Orari di ricevimento
Tutti giorni, previo appuntamento tramite email
Viale Regina Elena 291,
Laboratorio Immunologia e Immunopatologia
Piano 3
Curriculum
CURRENT POSITION
Dec 2022 to date: Associate Professor of General Pathology (SC 06/A2, SSD MED/04) at the Department of Molecular Medicine, Sapienza University of Rome, Rome, Italy.
EDUCATION
▪ 2006-2010: PhD degree in Immunological Sciences, Laboratory of Immunology, Department of Experimental Medicine, Policlinico Umberto I, “Sapienza” University of Rome.
▪ 2005-2006: Graduated with honors in Genomic Biotechnologies (two-years Master degree) University of Rome “La Sapienza”.
▪ 2001-2004: Graduated with honors in Biotechnologies (three-years Bachelor degree) University of Rome “La Sapienza”.
PREVIOUS POSITIONS
▪ 2010-2012: Supplemental Visiting Fellow at the Molecular Immunology and Inflammation Branch, Lymphocyte cell Biology Section, NIAMS, NIH, Bethesda, MD, USA. Dr. John J. O’Shea laboratory. Grant: Pasteur Institute-Cenci Bolognetti.
▪ 2012-2015: Visiting Fellow at the Molecular Immunology and Inflammation Branch, Lymphocyte cell Biology Section, NIAMS, NIH, Bethesda, MD, USA. Dr. John J. O’Shea laboratory.
▪ 2015-2016: Research Fellow (Federal Employee) at the Molecular Immunology and Inflammation Branch, Lymphocyte cell Biology Section, NIAMS, NIH, Bethesda, MD, USA. Dr. John J. O’Shea laboratory.
▪ 2016-2018: Guest Research Fellow at the Molecular Immunology and Inflammation Branch, Lymphocyte cell Biology Section, NIAMS, NIH, Bethesda, MD, USA.
▪ 2017-2019: Group leader, at the Department of Molecular Medicine, Sapienza University of Rome, Rome, Italy.
▪ 2019-2022: Assistant Professor (RTDB) of General Pathology (SC 06/A2, SSD MED/04) at the Department of Molecular Medicine, Sapienza University of Rome, Rome, Italy.
FELLOWSHIPS, AWARDS AND MEMBERSHIPS
▪ 2013: Research Highlights, in Nature Reviews Immunology (Olive Leavy) relative to the paper “Distinct requirements for T-bet in gut innate lymphoid cells”; Sciumè et al. 2012, published on the Journal of Experimental Medicine.
▪ 2016: NIH Group Merit Award 2016, for the innovation of my studies focused on the epigenetic programs underlying ILC development and effector functions, published on Cell.
▪ 2017: Member of the “European Crohn’s and Colitis Organisation” (Y-ECCO under 35), 2017.
▪ 2017-2021: Member of the SIICA junior faculty.
ORAL PRESENTATIONS AT CONFERENCES AND MEETINGS
▪ 6th National Conference SIICA, Italian Society of Immunology, Clinical Immunology and Allergology. Rome, 2008.
Membrane-bound CX3CL1 expression inhibits glioma cell invasiveness. Regulation by TGF-beta.
▪ 7th National Conference SIICA, Italian Society of Immunology, Clinical Immunology and Allergology. Bari, 2010.
CX3CR1 expression defines a KLRG1+ NK cell subset with impaired effector functions.
▪ Receptors and Cytokines in Innate Immunity, NIH, Bethesda, MD, 2013.
Distinct requirements for T-bet in gut innate lymphoid cells.
Invited speaker
▪ Barrier Immunity and Repair, NIH, Bethesda, MD, 2013.
Roles of STAT5 and STAT4 in innate lymphoid cells homeostasis and function.
Invited speaker
▪ 16th Annual Meeting of the Society for Natural Immunity. Taormina, Italy, 2016.
Developmental Acquisition of Regulomes Underlies Innate Lymphoid Cell Functionality.
Invited speaker
▪ Pasteur Institute Seminar Series, Rome, Italy, 2017.
Transcriptional and Epigenetic regulation of Innate lymphoid cell biology.
Invited speaker
▪ Roman day of Immunology, National Research Council, Rome, Italy, 2017.
JAK/STAT signals underlying innate lymphoid cell homeostasis and activation.
