CARLA GIORDANO

Carla Giordano
Curriculum Vitae

Place Rome
Date June 2nd

Part I- GENERAL INFORMATION
Researcher unique identifier(s): ORCID iD 0000-0002-3716-4303
Spoken Languages: Italian, English

Part II- EDUCATION
2007, PhD in Human Pathology, Sapienza, University of Rome
2003, Board in Anatomic Pathology Sapienza, University of Rome
1997, MD Degree Sapienza, University of Rome

Part III-PRE and POST-DOCTORAL TRAINING
1998-2001 Telethon fellowship, College of Physicians & Surgeons, Department of Neurology, Columbia University, New York, USA (Dr. MM Davidson and Dr. EA Schon)
2006-2008, Research Fellowship funded by Telethon (PI Valerio Carelli), Department of Experimental Medicine, Sapienza University of Rome
2008-2010 Senior Researcher at Department of Experimental Medicine, Sapienza University of Rome

Part IV- APPOINTMENTS
IV-A ACADEMIC APPOINTMENTS
2010-2020, Assistant Professor, Sapienza, University of Rome
2020-2024, Associate Professor, Sapienza, University of Rome
December 2024-now, Full Professor, Sapienza, University of Rome

IV-B OTHER APPOINTMENTS
Hospital Staff Position
2012-present, Staff Pathologist, Policlinico Umberto I, Sapienza, University of Rome

Part V- SOCIETY MEMBERSHIPS
2023-present, membership Society for Cardiovascular Pathology (SCVP),
2013-present, membership Association for European Cardiovascular Pathology (AECVP)
2008-present, membership Società Italiana di Anatomia Patologica (SIAPEC/IAP)
2016-2023, Coordinator Gruppo di Studio SIAPEC di Cardiopatologia (GIC)
2025, present membership Fondazione Italiana Linfomi

Part XI- MAIN RESEARCH INTERESTS
- Cardiovascular pathology
- Neuromuscular disease with attention to genetic metabolic disorders
- Gastrointestinal pathology, particularly non-neoplastic pediatric disease
- Hematopathology

My background in pathological anatomy allows me to extract important information from tissues. I
have learned to combine morphological analysis with cell and molecular biology, even at the singlecell
level. Therefore, my main expertise is in morpho-molecular correlation, which I have applied to
cardiovascular, neuro-muscular, gastrointestinal, and recently, hematopathology.

Cardiovascular pathology. My studies focused on the morphological and genetic substrates of
genetic and acquired cardiomyopathies and sudden cardiac death. Within the framework of national
and international scientific societies, I participated in the drafting of recommendations and
consensus documents for the pathological diagnostic approach to myocardial infarction, sudden
cardiac death, genetic cardiomyopathies, and at present, myocarditis (ongoing).

Neuromuscular pathology. Interest has been given to the variable penetrance of mitochondrial
diseases, analyzing the role of mitochondrial biogenesis in the modulation of clinical phenotype. I
applied the method of laser capturing microdissection to shed light on the role of mitochondrial
biogenesis in the modulation of the disease penetrance in LHON, in the mitochondrial
neurogastrointestinal encephalopathy (MNGIE) syndrome and cardiomyopathies due to mutations
in mitochondrial-tRNAs genes.
In addition, I described the morphological aspects of several animal models of mitochondrial
diseases.

Gastrointestinal pathology. The main research topics concern non-neoplastic pathology,
particularly the morphological and molecular substrates of visceral myopathies. Recently, my
research group set up a dual immunohistochemistry technique for detecting mucosal deposits of
transglutaminase 2 (TG2)-IgA, an early morphologic marker of celiac disease.

Hematopathology. The role of the Epstein-Barr virus in large B-cell lymphomas, specifically the
role of the viral protein EBNA2 in the immunologic escape of transformed cells, has recently been
investigated.

PART XII – SUMMARY OF SCIENTIFIC ACHIEVEMENTS

H index: 36 (Scopus), 40 (Google Scholar)

Citations: 3878 (Scopus), 5163 (Google Scholar)