GIUSEPPE BRUNO

Dept of Human Neuroscience
University of Rome “Sapienza”
Prof. Giuseppe BRUNO

Personal Data

Place and date of birth
ROMA 15-05-1956
Address:
Dept. Of Human Neurosciences – University of Rome “La Sapienza”
Viale dell’Università 30, 00185 Roma
Phone lab./mobile
06-49914020/3355902523
Fax 0649914732
E-mail giuseppe.bruno@uniroma1.it
brunotrials.sapienza@uniroma1.it
cogtrials.sapienza@uniroma1.it

Current position: Associate Professor – University of Rome “La Sapienza”
Neurology Consultant at University Hospital Policlinico Umberto I

Education and Qualifications:
- from 1982 to 1985 at the Experimental Therapeutics Branch NIH di Bethesda, Md. USA, (Prof. T.N. Chase) Clinical Fellow
- 1985 Board certification in Neurology
- 1989 PH.D. in Neurobiology
- from 1985 to 1992 at the I Clinica Neurologica, (Prof. A. Agnoli) , University of Roma “Sapienza".
- from 1992-2000 Staff Neurologist at the Neurologia A, NPC01A, Policlinico Umberto I, Università degli Studi di Roma "Sapienza".
- from 2000-2022 Aggregate Professor of Neurology and Neurology Consultant at University Hospital Policlinico Umberto I, Università degli Studi di Roma "Sapienza"
- from 1994- present : Chief of Memory Clinic, Dept. of Human Neuroscience, University of Rome “Sapienza”
- from 2012 - present: Member of the Executive and Scientific Board of SINdem (Italian Society of Neurology-Dementia)
- from 2016 – present: Member of the International Psychoanalytical Association
- from 2025 - 2028 Member of the National Ethics Committee Lazio Area 5

Teaching

School of Medicine, "D" channel, University of Rome "Sapienza"
School of Psychology, University of Rome "Sapienza
Residency training in Neurology, University of Rome "Sapienza"
Residency training in Neuropsychology, University of Rome "Sapienza"

Scientific Areas of Interest
Cognitive Neurology; Aging; Frailty and healthy aging; Epidemiology, genetics, neuropsychopharmacology of Alzheimer’s Disease and Dementias; Neuropsychiatry of aging disorders; Psychoanalysis.
Sites of research: Dept of Human Neuroscience, Sapienza University Rome; Istituto Superiore di Sanità/Dept of Cell biology and Neuroscience

Clinical Trial Experience
• Head of the sub-group "Family Alzheimer's Disease" in the project of the Ministry of Health - CCM on "Support for the quality of life of neurological patients with progressive physical and intellectual disability - Neurodegenerative diseases disabling young adults and their impact on the quality of life" from 09-01-2009 to 11-11-2010
• Scientific director of the three-year research program entitled: Multidimensional cognitive and behavioral assessment of subjects potentially exposed to critical events for the development of preventive strategies aimed at reducing vulnerability and increasing resilience "funded by the Presidency of the Council of Ministers. Amount of funding Euro 146,327.53 from 14-12-2017 to today
• Head of the University project entitled: TRAIN THE BRAIN: experimental study on the clinical and neurophysiological effects of a cognitive stimulation intervention in Alzheimer's disease from 08-05-2015 to today
• Principal Investigator of “A Phase 3 Double-blind, Randomized, Placebo-controlled, Multicenter Trial to Evaluate the Efficacy and Safety of AR1001 over 52 Weeks in Participants with Early Alzheimer’s Disease (Protocol AR1001-ADP3-US01; Sponsor: AriBio Co., Ltd.)
• Principal Investigator of “A Phase IIa, Randomized, Double-Blind, Placebo-Controlled, Multiple Dose, Multicenter, Parallel-Group Study to Investigate the Safety, Tolerability, and the Effect of Ro7269162 on Amyloid and non-Amyloid Disease-Related Biomarkers Following Daily Oral Administration in Participants at Risk for or at the Prodromal Stage of Alzheimer’s Disease” (Protocol BP44745; Sponsor: F. Hoffmann-La Roche Ltd)
• Principal Investigator of “Randomised, double-blind, placebo-controlled study to assess safety and efficacy of PRI-002 in patients with MCI or mild dementia due to Alzheimer’s Disease (AD)” (Protocol PRI-002-04; Sponsor: PRInnovation GmhB)
• Principal Investigator of “A Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Study to Assess the Efficacy, Safety, and Tolerability of BIIB080 in Subjects with Mild Cognitive Impairment Due to Alzheimer’s Disease or Mild Alzheimer’s Disease Dementia (Protocol 247AD201; Sponsor: Biogen)
• Principal Investigator of “A Phase 3b/4 Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Study to Verify the Clinical Benefit of Aducanumab (BIIB037) in Participants with Alzheimer’s Disease” from 15-06-2023 to today (Protocol 221AD305; Sponsor: Biogen)
• Principal Investigator of “Phase 3b Open-Label, Multicenter, Safety Study of BIIB037 (aducanumab) in Subjects with Alzheimer’s disease Who Had Previously Participated in the Aducanumab Studies 221AD103, 221AD301, 221AD302 and 221AD205” from 01-03-2021 to today (Protocol 221AD304; Sponsor: Biogen)
• Principal Investigator of “A Placebo-Controlled, Double-Blind, Parallel-Group, 18-Month Study With an Open-Label Extension Phase to Confirm Safety and Efficacy of BAN2401 in Subjects With Early Alzheimer’s Disease” from 01-03-2021 to today (Protocol BAN2401-G000-301; Sponsor: Eisai)
• Principal Investigator of “A Phase 2 Randomized, Double-Blind, Placebo Controlled, Multicenter Study to Evaluate the Efficacy and Safety of Al002 in Participants with Early Alzheimer’s Disease” from 27/09/2021 to today (Protocol AL002-2; Sponsor: Alector Inc.)
• Principal Investigator of “A Multicenter, Long-Term Extension Study to Evaluate the Safety, Tollerability, and Efficacy of AL002 in Partecipants with Alzheimer’s Disease (Protocol AL002-LTE; Sponsor: Alector, Inc.)
• Principal Investigator of “Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Study to Assess the Safety, Tolerability, and Efficacy of BIIB092 in Subjects with Mild Cognitive Impairment due to Alzheimer’s Disease or with Mild Alzheimer’s Disease” from 01-03-2021 to 09-11-2021 (Protocol 251AD201; Sponsor: Biogen)
• Principal Investigator of “An Open-Label, Multicenter, Rollover Study to Evaluate the Safety, Tolerability, and Efficacy of Long-Term Gantenerumab Administration in Participants with Alzheimer's Disease” from 02-08-2023 to 14-11-2022 (Protocol WN42171; Sponsor: F. Hoffmann-La Roche Ltd)

