LUCA MADARO

Researcher unique identifier(s): SCOPUS ID: 37091065100; ORCID ID: 0000-0003-0839-5724; RESEARCH ID: K-4629-2016

• EDUCATION
2014-Italian Biological License - University of Rome Tor Vergata, Italy
2011-PhD in Morphogenetic and cytology Science - Sapienza University of Rome, Italy
2008-II level Degree in Medical Cellular and Molecular Biotechnology - Sapienza University of Rome, Italy
2007-I level Degree in Biotechnology - Sapienza University of Rome, Italy

• CURRENT POSITION
2025 – Present Associate professor - DAHFMO, Sapienza University of Rome, Italy

• PREVIOUS POSITIONS
2022 – 2025 Researcher (RTDB) - DAHFMO, Sapienza University of Rome, Italy
2019–2022 Researcher (RTDA) - DAHFMO, Sapienza University of Rome, Italy
2015–2019 Research Biologist
Prof. PL Puri Lab - IRCCS Santa Lucia Foundation, Rome Italy
2014–2015 Postdoctoral Fellowship
Prof. PL Puri Lab - IRCCS Santa Lucia Foundation, Rome Italy
2011–2013 Postdoctoral Fellowship
Prof. M. Bouchè Lab - DAHFMO, Sapienza University of Rome, Italy

• FELLOWSHIPS AND AWARDS
2013 – 2014 AFM Telethon (Post-Doctoral Fellowship)
2013 EMBO Short term fellowship (Post-Doctoral Fellowship)
2011 – 2013 DPP NL Post-Doctoral fellowship
2012 Best presentation, Parent Project Award – IIM meeting 2012 – Acaya Lecce

• FUNDING INFORMATION (Grants as a PI-principal investigator or Co_PI)
2022-Present Program: PRIN 2022
2022-Present Program: AIRC MFAG 2022
2022-Present Program: AFM Telethon Research Grant (as PI)
2020-2022 Program: GFB Onlus (as PI)
2020-2021 Program: Università di Roma “La Sapienza” – Progetti Ateneo (as PI)
2020-2021 Program: AFM Telethon Trampoline 2019 (as PI)
2019-2021 Program: Roche per la Ricerca 2019 (as PI)
2018-2020 Program: Cariplo (as Co-PI, PI: Dr. Giovanni Tonon) Madaro.
2016-2019 Program: GR - Italian Ministry of Health (as PI)

• SUPERVISION OF GRADUATE STUDENTS AND POSTDOCTORAL FELLOWS
2017 – Present Tutor of 4 PhD Student and 4 Master Students
DAHFMO, Sapienza University of Rome, Italy
2012 – 2017 Tutor of 1 PhD Student and 2 Master Students
Department of Biology, University of Rome Tor Vergata, Italy

• TEACHING ACTIVITIES
2021 – Present Teacher of Histology –CL in Medicine and Surgery (canale A) – Sapienza University of Rome, Italy
2021 – Present Teacher of Histology –CL in TNPEE, Logopedics and Occupational Therapy – Sapienza University of Rome, Italy
2020 – Present Teacher of Histology – CL in Biotecnology – Sapienza University of Rome, Italy
2019 – Present Teacher of Histology – CL in Nursing – Sapienza University of Rome, Italy

• INSTITUTIONAL RESPONSIBILITIES
2019 – Present Member of the Teacher’s Committee of the PhD School in “Morphogenesis and Tissue Engineering” at Sapienza University of Rome, Italy

• REVIEWING ACTIVITIES
2021 – present Guest Editor for Special Issue "Skeletal Muscle Atrophy and Metabolic Adaptation" – MDPI – Metabolites (https://www.mdpi.com/journal/metabolites/special_issues/Muscle_Metabolic)
2018 – present Reviewer for Nature Communication, Advanced Science, The FASEB Journal, Journal of Clinical Medicine, IJMS, Cells, Antioxidants

• MEMBERSHIPS OF SCIENTIFIC SOCIETIES
2021 – Present Member of the “Società Italiana di Anatomia e Istologia”
2020 – Present Member of the “Collegio dei docenti di istologia ed embriologia”

• INTERNATIONAL CONGRESS
-Myogenesis – Gordon Research Conference, Lucca, 8-13 June 2025
-EMBO Workshop - 12 – 17 October 2024 | Catania, Sicily, Italy.
-Myogenesis – Gordon Research Conference, Lucca, 11-16 June 2023
-Myogenesis – Gordon Research Conference, Lucca, 9-14 June 2019
-Myogenesis – Gordon Research Conference, Lucca, 11-16 June 2017
-Myogenesis – Gordon Research Conference, Lucca, 21-26 June 2015
-Molecular Biology of Muscle Development and Regeneration, Acaya 14 May – 18 May 2014
-Society for Muscle Biology: development, function and repair of the muscle cell, New York, USA
-European Muscle Conferences, 2010 Padova, ITALY

