SILVANA GAETANI

Corso di Laurea Magistrale in Farmacia:
QUARTO ANNO,  SECONDO SEMESTRE

Corso di FARMACOLOGIA E FARMACOTERAPIA II (codice 10595435) - CANALE A-L
docente Prof.ssa Silvana Gaetani

Inizio lezioni: lunedì 10 marzo 2025 

calendario: 
lunedì dalle 10:00 alle 13:00 - Aula C1 Edificio CU024
martedì dalle 11:00 alle 13:00 - Aula B Edificio CU024
mercoledì dalle 09:00 alle 11:00 - Aula B Edificio CU024

Corso di Laurea Magistrale in Biotecnologie Farmaceutiche
PRIMO ANNO, SECONDO SEMESTRE

Corso di FARMACOLOGIA SPECIALE, FARMACOTERAPIA E BIOTECNOLOGIE FARMACOLOGICHE 

Modulo di FARMACOLOGIA SPECIALE E FARMACOTERAPIA
docente Prof.ssa Silvana Gaetani

Inizio lezioni: mercoledì 12 marzo 2025 

calendario:
mercoledì dalle 13:00 alle 15:00 - Aula C1 Edificio CU024
giovedì dalle 11:00 alle 13:00 - Aula B Edificio CU024

Pharmacology in Drug Discovery (PDD ): 

Masters in “Genetics and Molecular Biology” (Corso di Laurea Magistrale in Genetica e Biologia Molecolare)

Kind of Course: Related and integrative (Insegnamento OPZIONALE del Settore Affini e Integrativi)

Credits: 6CFU

Language: English (Il corso viene offerto in Inglese anche per gli studenti del canale italiano, che potranno sostenere l'esame finale in Italiano)

Classroom: Aula C Fisiologia Generale CU026

Address: Sapienza Campus - Piazzale Aldo Moro, 5 - 00185 Rome, Italy

Start date: 10-10-2024

Schedule: Tuesday and Thursday 4 p.m.-6 p.m. 

Contact: silvana.gaetani@uniroma1.it

tel: +39 49912538

office: room 12, third floor of Pharmacology Building (CU024)

Per ulteriori informazioni potete contattarmi al seguente indirizzo email:

silvana.gaetani@uniroma1.it

SILVANA GAETANI

Full Professor of Pharmacology, Sapienza University of Rome, Italy
Dept. of Physiology and Pharmacology "V. Erspamer" (PhysioPharm), Faculty of Pharmacy and Medicine

EDUCATION
-1998: Master in Biological Sciences magna cum laude. University of Lecce, Italy
-2003: Ph.D in Pharmacology (full score). University of Bari Italy, School of Medicine

OTHER QUALIFICATIONS
Graduate Minor in Bioethics, Univ. of Lecce, Italy
First Certificate in English, Univ. of Cambridge, UK
Accent reduction II for nonnative English speakers, Univ. of California Irvine, USA

ACADEMIC HISTORY
-2001-2004: Junior Specialist (2001-2002) and Post-Doctoral fellow (2003-2004), University of California Irvine Dept. of Pharmacology.
-2004-2005: Adjunct Assistant Professor of Pharmacology (Rientro dei Cervelli), Sapienza Univ.
-2005-2012: Assistant Professor (Ricercatore Universitario) of Pharmacology, Sapienza Univ.
-2012-2019: Associate Professor (Professore Associato) of Pharmacology, Sapienza Univ.
-since November 2019: Full Professor (Professore Ordinario) of Pharmacology, Sapienza Univ.

RESEARCH GRANTS AS COORDINATOR AND/OR PRINCIPAL INVESTIGATOR (PI)
2004-2008: Italian Ministry of University and Research (MIUR), Programma Rientro dei Cervelli (€139000)
2007-2008: Sapienza Univ. Intramural Research Grant (RICERCHE DI ATENEO FEDERATO) (€5300)
2007-2009: (NATIONAL COORDINATOR) MIUR National Research Grant (PRIN) (€158000)
2013-2017 (PI) MIUR Futuro in Ricerca (FIR) (€228798)
2014-2018: (PI) MIUR National Research Grant (PRIN) (€103386)
2013-2014: Sapienza Univ. Intramural Research Grant (RICERCHE UNIVERSITARIE 2013) (€25946)
2017-2020: (PI) MIUR National Research Grant (PRIN) (€40000)
2019-2021 (PI) MIUR National Research Grant (PRIN) (€114731)
2019-2022 Sapienza Univ. Intramural Research Grant (RICERCHE UNIVERSITARIE 2018) (€33800)
2022-2025 Sapienza Univ. Intramural Research Grant (RICERCHE UNIVERSITARIE 2021) (€63787)
2022-ongoing Sapienza Univ. Grant for equipment upgrades (ammodernamento infrastrutture) (€243872)
2025-ongoing Sapienza Horizon Haward (PI) (€12970)
2025-ongoing Sapienza Rome technopole, International Network (PI) (€20000)
2025-ongoing ERA4Health – NutriBrain (PI) (€1571164)

MAIN ACADEMIC ACTIVITIES AT SAPIENZA UNIVERSITY
-Director (Coordinatore) of the Doctorate Program in Pharmacology and Toxicology;
-Board member of the School of Post-graduate Specialization in Pharmacology and Clinical Toxicology;
-Member of the scientific didactic council of the Post-graduate Master Course in Clinical Nutrition and Metabolism;
-2008-2012 and 2017-present: ELECTED MEMBER OF THE DEPARTMENT ADVISORY BOARD (Giunta di Dipartimento)
-2017-present: ELECTED MEMBER OF THE FACULTY ADVISORY BOARD (Giunta di Facoltà)
-2008-2019: ELECTED MEMBER OF DIDACTIC COMMITTEE Master Course in Pharmaceutical Biotechnology
-2011-2012: MEMBER OF THE RESEARCH COMMITTEE (Commissione Ricerca di Ateneo)
-2012-present: Coordinator of the didactic quality team of the Master Course in Pharmaceutical Biotechnology
-2014-present: member of the “ANIMAL WELFARE BODY” (OBPA) of the Dept. PhysioPharm
-Teaching Pharmacology in the Master's Degrees in Pharmacy, Pharmaceutical Biotechnology, Genetics and Molecular Biology.
-Mentor of 20 PhD students (2006-present)
-Mentor of 65 master theses in Pharmaceutical Biotechnology, Medicinal Chemistry, Pharmacy, Neurobiology

