Ritratto di cecilia.battistelli@uniroma1.it

Tutti i giorni dalle ore 10 alle ore 19 previo appuntamento.

PERSONAL INFORMATIONS
Telephone +390649918236
E-mail cecilia.battistelli@uniroma1.it

EDUCATION AND TRAINING
2018 National Academic Qualification (ASN) as Associate Professor (BIO/13)
2012 PhD in Human Biology and Genetics at University of Rome Sapienza
Thesis title : MyoD regulates p57kip2 expression through a long-range chromatin interaction. Tutor: Prof. Rossella Maione, Department of Cellular Biotechnologies and Haematology- University of Rome Sapienza
2011 Italian Biological Licensure at University of Rome Sapienza
2008 Master Degree in Genetics & Molecular Biology with maximum grades (110/110 cum laude) at University of Rome Sapienza
Thesis title: Mechanisms regulating p57kip2 expression during muscle differentiation: role of DNA methylation. Tutors: Prof. Gabriella Augusti Tocco, Department of Cellular and Developmental Biology, University of Rome "Sapienza" and Prof. Rossella Maione, Department of Cellular Biotechnologies and Haematology, University of Rome "Sapienza
2007 Bachelor Degree in Biological Sciences with maximum grades (110/110 cum laude) at University of Rome Sapienza
Thesis title: Analysis of the regulation of microRNA biosynthesis. Tutor: Prof. Irene Bozzoni, Department of Genetics and Molecular Biology, University of Rome "Sapienza"

PROFESSIONAL EXPERIENCE
2018 Researcher (Assistant Professor) Dept. Molecular Medicine, Sapienza University of Rome
2017-2018 Guest Editor for the Frontiers in Pharmacology special Issue titled Molecular Mechanisms and New Therapeutic Targets in Epithelial to Mesenchymal Transition (EMT) and Fibrosis
2016-2017 Guest Editor for the Mediators of Inflammation special Issue titled Molecular Mechanisms in Epithelial to Mesenchymal Transition (EMT) and Fibrosis (MMEMT)
2015-2017 Research fellow, professional training. Prof. Marco Tripodi s lab. Sapienza University of Rome. Research on: Role of lncRNA Hotair in EMT and tumorigenesis.
2014 Research fellow, professional training. Prof. Marco Tripodi s lab. Research on: Regulation of epigenetic mechanisms in gene expression reprogramming during EMT mediated by the transcription factor Snail.
2013 Research fellow, professional training. Prof. Marco Tripodi s lab. Research on: Epigenetic modification involved in cellular reprogramming and differentiation.
2012 Research fellow, professional training. Prof. Marco Tripodi s lab. Research on: Molecular mechanisms controlling EMT/MET during liver stem cells differentiation.
2008-2011 PhD student. Prof. Rossella Maione s lab. Research on: Role of epigenetic regulation of gene expression.
2007-2008 Graduated student. Prof. Rossella Maione s lab. Research on: Mechanisms of regulation of the CDK inhibitor p57kip2 during muscle differentiation and role of DNA methylation.
2005-2007 Undergraduated student. Prof. Irene Bozzoni s lab. Research on: Mechanisms of regulation of microRNAs biosynthesis.

PERSONAL SKILLS AND COMPETENCES
Molecular Biology, Cellular Biology, Exosomes Biology, Informatics abilities and competences.
Languages: Italian (mother tongue), English, French