• SCIENTIFIC PUBLICATIONS
48 Ruggieri V, Scaricamazza S, Bracaglia A, D'Ercole C, Parisi C, D'Angelo P, Proietti D, Cappelletti C, Macone A, Lozanoska-Ochser B, Bouchè M, Latella L, Valle C, Ferri A, Giordani L, Madaro L. Polyamine metabolism dysregulation contributes to muscle fiber vulnerability in ALS. Cell Rep. 2025

47 Gloriani M, Cheli B, D'Ercole C, Ruggieri V, Cosentino M, Serrat Pineda M, Lozanoska-Ochser B, Grassi F, Bouché M, Madaro L, Sánchez Riera C. Sarcoglycans are enriched at the neuromuscular junction in a nerve-dependent manner. Cell Death Dis. 2025 Jan 22;16(1):37. doi: 10.1038/s41419-025-07353-1.

46 Catarinella G, Bracaglia A, Skafida E, Procopio P, Ruggieri V, Parisi C, De Bardi M, Borsellino G, Madaro L, Puri PL, Sacco A, Latella L. STAT3 inhibition recovers regeneration of aged muscles by restoring autophagy in muscle stem cells. Life Sci Alliance. 2024
45 Scaricamazza S, Nesci V, Salvatori I, Fenili G, Rosina M, Gloriani M, Paronetto MP, Madaro L, Ferri A, Valle C. Endurance exercise has a negative impact on the onset of SOD1-G93A ALS in female mice and affects the entire skeletal muscle-motor neuron axis. Front Pharmacol. 2024
44 Nicoletti C, Wei X, Etxaniz U, D'Ercole C, Madaro L, Perera R, Puri PL. Muscle denervation promotes functional interactions between glial and mesenchymal cells through NGFR and NGF. iScience. 2023
43 Cosentino M, Nicoletti C, Valenti V, Schirone L, Di Nonno F, Apa L, Zouhair M, Genovese D, Madaro L, Dinarelli S, Rossi M, Del Prete Z, Sciarretta S, Frati G, Rizzuto E, Musarò A. Remodeled eX vivo muscle engineered tissue improves heart function after chronic myocardial ischemia. Sci Rep. 2023
42 D'Ercole C, D'Angelo P, Ruggieri V, Proietti D, Virtanen L, Parisi C, Riera CS, Renzini A, Macone A, Marzullo M, Ciapponi L, Bonvissuto D, Sette C, Giordani L, Madaro L. Spatially resolved transcriptomics reveals innervation-responsive functional clusters in skeletal muscle. Cell Reports. 2022
41 Farup J, Just J, de Paoli F, Lin L, Jensen JB, Billeskov T, Roman IS, Cömert C, Møller AB, Madaro L, Groppa E, Fred RG, Kampmann U, Gormsen LC, Pedersen SB, Bross P, Stevnsner T, Eldrup N, Pers TH, Rossi FMV, Puri PL, Jessen N. Human skeletal muscle CD90+ fibro-adipogenic progenitors are associated with muscle degeneration in type 2 diabetic patients. Cell Metabolism. 2021
40 Renzini A., Riera C.S., Minic I., D’ercole C., Lozanoska‐ochser B., Cedola A., Gigli G., Moresi V., Madaro L. Metabolic remodeling in skeletal muscle atrophy as a therapeutic target Metabolites 2021
39 Proietti D, Giordani L, De Bardi M, D'Ercole C, Lozanoska-Ochser B, Amadio S, Volonté C, Marinelli S, Muchir A, Bouché M, Borsellino G, Sacco A, Puri PL, Madaro L. Activation of skeletal muscle-resident glial cells upon nerve injury. JCI Insight. 2021
38 Sánchez Riera C, Lozanoska-Ochser B, Testa S, Fornetti E, Bouché M, Madaro L. Muscle Diversity, Heterogeneity, and Gradients: Learning from Sarcoglycanopathies. Int J Mol Sci. 2021