Invited speaker
▪ 11th National Conference SIICA, Italian Society of Immunology, Clinical Immunology and Allergology. Bari, Italy, 2017.
Epigenetic regulation of Innate Lymphoid Cell Functionality.
Invited speaker
▪ 5th European Congress of Immunology (ECI). Amsterdam, the Netherlands, 2018.
NCR+ ILC3 maintain larger STAT4 reservoir via T-BET to regulate type 1 features upon IL-23 stimulation in mice.
Abstract selected for oral presentation
▪ WISC 2018: XXXI National Congress SIAAIC Joint Meeting SIAAIC/WAO. Personalised Medicine in Allergy: Biologics and Immunotherapy. Florence, Italy, 2018.
ILC1 in allergy and clinical immunology.
Invited speaker
▪ 2020-2021: Invited to give seminars by several national and international Institutions, including University of Ottawa, Canada; Karolinska Institute, Sweden; Charité University, Germany; Università Vita-Salute San Raffaele, Milan, Italy.
▪ 2022: 2022 International HBV Meeting 2022. Paris, France. Distinctive features of liver-resident NK cells and ILC subsets.
▪ 2022: SIPMeT Congress - "Pathophysiology of Disease" - 22-24 September 2022 - Ancona.
▪ 2023: Single-cell deep profiling for systems biology - 30 January 2023 - Roma.
▪ 2023: Immunology 2023 - American Association of Immunology, Washington DC, USA, 11-15 May, 2023.
▪ 2023: XIV SIICA National Congress, Verona, Italy, 22-25 May, 2023
▪ 2023: SIICA SYIS Joint Symposium - Multi-omics approaches in immunological research, Roma, Italy, 3-4 November, 2023.
▪ 2023: 35th AICC international meeting - “TRANSLATIONAL AND PRECISION MEDICINE: FROM PATIENT TO CELL AND BACK”, L’Aquila 4-6 December 2023.
▪ 2024: SIPMeT 2024 - Translational Pathophysiology, Udine 19-21 September 2024.
▪ 2024: 34th Annual Broad Institute / CSIBD Workshop, Cambridge (MA) 7-8 November 2024.
EDITORIAL/REVIEWING ACTIVITIES
Journals: Journal of Experimental Medicine, PNAS, European Journal of Immunology, Journal of Clinical investigation, Frontiers in Immunology (associate editor), Cells (reviewer board), IMJI, Cancers, Mucosal Immunology, Cytokine and Growth Factor Reviews (Guest editor 2018).
Grants: European Research Council (ERC) projects; Agence Nationale de la Recherche (ANR).
Publications
1: Pacella I, Pinzon Grimaldos A, Rossi A, Tucci G, Zagaglioni M, Potenza E,
Pinna V, Rotella I, Cammarata I, Cancila V, Belmonte B, Tripodo C, Pietropaolo
G, Di Censo C, Sciumè G, Licursi V, Peruzzi G, Antonucci Y, Campello S,
Guerrieri F, Iebba V, Prota R, Di Chiara M, Terrin G, De Peppo V, Grazi GL,
Barnaba V, Piconese S. Iron capture through CD71 drives perinatal and tumor-
associated Treg expansion. JCI Insight. 2024 Jul 2;9(15):e167967. doi:
10.1172/jci.insight.167967. PMID: 38954474; PMCID: PMC11383606.
2: Fionda C, Sciumè G. A little ER stress isn't bad: the IRE1α/XBP1 pathway
shapes ILC3 functions during intestinal inflammation. J Clin Invest. 2024 Jul
1;134(13):e182204. doi: 10.1172/JCI182204. PMID: 38949019; PMCID: PMC11213460.
3: Mediratta K, El-Sahli S, Marotel M, Awan MZ, Kirkby M, Salkini A, Kurdieh R,
Abdisalam S, Shrestha A, Di Censo C, Sulaiman A, McGarry S, Lavoie JR, Liu Z,
Lee SH, Li X, Sciumè G, D'Costa VM, Ardolino M, Wang L. Targeting CD73 with
flavonoids inhibits cancer stem cells and increases lymphocyte infiltration in a
triple-negative breast cancer mouse model. Front Immunol. 2024 Mar
27;15:1366197. doi: 10.3389/fimmu.2024.1366197. PMID: 38601156; PMCID:
PMC11004431.
