CHIARA MOZZETTA

Personal Information:
Chiara Mozzetta
ORCiD ID: 0002-7147-7266
Scopus ID: 22934763900
Born on 03/10/1979
Italian

Education:
Nov 2013
II level Master in Preclinical and Clinical Drug Development. Catholic University, Medical School, Rome, Italy.
Feb 2009
PhD in Genetics and Molecular Biology. University Sapienza, Italy.
Nov 2004
MSs in Biological Sciences (110/110 cum laude) University Sapienza, Italy.

Current Position(s):
March 2024-present
Associate Professor c/o Dept. Biology and Biotechnologies "C. Darwin", University Sapienza, Italy

Previous Positions:
01/01/23-28/02/24
“Primo Ricercatore” at Institute of Molecular Biology and Pathology (IBPM) - National Research Council (CNR).
28/12/18-31/12/22
Principal Investigator,
“Ricercatore III livello” at IBPM - CNR
01/05/16-27/12/18
Principal Investigator,
“RTD-A” (“chiamata diretta” for SIR grant) at University Sapienza of Rome, Dept. of Biology and Biotechnology “C. Darwin”
08/2013- 04/2016
Dr. Chiara Lanzuolo lab.
Research Associate (A/R Senior), National Research Council (CNR) of Italy, Rome. Institute of Cell Biology and Neurobiology (IBCN).
12/2010- 07/2013
Post-doc at UMR7216 CNRS/University Paris Cité, Paris (France). Dr. Slimane Ait-Si-Ali lab.
02/2009 - 11/2010
Post-doc at Fondazione S. Lucia (FSL), Rome (Italy). Dr. Pier Lorenzo Puri lab.
05/2009 - 08/2009
Visiting Research Scientist at Sanford-Burnham for Medical Research, La Jolla (CA, USA)
01/2005 - 01/2009
Post-graduate and PhD training, Dulbecco Telethon Institute c/o European Brain Research Institute/S. Lucia, Rome (Italy). Dr Pier Lorenzo Puri lab.

Fellowships and awards:
Fellowships
Dr. Ait-Si-Ali lab (UMR7216 CNRS, Paris):
9/2011-8/2013 EMBO Long-term post-doc fellowship (#LT-1283_2010).
1/2011-8/2011 FRM (Fondation pour la Recherche Médicale), post-doc fellowship (prematurely interrupted to start EMBO- LTF).
Dr. Puri lab (Rome/San Diego):
2010 Post-doc fellowship granted by AFM (Association Française contre les Myopathies) (#14863). 2009 Post-doc fellowship granted by AFM (#13952).
2008 PhD fellowship granted by AFM (#13323).

SUPERVISION OF GRADUATE STUDENTS; PhD POSTDOC STUDENTS:
since 2016
3 Postdocs (CNR-IBPM, Rome Italy)
3 PhD (PhD course “Cell and Developmental Biology”), University Sapienza of Rome.
6 Graduates in “Neurobiology",“Genetics and Molecular Biology” and “Biotechnology” MSs c/o University Sapienza of Rome.

TEACHING ACTIVITIES:
2024- present
Lecturer for “General Physiology” (9 CFU), BSc in Biological Sciences (L-13), Faculty of Sciences University Sapienza, Italy.
2017- present
Lecturer for “Animal Physiology” (6 CFU), BSc in Environmental Sciences (L-32), Faculty of Sciences University Sapienza, Italy.
2019- 2024
Lecturer for the course “Molecular Medicine” for Sapienza School for Advanced Studies (SSAS), University Sapienza, Italy.

ORGANISATION OF SCIENTIFIC MEETINGS:
18-22 Dec 2023
Co-organiser of the International Winter School in "Genome integrity and organization in physiology and pathology", University Sapienza, Italy.