CONGRESSES AND COURSES
22-24/11/2018 ABCD Meeting: Signal Transduction in Cancer Turin (Oral presentation)
19-24/8/2018 Gordon Research Conference - From Basic Research to Clinical Diagnostic and Therapeutic Applications of Extracellular Vesicles Newry (USA) (Poster presentation)
21-23/9/2017 ABCD meeting - Bologna
20-23/9/2016 - XIV FISV Congress Rome (Oral presentation)
30/9-1/10 2016 - XVII AIBG Congress Cagliari (Oral presentation)
3-5/10/2016 - IRB Barcelona BioMed Conference on "Epithelial transitions and cell migration; Learning from development to tackle disease" - Barcellona (Poster presentation)
29-30/10/2015 Coding and non-coding functions of the genome - Barcellona
17-19/9/2015 ABCD meeting - Bologna (Oral presentation)
7/9/2015 - RNA day 2015, the multi-faceted non coding RNA landscape Roma (Oral presentation)
24/6/2015 Course Il regolamento europeo sulla sperimentazione clinica, quali implicazioni sulla ricerca clinica indipendente? Quale impatto per i CE? Roma
29/10/2014 - Epigen Chromatin Seminar - Roma
1/10/2014 - Exploring the epigenome in health and disease - Roma
24-25-26-27/9/2014 - Congress FISV 2014- Pisa (Oral presentation)
23/6/2014 - International workshop on metabolism, diet and chronic disease - Roma
18/3/2014 - Epigen Chromatin Seminar Epigenetic regulation & ncRNA - Roma
13-14-15-16/11/2013 - Conference 6° International Epithelial-Mesenchymal transition meeting - Alicante
12-13/9/2013 - Conference RNA day 2013,the centrality of non coding RNA in gene-regulation - Roma (Oral presentation)
21-22-23-24/5/2013 - Course Epigenetic Rome Training School - Roma.
24/10/2012 - Workshop Biotecnologie, normativa e sicurezza organized by INAIL and Ministery of health- Roma
12-13-14/10/2012 - 9° annual meeting IIM- Acaya, Lecce. (Oral presentation)
24-25-26-27/9/ 2012 - 12° Congress FISV- Roma.
24-25-26/5/2012 - Frontiers in molecular biology congress SIBBM- Palermo. (Oral presentation)
13/4/2012 - Symposium BEMM - Roma. (Oral presentation)
20-21-22/10/2011 - Joint National Ph.D. Meeting- Gubbio.
1-5/6/2011 - Conference EMBO Chromatin and Epigenetics - Heidelberg
25-26/11/2010 Course Associazione Genetica Italiana Le malattie genetiche: Genetica, Epigenetica e altro - Cortona.
28-31/8/2010 - 9° Conference EMBL Transcription and Chromatin - Heidelberg
7-9/6/2010 - 22° Symposium Pasteur-Weizmann Stem cells: from basic biology to translational medicine - Roma
19-23/4/2010 - 9° Advanced course Cellule staminali tumorali: il vero bersaglio nella cura dei tumori - Collegio Ghislieri, Pavia.
3-4/12/2009 - Chromatin remodeling and human disease- First IRE annual workshop - Roma.
17-18/9/2009 Epigenetics World Congress - Berlin.
4-5-6/6/2009 Frontiers in molecular biology Congresso SIBBM- Napoli. (Oral presentation)

AWARDS
2018- AIRC award
2014- 3 years research fellowship from Sapienza University (AIRC project)
2013- TEMTIA award
2013- Research fellowship from Sapienza University
2012- IIM award
2012- SIBBM award
2012- Research fellowship from Sapienza University
2011- EMBO award
2010- Collegio Ghislieri award
2008- MIURST 3 years research PhD student fellowship