37 Berardi E, Madaro L, Lozanoska-Ochser B, Adamo S, Thorrez L, Bouche M, Coletti D. A Pound of Flesh: What Cachexia Is and What It Is Not. Diagnostics (Basel). 2021
36 Savoia C, Arrabito E, Parente R, Nicoletti C, Madaro L, Battistoni A, Filippini A, Steckelings UM, Touyz RM, Volpe M. Mas Receptor Activation Contributes to the Improvement of Nitric Oxide Bioavailability and Vascular Remodeling During Chronic AT1R (Angiotensin Type-1 Receptor) Blockade in Experimental Hypertension. Hypertension. 2020
35 De Paola E, Forcina L, Pelosi L, Pisu S, La Rosa P, Cesari E, Nicoletti C, Madaro L, Mercatelli N, Biamonte F, Nobili A, D'Amelio M, De Bardi M, Volpe E, Caporossi D, Sette C, Musarò A, Paronetto MP. Sam68 splicing regulation contributes to motor unit establishment in the postnatal skeletal muscle. Life Sci Alliance. 2020
34 Vacca V, Madaro L, De Angelis F, Proietti D, Cobianchi S, Orsini T, Puri PL, Luvisetto S, Pavone F, Marinelli S. Revealing the Therapeutic Potential of Botulinum Neurotoxin Type A in Counteracting Paralysis and Neuropathic Pain in Spinally Injured Mice.Toxins (Basel). 2020
33 Scaricamazza S, Salvatori I, Giacovazzo G, Loeffler JP, Renè F, Rosina M, Quessada C, Proietti D, Heil C, Rossi S, Battistini S, Giannini F, Volpi N, Steyn FJ, Ngo ST, Ferraro E, Madaro L, Coccurello R, Valle C, Ferri A. Skeletal-Muscle Metabolic Reprogramming in ALS-SOD1G93A Mice Predates Disease Onset and Is A Promising Therapeutic Target. iScience. 2020
32 Benedetti A, Fiore PF, Madaro L, Lozanoska-Ochser B, Bouché M. Targeting PKCθ Promotes Satellite Cell Self-Renewal. Int J Mol Sci. 2020
31 Fiore PF, Benedetti A, Sandonà M, Madaro L, De Bardi M, Saccone V, Puri PL, Gargioli C, Lozanoska-Ochser B, BouchLM. Lack of PKCθ Promotes Regenerative Ability of Muscle Stem Cells in Chronic Muscle Injury. Int J Mol Sci. 2020
30 Madaro L, Torcinaro A, De Bardi M, Pelizzola M, Diaferia G, Imeneo G, Bouchè M, Puri PL and De Santa F, MACROPHAGES FINE TUNE SATELLITE CELL FATE IN DYSTROPHIC SKELETAL MUSCLE OF MDX MICE, . Acepted for pubblication in Plos Genetics 2019
29 Biferali B, Proietti D, Mozzetta C, Madaro L., FIBRO-ADIPOGENIC PROGENITORS CROSS-TALK IN SKELETAL MUSCLE: THE SOCIAL NETWORK. Front Physiol. 2019
28 Apolloni S, Amadio S, Fabbrizio P, Morello G, Spampinato AG, Latagliata EC, Salvatori I, Proietti D, Ferri A, Madaro L, Puglisi-Allegra S, Cavallaro S, Volonté C. Histaminergic transmission slows progression of amyotrophic lateral sclerosis. J Cachexia Sarcopenia Muscle. 2019
27 Bouchè M, Lozanoska-Ochser B, Proietti D, Madaro L. Do neurogenic and cancer-induced muscle atrophy follow common or divergent paths? Eur J Transl Myol. 2018
26 Madaro L., Passafaro M., Sala D., Etxaniz U., Lugarini F., Proietti D.,Alfonsi MV., Nicoletti C., Gatto S., De Bardi M., Rojas-García R., Giordani L., Marinelli S., Pagliarini V., Sette C., Sacco A. and Puri PL. Denervation-activated stat3–il-6 signalling in fibro-adipogenic progenitors promotes myofibres atrophy and fibrosis. Nature Cell Biology. 2018