INSTITUTIONAL RESPONSIBILITIES:
2024-present
Academics Coordinator/Responsible for International Mobility for the Dept. Biology and Biotechnologies, Faculty of Sciences University Sapienza, Italy.
2018- present
Faculty committee, PhD course “Cell and Developmental Biology”, University Sapienza, Italy.
2017-2022
Member, Committee for Quality Assurance Management, BSc Environmental Sciences (L-32), Faculty of Sciences University Sapienza, Italy.
2016- to date Member of the examining committee for “General Physiology” for the BSc in Biological Sciences (L-13) and “Animal Physiology” for Natural Sciences (L-32) and Environmental
Sciences (L-32), Faculty of Sciences University Sapienza, Italy

REVIEWING ACTIVITIES:
2023-present
Review Panel member of the scientific committee for the French National Research Agency (Agence Nationale de la Recherche, ANR).
Since 2015
Invited Grants reviewer for AFM (Association Française contre les Myopathies, Muscular Dystrophy UK, French National Research Agency (ANR), German Research Foundation, Fondazione
Cariparo, National Science Center (Poland).
Since 2015
Invited reviewer of research articles for Nature Communications, Developmental Cell, EMBO reports, FASEB journal, Stem Cell Reports, The Journal of Physiology, Scientific reports, Cellular
and Molecular Life Sciences, Epigenomics, Medical Epigenetics; Frontiers Physiology.
2018
Lead Guest Editor of the Research Topic "Epigenetic Regulation of Stem Cell Plasticity in Tissue Regeneration and Disease” in Frontiers Cell & Developmental Biology.

Track Record:
Publications as main (first, last, corresponding) author:
1. Mozzetta C, Sartorelli V , Puri PL. HDAC inhibitors as pharmacological treatment for Duchenne muscular dystrophy: a discovery journey from bench to patients. Trends Mol Med. 2024 Feb 25.
Invited Review.
2. Mozzetta C. Epigenetic regulation of stem cells. Encyclopedia of Cell Biology 2nd edition Editor(s): Ralph A. Bradshaw, Gerald W. Hart, Philip D. Stah.l V olume 6, 2023, Pages 84-98. ISBN:
9780128216248.
3. Gualtieri A., Bianconi V . Licursi V ., Renzini A., Pieroni L., Mozzetta C. The RNA helicase DDX5 cooperates with EHMT2 to sustain alveolar rhabdomyosarcoma growth. Cell Reports, 2022,
40, Aug 30th.
4. De Stefano M.E., Ferretti V , Mozzetta C. Synaptic alterations as a neurodevelopmental trait of Duchenne muscular dystrophy. Neurobiology of Disease. 2022 Jun 15;168:105718.
5. Bianconi V . and Mozzetta C. Epigenetic control of muscle stem cells: time for a new dimension. Trends in Genetics, 2022 Jan 22. Invited review.
6. Macino M., Biferali B., Cipriano A., Ballarino M, Mozzetta C. Targeting the Expression of Long Noncoding RNAs in Murine Satellite Cells from Single Myofibers. Bio Protoc. 2021 Nov
5;11(21):e4209.
7. Biferali B., Bianconi V ., Fernandez Perez D., Pöhle Kronawitter S., Marullo F., Maggio R., Santini T., Polverino F., Biagioni S., Summa V ., Toniatti C., Pasini D., Stricker S., Di Fabio R.,
Chiacchiera F., Peruzzi G., Mozzetta C. Prdm16-mediated H3K9 methylation controls Fibro-Adipogenic Progenitors identity during skeletal muscle repair. Science Advances 2021, 7(23),
eabd9371
8. Cipriano A., Macino M., Bonaiuto G., Santini T., Biferali B., Peruzzi G., Colantoni A., Mozzetta C§, Ballarino M§. Epigenetic regulation of Wnt7b expression by the cis-acting long noncoding
RNA lnc-Rewind in muscle stem cells. Elife 2021, 10, pp. 1–25, e54782. § co-corresponding
9. Pegoli G., Lucini F., Mozzetta C§, Lanzuolo C#. Single Myofiber Isolation and Culture from a Murine Model of Emery-Dreifuss Muscular Dystrophy in Early Post-Natal Development. Jove
2020. §co-corresponding
10. Bianchi A.
*
, Mozzetta C.
*
, Pegoli G., Lucini F., Valsoni S., Rosti V ., Petrini C., Cortesi A., Gregoretti F., Antonelli L., Oliva G., De Bardi M., Rizzi R., Bodega B., Pasini D., Ferrari F., Bearzi
C., Lanzuolo C. Polycomb dysfunctional transcriptional repression contributes to Lamin A/C dependent muscular dystrophy. Journal of Clinical Investigation. 2020.
* equal
11. Chiacchiera F, Morey L, Mozzetta C. Editorial: Epigenetic Regulation of Stem Cell Plasticity in Tissue Regeneration and Disease. Front Cell Dev Biol 2020
12. Mozzetta C§ Tedesco FS. Challenging the "chromatin hypothesis" of cardiac laminopathies with LMNA mutant iPS cells. J Cell Biol. 2019. § corresponding
13. Biferali B., Proietti D., Mozzetta C. § and Madaro L.§. Fibro-Adipogenic Progenitors (FAPs) cross-talk in skeletal muscle: the social network. Frontiers Physiology 2019. § co-corresponding
14. Mozzetta C. Isolation and culture of muscle stem cells. Methods Mol Biol. 2016.
15. Mozzetta C§, Boyarchuk E, Pontis J, Ait-Si-Ali S§. Sound of Silence: The properties and functions of repressive lysine methyltransferases. Nature Review Molecular Cell Biology. 2015
Aug;16(8):499-513. § co-corresponding author
16. Mozzetta C§, Pontis J, Ait-Si-Ali S§. Functional crosstalks between lysine methyltransferases on histone substrates: the case of G9a/GLP and PRC2. Invited review Antioxidant & Redox
Signaling 2014 Nov 3. § corresponding author
17. Consalvi S, Saccone V , Mozzetta C§. Histone Deacetylase Inhibitors (HDACi): the potential of an epigenetic treatment for Duchenne Muscular Dystrophy. Epigenomics. Invited review.
2014;6(5):547-60. §corresponding author
18. Mozzetta C §, Pontis J, Fritsch L, Robin P, Portoso M, Proux C, Margueron R, Ait-Si-Ali S§ (2014). The Histone H3 Lysine 9 Methyltransferases G9a and GLP Regulate Polycomb Repressive
Complex 2-Mediated Gene Silencing. Molecular Cell. Jan 23;53(2):277-89 Epub 2014 Jan 2. § co-corresponding
19. Mozzetta C, Consalvi S, Saccone V , Tierney M, Diamantini A, Mitchell KJ, Marazzi G, Borsellino G, Battistini L, Sassoon D, Sacco A, Puri PL. Fibroadipogenic progenitors mediate the
ability of HDAC inhibitors to promote regeneration in dystrophic muscles of young, but not old Mdx mice. EMBO Molecular Medicine, 2013; doi:10.1002/emmm.201202096.

