ANDREA ISIDORI

Prof. Andrea M. Isidori is a Full Professor of Endocrinology at Sapienza University of Rome and Chair of the Advanced Endocrine Diagnostics Unit at Policlinico Umberto I, Rome. Since 1999, he has been conducting translational research in andrology and endocrinology, seamlessly integrating basic science with clinical applications. His work involves extensive international collaborations with institutions such as Queen Mary University of London and the University of Oxford.

Prof. Isidori is a leading authority in steroid hormone pathophysiology, with specialized expertise in male hypogonadism, adrenal tumors, pituitary disorders, and rare endocrine syndromes. He has published over 270 peer-reviewed articles in high-impact international journals, including Nature, NEJM, The Lancet, Science Translational Medicine, Circulation, and, most importantly, Andrology. His work has garnered an overall Impact Factor exceeding 1400, with more than 25,000 citations and a Google Scholar h-index of 82.

Prof. Isidori has held several prominent leadership roles within professional organizations. He served on the Executive Committee of the European Academy of Andrology (2014–2022), contributed to the International Consultation on Sexual Medicine (2015, 2024), and was Treasurer of the International Society of Andrology (2017–2020). Most recently, he served as President of the Italian Society of Andrology and Sexual Medicine (2021–2023).

Selected Publications

# Article ― Cit ― IF ― Author’s Role ― Article Type

1. Isidori AM, Caprio M, Strollo F, Moretti C, Frajese G, Isidori A, Fabbri A. "Leptin and androgens in male obesity: evidence for leptin contribution to reduced androgen levels." J Clin Endocrinol Metab 1999; 84:3673-3680 ― 495 ― 5.5 ― First author ― Original Investigation

2. Isidori AM, Kaltsas GA, Mohammed S, Morris DG, Jenkins P, Chew SL, Monson JP, Besser GM, Grossman AB. "Discriminatory value of the low-dose dexamethasone suppression test in establishing the diagnosis and differential diagnosis of Cushing's syndrome." J Clin Endocrinol Metab 2003; 88:5299-5306 ― 116 ― 5.9 ― First author ― Original Investigation

3. Isidori AM, Giannetta E, Greco EA, Gianfrilli D, Bonifacio V, Isidori A, Lenzi A, Fabbri A. "Effects of testosterone on body composition, bone metabolism and serum lipid profile in middle-aged men: a meta-analysis." Clin Endocrinol 2005; 63:280-293 ― 588 ― 3.5 ― First author & Corresponding ― Meta-Analysis

4. Isidori AM, Kaltsas GA, Pozza C, Frajese V, Newell-Price J, Reznek RH, Jenkins PJ, Monson JP, Grossman AB, Besser GM. "The ectopic adrenocorticotropin syndrome: clinical features, diagnosis, management, and long-term follow-up." J Clin Endocrinol Metab 2006; 91:371-377 ― 383 ― 5.8 ― First author ― Original Investigation

5. Isidori AM, Pozza C, Esposito K, Giugliano D, Morano S, Vignozzi L, Corona G, Lenzi A, Jannini EA. "Development and validation of a 6-item version of the female sexual function index (FSFI) as a diagnostic tool for female sexual dysfunction." J Sex Med 2010; 7:1139-1146 ― 256 ― 4.0 ― First author ― Original Investigation

6. Giannetta E§, Isidori AM§*, Galea N, Carbone l, Mandosi E, Vizza CD, Naro F, Morano S, Fedele F, Lenzi A. "Chronic Inhibition of cGMP phosphodiesterase 5A improves diabetic cardiomyopathy: a randomized, controlled clinical trial using magnetic resonance imaging with myocardial tagging." Circulation 2012; 125:2323-2333 ― 167 ― 21.1 ― Co-First author & Corresponding ― Original Investigation

7. Isidori AM*, Pozza C, Gianfrilli D, Giannetta E, Lemma A, Pofi R, Barbagallo F, Manganaro L, Martino G, Lombardo F, Cantisani V, Franco G, Lenzi A. "Differential diagnosis of nonpalpable testicular lesions: Qualitative and quantitative contrast-enhanced US of benign and malignant testicular tumors." Radiology 2014; 273:606-618 ― 107 ― 8.2 ― First author & Corresponding ― Original Investigation

8. Isidori AM*, Venneri MA, Graziadio C, Simeoli C, Fiore D, Hasenmajer V, Sbardella E, Gianfrilli D, Pozza C, Pasqualetti P, Morrone S, Santoni A, Naro F, Colao A, Pivonello R, Lenzi A. "Effect of once-daily, modified-release hydrocortisone versus standard glucocorticoid therapy on metabolism and innate immunity in patients with adrenal insufficiency (DREAM): a single-blind, randomised controlled trial". Lancet Diabetes Endocrinol 2018; 6:173-185 ― 164 ― 23.3 ― First author & Corresponding ― Original Investigation

9. Pofi R, Giannetta E, Feola T, Galea N, Barbagallo F, Campolo F, Badagliacca R, Barbano B, Ciolina F, Defeudis G, Filardi T, Sesti F, Minnetti M, Vizza CD, Pasqualetti P, Caboni P, Carbone l, Francone M, Catalano C, Pozzilli P, Lenzi A, Venneri MA, Gianfrilli D, Isidori AM*. "Sex-specific effects of daily tadalafil on diabetic heart kinetics in RECOGITO, a randomized, double-blind, placebo-controlled trial." Sci Transl Med. 2022;14(649):eabl503 ― 31 ― 17.1 ― Last author & Corresponding ― Original Investigation

10. Auchus RJ, Hamidi O, Pivonello R, Bancos l, Russo G, Witchel SF, Isidori AM, Rodien P, Srirangalingam U, Kiefer FW, Falhammar H, Merke DP, Reisch N, Sarafoglou K, Cutler GB Jr, Sturgeon J, Roberts E, Lin VH, Chan JL, Farber RH; "CAHtalyst Adult Trial Investigators Phase 3 Trial of Crinecerfont in Adult Congenital Adrenal Hyperplasia." N Engl J Med. 2024 Aug 8;391(6):504-514 ― 11 ― 96.2 ― Contributor ― Original Investigation

*, corresponding senior author;; §, equally co-first; °, in international collaborations, group leader for Rome Sapienza; the IF is year specific

Links:
https://www.scopus.corn/authid/detail.uri?authorld=55183511100
https://orcid.org/0000-0002-9037-5417
https://isidorilab.com/home