INTERNATIONAL MENTORSHIP ACTIVITIES (2015-PRESENT)
-Dr Florencia Andreoli, Unoversidad Nacional del Litoral Santa Fe, Argentina, Visiting Researcher (2013-2014)
-Prof. Yan Qiu, Yan Qiu Associate Professor del Medical College of Xiamen University, Cina, Visiting Professor (2015-2016)
-Dr Owein Guillemot-Legris, Université Catholique de Louvain, Brussels (Belgium), Visiting Fellow, through the Wallonie-Bruxelles International Excellence grant (2017)
-Prof. Fernando Rodriguez de Fonseca, Full Professor at the University of Malaga, Spain, Visiting Professor (2023)
-Ms Jessica de Sá, Visiting Brasilian Student, mobility program “science without borders” (2015)
-Ms Tatiana Soares Costa, Visiting Student from University of Coimbra, Partugal, Erasmus Plus program (2016-2017)
-Ms Vera Weinberg, Visiting Student from Utrecht University, the Netherlands, Erasmus Plus program (2017)
-Ms Dorien Smeets, Visiting Student from Utrecht University, the Netherlands, Erasmus Plus program (2018-2019)
-Ms Konstantina Karagiota, Visiting Student from University of West Attica, Greece, Erasmus Plus program (2023)

OTHER ACADEMIC ACTIVITIES
-February 2020-present: elected Coordinator of the Ph.D program in Pharmacology and Toxicology, Sapienza University of Rome
-2017-2020: Nominated Secretary (Referente) of the Ph.D program in Pharmacology and Toxicology, Sapienza Univ. of Rome
-2006-present: Member of the Board of Professors of the Ph.D program in Pharmacology and Toxicology, Sapienza Univ. of Rome
-2008-2012 and 2017-present: ELECTED MEMBER OF THE DEPARTMENT ADVISORY BOARD (Giunta di Dipartimento) of the Dept. of Physiology and Pharmacology “V. Erspamer”, Sapienza Univ. of Rome
-2017-present: ELECTED MEMBER OF THE FACULTY ADVISORY BOARD (Giunta di Facoltà) Faculty of Pharmacy and Medicine, Sapienza Univ. of Rome
-2008-2019: MEMBER OF DIDACTIC COMMITTEE Master Course in Pharmaceutical Biotechnology, Faculty of Pharmacy and Medicine, Sapienza Univ. of Rome
-2011-2012: MEMBER OF THE RESEARCH COMMITTEE of Sapienza Univ. of Rome
-2012-2023: Coordinator of the didactic quality team of the Master Course in Pharmaceutical Biotechnology, Faculty of Pharmacy and Medicine, Sapienza Univ. of Rome
-2014-2025: member of the “ANIMAL WELFARE BODY” (OBPA) of the Dept. of Physiology and Pharmacology “V. Erspamer”, Sapienza Univ. of Rome
-2015-2023: member of the ACADEMIC COMMITTEE for the evaluation of the PHARMACY PROFESSIONAL TRAINING, Faculty of Pharmacy and Medicine, Sapienza University of Rome
2016–2017: Academic Responsible for International Mobility (RAM), Degree Programme in Applied Pharmaceutical Sciences, Faculty of Pharmacy and Medicine, Sapienza University of Rome
2018–2024: Academic Responsible for International Mobility (RAM), Master Course in Pharmaceutical Biotechnology, Faculty of Pharmacy and Medicine, Sapienza University of Rome
2018-present: Member of the Monitoring Committee, Faculty of Pharmacy and Medicine, Sapienza University of Rome
-2017-2020: member of the PhD STEERING COMMITTEE (Comite d’accompagnement), Universitè Catholique de Louvain, Belgium
-2020- present MEMBER OF DIDACTIC COMMITTEE Master Course in Pharmacy, Faculty of Pharmacy and Medicine, Sapienza Univ. of Rome

SCIENCE COMMUNICATION (Third Mission) AND MAJOR COVERAGE IN NATIONAL AND INTERNATIONAL MEDIA AND WEB PORTALS
Intensive public engagement and science communication activity (2003–2025), including more than 25 interviews and features in national and international newspapers and magazines (e.g. ScienceDaily, Corriere della Sera, la Repubblica, El País, Frankfurter Allgemeine Zeitung, Focus), 8 radio interviews (RAI Radio 1 and national radio networks), 1 national television interview (RAI TV – Elisir), multiple institutional press releases, invited public lectures and museum events, science cafés, school outreach laboratories, and participation in public and institutional round tables, including a parliamentary event on public health and obesity prevention.

RESEARCH INTERESTS AND CITATIONS
SG is author of 98 papers published in peer reviewed journals included in the most important databases (SCOPUS, ISI, PUBMED), which include papers published in high impact journals (Nature, Nature Medicine, Cell Metabolism, Journal of Biological Chemistry, Trends in Molecular Medicine, Journal of Neuroscience, Neuropsychopharmacology, PNAS, Neuroscience and Biobehavioural Reviews). Dr Gaetani’s research activities focus on the study of the therapeutic potential of exogenous modulators of the endocannabinoid/paracannabinoid system (particularly direct and indirect agonists) in experimental models of neuropsychiatric, metabolic and/or neurodegenerative diseases, (particularly eating disorders, mood disorders, obesity, Alzheimer's disease). The results of these activities have been reported in 98 scientific publications (H index: 44; 8659 citations - SCOPUS), many lectures and conference presentations.