4: Carnevale S, Ponzetta A, Rigatelli A, Carriero R, Puccio S, Supino D, Grieco
G, Molisso P, Di Ceglie I, Scavello F, Perucchini C, Pasqualini F, Recordati C,
Tripodo C, Belmonte B, Mariancini A, Kunderfranco P, Sciumè G, Lugli E, Bonavita
E, Magrini E, Garlanda C, Mantovani A, Jaillon S. Neutrophils Mediate Protection
Against Colitis and Carcinogenesis by Controlling Bacterial Invasion and IL22
Production by γδ T Cells. Cancer Immunol Res. 2024 Apr 2;12(4):413-426. doi:
10.1158/2326-6066.CIR-23-0295. PMID: 38349973; PMCID: PMC10985471.
5: Scarno G, Mazej J, Laffranchi M, Di Censo C, Mattiola I, Candelotti AM,
Pietropaolo G, Stabile H, Fionda C, Peruzzi G, Brooks SR, Tsai WL, Mikami Y,
Bernardini G, Gismondi A, Sozzani S, Di Santo JP, Vosshenrich CAJ, Diefenbach A,
Gadina M, Santoni A, Sciumè G. Divergent roles for STAT4 in shaping
differentiation of cytotoxic ILC1 and NK cells during gut inflammation. Proc
Natl Acad Sci U S A. 2023 Oct 3;120(40):e2306761120. doi:
10.1073/pnas.2306761120. Epub 2023 Sep 27. PMID: 37756335; PMCID: PMC10556635.
6: Molfetta R, Lecce M, Milito ND, Putro E, Pietropaolo G, Marangio C, Scarno G,
Moretti M, De Smaele E, Santini T, Bernardini G, Sciumè G, Santoni A, Paolini R.
SCF and IL-33 regulate mouse mast cell phenotypic and functional plasticity
supporting a pro-inflammatory microenvironment. Cell Death Dis. 2023 Sep
20;14(9):616. doi: 10.1038/s41419-023-06139-7. PMID: 37730723; PMCID:
PMC10511458.
7: Sozio F, Schioppa T, Laffranchi M, Salvi V, Tamassia N, Bianchetto-Aguilera
FM, Tiberio L, Bonecchi R, Bosisio D, Parmentier M, Bottazzi B, Leone R, Russo
E, Bernardini G, Garofalo S, Limatola C, Gismondi A, Sciumè G, Mantovani A, Del
Prete A, Sozzani S. CCRL2 Expression by Specialized Lung Capillary Endothelial
Cells Controls NK-cell Homing in Lung Cancer. Cancer Immunol Res. 2023 Sep
1;11(9):1280-1295. doi: 10.1158/2326-6066.CIR-22-0951. PMID: 37343073.
8: Garofalo S, Cocozza G, Mormino A, Bernardini G, Russo E, Ielpo D, Andolina D,
Ventura R, Martinello K, Renzi M, Fucile S, Laffranchi M, Mortari EP, Carsetti
R, Sciumè G, Sozzani S, Santoni A, Tremblay ME, Ransohoff RM, Limatola C.
Natural killer cells and innate lymphoid cells 1 tune anxiety-like behavior and
memory in mice via interferon-γ and acetylcholine. Nat Commun. 2023 May
29;14(1):3103. doi: 10.1038/s41467-023-38899-3. PMID: 37248289; PMCID:
PMC10227025.
9: Lim JX, Lai CY, Mallett GE, McDonald D, Hulme G, Laba S, Shapanis A, Payne M,
Patterson W, Alexander M, Coxhead J, Filby A, Plummer R, Lovat PE, Sciume G,
Healy E, Amarnath S. Programmed cell death-1 receptor-mediated regulation of
Tbet+NK1.1- innate lymphoid cells within the tumor
microenvironment. Proc Natl Acad Sci U S A. 2023 May 2;120(18):e2216587120. doi:
10.1073/pnas.2216587120. Epub 2023 Apr 25. PMID: 37098069; PMCID: PMC10161089.
10: Smith KJ, Sciumè G, Amarnath S. Twenty-One Flavors of Type 1 Innate Lymphoid
Cells with PD-1 (Programmed Cell Death-1 Receptor) Sprinkles. Discov Immunol.
2023 Feb 7;2(1):kyad003. doi: 10.1093/discim/kyad003. PMID: 38567059; PMCID:
PMC10917210.
