR sequences and protein components. FEBS Lett. 2003;547(1-3):119-24.
34. Cervoni L, Pietrangeli P, Chichiarelli S, Altieri F, Egistelli L, Turano C, Lascu I, Giartosio A. In vivo cross-linking of nm23/nucleoside diphosphate kinaseto the PDGF-A gene promoter. Mol Biol Rep. 2003;30(1):33-40.
35. Masciarelli S, Mattioli B, Galletti R, Samoggia P, Chichiarelli S, Mearini G, Mattia E. Antisense to Epstein Barr Virus-encoded LMP1 does not affect thetranscription of viral and cellular proliferation-related genes, but inducesphenotypic effects on EBV-transformed B lymphocytes. Oncogene. 2002;21(26):4166-70.
36. Coppari S, Altieri F, Ferraro A, Chichiarelli S, Eufemi M, Turano C. Nuclear localization and DNA interaction of protein disulfide isomerase ERp57 inmammalian cells. J Cell Biochem. 2002;85(2):325-33.
37. Chichiarelli S, Coppari S, Turano C, Eufemi M, Altieri F, Ferraro A. Immunoprecipitation of DNA-protein complexes cross-linked bycis-diamminedichloroplatinum. Anal Biochem. 2002;302(2):224-9.
38. Mattia E, Ceridono M, Chichiarelli S, D'Erme M. Interactions of Epstein-Barr virus origins of replication with nuclear matrix in the latent and in the lyticphases of viral infection. Virology. 1999;262(1):9-17.
39. Ferraro A, Altieri F, Coppari S, Eufemi M, Chichiarelli S, Turano C. Binding of the protein disulfide isomerase isoform ERp60 to the nuclear matrix-associatedregions of DNA. J Cell Biochem.1999;72(4):528-39.
40. Cervoni L, Ferraro A, Eufemi M, Altieri F, Chichiarelli S, Turano C. Cross-linked telomere-protein complexes from chicken erythrocyte nuclei:isolation by a new procedure. Biochem Biophys Res Commun. 1999;254(3):517-21.
41. Mattia E, Eufemi M, Chichiarelli S, Ceridono M, Ferraro A. Differentiation-specific nuclear matrix proteins cross-linked to DNA by cis-diammine dichloroplatinum. Exp Cell Res. 1998;238(1):216-9.
42. Mattia E, Chichiarelli S, Hickish T, Gaeta A, Mancini C, Cunningham D, vanRenswoude J. Inhibition of in vitro proliferation of Epstein Barr Virus infected B cells by an antisense oligodeoxynucleotide targeted against EBV latent membrane protein LMP1. Oncogene. 1997;15(4):489-93.

Text Chapter: Gaucci E, Altieri F, Chichiarelli S Unexpected Plasma Membrane Location for a Disulfide Isomerase Protein. CELL BIOLOGY RESEARCH PROGRESS Chapter 2, pg 25-42 - Nova Science Publishers, Inc. (2013).