SG is author, also, of more than 150 abstracts presented (also upon invitation) in prestigious national and international scientific meetings (e.g. The Neuroscience meeting held by the Society for Neurocience; The World Congress of Pharmacology; The meeting of the International Cannabinoid Society, etc ).
SG is author of 4 books on the Basic principles of Pharmacology for Master Students
SG gave 9 invited plenary lectures at Italian and International Universities (including Wakayama Medical Univ., Japan, Univ. of Lille, France, and European Research Institute of Rome, Italy, University of Cardiff, UK).
SG is author of 2 international patents

LIST OF PUBLICATIONS ON PEER REVIEWD SCIENTIFIC JOURNALS
1. Trabace L, Coluccia A, Gaetani S, Tattoli M, Cagiano R, Pietra C, Kendrick KM, Cuomo V. In vivo neurochemical effects of the acetylcholinesterase inhibitor ENA713 in rat hippocampus. Brain Research 2000 865(2):268-71
2. Tattoli M, Cagiano R, Gaetani S, Ghiglieri V, Giustino A, Mereu G, Trabace L, Cuomo V. Neurofunctional effects of developmental alcohol exposure in alcohol-preferring and alcohol-nonpreferring rats. Neuropsychopharmacology 2001 24(6):691-705
3. Rodriguez de Fonseca F, Navarro M, Gomez R, Escuredo L, Nava F, Fu J, Murillo-Rodriguez E, Giuffrida A, LoVerme J, Gaetani S, Kathuria S, Gall C, Piomelli D. An anorexic lipid mediator regulated by feeding. Nature 2001 414(6860):209-12. I.F. 2017: 41,577
4. Cagiano R, Cassano T, Coluccia A, Gaetani S, Giustino A, Steardo L, Tattoli M, Trabace L, Cuomo V. Genetic factors involved in the effects of developmental low-level alcohol induced behavioral alterations in rats. Neuropsychopharmacology 2002 26(2):191-203
5. Kathuria S, Gaetani S, Fegley D, Valino F, Duranti A, Tontini A, Mor M, Tarzia G, Rana GL, Calignano A, Giustino A, Tattoli M, Palmery M, Cuomo V, Piomelli D. Modulation of anxiety through blockade of anandamide hydrolysis. Nature Medicine 2003 9(1):76-81
6. Gaetani S, Oveisi F and Piomelli D. Modulation of meal pattern in the rat by the anorexic lipid mediator oleoylethanolamide. Neuropsychopharmacology 2003 28(7):1311-6.
7. Fu J, Gaetani S, Oveisi F, Lo Verme J, Serrano A, Rodriguez De Fonseca F, Rosengarth A, Luecke H, Di Giacomo B, Tarzia G, Piomelli D. Oleylethanolamide regulates feeding and body weight through activation of the nuclear receptor PPAR-alpha. Nature 2003 425(6953):90-3.
8. Gaetani S, Cuomo V, Piomelli D. Anandamide hydrolysis: a new target for anti-anxiety drugs? Trends in Molecular Medicine 2003 9(11):474-8.
9. Oveisi F, Gaetani S, Eng KTP, Piomelli D Oleoylethanolamide inhibits food intake in free-feeding rats after oral administration. Pharmacological Research 2004 49(5):461-466
10. Fegley D, Gaetani S, Duranti A, Tontini A, Mor M, Tarzia G, Piomelli D Characterization of the fatty-acid amide hydrolase inhibitor URB597: Effects on anandamide and oleoylethanolamide deactivation. The Journal of Pharmacology and Experimental Therapeutics 2005 313(1):352-8
11. LoVerme J, Gaetani S, Fu J, Oveisi F, Burton K and Piomelli D Regulation of food intake by oleoylethanolamide Cellular and Molecular Life Sciences 2005 62(6):708-16
12. Fu J, Oveisi F, Gaetani S, Lin E, Piomelli D. Oleoylethanolamide, an endogenous PPAR-alpha agonist, lowers body weight and hyperlipidemia in obese rats. Neuropharmacology. 2005 48(8):1147-53
13. Astarita G, Di Giacomo B, Gaetani S, Oveisi F, Compton TR, Rivara S, Tarzia G, Mor M, Piomelli D. Pharmacological characterization of hydrolysis-resistant analogs of oleoylethanolamide with potent anorexiant properties. Journal of Pharmacology and Experimental Therapeutics 2006 318(2):563-70
14. Loverme J, Guzman M, Gaetani S, Piomelli D. Cold exposure stimulates synthesis of the bioactive lipid oleoylethanolamide in rat adipose tissue. Journal of Biological Chemistry 2006 281(32):22815-8
15. Fu J, Astarita G, Gaetani S, Kim J, Cravatt BF, Mackie K, Piomelli D. Food intake regulates oleoylethanolamide formation and degradation in the proximal small intestine. Journal of Biological Chemistry 2007 282(2):1518-28
16. Campolongo P, Trezza V, Cassano T, Gaetani S, Morgese MG, Ubaldi M, Soverchia L, Antonelli T, Ferraro L, Massi M, Ciccocioppo R, Cuomo V. Perinatal exposure to delta-9-tetrahydrocannabinol causes enduring cognitive deficits associated with alteration of cortical gene expression and neurotransmission in rats. Addiction Biology 2007 12(3-4):485-95
17. Castaldo P, Magi S, Gaetani S, Cassano T, Ferraro L, Antonelli T, Amoroso S, Cuomo V. Prenatal exposure to the cannabinoid receptor agonist WIN 55,212-2 increases glutamate uptake through overexpression of GLT1 and EAAC1 glutamate transporter subtypes in rat frontal cerebral cortex. Neuropharmacology. 2007 53(3):369-78. I.F. 2017: 4,249