Training on ICH/GCP
ICH GCP Training Certificate E6 (R2), The Global Health Network on 27-feb-2025

Peer reviewed publications
Babiloni C, Arakaki X, Baez S, Barry RJ, Benussi A, Blinowska K, Bonanni L, Borroni B, Bayard JB, Bruno G, Cacciotti A, Carducci F, Carino J, Carpi M, Conte A, Cruzat J, D'Antonio F, Della Penna S, Del Percio C, De Sanctis P, Escudero J, Fabbrini G, Farina FR, Fraga FJ, Fuhr P, Gschwandtner U, Güntekin B, Guo Y, Hajos M, Hallett M, Hampel H, Hanoğlu L, Haraldsen I, Hassan M, Hatlestad-Hall C, Horváth AA, Ibanez A, Infarinato F, Jaramillo-Jimenez A, Jeong J, Jiang Y, Kamiński M, Koch G, Kumar S, Leodori G, Li G, Lizio R, Lopez S, Ferri R, Maestú F, Marra C, Marzetti L, McGeown W, Miraglia F, Moguilner S, Moretti DV, Mushtaq F, Noce G, Nucci L, Ochoa J, Onorati P, Padovani A, Pappalettera C, Parra MA, Pardini M, Pascual-Marqui R, Paulus W, Pizzella V, Prado P, Rauchs G, Ritter P, Salvatore M, Santamaria-García H, Schirner M, Soricelli A, Taylor JP, Tankisi H, Tecchio F, Teipel S, Kodamullil AT, Triggiani AI, Valdes-Sosa M, Valdes-Sosa P, Vecchio F, Vossel K, Yao D, Yener G, Ziemann U, Kamondi A. Alpha rhythm and Alzheimer's disease: Has Hans Berger's dream come true? Clin Neurophysiol. 2025 Apr;172:33-50. doi: 10.1016/j.clinph.2025.02.256. Epub 2025 Feb 13. PMID: 39978053.
Manzini V, Cappelletti P, Orefice NS, Brentari I, Rigby MJ, Lo Giudice M, Feligioni M, Rivabene R, Crestini A, Manfredi F, Talarico G, Bruno G, Corbo M, Puglielli L, Denti MA, Piscopo P. miR-92a-3p and miR-320a are Upregulated in Plasma Neuron-Derived Extracellular Vesicles of Patients with Frontotemporal Dementia. Mol Neurobiol. 2025 Feb;62(2):2573-2586. doi: 10.1007/s12035-024-04386-z. Epub 2024 Aug 14. PMID: 39138758; PMCID: PMC11772464.
Toccaceli Blasi, M., Alfano, A.R., Salzillo, M., ... Bruno, G., Canevelli, M. Sex-specific clinical and neurobiological correlates of fatigue in older adults GeroScience, 2025, 47(1), pp. 1151–1160
D'Antonio, F., Vivacqua, G., Serrentino, M., ... Fabbrini, G., Bruno, G. Salivary biomarkers for the molecular diagnosis of dementia with Lewy bodiesJournal of Alzheimer's disease : JAD, 2025, 104(2), pp. 452–462
Bechi Gabrielli, G., D'Antonio, F., Di Vita, A., ... Bruno, G., Guariglia, C. Mind's eye in the Alzheimer's disease spectrum continuum. Journal of Alzheimer's disease : JAD, 2025, 103(1), pp. 194–207
Salamone, E.M., Carpi, M., Noce, G., ... Antonini, A., Babiloni, C. Abnormal electroencephalographic rhythms from quiet wakefulness to light sleep in Alzheimer's disease patients with mild cognitive impairment Clinical Neurophysiology, 2025, 171, pp. 164–181
De Bartolo MI, Ojha A, Leodori G, Piervincenzi C, Vivacqua G, Pietracupa S, Costanzo M, D'Antonio F, Barbetti S, Margiotta R, Bruno G, Conte A, Berardelli A, Fabbrini G, Pantano P, Belvisi D. Association of Early fMRI Connectivity Alterations With Different Cognitive Phenotypes in Patients With Newly Diagnosed Parkinson Disease. Neurology. 2025 Jan 14;104(1):e210192. doi: 10.1212/WNL.0000000000210192. Epub 2024 Dec 19. PMID: 39700449.
Toccaceli Blasi M, Raffaele F, Belvisi D, Buscarnera S, Bruno G, Fabbrini G, Canevelli M. Frailty and hospital outcomes among patients with neurological disorders. Neurol Sci. 2025 Apr 3. doi: 10.1007/s10072-025-08144-4. Epub ahead of print. PMID: 40178742.
Del Percio, C., Lizio, R., Lopez, S., ... Frisoni, G.B., Babiloni, C. Resting-State EEG Alpha Rhythms Are Related to CSF Tau Biomarkers in Prodromal Alzheimer’s Disease. International Journal of Molecular Sciences, 2025, 26(1), 356
