Imaging and Radiotherapy techniques REPLICA E - REGIONE MOLISE - IRCCS NEUROMED POZZILLI

1. Definition of pharmacology, pharmacodynamics, pharmacokinetics, modes of drug administration and absorption routes. 2. Principles of radioactivity. Definition of radiopharmaceuticals, good preparation standards (NBUPR). 3. Molybdenum / technetium generator ("dry" and "damp" generators, generator output). Technique Chemistry, Radiation Marking Principles: Lewis Acids and Bases, Sn-Tc Redox Reduction, Tc, "hot" and "cold" marking 4. Pertechnetate (TcO4-) as a radiopharmaceutical. Radiopharmaceuticals for imaging of the osteoarticular and cardiovascular system. 5. Radiopharmaceuticals for brain imaging, genitourinary urinary system, radiocolloid and pertecnegas imaging. 99mTc-HMPAO and cell marking techniques. 6. Marking with iodine (123I, 131I) and with radiometals (111In, 68Ga, 177Lu, 90Y). 7. SPECT receptor receptors (123I-MIBG, 111In-Octreoscan) 8. Cyclotron and PET radiopharmaceuticals (18FDG, 18F-choline, 18FLT, 18F-MISO, 18F-DOPA). Radiopharmaceuticals for amyloid. 9. Radiopharmaceuticals for radiometabolic therapy (131I, 131I-MIBG, 177Lu-DOTATATE / 90Y-DOTATOC, 90Y microspheres, 223RaCl2). 10. Quality Controls (TLC, Radiochromatography).

Basic knowledge of physics, organic chemistry, anatomy, physiology, pathophysiology, and pathology is recommended.

Farmacologia generale e speciale Anna Maria Di Giulio, Alfredo Gorio, Stephana Carrelli, Silvano Gabriele

Lectures

The required attendance is 66%

The oral assessment is based on topics covered in the syllabus

Updated references provided during lectures