18. Trezza V, Campolongo P, Cassano T, MachedaT, Dipasquale P, Carratù MR, Gaetani S, Cuomo V. Effects of perinatal exposure to delta-9-tetrahydrocannabinol on the emotional reactivity of the offspring: a longitudinal behavioral study in wistar rats. Psychopharmacology 2008, 198(4):529-37
19. Gaetani S, Kaye W, Cuomo V, Piomelli D. Role of endocannabinoids and their analogues in obesity and eating disorders. Eating and weight disorders 2008, 13(3):e42-8
20. Schwartz GJ, Fu J, Astarita G, Xiaosong Li1, Gaetani S, Campolongo P, Cuomo V, Piomelli D. The lipid messenger OEA links dietary fat intake to satiety. Cell Metabolism 2008, 8(4):281-8
21. Morgese MG, Cassano T, Gaetani S, Macheda T, Laconca L, Dipasquale P, Ferraro L, Antonelli T, Cuomo V, Giuffrida A. Neurochemical changes in the striatum of dyskinetic rats after administration of the cannabinoid agonist WIN55,212-2. Neurochemistry International 2009 54(1):56-64
22. Ferraro L, Tomasini Mc, Tanganelli S, Mazza R, Coluccia A, Carratu' MR, Gaetani S, Cuomo V, Antonelli T. Developmental exposure to methylmercury elicits early cell death in the cerebral cortex and long-term memory deficits in the rat. International Journal of Developmental Neuroscience 2009 27: 165–174
23. Celentano M, Caprioli D, Di Pasquale P, Cardillo V, Nencini P, Gaetani S, Badiani A. Drug context differently regulates cocaine versus heroin self-administration and cocaine- versus heroin-induced Fos mRNA expression in the rat. Psychopharmacology 2009, 204(2):349-60
24. Antonelli T, Tomasini MC, Mazza R, Fuxe K, Gaetani S, Cuomo V, Tanganelli S, Ferraro L. Cannabinoid CB1 and Cholecystokinin CCK2 receptors modulate, in an opposing way, electrically-evoked [3H]GABA efflux from rat cerebral cortex cell cultures. Possible relevance for cortical GABA transmission and anxiety. Journal of Pharmacology and Experimental Therapeutics 2009, 329(2):708-17
25. Gaetani S, Dipasquale P, Romano A, Righetti L, Cassano T, Piomelli D and Cuomo V. The endocannabinoid system as a target for novel anxiolytic and antidepressant drugs. International Review of Neurobiology 2009, 85: 57-72
26. Cassano T*, Gaetani S*, Morgese MG, Macheda T, Laconca L, Dipasquale P, Taltavull J, Shippenberg TS, Cuomo V, Gobbi G Monoaminergic changes in locus coeruleus and dorsal raphe nucleus following noradrenaline depletion. Neurochemical Research 2009 34(8):1417-26 *equal contribution
27. Ferraro L, Tomasini MC, Beggiato S, Gaetani S, Cassano T, Cuomo V, Amoroso S, Tanganelli S, Antonelli T. Short- and long-term consequences of prenatal exposureto the cannabinoid agonist WIN55,212-2 on rat glutamate transmission and cognitive functions. Journal of Neural Transmission 2009, 116(8): 1017-27
28. vanRijn CM, Gaetani S, Santolini I, Badura A, Gabova A, Fu J, Watanabe M, Cuomo V, vanLuijtelaar G, Nicoletti F, and Ngomba RT Wag/rij rats show a reduced expression of CB1 receptors in thalamic nuclei and respond to the CB1 receptor agonist, R(+)WIN55,212-2, with a reduced incidence of spike-wave discharges. Epilepsia 2010 51(8):1511-21
29. Gaetani S, Fu J, Cassano T, Dipasquale, Romano A, Righetti L, Cianci S, Laconca L, Giannini E, Scaccianoce S, Mairesse J, Cuomo V, and Piomelli D The fat-induced satiety factor OEA suppresses feeding through central release of oxytocin. Journal of Neuroscience 2010 30(24):8096-101
30. Cassano T*, Gaetani S*, Macheda T, Laconca L, Romano A, Morgese MG, Cimmino CS, Chiarotti F, Bambico FR, Gobbi G, Cuomo V, and Piomelli D Evaluation of the emotional phenotype and serotonergic neurotransmission of fatty acid amide hydrolase-deficient mice. Psychopharmacology, 2010 214(2):465-76 *equal contribution
31. Dipasquale P, Romano A, Cianci S, Righetti L, Gaetani S Oleoylethanolamide: a new player in energy metabolism control. Role in food intake Drug Discovery Today: Disease Mechanisms 2011, 7(3–4): e159-e226
32. Fu J, DiPatrizio NV, Guijarro A, Schwartz GJ, Li X, Gaetani S, Astarita G, Piomelli D Sympathetic activity controls fat-induced OEA signaling in small intestine Journal of Neuroscience 2011 31(15):5730-6
33. Cassano T, Romano A, Macheda T, Colangeli R, Cimmino CS, Petrella A, LaFerla FM, Cuomo V, Gaetani S, Olfactory memory is impaired in a triple transgenic model of Alzheimer disease, Behavioural Brain Research 2011, 31;224(2):408-12
34. Trapani A, De Giglio E, Cafagna D, Denora N, Agrimi G, Cassano T, Gaetani S, Cuomo V, Trapani G. Characterization and evaluation of chitosan nanoparticles for dopamine brain delivery. International Journal of Pharmaceutics. 2011 419(1-2):296-307
35. Cassano T, Serviddio G, Gaetani S, Romano A, Dipasquale P, Cianci S, Bellanti F, Laconca L, Romano AD, Padalino I, LaFerla FM, Nicoletti F, Cuomo V, Vendemiale V Glutamatergic alterations and mitochondrial impairment in a murine model of Alzheimer disease Neurobiology of Aging 2012 33(6):1121.e1-12