Buscarnera S, Canevelli M, Bruno G, Garibotto V, Frisoni GB, Ribaldi F. Unraveling the link between frailty and Alzheimer's disease biomarkers in patients with mild cognitive impairment. Geroscience. 2025 Feb 10. doi: 10.1007/s11357-025-01547-3. Epub ahead of print. PMID: 39930290.
Albanese GM, Gharbiya M, Visioli G, Panigutti M, Margarella A, Romano E, Mastrogiuseppe E, Sepe-Monti M, Bruno G, D'Antonio F. Neuroretinal and microvascular retinal features in dementia with Lewy body assessed by optical coherence tomography angiography. Neurol Sci. 2025 Jan;46(1):185-194. doi: 10.1007/s10072-024-07683-6. Epub 2024 Aug 17. PMID: 39152330; PMCID: PMC11698750.
Di Santo A, Malimpensa L, Canevelli M, Zampelli A, Belvisi D, Leodori G, Forte F, Giannantoni A, Bruno G, Conte A, Ferrazzano G. Frailty and urinary symptoms share pathophysiological mechanisms involved in disease progression in people with multiple sclerosis. Neurol Sci. 2025 Mar 18. doi: 10.1007/s10072-025-08089-8. Epub ahead of print. PMID: 40100557.
Del Percio C, Lizio R, Lopez S, Noce G, Jakhar D, Carpi M, Bölükbaş B, Soricelli A, Salvatore M, Güntekin B, Yener G, Massa F, Arnaldi D, Famà F, Pardini M, Ferri R, Salerni M, Lanuzza B, Stocchi F, Vacca L, Coletti C, Marizzoni M, Taylor JP, Hanoğlu L, Helvacı Yılmaz N, Kıyı İ, Özbek-İşbitiren Y, Frisoni GB, Cuoco S, Barone P, D'Anselmo A, Bonanni L, Biundo R, D'Antonio F, Bruno G, Giubilei F, De Pandis F, Rotondo R, Antonini A, Babiloni C. Resting-state electroencephalographic rhythms depend on sex in patients with dementia due to Parkinson's and Lewy Body diseases: An exploratory study. Neurobiol Dis. 2025 Mar;206:106807. doi: 10.1016/j.nbd.2025.106807. Epub 2025 Jan 22. PMID: 39855475.
Marra C, Beccia F, Caffarra P, L'Abbate F, Agosta F, Benussi A, Bonanni L, Bruni AC, Bruno G, Cappa SF, Cerami C, Di Lorenzo F, Ferrarese C, Galimberti D, Guarnieri B, Mariani C, Nacmias B, Pantoni L, Piccoli T, Perani D, Rainero I, Tagliavini F, Venneri A, Boccia S, Cagnin A, Calabrò GE, Bozzali M; SINdem DELPHI Consensus Group. Towards a new Value-based scenario for the management of dementia in Italy: a SINdem delphi consensus study. Neurol Sci. 2025 Apr 16. doi: 10.1007/s10072-025-08143-5. Epub ahead of print. PMID: 40237973.
Vaccaro, R., Lorenzini, P., Giaquinto, F., ... Ahmad, O., Accardo, E. Neuropsychological tests at the Italian Centers for Cognitive Disorders and Dementias: results from a survey on 450 specialized services. Aging Clinical and Experimental Research, 2025, 37(1), 1
D'Antonio F, Teghil A, Boccia M, Bechi Gabrielli G, Giulietti G, Conti D, Suppa A, Fabbrini A, Fiorelli M, Caramia F, Bruno G, Guariglia C, Aarsland D, Ffytche D. Distinct grey and white matter changes are associated with the phenomenology of visual hallucinations in Lewy Body Disease. Sci Rep. 2024 Jun 26;14(1):14748. doi: 10.1038/s41598-024-65536-w. PMID: 38926597; PMCID: PMC11208453.
Di Nolfi A, Giusti A, Canevelli M, Vanacore N, Pomati S, Cova I, Ancidoni A, Marchetti F, Zambri F; ImmiDem Study Group. Dementia among migrants in Italy: a qualitative study of the ImmiDem project. Ann Ist Super Sanita. 2024 Oct-Dec;60(4):264-273. doi: 10.4415/ANN_24_04_05. PMID: 39699980.
Conti D, Bechi Gabrielli G, Panigutti M, Zazzaro G, Bruno G, Galati G, D'Antonio F. Neuroanatomical and clinical correlates of prodromal dementia with Lewy bodies: a systematic literature review of neuroimaging findings. J Neurol. 2024 Dec 12;272(1):38. doi: 10.1007/s00415-024-12726-1. PMID: 39666108.
