LAURA DI MAGNO

NAME AND QUALIFICATION
Laura Di Magno, PhD

EDUCATION AND TRAINING
November 2009 - October 2012 Università degli Studi dell’Aquila – L’Aquila: PhD Student, Biotechnology
February 2007 - July 2009 "Sapienza" University of Rome – Rome: Master's degree, Medical Molecular and Cellular Biotechnology, magna cum laude.
October 2003 - February 2007 "Sapienza" University of Rome – Rome: Bachelor's degree, Biotechnology, magna cum laude.

EMPLOYMENT AND RESEARCH EXPERIENCE
May 2024 – Date Tenure track researcher at the Department of Molecular Medicine "Sapienza" University of Rome - Italy, SSD: MEDS-02/A
April 2024 Post-doctoral fellow at Istituto Pasteur - Fondazione Cenci Bolognetti, Rome - Italy.
April 2022 – March 2024 Post-doctoral fellow at Fondazione Umberto Veronesi - Italy.
May 2020 - March 2022 Research fellow - Department of Molecular Medicine - "Sapienza" University of Rome - Italy.
January 2020 - April 2020 Post-doctoral fellow at Istituto Pasteur - Fondazione Cenci Bolognetti, Rome - Italy.
July 2014 – December 2019 Post-doctoral fellow at Italian Institute of Technology, Center for Life Nano Sciences@Sapienza, Rome - Italy.
June 2013 - June 2014 Post-doctoral fellow at Istituto Pasteur - Fondazione Cenci Bolognetti, Rome - Italy.

QUALIFICATIONS
January 2022 National scientific qualification SC 06/N1 – MED/46.
February 2022 National scientific qualification SC 06/A2 – MED/04.

TEACHING EXPERIENCE
2025-Date Teacher of “General Pathology and Pathophysiology” in Nursing course G - ASL Roma 5 - "Sapienza" University of Rome - Italy
2025-Date Member of the academic board in the PhD course of Molecular Medicine - "Sapienza" University of Rome - Italy
2024-Date Teacher in the PhD course of Molecular Medicine - "Sapienza" University of Rome - Italy.
2023-2024 Attività didattica elettiva (ADE) in the Master' s course of Medicine and Surgery (CLF) - "Sapienza" University of Rome - Italy.
2022-2023 Dissemination activity at I.S.S. Curie Levi, Collegno (Italy) – Fondazione Umberto Veronesi.
2018-2021 Lecturer of “Molecular Medicine: Molecular Oncology”, in the PhD course of Molecular
Medicine - "Sapienza" University of Rome - Italy.

CONFERENCES
2024 Poster presentation “Translational Pathophysiology”, SIPMeT, Udine, Italy.
2023 Invited speaker at the international scientific conference “BBSRC International Partnering Award - The GLI transcription factors: from upstream regulators to downstream targets”, University of Leeds, Leeds, UK. Oral presentation title: "Targeting metabolic and redox vulnerabilities to treat Shh medulloblastoma"
2023 Poster presentation "General pathology: the trunk of the tree of medicine", SIPMeT, Parma, Italy. Presentation title: "Novel n-(heterocyclylphenyl)benzenesulfonamide sharing an unreported binding site with TCF-4 at the β-catenin armadillo repeats domain as anticancer agent"
2022 Selected speaker at the international scientific conference “International Conference on Advanced Molecular Medicine”, Grand Hotel Duca d’Este, Tivoli, Rome (Italy). Oral presentation title: "Selective targeting of redox alterations in medulloblastoma tumors through nanotechnology-based delivery systems"
2022 Presentation at the scientific conference "Pathophysiology of Disease" - SIPMeT, Ancona, Italy. Presentation title: "Selective targeting of redox alterations in medulloblastoma tumors through nanotechnology-based delivery systems"
2021 Presentation at the scientific conference “Molecular pathology: from bench to bedside - SIPMeT Young Scientists Meeting 2021”, Perugia, Italy. Presentation title: "Tumor-targeting niosomes for phenformin brain delivery in medulloblastoma therapy"
2021 Selected speaker at the international scientific conference "III International AICC Exosome Meeting", online meeting. Oral presentation title: "Tumor-targeting niosomes for phenformin brain delivery in medulloblastoma therapy"
2018 Presentation at the scientific conference "34th SIPMeT National Congress", Centro Congressi Hotel Baia Verde, Catania, Italy. Presentation title: "Phenformin Inhibits Tumor Growth Through a Complex I Independent Redox/Corepressor Module"
2018 Invited speaker at the international scientific conference "23rd World Congress on
Advances in Oncology and 22nd International Symposium on Molecular Medicine", The New Athens Metropolitan Hotel, Athens, Greece. Oral presentation title: “Targeting metabolic vulnerabilities to treat Shh medulloblastoma”
2014 Presentation at the international scientific conference "AMPK: Biological Action and Therapeutic Perspectives", Renaissance Tuscany - Il Ciocco Resort, Lucca, Italy. Presentation title: "Hedgehog/AMPKmediated control of polyamine metabolism supports neuronal and medulloblastoma cell growth"
2014 Speaker at the "L'Istituto Pasteur e i suoi giovani scienziati: ricerche "in crescita"", University “La Sapienza”, Rome, Italy. Oral presentation title: "Druggable glycolytic requirement for Hedgehog-dependent neuronal and medulloblastoma growth"

ORGANIZATION
2022 Member of the Local Committee at the international scientific conference "Sixth International Conference on Polyamines: Biochemical, Physiological and Clinical Perspectives”, Grand Hotel Duca d’Este, Tivoli, Rome (Italy)

HONORS AND AWARDS
2022 Postdoctoral Fellowship, Fondazione Umberto Veronesi.
2021 Best Oral Communication Award. III International AICC Exosome Meeting, 7th-8th June 2021.
Presentation title: "Tumor-targeting niosomes for phenformin brain delivery in medulloblastoma therapy”
2021 Annual Reserch Grant for “Starting Research” “Sapienza” University of Rome
2018 Best Poster Award. 34th SIPMeT National Congress, Catania, Italy.
Poster title: “Phenformin Inhibits Tumor Growth Through a Complex I-Independent Redox/Corepressor Module”
2017 Postdoctoral Fellowship, Italian Institute of Technology (IIT).
2014 Postdoctoral Fellowship, Italian Institute of Technology (IIT).
2009 PhD Scholarship, Università degli Studi dell'Aquila.