36. Mairesse J, Silletti V, Laloux C, Zuena AR, Giovine A, Consolazione M, van Camp G, Malagodi M, Gaetani S, Cianci S, Catalani A, Mennuni G, Mazzetta A, van Reeth O, Gabriel C, Mocaër E, Nicoletti F, Morley-Fletcher S, Maccari S. Chronic agomelatine treatment corrects the abnormalities in the circadian rhythm of motor activity and sleep/wake cycle induced by prenatal restraint stress in adult rats. International Journal of Neuropsychopharmacology 2013 16(2):323-38
37. Romano A, Cassano T, Tempesta B, Cianci S, Dipasquale P, Coccurello R, Cuomo V, Gaetani S. The satiety signal oleoylethanolamide stimulates oxytocin neurosecretion from rat hypothalamic neurons. Peptides. 2013 49C:21-26
38. Romano A, Potes CS, Tempesta B, Cassano T, Cuomo V, Lutz T, Gaetani S. Hindbrain noradrenergic input to the hypothalamic PVN mediates the activation of oxytocinergic neurons induced by the satiety factor oleoylethanolamide. American Journal of Physiology-Endocrinology And Metabolism. 2013. 305(10):E1266-73
39. Aureli C, Cassano T, Masci A, Francioso A, Martire S, Cocciolo A, Chichiarelli S, Romano A, Gaetani S, Mancini P, Fontana M, d'Erme M, Mosca L. 5-S-Cysteinyldopamine neurotoxicity: influence on the expression of alpha-Synuclein and of ERp57 in cellular and animal models of Parkison’s disease. Journal of Neuroscience Research. 2014 92(3):347-58
40. Bedse G, Romano A, Cianci S, Lavecchia AM, Pace L, Elphick MR, LaFerla FM, Vendemiale G, Grillo C, Altieri F, Cassano T and Gaetani S. Altered expression of the CB1 cannabinoid receptor in the triple transgenic mouse model of Alzheimer’s disease. Journal of Alzheimers Disease. 2014 40(3):701-12
41. Schepisi C Cianci S, Bedse G, Fu J, Gaetani S, Nencini P. Differences in the structure of drinking, cart expression and dopamine turnover between polydipsic and non polydipsic rats in the quinpirole model of psychotic polydipsia. Psychopharmacology. 2014 231(19):3889-97
42. Romano A, Coccurello R, Giacovazzo G, Bedse G, Moles A and Gaetani S. Oleoylethanolamide: a novel potential pharmacological alternative to cannabinoid antagonists for the control of appetite. BioMed Research International (formerly titled Journal of Biomedicine and Biotechnology) 2014 2014:203-425
43. Romano A, Karimian Azarib E, Tempesta B, Mansourib A, Micioni Di Bonaventura MV, Ramachandran D, Lutz TA, Bedse G, Langhans W, and Gaetani S. High dietary fat intake influences the activation of specific hindbrain and hypothalamic nuclei by the satiety factor oleoylethanolamide. Physiology & Behavior 2014 136:55-62
44. Karimian Azari E, Ramachandran D, Weibel S, Arnold M, Romano A, Gaetani S, Langhans W, and Mansouri A. Vagal afferents are not necessary for the satiety effect of the gut lipid messenger oleoylethanolamide (OEA). American Journal Of Physiology-Regulatory Integrative And Comparative Physiology 2014 307(2):R167-78
45. Bedse G, Colangeli R, Lavecchia AM, Romano A, Altieri F, Cifani C, Cassano T, Gaetani S. Role of the basolateral amygdala in mediating the effects of the fatty acid amide hydrolase inhibitor URB597 on HPA axis response to stress. European Neuropsychopharmacology 2014 24(9):1511-23
46. Provensi G, Munari L, Umehara H, Coccurello R, Giacovazzo G, Galeotti N, Nosi D, Gaetani S, Romano A, Moles A, Blandina P and Passani MB. The satiety factor oleoylethanolamide recruits the brain histaminergic system to inhibit food intake, Proceedings Of The National Academy Of Sciences Of The United States Of America. 2014, 111(31):11527-32
47. Micioni Di Bonaventura MV, Ciccocioppo R, Romano A, Bossert J, Rice K, Ubaldi M, St. Laurent R, Gaetani S, Massi M, Shaham Y, Cifani C. Role of bed nucleus of the stria terminalis corticotrophin-releasing factor receptors in frustration stress-induced binge-like palatable food consumption in female rats with a history of food restriction. Journal of Neuroscience 2014, 34:11316-24
48. D'Addario C, Micioni Di Bonaventura MV, Pucci M, Romano A, Gaetani S, Ciccocioppo R, Cifani C, Maccarrone M. Endocannabinoid signaling and food addiction. Neuroscience And Biobehavioral Reviews. 2014 47C:203-224
49. Michetti C, Romano E, Altabella L, Caruso A, Castelluccio P, Bedse G, Gaetani S, Canese R, Laviola G, Scattoni ML. Mapping pathological phenotypes in reelin mutant mice. Frontiers in Pediatrics. 2014 2:95
50. Mancuso C and Gaetani S. Preclinical and clinical issues in Alzheimer’s disease drug research and development. Frontiers in Pharmacology. 2014 5:234
51. Romano A, Pace L, Tempesta B, Lavecchia AM, Macheda T, Bedse G, Petrella A, Vendemiale G, Gaetani S, Cassano T. Depressive-like behaviour is paired to monoaminergic alteration in a murine model of Alzheimer's disease. International Journal of Neuropsychopharmacology 2014 31;18(4)