Babiloni C, Noce G, Tucci F, Jakhar D, Ferri R, Panerai S, Catania V, Soricelli A, Salvatore M, Nobili F, Arnaldi D, Famà F, Buttinelli C, Giubilei F, Onofrj M, Stocchi F, Vacca L, Radicati F, Fuhr P, Gschwandtner U, Ransmayr G, Parnetti L, Marizzoni M, D'Antonio F, Bruno G, De Lena C, Güntekin B, Yıldırım E, Hanoğlu L, Yener G, Hünerli D, Taylor JP, Schumacher J, McKeith I, Frisoni GB, Antonini A, Ferreri F, Bonanni L, De Pandis MF, Del Percio C. Poor reactivity of posterior electroencephalographic alpha rhythms during the eyes open condition in patients with dementia due to Parkinson's disease. Neurobiol Aging. 2024 Mar;135:1-14. doi: 10.1016/j.neurobiolaging.2023.11.010. Epub 2023 Nov 28. PMID: 38142464.
Bacigalupo I, Giaquinto F, Salvi E, Carnevale G, Vaccaro R, Matascioli F, Remoli G, Vanacore N, Lorenzini P; Permanent Table of the National Dementia Plan Study Group and the CCDDs Study Group. A new national survey of centers for cognitive disorders and dementias in Italy. Neurol Sci. 2024 Feb;45(2):525-538. doi: 10.1007/s10072-023-06958-8. Epub 2023 Aug 18. PMID: 37592124; PMCID: PMC10791890.
Gasparini M, Scandola M, Amato S, Salati E, Facci E, Gobbetto V, Bruno G, Vanacore N, Gambina G, Moro V. Normative data beyond the total scores: a process score analysis of the Rey's 15 word test in healthy aging and Alzheimer's Disease. Neurol Sci. 2024 Jan 22. doi: 10.1007/s10072-024-07330-0. Epub ahead of print. Erratum in: Neurol Sci. 2024 Mar 15;: PMID: 38253743.
Teghil A, Boccia M, Di Vita A, Zazzaro G, Sepe Monti M, Trebbastoni A, Talarico G, Campanelli A, Bruno G, Guariglia C, de Lena C, D'Antonio F. Multidimensional assessment of time perception along the continuum of Alzheimer's Disease and evidence of alterations in subjective cognitive decline. Sci Rep. 2023 Dec 13;13(1):22117. doi: 10.1038/s41598-023-49222-x. PMID: 38092802; PMCID: PMC10719320.
Cannavacciuolo A, Paparella G, Salzillo M, Colella D, Canevelli M, Costa D, Birreci D, Angelini L, Guerra A, Ricciardi L, Bruno G, Berardelli A, Bologna M. Facial emotion expressivity in patients with Parkinson's and Alzheimer's disease. J Neural Transm (Vienna). 2024 Jan;131(1):31-41. doi: 10.1007/s00702-023-02699-2. Epub 2023 Oct 7. PMID: 37804428; PMCID: PMC10770202.
Canevelli M, Wallace LMK, Bruno G, Cesari M, Rockwood K, Ward DD. Frailty is associated with the clinical expression of neuropsychological deficits in older adults. Eur J Neurol. 2024 Jan;31(1):e16072. doi: 10.1111/ene.16072. Epub 2023 Sep 22. PMID: 37738515.
Babiloni C, Lopez S, Noce G, Ferri R, Panerai S, Catania V, Soricelli A, Salvatore M, Nobili F, Arnaldi D, Famà F, Massa F, Buttinelli C, Giubilei F, Stocchi F, Vacca L, Marizzoni M, D'Antonio F, Bruno G, De Lena C, Güntekin B, Yıldırım E, Hanoğlu L, Yener G, Yerlikaya D, Taylor JP, Schumacher J, McKeith I, Bonanni L, Pantano P, Piervincenzi C, Petsas N, Frisoni GB, Del Percio C, Carducci F. Relationship between default mode network and resting-state electroencephalographic alpha rhythms in cognitively unimpaired seniors and patients with dementia due to Alzheimer's disease. Cereb Cortex. 2023 Oct 9;33(20):10514-10527. doi: 10.1093/cercor/bhad300. Erratum in: Cereb Cortex. 2023 Sep 16;: PMID: 37615301; PMCID: PMC10588004.
Remoli G, Tariciotti L, Remore LG, Palmisciano P, Sciancalepore F, Canevelli M, Lacorte E, Da Re F, Bruno G, Ferrarese C, Appollonio I, Locatelli M, Vanacore N. An updated overview of recent and ongoing deep brain stimulation (DBS) trials in patients with dementia: a systematic review. Neurol Sci. 2023 Oct;44(10):3395-3427. doi: 10.1007/s10072-023-06821-w. Epub 2023 May 19. PMID: 37204563.