MEMBERSHIPS
2021-2023 Member of the Associazione Italiana di Colture Cellulari (AICC)
2018-2024 Member of Società Italiana di Patologia e Medicina Translazionale (SIPMeT)

COURSES AND CERTIFICATIONS
2023 Training course (D.M 5 agosto 2021) accredited by the Italian Ministry of Health
0024495-12/10/2022-DGSAF-MDS-P. Functions: B. Modules: 9, 11.
2022 Training course (D.M 5 agosto 2021) accredited by the Italian Ministry of Health
0024495-12/10/2022-DGSAF-MDS-P. Functions: A, C, D. Modules: 1, 2, 3.1, 4, 5, 6.1, 7, 10, 20.
2019 FELASA accredited course - Cat. B (N. F023/09, #12/2019). Functions: A, C, D. Modules: 10, 20, 21, 22. Species: M, R.)

RESEARCH AREAS
2007-2009 CRTC1-AP1 axis: study of the role of CRTC1-MAML2 fusion oncogene in the pathogenesis of mucoepidermoid carcinomas.
2009-2014 Metabolic reprogramming: study of the role of aerobic glycolysis in the proliferation and
growth of normal and tumor brain cells;
2009-2016 Energy sensors: examining the biochemical mechanisms of action of the energy sensor AMPK in the pathogenesis of brain tumors;
2016 - Date NADH homeostasis: investigating the molecular mechanism of action of the antidiabetic drug phenformin as anticancer agent;
2009 - Date Metabolic targeting: study of pharmacological inhibitors in glucose, redox and energy pathways;
2020 – Date Drug design and biological validation: screening and identification of new bioactive compounds for cancer therapy.

PUBLICATIONS AS FIRST/CO-FIRST AUTHOR (*CO-FIRST AUTHORS)
1) Masci D*, Puxeddu M*, Di Magno L*, et al. J Med Chem. 2023 Nov 9;66(21):14824-14842. ISSN: 00222623
2) Nalli M*, Di Magno L*, Wen Y*, Liu X*, et al. ACS Pharmacol Transl Sci. 2023 Jul 3;6(7):1087-1103. ISSN: 25759108
3) Di Magno L, et al. Eur J Med Chem. 2022 Oct 5;240:114605. ISSN: 02235234
4) Di Magno L, et al. Cancers (Basel). 2022 Jun 30;14(13):3220. ISSN: 20726694
5) Di Magno L, et al. ChemMedChem. 2020 Dec 3;15(23):2264-2268. ISSN: 18607179
6) Di Magno L, et al. Cell Rep. 2020 Feb 11;30(6):1735-1752.e7. ISSN: 22111247
7) Antonucci L*, Di Magno L*, et al. Int J Oncol. 2019 Feb;54(2):505-514. ISSN: 10196439
8) Coni S*, Di Magno L*, et al. Cells. 2019 Feb 11;8(2). pii: E150. ISSN: 20734409
9) Di Magno L, et al. Oncotarget. 2016 Feb 23;7(8):9538-49. ISSN: 19492553
10) Di Magno L, et al. Biochim Biophys Acta. 2015 Aug;1856(1):62-72. ISSN: 0304419X
11) Di Magno L, et al. Cell Cycle. 2014;13(21):3404-13. ISSN: 15384101

SELECTED RELEVANT PUBLICATIONS (CO-AUTHOR)
1) Renzi S, Digiacomo L, Pozzi D, Quagliarini E, Vulpis E, Giuli MV, Mancusi A, Natiello B, Pignataro MG, Canettieri G, Di Magno L, et al. Nat Commun. 2024
Oct 23;15(1):9119. ISSN: 20411723
2) Coni S, Bordone R, Ivy DM, Yurtsever ZN, Di Magno L, et al. Cancer Lett. 2023 Apr 10;559:216120. ISSN: 03043835
3) Cardinale V, Carpino G, Overi D, Safarikia S, Zhang W, Kanke M, Franchitto A, Costantini D, Riccioni O, Nevi L, Chiappetta M, Onori P, Franchitto M, Bini S, Hung YH, Lai Q, Zizzari I, Nuti M, Nicoletti C, Checquolo S, Di Magno L, et al. J Hepatol. 2023 Jan;78(1):165-179. ISSN: 01688278
4) Coni S, Serrao SM, Yurtsever ZN, Di Magno L, et al. Cell Death Dis. 2020 Dec 10;11(12):1045. ISSN: 20414889
5) Bufalieri F, Infante P, Bernardi F, Caimano M, Romania P, Moretti M, Lospinoso Severini L,Talbot J, Melaiu O, Tanori M, Di Magno L, et al. Nat Commun. 2019
Jul 24;10(1):3304. ISSN: 20411723
6) D'Amico D, Antonucci L, Di Magno L, et al. Dev Cell. 2015 Oct 12;35(1):21-35. ISSN: 15345807
7) Canettieri G, Coni S, Della Guardia M, Nocerino V, Antonucci L, Di Magno L, et al. Proc Natl Acad Sci U S A. 2009 Feb 3;106(5):1445-50. ISSN: 10916490