11: Fionda C, Ruggeri S, Sciumè G, Laffranchi M, Quinti I, Milito C, Palange P,
Menichini I, Sozzani S, Frati L, Gismondi A, Santoni A, Stabile H. Age-dependent
NK cell dysfunctions in severe COVID-19 patients. Front Immunol. 2022 Nov
17;13:1039120. doi: 10.3389/fimmu.2022.1039120. PMID: 36466890; PMCID:
PMC9713640.
12: Fionda C, Scarno G, Stabile H, Molfetta R, Di Censo C, Gismondi A, Paolini
R, Sozzani S, Santoni A, Sciumè G. NK Cells and Other Cytotoxic Innate
Lymphocytes in Colorectal Cancer Progression and Metastasis. Int J Mol Sci. 2022
Jul 16;23(14):7859. doi: 10.3390/ijms23147859. PMID: 35887206; PMCID:
PMC9322916.
13: Hasim MS, Marotel M, Hodgins JJ, Vulpis E, Makinson OJ, Asif S, Shih HY,
Scheer AK, MacMillan O, Alonso FG, Burke KP, Cook DP, Li R, Petrucci MT, Santoni
A, Fallon PG, Sharpe AH, Sciumè G, Veillette A, Zingoni A, Gray DA, McCurdy A,
Ardolino M. When killers become thieves: Trogocytosed PD-1 inhibits NK cells in
cancer. Sci Adv. 2022 Apr 15;8(15):eabj3286. doi: 10.1126/sciadv.abj3286. Epub
2022 Apr 13. PMID: 35417234; PMCID: PMC9007500.
14: Capuano C, Pighi C, Battella S, Pulcinelli F, Santoro C, Ferretti A,
Turriziani O, De Federicis D, Fionda C, Sciumè G, Galandrini R, Palmieri G.
(Auto)Antibody Responses Shape Memory NK Cell Pool Size and Composition.
Biomedicines. 2022 Mar 8;10(3):625. doi: 10.3390/biomedicines10030625. PMID:
35327427; PMCID: PMC8945707.
15: Grimaldi A, Pietropaolo G, Stabile H, Kosta A, Capuano C, Gismondi A,
Santoni A, Sciumè G, Fionda C. The Regulatory Activity of Noncoding RNAs in
ILCs. Cells. 2021 Oct 14;10(10):2742. doi: 10.3390/cells10102742. PMID:
34685721; PMCID: PMC8534545.
16: Di Censo C, Marotel M, Mattiola I, Müller L, Scarno G, Pietropaolo G,
Peruzzi G, Laffranchi M, Mazej J, Hasim MS, Asif S, Russo E, Tomaipitinca L,
Stabile H, Lee SH, Vian L, Gadina M, Gismondi A, Shih HY, Mikami Y, Capuano C,
Bernardini G, Bonelli M, Sozzani S, Diefenbach A, Ardolino M, Santoni A, Sciumè
G. Granzyme A and CD160 expression delineates ILC1 with graded functions in the
mouse liver. Eur J Immunol. 2021 Nov;51(11):2568-2575. doi:
10.1002/eji.202149209. Epub 2021 Aug 19. PMID: 34347289; PMCID: PMC9292164.
17: Pietropaolo G, Scarno G, Stabile H, Grimaldi A, Gismondi A, Santoni A,
Sciumè G. NK cell and ILC heterogeneity in colorectal cancer. New perspectives
from high dimensional data. Mol Aspects Med. 2021 Aug;80:100967. doi:
10.1016/j.mam.2021.100967. Epub 2021 May 1. PMID: 33941383.
18: Fernando N, Sciumè G, O'Shea JJ, Shih HY. Multi-Dimensional Gene Regulation
in Innate and Adaptive Lymphocytes: A View From Regulomes. Front Immunol. 2021
Mar 25;12:655590. doi: 10.3389/fimmu.2021.655590. PMID: 33841440; PMCID:
PMC8034253.
19: Mikami Y, Philips RL, Sciumè G, Petermann F, Meylan F, Nagashima H, Yao C,
Davis FP, Brooks SR, Sun HW, Takahashi H, Poholek AC, Shih HY, Afzali B, Muljo
SA, Hafner M, Kanno Y, O'Shea JJ. MicroRNA-221 and -222 modulate intestinal
inflammatory Th17 cell response as negative feedback regulators downstream of
interleukin-23. Immunity. 2021 Mar 9;54(3):514-525.e6. doi:
10.1016/j.immuni.2021.02.015. Epub 2021 Mar 2. PMID: 33657395; PMCID:
PMC8025838.