Zingaropoli MA, Pasculli P, Barbato C, Petrella C, Fiore M, Dominelli F, Latronico T, Ciccone F, Antonacci M, Liuzzi GM, Talarico G, Bruno G, Galardo G, Pugliese F, Lichtner M, Mastroianni CM, Minni A, Ciardi MR. Biomarkers of Neurological Damage: From Acute Stage to Post-Acute Sequelae of COVID-19. Cells. 2023 Sep 13;12(18):2270. doi: 10.3390/cells12182270. PMID: 37759493; PMCID: PMC10526816.
Taglino, F., Cumbo, F., Antognoli, G., Arisi, I., Mara D’Onofrio, Perazzoni, F., . . . Bruno, G.,…Bertolazzi, P. (2023). An ontology-based approach for modelling and querying Alzheimer’s disease data. BMC Medical Informatics and Decision Making, 23, 1-15. doi:https://doi.org/10.1186/s12911-023-02211-6
Valletta, M, Vetrano, DL, Xia, X, Rizzuto, D, Roso-Llorach, A, Calderón-Larrañaga, A, …Bruno, G, …et al. Multimorbidity patterns and 18-year transitions from normal cognition to dementia and death: A population-based study. J Intern Med. 2023; 294: 326–335.
Pennacchia, F., Rusi, E., Wael, A. R., Zingaropoli, M. A., Pasculli, P., Talarico, G., . . . Bruno, G… Fiore, M. (2023). Blood biomarkers from the emergency department disclose severe omicron COVID-19-associated outcomes. Microorganisms, 11(4), 925. doi:https://doi.org/10.3390/microorganisms11040925
Viola Baione; Marco Canevelli; Daniele Belvisi; Maria Chiara Buscarinu; Gianmarco Bellucci; Roberta Fantozzi; Carolina Gabri Nicoletti; Giorgia Malatuni; Antonio Cortese; Laura De Giglio; Matteo Tartaglia; Gina Ferrazzano; Leonardo Malimpensa; Giorgio Leodori; Giuseppe Bruno; Elisabetta Ferraro; Girolama Alessandra Marfia; Diego Centonze; Marco Salvetti; Antonella Conte: Frailty and relapse activity in multiple sclerosis: A longitudinal observation. Multiple Sclerosis and Related Disorders, Volume 72, April 2023, 104603; ISSN 22110348; DOI 10.1016/j.msard.2023.104603
Carrarini, Claudia; Calisi, Dario; De Rosa, Matteo Alessandro; Angelo Di Iorio; Damiano D’Ardes;… Bruno, Giuseppe…e altri:  QEEG abnormalities in cognitively unimpaired patients with delirium. Journal of Neurology, Neurosurgery and Psychiatry; London (Oct 2022) Volume 94 Issue 3 Page 251-254. DOI:10.1136/jnnp-2022-330010
Toccaceli Blasi, Marco; Valletta, Martina; Trebbastoni, Alessandro; D’Antonio, Fabrizia; Talarico, Giuseppina; Campanelli, Alessandra; Sepe Monti, Micaela; Salati, Emanuela; Gasparini, Marina; Buscarnera, Simona; Salzillo, Martina; Canevelli, Marco; Bruno, Giuseppe: Sundowning in Patients with Dementia: Identification, Prevalence, and Clinical Correlates. Journal of Alzheimer's Disease, 2023, vol. 94, no. 2, pp. 601-610, DOI: 10.3233/JAD-230094
Piscopo P., Grasso M., Manzini V., Zeni A., Castelluzzo M., Fontana F., Talarico G., Castellano A.E., Rivabene R., Crestini A., Bruno G., Ricci L., Denti M.A. : Identification of miRNAs regulating MAPT expression and their analysis in plasma of patients with dementia (2023) Frontiers in Molecular Neuroscience, 16, art. no. 1127163 DOI: 10.3389/fnmol.2023.1127163
Giulia Remoli; Leonardo Tariciotti; Luigi Gianmaria Remore; Paolo Palmisciano; Francesco Sciancalepore; Marco Canevelli; Eleonora Lacorte; Fulvio Da Re; Giuseppe Bruno; Carlo Ferrarese; Ildebrando Appollonio; Marco Locatelli; Nicola Vanacore: An updated overview of recent and ongoing deep brain stimulation (DBS) trials in patients with dementia: a systematic review Neurological Sciences (2023) https://doi.org/10.1007/s10072-023-06821-w
Babiloni, C., Noce, G., Di Bonaventura, C., Lizio, R., Eldellaa, A., Tucci, F., . . . Del Percio, C. (2022). Alzheimer's disease with epileptiform EEG activity: Abnormal cortical sources of resting state delta rhythms in patients with amnesic mild cognitive impairment. Journal of Alzheimer's Disease, 88(3), 903-931. doi:10.3233/JAD-220442