52. Bedse G, Romano A, Lavecchia AM, Cassano T and Gaetani S. The role of endocannabinoid signaling in the molecular mechanisms of neurodegeneration in Alzheimer disease. Journal of Alzheimer’s disease 2015 43(4):1115-36
53. Stoppoloni D, Politi L, Leopizzi M, Gaetani S, Guazzo R, Basciani S, Moreschini O, De Santi M, Scandurra R, Scotto d'Abusco A. Effect of glucosamine and its peptidyl-derivative on the production of extracellular matrix components by human primary chondrocytes. Osteoarthritis and Cartilage. 2015 23(1):103-13
54. Bedse G, Romano A, Tempesta B, Lavecchia M, Pace L, Bellomo A, Duranti A, Micioni di Bonaventura MV, Cifani C, Cassano T, Gaetani S. Inhibition of anandamide hydrolysis enhances noradrenergic and GABAergic transmission in the prefrontal cortex and basolateral amygdala of rats subjected to acute swim stress. Journal of Neuroscience Research 2015 93(5):777-87
55. Romano A, Tempesta B, Provensi G, Passani MB, Gaetani S. Central mechanisms mediating the hypophagic effects of oleoylethanolamide and N-acylphosphatidylethanolamines: different lipid signals? Frontiers in Pharmacology. 2015 6:137. doi: 10.3389/fphar.2015.00137
56. Giudetti AM, Romano A, Lavecchia AM, Gaetani S. The role of brain cholesterol and its oxidized products in Alzheimer's disease. Current Alzheimer Research 2016;13(2):198-205
57. Cassano T, Pace L, Bedse G, Lavecchia AM, De Marco F, Gaetani S, Serviddio G. Glutamate and Mitochondria: Two Prominent Players in the Oxidative Stress-Induced Neurodegeneration. Current Alzheimer research. 2016;13(2):185-97
58. Romano A, Tempesta B, Micioni Di Bonaventura MV and Gaetani S From Autism to Eating Disorders and More: The Role of Oxytocin in Neuropsychiatric Disorders. Frontiers in neuroscience 2016 9:497. doi: 10.3389/fnins.2015.00497
59. Gatta E, Lefebvre T, Gaetani S, Dos Santos M, Marrocco J, Cassano T, Nicoletti F, Maccari S, Mairesse J Evidence for an imbalance between tau O-GlcNAcylation and phosphorylation in the hippocampus of a mouse model of Alzheimer's disease. Pharmacological Research 2016 105:186-197
60. Gaetani S and Cassano T. From obesity resistance to obesity prediction and prevention? Frontiers in Neuroscience 2016 10:369
61. Gaetani S, Romano A, Provensi G, Ricca V, Lutz T, Passani MB. Eating disorders: from bench to bedside and back Journal of Neurochemistry 2016 139(5):691-699
62. Romano A, Serviddio G, Calcagnini S, Villani R, Giudetti AM, Cassano T, Gaetani S. Linking lipid peroxidation and neuropsychiatric disorders: focus on 4-hydroxy-2-nonenal. Free Radical Biology And Medicine. 2017 111:281-293
63. Romano A, Koczwara JB, Gallelli CA, Vergara D, Micioni Di Bonaventura MV, Gaetani S*, Giudetti AM Fats for thoughts: an update on brain fatty acid metabolism. The International Journal of Biochemistry & Cell Biology 2017 84:40-45
64. Cassano T, Calcagnini S, Pace L, De Marco F, Romano A, Gaetani S. Cannabinoid receptor 2 signaling in neurodegenerative disorders: from pathogenesis to a promising therapeutic target. Frontiers in Neuroscience 2017 doi: 10.3389/fnins.2017.00030
65. Coccurello R, Romano A, Giacovazzo G, Tempesta B, Fiore M, Giudetti AM, Marrocco I, Altieri F, Moles A, Gaetani S. Increased intake of energy-dense diet and negative energy balance in a mouse model of chronic psychosocial defeat. European Journal of Nutrition 2017 doi: 10.1007/s00394-017-1434-y
66. Bellanti F, Iannelli G, Blonda M, Tamborra R, Villani R, Romano A, Calcagnini S, Mazzoccoli G, Vinciguerra M, Gaetani S, Giudetti AM, Vendemiale G, Cassano T, Serviddio G. Alterations of clock gene RNA expression in brain regions of a triple transgenic model of alzheimer disease. Journal of Alzheimer’s disease 2017 59(2):615-631
67. Romano A, Gallelli CA, Koczwara JB, Braegger FE, Vitalone A, Falchi M, Micioni Di Bonaventura MV, Cifani C, Cassano T, Lutz TA, Gaetani S. Role of the area postrema in the hypophagic effects of oleoylethanolamide. Pharmacol Res. 2017 122:20-34
68. Scuderi C, Bronzuoli MR, Facchinetti R, Pace L, Ferraro L, Broad KD, Serviddio G, Bellanti F, Palombelli G, Carpinelli G, Canese R, Gaetani S, Steardo L Jr, Steardo L, Cassano T. Ultramicronized palmitoylethanolamide rescues learning and memory impairments in a triple transgenic mouse model of Alzheimer's disease by exerting anti-inflammatory and neuroprotective effects. Transl Psychiatry. 2018 Jan 31;8(1):32. doi: 10.1038/s41398-017-0076-4
69. Costa A, Cristiano C, Cassano T, Gallelli CA, Gaetani S, Ghelardini C, Blandina P, Calignano A, Passani MB, Provensi G. Histamine-deficient mice do not respond to the antidepressant-like effects of oleoylethanolamide. Neuropharmacology. 2018 Mar 26;135:234-241
