THREE-DIMENSIONAL MODELING

Course objectives

General skills The course includes two modules: one of Histology and one of Embryology. The main objective of the course is to lead the student to know the structural and ultrastructural characteristics of the tissues, correlating the structure to function, and to understand the morphogenic processes through which a body is built during embryogenesis, with a comparative vision to different animal models (mainly vertebrates). General skills – Module of Histology The course is focussed on the study of the morpho-functional characteristics of the tissue, and on the general mechanisms regulating their omeostasis. The objective of the course is to lead the student to understand the structural and ultra-structural organization of cells and tissues and to correlate structure to function. Moreover, to know the methodological and experimental aspects of histology and how to identify and describe the histological structure of a microscope slide. The course requires established knowledge of cell biology, as well as general notions of inorganic and organic chemistry. The course includes lectures integrated with two laboratory sessions, dedicated to the observation and recognition of histological sections of the different tissues. General skills – Module of Embryology The course is focused on the study of embryology and the different phases of embryogenesis and on the gametogenesis and fertilization processes. The main aim of the course is to acquire the basic knowledge of the various phases of embryogenesis with a comparative view on different animal models (mainly vertebrates), of the maturation of gametes and the mechanisms of fertilization. The course requires established knowledge of cell biology. The course includes lectures integrated with one laboratory session, dedicated to the observation and recognition of histological sections of vertebrate embryos at various developmental stages. Specific skills – Module of Histology A) Knowledge and understanding - Knowledge of the structural and ultrastructural organization of the tissues - Knowledge and understanding the correlation between structure and function - Knowledge and understanding the general mechanisms regulating tissue homeostasis B) Applying knowledge and understanding - learning how to use the appropriate terminology - learning the methods used in histology - learning how to recognize the structure of a tissue at Light Microscope and its location within the organ. C) Autonomy of judgment - acquiring critical judgment skills, through the study of methodological and experimental aspects of histology, as well as their present and future value in the biomedical applications and physiopathology. D) Communication skills - Learning how to present the acquired knowledge in an interview, using proper scientific language and knowing how to integrate, discuss and analyze in a critical way what has been learned. E) Learning skills - learning the appropriate terminology - learning to connect and integrate the acquired knowledge in a logical way - learning to identify the most relevant topics and their potential applicability to current problems. Specific skills – Module of Embryology A) Knowledge and understanding - Knowledge of the main events of embryogenesis - Knowledge and understanding of the various stages of embryo development with a comparative vision - Knowledge and understanding of the germ line formation and the gametes maturation. B) Applying knowledge and understanding - learning how to use the appropriate terminology - learning how to recognize the various phases of embryogenesis - learning how to recognize the various embryos and the main tissues and organs in development in images and diagrams C) Autonomy of judgment - acquiring critical judgment skills, through the historical study of the embryological knowledge - evaluation of the acquired knowledge through a written test D) Communication skills - Learning how to present the acquired knowledge in a written test using proper scientific language and knowing how to integrate, discuss and analyze in a critical way what has been learned E) Learning skills - learning the appropriate terminology - learning to connect and integrate the acquired knowledge in a logical way - learning to identify the most relevant topics and their potential applicability to current problems.

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LUCA MADARO Lecturers' profile

Program - Frequency - Exams

Course program
-How to study cells and tissues. Histological techniques: overview of methods in cytology and histology; tissue preparation for microscopic examination; light and electronic instruments for studying cells and tissues. Basics of histochemistry and immuno-histochemistry. Cell integration. Differentiation. Notion of tissue, organ and system. Tissue renewal; stem cells and cell lineage kinetics. -Epithelial tissue. Specializations of cells surface and cell polarity. Lining epithelia. Glands. Connective Tissues. General structure and functions of connective tissue. -Connective tissue proper: extracellular matrix, fibers, ground substance and cells. Cartilage: types of cartilage; chondrogenesis and cartilage growth. Bone: bone architecture and functions. Osteogenesis; bone remodeling and homeostasis. Blood: plasma, erythrocytes, leucocytes, platelets. Hemopoiesis. Basics of immune system and organs. -Muscle tissues: morphology and functional characteristics of skeletal, cardiac muscle and smooth muscle. -Nervous tissue. Neurons. Nerve fibers. Synapses. Neuroglia. Peripheral nerve terminals.
Prerequisites
It is useful that the student has acquired, at the beginning of the didactic activities foreseen by the teaching of histology and embryology, the basics of cell biology (structure of a cell, the cytoskeleton, cell organelles and their functions, the extracellular matrix, etc.).
Books
AA. VV, Elementi di Istologia e cenni di Embriologia, Piccin; L.P. Gartner e J.L. Hiatt, Atlante a colori e Testo di Istologia, Piccin; A.L. Mescher, Junqueira Istologia, Testo e Atlante, Piccin; AA. VV. Istologia di Monesi, Piccin Pawlina W. & Ross M.H. , Istologia 3ed, Testo e Atlante, Ambrosiana LINK ATLANTE: https://www.histologyguide.com/slidebox/slidebox.html
Frequency
attendance is not mandatory
Exam mode
To pass the exam the student must obtain not less than 18/30 in each module of the course. The student must demonstrate that he has acquired sufficient knowledge of the topics covered during the course. To achieve a score of 30/30 cum laude the student must instead demonstrate that he has acquired excellent knowledge of all the topics covered during the course, showing ability with the use of technical terms and correct linguistic expressions. Evaluation elements: • Knowledge check and adequacy of the answers • Reasoning of the student and ability to relate topics • Correct use of language
Bibliography
AA. VV, Elementi di Istologia e cenni di Embriologia, Piccin; L.P. Gartner e J.L. Hiatt, Atlante a colori e Testo di Istologia, Piccin; A.L. Mescher, Junqueira Istologia, Testo e Atlante, Piccin; AA. VV. Istologia di Monesi, Piccin Pawlina W. & Ross M.H. , Istologia 3ed, Testo e Atlante, Ambrosiana LINK ATLANTE: https://www.histologyguide.com/slidebox/slidebox.html
  • Academic year2025/2026
  • CourseBiotechnologies
  • CurriculumSingle curriculum
  • Year1st year
  • Semester2nd semester
  • SSDBIO/17
  • CFU3