Industrial pharmacy

General expected learning outcomes The course of Medicinal Chemistry and Toxicology 2 aims to teach the student, in different therapeutic categories, the drugs that represent milestones in the treatment of related diseases, the drug discovery process that led to their identification, the relationships between chemical structure and biological activity, chemical synthesis, molecular mechanism, pharmacological and toxicological effects, the main side effects, the possibility of combined treatments, social and economic implications. Specific expected learning outcomes 1. Knowledge and understanding The student will know all the aforementioned aspects concerning nervous system drugs, both depressive (neuroleptic, anti-anxiety, hypnotics-sedatives, anticonvulsants, anti-Parkinson’s) and stimulants (analectics, antidepressants), narcotic and non-narcotic analgesic drugs, cardiovascular drugs (antiarrhythmics, vasodilators of the coronary, antihypertensive, diuretic, hypolipidemic agents), drugs of the autonomous nervous system (adrenergic and cholinergic), sexual and cortical steroids. 2. Applying knowledge and understanding At the end of the course the student will recognize a drug belonging to a mentioned category, from another not belonging to the same therapeutic area. He will know which are the most relevant structure-activity relationships in a serie of drugs, and which are the points of the drug that can be chemically modified and which ones can not be altered otherwise the loss of biological activity. He will know the main organic reactions that lead to the synthesis of various drugs. He will know what are the chemical requirements for a molecule to be ligand of a particular receptor, enzyme or ion channel that represents the target of known drugs. He will know the most important and widespread therapeutic problems and therapeutic solutions available to cope and effectively treat the various diseases. 3. Making judgements The lessons will be all interactive, in which the teacher will ask the students continuous questions to stimulate them and develop their critical sense. These questions will also serve to evaluate and solicit students to make connections with everything studied so far, avoiding to consider the study of the subject a study in itself but integrating the pharmaceutical chemistry in light of the knowledge already acquired, both chemical (inorganic, organic, biochemical chemistry) than biological (anatomy, physiology, pathology, pharmacology, pharmacognosy, toxicology). 4. Communication skills The evaluation of the student's study will be carried out only with an oral exam, which will focus on all the topics of the program, testing the student's communication skills with respect to what he has learned. 5. Learning skills The student will find the deepening of what he heard in class on the recommended texts. This research work will serve to enable him to rediscover the topics dealt in the future, when the memories of the concepts taught in the classroom will be blurred. The texts will remain the reference point of the student who will know where to go to find in detail the notions that are partly forgotten.