Belvisi, D., Canevelli, M., Baione, V., Buscarinu, M. C., Pellicciari, G., Fantozzi, R., . . . Conte, A. (2021). Operationalization of a frailty index in patients with multiple sclerosis: A cross-sectional investigation. Multiple Sclerosis Journal, 27(12), 1939-1947. doi:10.1177/1352458520987541
Belvisi, D., Canevelli, M., Costanzo, M., Giangrosso, M., Fabbrini, A., Borraccino, A., . . . Fabbrini, G. (2022). The role of frailty in Parkinson’s disease: A cross-sectional study. Journal of Neurology, 269(6), 3006-3014. doi:10.1007/s00415-021-10873-3
Canevelli, M., Arisi, I., Bacigalupo, I., Arighi, A., Galimberti, D., Vanacore, N., . . . Bruno, G. (2021). Biomarkers and phenotypic expression in Alzheimer’s disease: Exploring the contribution of frailty in the Alzheimer’s disease neuroimaging initiative. GeroScience, 43(2), 1039-1051. doi:10.1007/s11357-020-00293-y
Canevelli, M., Bersani, F. S., Sciancalepore, F., Salzillo, M., Cesari, M., Tarsitani, L., . . . Bruno, G. (2022). Frailty in caregivers and its relationship with psychological stress and resilience: A cross-sectional study based on the deficit accumulation model. Journal of Frailty and Aging, 11(1), 59-66. doi:10.14283/jfa.2021.29
Canevelli, M., Bruno, G., Valletta, M., & Cesari, M. (2022). Could there be frailty in the discrepancy between lesions and symptoms of Alzheimer’s disease? Journal of Frailty and Aging, 11(3), 248-249. doi:10.14283/jfa.2022.43
Canevelli, M., Cova, I., Remoli, G., Bacigalupo, I., Salvi, E., Maestri, G., . . . Visco, C. (2022). A nationwide survey of italian centers for cognitive disorders and dementia on the provision of care for international migrants. European Journal of Neurology, 29(7), 1892-1902. doi:10.1111/ene.15297
D'Antonio, F., Tremolizzo, L., Zuffi, M., Pomati, S., Farina, E., Alberoni, M., . . . Vista, M. (2022). Clinical perception and treatment options for behavioral and psychological symptoms of dementia (BPSD) in italy. Frontiers in Psychiatry, 13 doi:10.3389/fpsyt.2022.843088
Piscopo P, Manzini V, Rivabene R, Crestini A, Le Pera L, Pizzi E, Veroni C, Talarico G, Peconi M, Castellano AE, D'Alessio C, Bruno G, Corbo M, Vanacore N, Lacorte E. A Plasma Circular RNA Profile Differentiates Subjects with Alzheimer's Disease and Mild Cognitive Impairment from Healthy Controls. Int J Mol Sci. 2022 Oct 31;23(21):13232. doi: 10.3390/ijms232113232. PMID: 36362022; PMCID: PMC9658433.
Valletta, M., Canevelli, M., D'Antonio, F., Trebbastoni, A., Talarico, G., Campanelli, A., . . . Bruno, G. (2022). Prevalence and safety of COVID-19 vaccination in community-dwelling people with dementia: Findings from a tertiary memory clinic in italy. Journal of Alzheimer's Disease, 87(4), 1467-1474. doi:10.3233/JAD-220077
Zucca, M., Isella, V., Lorenzo, R. D., Marra, C., Cagnin, A., Cupidi, C., . . . Bergamelli, C. (2021). Being the family caregiver of a patient with dementia during the coronavirus disease 2019 lockdown. Frontiers in Aging Neuroscience, 13 doi:10.3389/fnagi.2021.653533
Canevelli, M., Arisi, I., Bacigalupo, I., ...Cesari, M., Bruno, G. Biomarkers and phenotypic expression in Alzheimer’s disease: exploring the contribution of frailty in the Alzheimer’s Disease Neuroimaging Initiative. GeroScience, 2021, 43(2), pp. 1039–1051 doi: 10.1007/s11357-020-00293-y. Epub 2020 Nov 19. PMID: 3321021 IF 8.878
Remoli, G., Canevelli, M., Robertazzo, U.M., ...Vanacore, N., Bruno, G. Supporting and Protecting People with Dementia in the COVID-19 Pandemic. Journal of Alzheimer's Disease, 2021, 83(1), pp. 43–49 doi: 10.3233/JAD-210264. PMID: 34219720
IF 4.472