70. Gallelli CA, Calcagnini S, Romano A, Koczwara JB, de Ceglia M, Dante D, Villani R, Giudetti AM, Cassano T, Gaetani S. Modulation of the Oxidative Stress and Lipid Peroxidation by Endocannabinoids and Their Lipid Analogues. Antioxidants (Basel). 2018 Jul 18;7(7).
71. Tramutola A, Sharma N, Barone E, Lanzillotta C, Castellani A, Iavarone F, Vincenzoni F, Castagnola M, Butterfield DA, Gaetani S, Cassano T, Perluigi M, Di Domenico F. Proteomic identification of altered protein O-GlcNAcylation in a triple transgenic mouse model of Alzheimer's disease. Biochim Biophys Acta Mol Basis Dis. 2018 Jul 18. pii: S0925-4439(18)30260-6
72. Barone E, Tramutola A, Triani F, Calcagnini S, Di Domenico F, Ripoli C, Gaetani S, Grassi C, Butterfield DA, Cassano T, Perluigi M. Biliverdin Reductase-A Mediates the Beneficial Effects of Intranasal Insulin in Alzheimer Disease. Molecular Neurobiology. 2018 Aug 2. doi: 10.1007/s12035-018-1231-5
73. Giudetti AM, Testini M, Vergara D, Priore P, Damiano F, Gallelli CA, Romano A, Villani R, Cassano T, Siculella L, Gnoni GV, Moles A, Coccurello R, Gaetani S. Chronic psychosocial defeat differently affects lipid metabolism in liver and white adipose tissue and induces hepatic oxidative stress in mice fed on a high-fat diet. FASEB Journal 2019 Jan;33(1):1428-1439
74. Cassano T, Magini A, Giovagnoli S, Polchi A, Calcagnini S, Pace L, Lavecchia MA, Scuderi C, Bronzuoli MR, Ruggeri L, Gentileschi MP, Romano A, Gaetani S, De Marco F, Emiliani C, Dolcetta D. Early intrathecal infusion of everolimus restores cognitive function and mood in a murine model of Alzheimer's disease. Experimental Neurology. 2018 Sep 19. pii: S0014-4886(18)30489-8
75. Micioni Di Bonaventura MV, Pucci M, Giusepponi ME, Romano A, Lambertucci C, Volpini R, Micioni Di Bonaventura E, Gaetani S, Maccarrone M, D'Addario C, Cifani C. Regulation of adenosine A(2A) receptor gene expression in a model of binge eating in the amygdaloid complex of female rats. J Psychopharmacol. 2019 33(12):1550-1561
76. Lupo G, Gaetani S, Cacci E, Biagioni S, Negri R. Molecular Signatures of the Aging Brain: Finding the Links Between Genes and Phenotypes. Neurotherapeutics. 2019 16(3):543-553
77. Cassano T, Calcagnini S, Carbone A, Bukke VB, Orkisz S, Villani R, Romano A, Avolio C and Gaetani S Pharmacological Treatment of Depression in Alzheimer’s Disease: A Challenging Task, Front. Pharmacol. 2019, doi: 10.3389/fphar.2019.01067
78. De Deurwaerdere P, Gaetani S, Vaughan RA. Old neurochemical markers, new functional directions?: An Editorial for 'Distinct gradients of various neurotransmitter markers in caudate nucleus and putamen of the human brain' on doi: 10.1111/jnc.14897. J Neurochem. 2020 Jan 9:e14929. doi: 10.1111/jnc.14929
79. Mancuso C, Gaetani S. Editorial: Alzheimer's Disease: Original Mechanisms and Translational Impact. Front Pharmacol. 2020 11:157.
80. Cifani C, Avagliano C, Micioni Di Bonaventura E, Giusepponi ME, De Caro C, Cristiano C, La Rana G, Botticelli L, Romano A, Calignano A, Gaetani S, Micioni Di Bonaventura MV, Russo R. Modulation of Pain Sensitivity by Chronic Consumption of Highly Palatable Food Followed by Abstinence: Emerging Role of Fatty Acid Amide Hydrolase. Front Pharmacol. 2020 11:266
81. Romano A, Micioni Di Bonaventura MV, Gallelli CA Koczwara JB, Smeets D, Giusepponi ME, De Ceglia M, Friuli M, Micioni Di Bonaventura E, Scuderi C, Vitalone A, Tramutola A, Altieri F, Lutz TA, Giudetti AM, Cassano T, Cifani C and Gaetani S Oleoylethanolamide decreases frustration stress-induced binge-like eating in female rats: a novel potential treatment for binge eating disorder Neuropsychopharmacology 2020 45(11):1931-1941
82. Romano A, Friuli M, Cifani C, Gaetani S. Oxytocin in the neural control of eating: At the crossroad between homeostatic and non-homeostatic signals. Neuropharmacology. 2020 171:108082. doi: 10.1016/j.neuropharm.2020.108082.
83. Giudetti AM*, Micioni Di Bonaventura MV, Ferramosca A, Longo S, Micioni Di Bonaventura E, Friuli M, Romano A, Gaetani S*§, Cifani C§ Brief daily access to cafeteria-style diet impairs hepatic metabolism even in the absence of excessive body weight gain in rats FASEB 2020 34(7):9358-9371 *CORRESPONDING AUTHOR; §CO-LAST AUTHORS
84. Conte E, Romano A, De Bellis M, De Ceglia ML, Carratù MR, Gaetani S, Maqoud F, Tricarico D, Camerino C Oxtr/TRPV1 expression and acclimation of skeletal muscle to cold-stress in male mice J Endocrinol 2021 249(2):135-148
85. Romano A, Friuli M, Del Coco L, Longo S, Vergara D, Del Boccio P, Valentinuzzi S, Cicalini I, Fanizzi FP, Gaetani S*, Giudetti AM. Chronic Oleoylethanolamide Treatment Decreases Hepatic Triacylglycerol Level in Rat Liver by a PPARγ/SREBP-Mediated Suppression of Fatty Acid and Triacylglycerol Synthesis. Nutrients. 2021 Jan 27;13(2):394. doi: 10.3390/nu13020394. *Co-last author