20: Sciumè G, Mikami Y, Jankovic D, Nagashima H, Villarino AV, Morrison T, Yao
C, Signorella S, Sun HW, Brooks SR, Fang D, Sartorelli V, Nakayamada S, Hirahara
K, Zitti B, Davis FP, Kanno Y, O'Shea JJ, Shih HY. Rapid Enhancer Remodeling and
Transcription Factor Repurposing Enable High Magnitude Gene Induction upon Acute
Activation of NK Cells. Immunity. 2020 Oct 13;53(4):745-758.e4. doi:
10.1016/j.immuni.2020.09.008. Epub 2020 Oct 2. PMID: 33010223; PMCID:
PMC7572751.
21: van den Hoogen B, Santoni A, Sciumé G, Bowie A, O'Farrelly C, O'Neill L,
Anthonsen M, Pardali K, Young S, Bergthaler A, Manel N, Zahn R, Kikkert M,
Snijder E, van Kuppeveld F, Fouchier R, Hiscott J. Immunometabolism pathways as
the basis for innovative anti-viral strategies (INITIATE): A Marie Sklodowska-
Curie innovative training network. Virus Res. 2020 Oct 2;287:198094. doi:
10.1016/j.virusres.2020.198094. Epub 2020 Jul 28. PMID: 32730781; PMCID:
PMC7384980.
22: Scarno G, Pietropaolo G, Di Censo C, Peruzzi G, Sciumè G. Assessing
Phosphorylation of STAT Transcription Factors in Mouse Innate Lymphoid Cells.
Methods Mol Biol. 2020;2121:59-70. doi: 10.1007/978-1-0716-0338-3_6. PMID:
32147786.
23: Vian L, Le MT, Gazaniga N, Kieltyka J, Liu C, Pietropaolo G, Dell'Orso S,
Brooks SR, Furumoto Y, Thomas CJ, O'Shea JJ, Sciumè G, Gadina M. JAK Inhibition
Differentially Affects NK Cell and ILC1 Homeostasis. Front Immunol. 2019 Dec
19;10:2972. doi: 10.3389/fimmu.2019.02972. PMID: 31921209; PMCID: PMC6930870.
24: Scarno G, Pietropaolo G, Di Censo C, Gadina M, Santoni A, Sciumè G.
Transcriptional, Epigenetic and Pharmacological Control of JAK/STAT Pathway in
NK Cells. Front Immunol. 2019 Oct 17;10:2456. doi: 10.3389/fimmu.2019.02456.
PMID: 31681330; PMCID: PMC6811606.
25: Bonanni V, Sciumè G, Santoni A, Bernardini G. Bone Marrow NK Cells: Origin,
Distinctive Features, and Requirements for Tissue Localization. Front Immunol.
2019 Jul 10;10:1569. doi: 10.3389/fimmu.2019.01569. PMID: 31354722; PMCID:
PMC6635729.
26: Sciumè G, Fionda C, Stabile H, Gismondi A, Santoni A. Negative regulation of
innate lymphoid cell responses in inflammation and cancer. Immunol Lett. 2019
Nov;215:28-34. doi: 10.1016/j.imlet.2019.01.011. Epub 2019 Jan 31. PMID:
30711614.
27: Stabile H, Scarno G, Fionda C, Gismondi A, Santoni A, Gadina M, Sciumè G.
JAK/STAT signaling in regulation of innate lymphoid cells: The gods before the
guardians. Immunol Rev. 2018 Nov;286(1):148-159. doi: 10.1111/imr.12705. PMID:
30294965; PMCID: PMC6178832.
28: Sciumè G. Guest editorial: Innate lymphocytes: Development, homeostasis, and
disease. Cytokine Growth Factor Rev. 2018 Aug;42:1-4. doi:
10.1016/j.cytogfr.2018.08.002. Epub 2018 Aug 15. PMID: 30219180.