LIST OF PUBLICATIONS
1) Busanello A *, Battistelli C *, Carbone M, Mostocotto C, Maione R.
MyoD regulates p57kip2 expression by interacting with a distant cis-element and modifying a higher order chromatin structure. Nucleic Acids Res. 2012 Sep 1;40(17):8266-75.Epub 2012 Jun 26. PubMed PMID: 22740650; PubMed Central PMCID: PMC3458561. IF: 9.112
* Joint first authors
2) Montaldo C, Mattei S, Baiocchini A, Rotiroti N, Del Nonno F, Pucillo LP, Cozzolino AM, Battistelli C, Amicone L, Ippolito G, van Noort V, Conigliaro A, Alonzi T, Tripodi M, Mancone C.
Spike-in SILAC proteomic approach reveals the vitronectin as an early molecular signature of liver fibrosis in hepatitis C infections with hepatic iron overload. Proteomics. 2014 May;14(9):1107-15. doi: 10.1002/pmic.201300422. PubMed PMID: 24616218. IF: 3.807
3) Battistelli C, Busanello A, Maione R.
Functional interplay between MyoD and CTCF in regulating long-range chromatin interactions during differentiation. J Cell Sci. 2014 Sep 1;127(Pt 17):3757-67. doi: 10.1242/jcs.149427. Epub 2014 Jul 7. PubMed PMID: 25002401. IF: 5.432
4) Mostocotto C *, Carbone M *, Battistelli C, Ciotti A, Amati P, Maione R.
Poly(ADP-ribosyl)ation is required to modulate chromatin changes at c-MYC promoter during emergence from quiescence. PLoS One. 2014 Jul 21;9(7):e102575. doi: 10.1371/journal.pone.0102575. eCollection 2014. PubMed PMID: 25047032; PubMed Central PMCID: PMC4105440. IF: 3.234
* Joint first authors
5) C. Cicchini *, V. De Nonno *, C. Battistelli, A. M. Cozzolino, M. De Santis Puzzonia, S. A. Ciafrè, L. Amicone and M. Tripodi.
Epigenetic control of EMT/MET dynamics: HNF4a impacts DNMT3s through miRs-29. Biochim Biophys Acta. 2015 Aug;1849(8):919-29. doi: 10.1016/j.bbagrm.2015.05.005. Epub 2015 May 21. IF: 6.332
* Joint first authors
6) A. M. Cozzolino, V. Noce, C. Battistelli, A. Marchetti, G. Grassi, C. Cicchini, M. Tripodi and L. Amicone
Modulating the Substrate Stiffness to Manipulate Differentiation of Resident Liver Stem Cells and to Improve the Differentiation State of Hepatocytes. Stem Cells International
Volume 2016 (2016), Article ID 5481493 http://dx.doi.org/10.1155/2016/5481493 IF: 2.813
7) R. Strippoli, R. Moreno-Vicente, C. Battistelli, C. Cicchini, V. Noce, L. Amicone, A. Marchetti, M. A. del Pozo and M. Tripodi
Molecular Mechanisms Underlying Peritoneal EMT and Fibrosis. Stem Cells International Volume 2016 (2016), Article ID 3543678, http://dx.doi.org/10.1155/2016/3543678 IF: 2.813
8) C. Cicchini, C. Battistelli and M. Tripodi
SETDB1 is a new promising target in HCC therapy. Chin Clin Oncol. 2016 Dec;5(6):73. doi: 10.21037/cco.2016.05.04.
9) C. Battistelli *, C. Cicchini *, L. Santangelo, A. Tramontano, L. Grassi, F. J. Gonzalez, V. de Nonno, G. Grassi, L. Amicone and M. Tripodi.
The interaction between Snail and the lncRNA HOTAIR governs Ezh2-mediated epigenetic modifications during EMT. Oncogene. 2017 Feb 16;36(7):942-955. doi: 10.1038/onc.2016.260 IF: 8.459
* Joint first authors
10) L. Santangelo *, G. Giurato *, C. Cicchini, C. Montaldo, C. Mancone, R. Tarallo, C. Battistelli, T. Alonzi, A. Weisz and M. Tripodi
The RNA binding protein SYNCRIP is a component of the exosomal machinery controlling
microRNAs sorting. Cell Rep. 2016 Oct 11;17(3):799-808. doi: 10.1016/j.celrep.2016.09.031. IF: 8.358
* Joint first authors
11) O. Andresini *, A. Ciotti *, M.N. Rossi, C. Battistelli and R. Maione
DNA methylation at the KvDMR1 region controls the induction of p57 in muscle cells. Epigenetics. 2016 Nov;11(11):791-803. IF: 4.780
* Joint first authors
12) L. Santangelo, C. Battistelli, C. Montaldo, F. Citarella, R. Strippoli and C. Cicchini
Functional Roles and Therapeutic Applications of Exosomes in Hepatocellular Carcinoma. Biomed Res Int. 2017;2017:2931813. doi: 10.1155/2017/2931813. IF: 1.579