Canevelli M, Vanacore N, Blasimme A, Bruno G, Cesari M. Overtreating Alzheimer's Disease. J Prev Alzheimers Dis. 2021;8(2):234-236. doi: 10.14283/jpad.2020.74. PMID: 33569572
IF 3.149

Innocenzo Rainero, Amalia C. Bruni, Camillo Marra, Annachiara Cagnin, Laura Bonanni, Chiara Cupidi, Valentina Laganà, Elisa Rubino, Alessandro Vacca, Raffaele Di Lorenzo, Paolo Provero, Valeria Isella1, Nicola Vanacore, Federica Agosta, Ildebrando Appollonio, Paolo Caffarra1 Cinzia Bussè, Renato Sambati, Davide Quaranta, Valeria Guglielmi, Giancarlo Logroscino, Massimo Filippi, Gioacchino Tedeschi, Carlo Ferrarese and the SINdem COVID-19 Study Group. The Impact of COVID-19 Quarantine on Patients With Dementia and Family Caregivers: A Nation-Wide Survey. Front. Aging Neurosci., 18 January 2021 | https://doi.org/10.3389/fnagi.2020.625781
IF 4.364

Belvisi D, Canevelli M, Baione V, Buscarinu MC, Pellicciari G, Fantozzi R, Creta A, Cecchi G, Cola G, Nicoletti CG, Cortese A, De Giglio L, Tartaglia M, Crisafulli SG, Bruno G, Ferraro E, Marfia GA, Centonze D, Salvetti M, Conte A. Operationalization of a frailty index in patients with multiple sclerosis: A cross-sectional investigation. Mult Scler. 2021 Feb 10:1352458520987541. doi: 10.1177/1352458520987541.
IF 5.412
Sarli, G., De Marco, M., Hallikainen, M., ...Bruno, G., Venneri, A. Regional Strength of Large-Scale Functional Brain Networks is Associated with Regional Volumes in Older Adults and in Alzheimer's Disease. Brain Connectivity, 2021, 11(3), pp. 201–212 doi: 10.1089/brain.2020.0899. Epub 2021 Jan 28. PMID: 33307980 IF 2.262
Canevelli M, Remoli G, Toccaceli Blasi M, Tariciotti L, Sarli G, Valletta M, D'Antonio F, Vanacore N, Cesari M, Bruno G. Ongoing Research Protocols for the Pharmacological Treatment of Neuropsychiatric Symptoms in Dementia. J Frailty Aging. 2021;10(1):22-30. doi: 10.14283/jfa.2020.36.
NA