29: Mikami Y, Scarno G, Zitti B, Shih HY, Kanno Y, Santoni A, O'Shea JJ, Sciumè
G. NCR+ ILC3 maintain larger STAT4 reservoir via T-BET to regulate
type 1 features upon IL-23 stimulation in mice. Eur J Immunol. 2018
Jul;48(7):1174-1180. doi: 10.1002/eji.201847480. Epub 2018 Apr 16. PMID:
29524223; PMCID: PMC11170443.
30: Sciumè G, Shih HY, Mikami Y, O'Shea JJ. Epigenomic Views of Innate Lymphoid
Cells. Front Immunol. 2017 Nov 13;8:1579. doi: 10.3389/fimmu.2017.01579. PMID:
29250060; PMCID: PMC5715337.
31: Antonangeli F, Soriani A, Cerboni C, Sciumè G, Santoni A. How Mucosal
Epithelia Deal with Stress: Role of NKG2D/NKG2D Ligands during Inflammation.
Front Immunol. 2017 Nov 20;8:1583. doi: 10.3389/fimmu.2017.01583. PMID:
29209320; PMCID: PMC5701928.
32: Villarino AV, Sciumè G, Davis FP, Iwata S, Zitti B, Robinson GW,
Hennighausen L, Kanno Y, O'Shea JJ. Subset- and tissue-defined STAT5 thresholds
control homeostasis and function of innate lymphoid cells. J Exp Med. 2017 Oct
2;214(10):2999-3014. doi: 10.1084/jem.20150907. Epub 2017 Sep 15. PMID:
28916644; PMCID: PMC5626390.
33: Sciumè G, Le MT, Gadina M. HiJAKing Innate Lymphoid Cells? Front Immunol.
2017 Apr 13;8:438. doi: 10.3389/fimmu.2017.00438. PMID: 28450869; PMCID:
PMC5390009.
34: Furumoto Y, Smith CK, Blanco L, Zhao W, Brooks SR, Thacker SG, Abdalrahman
Z, Sciumè G, Tsai WL, Trier AM, Nunez L, Mast L, Hoffmann V, Remaley AT, O'Shea
JJ, Kaplan MJ, Gadina M. Tofacitinib Ameliorates Murine Lupus and Its Associated
Vascular Dysfunction. Arthritis Rheumatol. 2017 Jan;69(1):148-160. doi:
10.1002/art.39818. PMID: 27429362; PMCID: PMC5195893.
35: Shih HY, Sciumè G, Mikami Y, Guo L, Sun HW, Brooks SR, Urban JF Jr, Davis
FP, Kanno Y, O'Shea JJ. Developmental Acquisition of Regulomes Underlies Innate
Lymphoid Cell Functionality. Cell. 2016 May 19;165(5):1120-1133. doi:
10.1016/j.cell.2016.04.029. Epub 2016 May 5. PMID: 27156451; PMCID: PMC4874839.
36: Ponzetta A, Benigni G, Antonangeli F, Sciumè G, Sanseviero E, Zingoni A,
Ricciardi MR, Petrucci MT, Santoni A, Bernardini G. Multiple Myeloma Impairs
Bone Marrow Localization of Effector Natural Killer Cells by Altering the
Chemokine Microenvironment. Cancer Res. 2015 Nov 15;75(22):4766-77. doi:
10.1158/0008-5472.CAN-15-1320. Epub 2015 Oct 5. PMID: 26438594.
37: Yang XP, Jiang K, Hirahara K, Vahedi G, Afzali B, Sciume G, Bonelli M, Sun
HW, Jankovic D, Kanno Y, Sartorelli V, O'Shea JJ, Laurence A. EZH2 is crucial
for both differentiation of regulatory T cells and T effector cell expansion.
Sci Rep. 2015 Jun 19;5:10643. doi: 10.1038/srep10643. PMID: 26090605; PMCID:
PMC4473539.
38: Hirahara K, Onodera A, Villarino AV, Bonelli M, Sciumè G, Laurence A, Sun
HW, Brooks SR, Vahedi G, Shih HY, Gutierrez-Cruz G, Iwata S, Suzuki R, Mikami Y,
Okamoto Y, Nakayama T, Holland SM, Hunter CA, Kanno Y, O'Shea JJ. Asymmetric
Action of STAT Transcription Factors Drives Transcriptional Outputs and Cytokine
Specificity. Immunity. 2015 May 19;42(5):877-89. doi:
10.1016/j.immuni.2015.04.014. PMID: 25992861; PMCID: PMC11037422.