13) C. Battistelli, M. Tripodi and C. Cicchini
Targeting of polycombs to DNA in EMT
Oncotarget, 2017, Vol. 8, (No. 35), pp: 57936-57937 IF: 5.168
14) P. Magistri *, C. Battistelli *, G. Toietta *, R. Strippoli, A. Sagnotta, A. Forgione, F. Di Benedetto, S. Uccini, P. Vittorioso, F. D Angelo, P. Aurello, G. Ramacciato and G. Nigri
In vivo bioluminescence-based monitoring of liver metastases from colorectal cancer: an experimental model
Journal of Microscopy and Ultrastructure doi: 10.1016/j.jmau.2017.08.001
* Joint first authors
15) Magistri P, Battistelli C, Assirati G, Mereu F, Tarantino G, Guerrini GP, Ballarin R, Di Benedetto F.
Promotion of proliferation and metastasis of hepatocellular carcinoma by LncRNA00673 based on the targeted-regulation of notch signaling pathway.
Eur Rev Med Pharmacol Sci. 2017 Oct;21(19):4261-4262.
16) Magistri P*, Battistelli C*, Strippoli R*, Petrucciani N, Pellinen T, Rossi L, Mangogna L, Aurello P, D'Angelo F, Tripodi M, Ramacciato G, Nigri G. * Joint first authors
SMO Inhibition Modulates Cellular Plasticity and Invasiveness in Colorectal Cancer.
Front Pharmacol. 2018 Feb 2;8:956. doi: 10.3389/fphar.2017.00956. eCollection 2017.IF: 4.400
17) Rossi L*, Battistelli C*, de Turris V, Noce V, Zwergel C, Valente S, Moioli A, Manzione A, Palladino M, Bordoni V, Domenici A, Menè P, Mai A, Tripodi M, Strippoli R.* Joint first authors
HDAC1 inhibition by MS-275 in mesothelial cells limits cellular invasion and promotes MMT reversal
Sci Rep. 2018 May 31;8(1):8492. doi: 10.1038/s41598-018-26319-2. IF: 4.259
18) Barbara Fazi, Sabrina Garbo, Nicola Toschi, Annunziato Mangiola, Malinska Lombari, Daria Sicari, Cecilia Battistelli, S Galardi, Alessandro Michienzi, Gianluca Trevisi, Rona HarariSteinfeld,
Carla Cicchini, Silvia Anna Ciafre
The lncRNA H19 positively affects the tumorigenic properties of glioblastoma cells and contributes to NKD1 repression through the recruitment of EZH2 on its promoter
Oncotarget. 2018 Feb 14;9(21):15512-15525. doi: 10.18632/oncotarget.24496. eCollection 2018 Mar 20. IF: 5.168
19) Fruzsina Hobor, Andre Dallmann, Neil J. Ball, Carla Cicchini, Cecilia Battistelli, Roksana W. Orgrodowicz, Evangelos Christodoulou, Stephen R. Martin, Alfredo Castello, Marco Tripodi, Ian A. Taylor, Andres Ramos
A cryptic RNA-binding domain mediates Syncrip recognition and exosomal partitioning of miRNA targets
Nat Commun. 2018 Feb 26;9(1):831. doi: 10.1038/s41467-018-03182-3. IF: 12.124
20) Laura Santangelo, Veronica Bordoni, Claudia Montaldo, Eleonora Cimini, Alessandra Zingoni, Cecilia Battistelli, Gianpiero D Offizi, Maria Rosaria Capobianchi, Angela Santoni, Marco Tripodi, Chiara Agrati
Hepatitis C virus direct-acting antivirals therapy impacts on extracellular vesicles microRNAs content and on their immunomodulating properties.
Liver Int. 2018 Jan 22. doi: 10.1111/liv.13700. IF: 4.5
21) Cecilia Battistelli, Giovanna Sabarese, Laura Santangelo, Claudia Montaldo, Frank J. Gonzalez, Marco Tripodi, Carla Cicchini
The lncRNA HOTAIR transcription is controlled by HNF4 -induced chromatin topology modulation
Cell Death Differ. 2018 Aug 28. doi: 10.1038/s41418-018-0170-z. IF: 8
22) Stazi Giulia*; Battistelli Cecilia*; Piano Valentina*; Mazzone Roberta; Marrocco Biagina; Louie Sharon; Zwergel Clemens; Antonini Lorenzo; Patsilinakos Alexandros; Ragno Rino; Viviano Monica; Sbardella Gianluca; Strippoli Raffaele; Marchetti Alessandra; Tripodi Marco; Nomura Daniel; Mattevi Andrea; Mai Antonello; Valente Sergio
Development of Alkyl Glycerone Phosphate Synthase Inhibitors: Structure-Activity Relationship and Effects on Ether Lipids and Epithelial-Mesenchymal Transition in Cancer Cells
* Joint first authors
European Journal Of Medicinal Chemistry IF: 4.816