86. Rani B, Santangelo A, Romano A, Koczwara JB, Friuli M, Provensi G, Blandina P, Casarrubea M, Gaetani S, Passani MB, Costa A. Brain histamine and oleoylethanolamide restore behavioral deficits induced by chronic social defeat stress in mice Neurobiology of Stress 2021 14:100317. doi: 10.1016/j.ynstr.2021.100317
87. Giudetti AM, Vergara Longo S, Friuli M, Eramo B, Tacconi S, Fidaleo M, Dini L, Romano A and Gaetani S. Oleoylethanolamide reduces hepatic oxidative stress and endoplasmic reticulum stress in high-fat diet-fed rats. Antioxidants 2021, 10(8), 1289; https://doi.org/10.3390/antiox10081289
88. de Ceglia M,Juan Decara, Gaetani S and Rodríguez de Fonseca F Obesity as a condition determined by food addiction: should brain endocannabinoid system alterations be the cause and its modulation the solution? Pharmaceuticals 2021 14(10):1002. doi: 10.3390/ph14101002
89. Di Giacomo S, Percaccio E, Gullì M, Romano A, Vitalone A, Mazzanti G, Gaetani S, Di Sotto A. Recent Advances in the Neuroprotective Properties of Ferulic Acid in Alzheimer's Disease: A Narrative Review. Nutrients. 2022 Sep 8;14(18):3709. doi: 10.3390/nu14183709
90. Micioni Di Bonaventura E, Botticelli L, Del Bello F, Giorgioni G, Piergentili A, Quaglia W, Romano A, Gaetani S, Micioni Di Bonaventura MV, Cifani C. Investigating the role of the central melanocortin system in stress and stress-related disorders. Pharmacol Res. 2022 Nov;185:106521. doi: 10.1016/j.phrs.2022.106521.
91. Cassano T, Giamogante F, Calcagnini S, Romano A, Lavecchia AM, Inglese F, Paglia G, Bukke VN, Romano AD, Friuli M, Altieri F, Gaetani S. PDIA3 Expression Is Altered in the Limbic Brain Regions of Triple-Transgenic Mouse Model of Alzheimer's Disease. Int J Mol Sci. 2023 Feb 3;24(3):3005. doi: 10.3390/ijms24033005..
92. de Ceglia M, Micioni Di Bonaventura MV, Romano A, Friuli M, Micioni Di Bonaventura E, Gavito AL, Botticelli L, Gaetani S, de Fonseca FR, Cifani C. Anxiety associated with palatable food withdrawal is reversed by the selective FAAH inhibitor PF-3845: A regional analysis of the contribution of endocannabinoid signaling machinery. Int J Eat Disord. 2023 Jun;56(6):1098-1113. doi: 10.1002/eat.23917
93. Romano A, Friuli M, Eramo B, Gallelli CA, Koczwara JB, Azari EK, Paquot A, Arnold M, Langhans W, Muccioli GG, Lutz TA, Gaetani S. "To brain or not to brain": evaluating the possible direct effects of the satiety factor oleoylethanolamide in the central nervous system. Front Endocrinol (Lausanne). 2023 May 10;14:1158287. doi: 10.3389/fendo.2023.1158287.
94. Tacconi S., Longo S., Guerra F., Moliterni C., Friuli M., Romano A., Gaetani S., Paradiso V. M., Difonzo G., Caponio F., Lofrumento D., vergara D., Bucci C., Dini L., Giudetti A. M. An aqueous olive leaf extract ({OLE}) ameliorates parameters of oxidative stress associated with lipid accumulation and induces lipophagy in human hepatic cells. Food & Function, 2023 vol. 14, p. 5805-5819, ISSN: 2042-6496, doi: 10.1039/d3fo00817g
95. Bove M, Palmieri MA, Santoro M, Agosti LP, Gaetani S, Romano A, Dimonte S, Costantino G, Sikora V, Tucci P, Schiavone S, Morgese MG, Trabace L. Amygdalar neurotransmission alterations in the BTBR mice model of idiopathic autism. Transl Psychiatry. 2024 Apr 17;14(1):193.
96. de Ceglia M, Romano A, Micioni Di Bonaventura MV, Gavito AL, Botticelli L, Micioni Di Bonaventura E, Friuli M, Cifani C, Rodriguez de Fonseca F, Gaetani S. Cafeteria diet abstinence induces depressive behavior and disrupts endocannabinoid signaling in dopaminergic areas: a preclinical study. Curr Neuropharmacol. 2025;23(4):458-474. doi: 10.2174/1570159X23666241107160840
97. de Ceglia M, Rasheed N, Tovar R, Pareja-Cerbán I, Arias-Sáez A, Gavito A, Gaetani S, Cifani C, Rodríguez de Fonseca F, Decara J. A Combined GLP-1/PPARa/CB1-Based Therapy to Restore the Central and Peripheral Metabolic Dysregulation Induced by a High-Fructose High-Fat Diet. Int J Mol Sci. 2025 Mar 7;26(6):2420. doi: 10.3390/ijms26062420.
98. Costa A, Di Bonaventura EM, Botticelli L, Eramo B, Gaetani S, Passani MB, Cifani C, Micioni Di Bonaventura MV, Provensi G. Brain histaminergic system: an emerging target for the treatment of feeding and eating-related disorders. Pharmacol Res. 2025 Sep 12:107949. doi: 10.1016/j.phrs.2025.107949.

CONTRIBUTION TO TEXTBOOKS
1. “Principi di Farmacologia”, in “Argomenti di anestesia e rianimazione per le professioni sanitarie” Piccin Nuova Libraria Spa, 2006
2. “Rang & Dale Farmacologia” 8° edizione, 2016; Curatori: A Gorio, AM Di Giulio; Edizioni EDRA
3. “Manuale di Farmacoterapia” Edizioni Idelson Gnocchi, 2019
4. “Rossi F, Cuomo V, Riccardi C. Farmacologia: principi di base e applicazioni terapeutiche (V ed.). Torino: Edizioni Minerva Medica; 2023