Complete list of publications here: https://pubmed.ncbi.nlm.nih.gov/?term=Mozzetta+Chiara&sort=date

FUNDINGS AS PRINCIPAL INVESTIGATOR (PI) (since 2015):
2023-28
AIRC (Italian Association for Cancer Research) Investigator Grant. 630000 eur /5 years.
2022-25
Muscular Dystrophy Association (MDA). 279300 $/3 years. From October 2022
2020
Sarcoma Foundation of america (SFA). 50000 $/1 year.
2019-2020
AFM-Telethon: 82000 eur/2 years.
2018
Integrated projects “LIFE 2020” POR FESR LAZIO 2014: In partnership with IRBM (Pomezia, Italy). 277489 eur/18 months
2017-2021
MyFIRST AIRC grant, Italian Association for Cancer Research (AIRC). 222600 eur/3 years
2016-2020
Scientific Independence of Young Researcher (SIR), Italian Ministry of University and Research: Project Id # RBSI14QMG0. 459800 eur/3 years

INVITED ORAL PRESENTATIONS:
8-13/06/25 Gordon Research Conference Myogenesis Il Ciocco Lucca (Italy)
11-13/12/23 RENOIR final meeting, Lyon (France)
20-23/10/22
Interuniversity Institute of Myology (IIM), XIX Annual Meeting. Assisi (Italy). Keynote speaker.
24-29/07/22
FASEB conference: The Skeletal Muscle Stem Cells and Regeneration Conference, New Orleans (USA)
14-19/11/21
Frontiers in Myogenesis Conference, Herradura (Costa Rica).
24/05/21
Epigenetics Monday Seminars, University of Trento, CIBIO (Italy).
24/03/17
Seminar series “The Nucleus and the control of gene expression”, PhD School in Biomedical Sciences and Biotechnology. University of Udine (Italy).
26-27/09/ 2016
1st EMBL/Sapienza PhD meeting “Chromatin & Epigenetics”, Rome (Italy).