PUBLICATIONS UNDER REVISION:
1) YAP integrates the regulatory Snail/HNF4 circuitry determining liver cell fate
Authors: Valeria Noce, Cecilia Battistelli, Angela Maria Cozzolino, Carla Cicchini, Raffaele Strippoli,
Marco Tripodi, Alessandra Marchetti and Laura Amicone
2) Identification of a Novel Quinoline-Based Compound Highly Potent in Cancer Cells
Authors: Clemens Zwergel, Michael Schnekenburger, Federica Sarno, Cecilia Battistelli, Maria Cristina Manara, Giulia Stazi, Roberta Mazzone, Rossella Fioravanti,1 Christina Gros, Frédéric Ausseil, Cristina Florean, Angela Nebbioso, Raffaele Strippoli, Toshikazu Ushijima, Katia Scotlandi, Marco Tripodi, Paola B. Arimondo, Lucia Altucci, Marc Diederich, Antonello Mai and Sergio Valente

DIDACTIC ACTIVITY
1) Tecniche ortopediche (abilitante alla professione sanitaria di Tecnico ortopedico) - Roma Azienda Ospedaliera Sant Andrea L/SNT3
Cod. 30023
Teaching: Biology (cod. 1056296)
CFU: 2
Structure: SCIENZE MEDICO-CHIRURGICHE E DI MEDICINA TRASLAZIONALE
a.a. 2018-2019
2) Tecniche di fisiopatologia cardiocircolatoria e perfusione cardiovascolare (abilitante alla professione sanitaria di Tecnico di fisiopatologia cardiocircolatoria e perfusione cardiovascolare) - Roma Azienda Policlinico Umberto I L/SNT3
Cod. 29996
Teaching: Applied Biology (cod. 1035043)
CFU: 2
Structure: SCIENZE CARDIOVASCOLARI, RESPIRATORIE, NEFROLOGICHE, ANESTESIOLOGICHE E GERIATRICHE
a.a. 2018-2019
3) Medicina e chirurgia 'C' LM-41
Cod. 30007
Teaching: Biology and Genetics I Cellular Biology (cod. 1026264)
CFU: 2 of 4
Structure: SCIENZE RADIOLOGICHE, ONCOLOGICHE E ANATOMO-PATOLOGICHE
a.a. 2018-2019