Canevelli M, Arisi I, Bacigalupo I, Arighi A, Galimberti D, Vanacore N, D'Onofrio M, Cesari M, Bruno G; Alzheimer’s Disease Neuroimaging Initiative. Biomarkers and phenotypic expression in Alzheimer's disease: exploring the contribution of frailty in the Alzheimer's Disease Neuroimaging Initiative. Geroscience. 2020 Nov 19. doi: 10.1007/s11357-020-00293-y.
IF 6.444

Canevelli M, Remoli G, Trentin F, Riccardi G, Tariciotti L, Risoleo G, Ancidoni A, Bruno G, Cesari M, Vanacore N, Raparelli V. The Pipeline of Therapeutics Testing During the Emergency Phase of the COVID-19 Outbreak. Front Med (Lausanne). 2020 Sep 24;7:552991. doi: 10.3389/fmed.2020. IF 3.9

Canevelli M, Remoli G, Bacigalupo I, Valletta M, Toccaceli Blasi M, Sciancalepore F, Bruno G, Cesari M, Vanacore N. Use of Biomarkers in Ongoing Research Protocols on Alzheimer's Disease. J Pers Med. 2020 Jul 24;10(3):68. doi: 10.3390/jpm10030068.
IF 4.433

Canevelli M, Bruno G, Cesari M. Providing Simultaneous COVID-19-sensitive and Dementia-Sensitive Care as We Transition from Crisis Care to Ongoing Care. J Am Med Dir Assoc. 2020 Jul;21(7):968-969. doi: 10.1016/j.jamda.2020.05.025.
IF 4.367

Annachiara Cagnin, Raffaele Di Lorenzo, Camillo Marra, Laura Bonanni, Chiara Cupidi, Valentina Laganà, Elisa Rubino, Alessandro Vacca, Paolo Provero, Valeria Isella1, Nicola Vanacore, Federica Agosta, Ildebrando Appollonio, Paolo Caffarra, Ilaria Pettenuzzo, Renato Sambati, Davide Quaranta, Valeria Guglielmi, Giancarlo Logroscino, Massimo Filippi, Gioacchino Tedeschi, Carlo Ferrarese, Innocenzo Rainero, Amalia C. Bruni and SINdem COVID-19 Study Group. Behavioral and Psychological Effects of Coronavirus Disease-19 Quarantine in Patients With Dementia. Front. Psychiatry, 09 September 2020 doi.org/10.3389/fpsyt.2020.578015
IF 2.849

Canevelli M, Valletta M, Toccaceli Blasi M, Remoli G, Sarti G, Nuti F, Sciancalepore F, Ruberti E, Cesari M, Bruno G. Facing Dementia During the COVID-19 Outbreak. J Am Geriatr Soc. 2020 Aug;68(8):1673-1676. doi: 10.1111/jgs.16644.
IF 4.18

Cinzia Mallozzi, Alessio Crestini, Carmen D'Amore, Paola Piscopo, Marisa Cappella, Federica Perrone, Giuseppina Talarico, Giuseppe Bruno, Nicola Vanacore, Annamaria Confaloni. Activation of Tyrosine Phosphorylation Signaling in Erythrocytes of Patients with Alzheimer’s Disease. Neuroscience Volume 433, 1 May 2020, Pages 36-41 doi.org/10.1016/j.neuroscience.2020.02.050
IF 3.056

Bersani FS, Canevelli M, Cesari M, Maggioni E, Pasquini M, Wolkowitz OM, Ferracuti S, Biondi M, Bruno G. Frailty Index as a clinical measure of biological age in psychiatry. J Affect Disord. 2020 May 1;268:183-187. doi: 10.1016/j.jad.2020.03.015.
IF 3.892

Canevelli M, Lacorte E, Cova I, Cascini S, Bargagli AM, Angelici L, Giusti A, Pomati S, Pantoni L, Vanacore N; ImmiDem Study Group. Dementia among migrants and ethnic minorities in Italy: rationale and study protocol of the ImmiDem project. BMJ Open. 2020 Jan 7;10(1):e032765. doi: 10.1136/bmjopen-2019-032765.
IF 2.496

In compliance with the GDPR and the Italian Legislative Decree no. 196 dated 30/06/2003, I hereby authorize you to use and process my personal details contained in this document

Rome, 30th of April 2025

Prof Giuseppe Bruno