Industrial pharmacy

General expected learning outcomes This course leads students towards a rational learning of Drug Design, giving them, after some general notes, a proper preparation about: a) targets, molecular interaction drug-target, consequences of these interactions basics of pharmacokinetic and pharmacodynamic; b) basics and strategies of drug design. Particular remarks will be on invention, discovery, design, identificatio, preparation of drugs, metabolism, molecular mechanism of action and structure-activity relationships. Specific expected learning outcomes 1. Knowledge and understanding The students will know and will be able to understand all aspects about pharmacokinetic and pharmacodynamic, drug targets, drug-target interactions, the consequences of these interactionsgeneral principles and strategies of drug discovery and design, the invention, discovery design identification of some specific drugs presented like case-studies, their metabolism, mechanism of action, and structure-activity relationships. 2. Applying knowledge and understanding At the end of the course the student, applying the aquired knowledge, will be able to plan the design of a drug, starting form the decision about the therapeutic area, fenotypic approach, target based approach, study of drug-target interactions, hit to lead and lead to candidate development, going ahead to the application of synthetic strategies and technologies, including CADD, up to the right comprehension of the relevance of ADMA-Tox properties for strong candidate to the clinical development. 3. Making judgements At the end of the course the student will be able to eavluate the appropriate approach to the design of a specific drug. This critical and judgement ability, will be obtained thanks to continuous interactivity hold during the course. In fact the teacher will ask questions very frequently to stimulate students to link the actual topics to all the topics studied up to that time, so that the study will not be isolated, but integrated matter with the aquired knowledge. At the end of the course the stundent will hold a presentation about an innovative recent drug. 4. Communication skills The student will be able to communicate the knowledge comprehended by the course and will apply during the oral exam that will focus on the topics of the syllabus. The student is stimulated to communicate in an inteactive way during the classroom and, at the end of the course and after the exam, will be able to communicate effectively his/her knowledge in the drug design field to specialists and non-specialists, in a more technical and detailed, and in an educational way, respectively. 5. Learning skills The student will find details of lessons on the suggested textbooks and in the scientific literature and will have ability to use them to pursue an indipendent preparation. This will be useful to teh studento to find again topics of the matte raso in future time when the memory of the concepts described in the lesson room will be softer. The textbooks will remain the benchmark for student that will be able to find again details of forgotten notions.