Nursing REPLICA ASL ROMA 2

Drugs: mechanisms of action, drug effects, phases of drug trials Pharmacokinetics: definition and fate of drugs in the body, pharmacokinetic phases (absorption, distribution, metabolism, drug elimination, renal and extrarenal drug excretion); main pharmacokinetic variables, main types of barriers, drug transport across membranes, drug disappearance kinetics, kinetics of continuous and repeated administration, achievement of steady state Drug administration: dosage forms and routes of administration (oral, sublingual, rectal, intravascular, subcutaneous and intramuscular, intrathecal, pulmonary, nasal, transdermal, topical). Drug storage methods Drug bioavailability and distribution (volume of distribution, drug-protein binding, factors that affect drug distribution) Drug metabolism (metabolic systems involved, classification of metabolic reactions, induction and activation, phase 2 metabolism). Pharmacokinetic parameters: bioavailability, apparent volume of distribution, plasma half-life, clearance. Pharmacodynamics, definition of the site of action, drug receptors (intracellular receptors, drug-receptor interactions, intrinsic activity, agonist drugs, inverse agonists, agonist-antagonists, antagonists) Pharmacological activity, therapeutic index, safety and efficacy profiles. Drug interactions (synergistic and antagonistic effects), pharmacokinetic and pharmacodynamic interactions. Individual differences in drug response. Drug toxicity (different types of toxicity, drug allergy). Physiological changes during pregnancy and distribution to the fetus. Detergents and disinfectants Knowledge of drug use guidelines, appropriateness and adherence to therapy. Ability to read drug product labels, prepare and dose according to the Official Pharmacopoeia (F.U.). Overview of pharmacovigilance.

Farmacologia generale e molecolare (F.Clementi, G. Fumagalli) EDRA ed.5 ed.; Lezioni di farmacologia generale (R. Rimondini- Giorgini, L.Barbieri) Alma mater studiorum ed. 1 ed. Farmacologia per le lauree triennali e magistrali (di Taglialatela - Cantarella - Leone - Mattioli - Moretti - Pignataro – Vanzetta) Sorbona ed. IV ed. Slides of the lessons