Titolo Rivista Anno
Molecular mechanisms and new therapeutic targets in epithelial to mesenchymal transition (EMT) and fibrosis FRONTIERS IN PHARMACOLOGY 2020
Novel quinoline compounds active in cancer cells through coupled DNA methyltransferase inhibition and degradation CANCERS 2020
Design of first-in-class dual EZH2/HDAC inhibitor: biochemical activity and biological evaluation in cancer cells ACS MEDICINAL CHEMISTRY LETTERS 2020
Discovery of phenylselenoether-hydantoin hybrids as ABCB1 efflux pump modulating agents with cytotoxic and antiproliferative actions in resistant T-lymphoma EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY 2020
Caveolin1 and YAP drive mechanically induced mesothelial to mesenchymal transition and fibrosis CELL DEATH & DISEASE 2020
Poly(ADP-ribose) Polymerase 1 (PARP1) restrains MyoD-dependent gene expression during muscle differentiation SCIENTIFIC REPORTS 2020
The innovative potential of selenium-containing agents for fighting cancer and viral infections DRUG DISCOVERY TODAY 2020
Design and functional validation of a mutant variant of the lncRNA HOTAIR to counteract Snail function in Epithelial-to-Mesenchymal Transition CANCER RESEARCH 2020
Nutlin-3a enhances natural killer cell-mediated killing of neuroblastoma by restoring p53-dependent expression of ligands for NKG2D and DNAM-1 receptors CANCER IMMUNOLOGY RESEARCH 2020
Development of alkyl glycerone phosphate synthase inhibitors: Structure-activity relationship and effects on ether lipids and epithelial-mesenchymal transition in cancer cells EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY 2019
Identification of a novel quinoline-based DNA demethylating compound highly potent in cancer cells CLINICAL EPIGENETICS 2019
TGFβ impairs HNF1α functional activity in Epithelial-to-Mesenchymal Transition interfering with the recruitment of CBP/p300 acetyltransferases FRONTIERS IN PHARMACOLOGY 2019
YAP integrates the regulatory Snail/HNF4α circuitry controlling epithelial/hepatocyte differentiation CELL DEATH & DISEASE 2019
SMO inhibition modulates cellular plasticity and invasiveness in colorectal cancer FRONTIERS IN PHARMACOLOGY 2018
A cryptic RNA-binding domain mediates Syncrip recognition and exosomal partitioning of miRNA targets NATURE COMMUNICATIONS 2018
Hepatitis C virus direct-acting antivirals therapy impacts on extracellular vesicles microRNAs content and on their immunomodulating properties LIVER INTERNATIONAL 2018
HDAC1 inhibition by MS-275 in mesothelial cells limits cellular invasion and promotes MMT reversal OPEN ACCESS SCIENTIFIC REPORTS 2018
The lncRNA H19 positively affects the tumorigenic properties of glioblastoma cells and contributes to NKD1 repression through the recruitment of EZH2 on its promoter ONCOTARGET 2018
The lncRNA HOTAIR transcription is controlled by HNF4α-induced chromatin topology modulation CELL DEATH AND DIFFERENTIATION 2018
Insegnamento Codice Anno Corso - Frequentare
SCIENZE BIOMEDICHE I 1056296 2020/2021 Tecniche ortopediche (abilitante alla professione sanitaria di Tecnico ortopedico) - Roma Azienda Ospedaliera Sant’Andrea
BASI CELLULARI E MOLECOLARI DELLA VITA 1035043 2020/2021 Tecniche di fisiopatologia cardiocircolatoria e perfusione cardiovascolare (abilitante alla professione sanitaria di Tecnico di fisiopatologia cardiocircolatoria e perfusione cardiovascolare) - Roma Azienda Policlinico Umberto I
BASI MOLECOLARI E CELLULARI DELLA VITA 1034944 2020/2021 Ostetricia (abilitante alla professione sanitaria di Ostetrica/o) - Corso di laurea A - Roma Azienda Policlinico Umberto I
SCIENZE BIOMEDICHE I 1056296 2019/2020 Tecniche ortopediche (abilitante alla professione sanitaria di Tecnico ortopedico)
BASI CELLULARI E MOLECOLARI DELLA VITA 1035043 2019/2020 Tecniche di fisiopatologia cardiocircolatoria e perfusione cardiovascolare (abilitante alla professione sanitaria di Tecnico di fisiopatologia cardiocircolatoria e perfusione cardiovascolare)
BASI MOLECOLARI E CELLULARI DELLA VITA 1034944 2019/2020 Ostetricia (abilitante alla professione sanitaria di Ostetrica/o) ROMA - Corso di laurea A - Azienda Policlinico Umberto I
BASI CELLULARI E MOLECOLARI DELLA VITA 1035043 2018/2019 Tecniche di fisiopatologia cardiocircolatoria e perfusione cardiovascolare (abilitante alla professione sanitaria di Tecnico di fisiopatologia cardiocircolatoria e perfusione cardiovascolare)
SCIENZE BIOMEDICHE I 1056296 2018/2019 Tecniche ortopediche (abilitante alla professione sanitaria di Tecnico ortopedico)
BIOLOGIA E GENETICA 1026264 2018/2019 Medicina e chirurgia 'C'
Dipartimento
MEDICINA MOLECOLARE
SSD

BIO/13