39: Shih HY, Sciumè G, Poholek AC, Vahedi G, Hirahara K, Villarino AV, Bonelli
M, Bosselut R, Kanno Y, Muljo SA, O'Shea JJ. Transcriptional and epigenetic
networks of helper T and innate lymphoid cells. Immunol Rev. 2014
Sep;261(1):23-49. doi: 10.1111/imr.12208. PMID: 25123275; PMCID: PMC4321863.
40: Steward-Tharp SM, Laurence A, Kanno Y, Kotlyar A, Villarino AV, Sciume G,
Kuchen S, Resch W, Wohlfert EA, Jiang K, Hirahara K, Vahedi G, Sun HW,
Feigenbaum L, Milner JD, Holland SM, Casellas R, Powrie F, O'Shea JJ. A mouse
model of HIES reveals pro- and anti-inflammatory functions of STAT3. Blood. 2014
May 8;123(19):2978-87. doi: 10.1182/blood-2013-09-523167. Epub 2014 Mar 14.
PMID: 24632714; PMCID: PMC4014840.
41: Meylan F, Hawley ET, Barron L, Barlow JL, Penumetcha P, Pelletier M, Sciumè
G, Richard AC, Hayes ET, Gomez-Rodriguez J, Chen X, Paul WE, Wynn TA, McKenzie
AN, Siegel RM. The TNF-family cytokine TL1A promotes allergic immunopathology
through group 2 innate lymphoid cells. Mucosal Immunol. 2014 Jul;7(4):958-68.
doi: 10.1038/mi.2013.114. Epub 2013 Dec 25. PMID: 24368564; PMCID: PMC4165592.
42: Ponzetta A, Sciumè G, Benigni G, Antonangeli F, Morrone S, Santoni A,
Bernardini G. CX3CR1 regulates the maintenance of KLRG1+ NK cells into the bone
marrow by promoting their entry into circulation. J Immunol. 2013 Dec
1;191(11):5684-94. doi: 10.4049/jimmunol.1300090. Epub 2013 Nov 1. PMID:
24184559.
43: Roychoudhuri R, Hirahara K, Mousavi K, Clever D, Klebanoff CA, Bonelli M,
Sciumè G, Zare H, Vahedi G, Dema B, Yu Z, Liu H, Takahashi H, Rao M, Muranski P,
Crompton JG, Punkosdy G, Bedognetti D, Wang E, Hoffmann V, Rivera J, Marincola
FM, Nakamura A, Sartorelli V, Kanno Y, Gattinoni L, Muto A, Igarashi K, O'Shea
JJ, Restifo NP. BACH2 represses effector programs to stabilize T(reg)-mediated
immune homeostasis. Nature. 2013 Jun 27;498(7455):506-10. doi:
10.1038/nature12199. Epub 2013 Jun 2. PMID: 23728300; PMCID: PMC3710737.
44: Bernardini G, Sciumè G, Santoni A. Differential chemotactic receptor
requirements for NK cell subset trafficking into bone marrow. Front Immunol.
2013 Jan 30;4:12. doi: 10.3389/fimmu.2013.00012. PMID: 23386850; PMCID:
PMC3558687.
45: Sciumé G, Hirahara K, Takahashi H, Laurence A, Villarino AV, Singleton KL,
Spencer SP, Wilhelm C, Poholek AC, Vahedi G, Kanno Y, Belkaid Y, O'Shea JJ.
Distinct requirements for T-bet in gut innate lymphoid cells. J Exp Med. 2012
Dec 17;209(13):2331-8. doi: 10.1084/jem.20122097. Epub 2012 Dec 3. PMID:
23209316; PMCID: PMC3526352.
46: Hirahara K, Ghoreschi K, Yang XP, Takahashi H, Laurence A, Vahedi G, Sciumè
G, Hall AO, Dupont CD, Francisco LM, Chen Q, Tanaka M, Kanno Y, Sun HW, Sharpe
AH, Hunter CA, O'Shea JJ. Interleukin-27 priming of T cells controls IL-17
production in trans via induction of the ligand PD-L1. Immunity. 2012 Jun
29;36(6):1017-30. doi: 10.1016/j.immuni.2012.03.024. Epub 2012 Jun 21. PMID:
22726954; PMCID: PMC3785111.
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