25 Malecova B, Gatto S, Etxaniz U, Passafaro M, Cortez A, Nicoletti C, Giordani L, Torcinaro A, De Bardi M, Bicciato S, De Santa F, Madaro L, Puri PL. Dynamics of cellular states of fibro-adipogenic progenitors during myogenesis and muscular dystrophy. Nature Comunications. 2018
24 Milan M, Pace V, Maiullari F, Chirivì M, Baci D, Maiullari S, Madaro L, Maccari S, Stati T, Marano G, Frati G, Puri PL, De Falco E, Bearzi C, Rizzi R. GIVINOSTAT REDUCES ADVERSE CARDIAC REMODELING THROUGH REGULATING FIBROBLASTS ACTIVATION. Cell Death Dis. 2018
23 D'Agostino M, Torcinaro A, Madaro L, Marchetti L, Sileno S, Beji S, Salis C, Proietti D, Imeneo G, C Capogrossi M, De Santa F, Magenta A. ROLE OF miR-200c IN MYOGENIC DIFFERENTIATION IMPAIRMENT VIA P66SHC: IMPLICATION IN SKELETAL MUSCLE REGENERATION OF DYSTROPHIC MDX MICE. Oxid Med Cell Longev. 2018
22 Marrocco V, Fiore P, Benedetti A, Pisu S, Rizzuto E, Musarò A, Madaro L, Lozanoska-Ochser B, Bouché M. PHARMACOLOGICAL INHIBITION OF PKCθ COUNTERACTS MUSCLE DISEASE IN A MOUSE MODEL OF DUCHENNE MUSCULAR DYSTROPHY. EBioMedicine. 2017
21 Farup J, Torcinaro A, Madaro L. SKELETAL MUSCLE STEM CELL DEFECTS IN BURN-INDUCED CACHEXIA. J Physiol. 2016
20 Fiacco E, Castagnetti F, Bianconi V, Madaro L, De Bardi M, Nazio F, D'Amico A, Bertini E, Cecconi F, Puri PL, Latella L. AUTOPHAGY REGULATES SATELLITE CELL ABILITY TO REGENERATE NORMAL AND DYSTROPHIC MUSCLE. Cell Death Differ. 2016
19 Malecova, B., Dall’Agnese, A., Madaro, L., Gatto, S., Toto, P.C., Albini, S., Ryan, T., Tora, L., Puri, P.L. TBP/TFIID-DEPENDENT ACTIVATION OF MYOD TARGET GENES IN SKELETAL MUSCLE CELLS. Elife. 2016
18 Chiappalupi, S., Luca, G., Mancuso, F., Madaro, L., Fallarino, F., Nicoletti, C., Calvitti, M., Arato, I., Falabella, G., Salvadori, L., Di Meo, A. Bufalari, A., Giovagnoli, S., Calafiore, R., Donato, R., Sorci, G. EFFECTS OF INTRAPERITONEAL INJECTION OF MICROENCAPSULATED SERTOLI CELLS ON CHRONIC AND PRESYMPTOMATIC DYSTROPHIC MICE Data Brief. 2015
17 Smeriglio P., Alonso-Martin S., Masciarelli S., Madaro L., Iosue I., MarroccoV., Relaix F., Fazi F., Marazzi G., Sassoon DA., Bouché M. PHOSPHOTYROSINE PHOSPHATASE INHIBITOR BISPEROXOVANADIUM ENDOWS MYOGENIC CELLS WITH ENHANCED MUSCLE STEM CELL FUNCTIONS VIA EPIGENETIC MODULATION OF SCA-1 AND PW1 PROMOTERS. FASEB J. 2016
16 Chiappalupi S, Luca G, Mancuso F, Madaro L, Fallarino F, Nicoletti C, Calvitti M, Arato I, Falabella G, Salvadori L, Di Meo A, Bufalari A, Giovagnoli S, Calafiore R, Donato R, Sorci G. INTRAPERITONEAL INJECTION OF MICROENCAPSULATED SERTOLI CELLS RESTORES MUSCLE MORPHOLOGY AND PERFORMANCE IN DYSTROPHIC MICE Biomaterials. 2016
15 Farup J., Madaro L., Puri PL. and Mikkelsen UR. INTERACTIONS BETWEEN MUSCLE STEM CELLS, MESENCHYMAL-DERIVED CELLS AND IMMUNE CELLS IN MUSCLE HOMEOSTASIS, REGENERATION AND DISEASE. Cell Death Dis. 2015
14 Faggi, F., Chiarelli, N., Colombi, M., Mitola, S., Ronca, R., Madaro, L., Bouche, M., Poliani, P.L., Vezzoli, M., Longhena, F., Monti, E., Salani, B., Maggi, D., Keller, C., Fanzani, A. CAVIN-1 AND CAVEOLIN-1 ARE BOTH REQUIRED TO SUPPORT CELL PROLIFERATION, MIGRATION AND ANCHORAGE-INDEPENDENT CELL GROWTH IN RHABDOMYOSARCOMA. Lab Invest. 2015
13 Madaro L., Latella L. FOREVER YOUNG: REJUVENATING MUSCLE SATELLITE CELLS. Front Aging Neurosci. 2015
12 Marrocco V, Fiore P, Madaro L, Crupi A, Lozanoska-Ochser B, Bouché M. TARGETING PKCΘ IN SKELETAL MUSCLE AND MUSCLE DISEASES: GOOD OR BAD? Biochem Soc Trans. 2014
11 Camerino G, De Bellis M, Cannone M, Liantonio A, Musara K, Romano R, Madaro L, Bouche’ M, Desaphy J, Conte Camerino D, Pierno S. PROTEIN KINASE C-THETA (PKC-θ) MODULATES THE CLC-1 CHLORIDE CHANNEL ACTIVITY AND SKELETAL MUSCLE PHENOTYPE: A BIOPHYSICAL AND GENE EXPRESSION STUDY IN MOUSE MODELS LACKING THE PKCθ Pflugers Arch. 2014
10 Saccone V. , Consalvi S., Giordani L., Mozzetta C., Barozzi I., Sandona M., Ryan T., Rojas Munoz A., Madaro L., Fasanaro P., Borsellino G., De Bardi M., Frigè G.M., Termanini A., Sun X., Rossant J., Bruneau B. Mercola M., Minucci S., Puri P.L. HDAC-REGULATED MYOMIRS CONTROL BAF60 VARIANT EXCHANGE AND DIRECT THE FUNCTIONAL PHENOTYPE OF FIBROADIPOGENIC PROGENITORS IN DYSTROPHIC MUSCLES Genes Dev. 2014
9 Madaro L, Bouché M. FROM INNATE TO ADAPTIVE IMMUNE RESPONSE IN MUSCULAR DYSTROPHIES AND SKELETAL MUSCLE REGENERATION: THE ROLE OF LYMPHOCYTES Biomed Res Int. 2014
8 Savoia C, Arrabito E, Parente R, Sada L, Madaro L, Nicoletti C, Zezza L, Alonzo A, Rubattu S, Michelini S, Muller Dn, Volpe M. THE DIRECT RENIN INHIBITOR ALISKIREN IMPROVES VASCULAR REMODELING IN TRANSGENIC RATS HARBORING HUMAN RENIN AND ANGIOTENSINOGEN GENES. Clin Sci (Lond). 2013
7 Madaro L, Antonangeli F, Favia A, Esposito B, Biamonte F, Bouché M, Ziparo E, Sica G, Filippini A, D'Alessio A. KNOCK DOWN OF CAVEOLIN-1 AFFECTS MORPHOLOGICAL AND FUNCTIONAL HALLMARKS OF HUMAN ENDOTHELIAL CELLS. J Cell Biochem. 2013
6 Madaro L, Marrocco V, Carnio S, Sandri M, And Bouché M, INTRACELLULAR SIGNALING IN ER-STRESS INDUCED AUTOPHAGY IN SKELETAL MUSCLE CELLS. FASEB J. 2013
5 Madaro L, Pelle A, Nicoletti C, Crupi A, Marrocco V, Bossi G, Soddu S. And Bouché M, PKC THETA ABLATION IMPROVES HEALING IN A MOUSE MODEL OF MUSCULAR DYSTROPHY, PLoS One. 2012
4 Verga Falzacappa C, Mangialardo C, Madaro L, Raffa S, Ranieri D, Stigliano A, Torrisi Mr, Bouchè M, Toscano V And Misiti S, THYROID HORMONE T3 COUNTERACTS STZ INDUCED DIABETES IN MOUSE PLoS One. 2011
3 Madaro L., Marrocco V., Fiore P., Aulino P., Adamo S. Molinaro M. And Bouchè M., PKCθ SIGNALING IS REQUIRED FOR MYOBLAST FUSION BY REGULATING THE EXPRESSION OF CAVEOLIN-3 AND β1D INTEGRIN UPSTREAM FOCAL ADHESION KINASE, Mol Biol Cell. 2011
2 Paoletti R., Maffei A., Madaro L., Notte A., Stanganello E., Cifelli G., Carullo P., Molinaro M., Lembo G., And Bouché M., PROTEIN KINASE C THETA IS REQUIRED FOR CARDIOMYOCYTE SURVIVAL AND CARDIAC REMODELLING, Cell Death Dis. 2010
1 Madaro L. , Smeriglio P. , Molinaro M. And Bouchè M., UNILATERAL IMMOBILIZZATION: A SIMPLE MODEL OF LIMB ATROPHY IN MICE, Basic And Applied Myology, 18 (5): 149-153, 2008