Ritratto di Fabio.Altieri@uniroma1.it

Si avvisano gli studenti le lezioni dei corsi di "Biochimica" (LMCU in Farmacia) e "Biologia Molecolare" (LMCU in CTF) saranno fruibili sia in presenza (compatibilmente con le necessarie misure di sicurezza), sia a distanza in modalità sincrona,

Le lezioni a distanza si svolgeranno in videoconferenza attraverso la piattaforma MEET di Google, seguendo gli orari consueti del corso
 
Per partecipare alla riunione video utilizzare i seguenti link:
 

"Biochimica"   https://meet.google.com/srr-wpoh-brm

 

"Biologia Molecolare"  https://meet.google.com/xyk-kyeg-eiz

A partire dal 16 ottobre le lezioni del corso di "Biologia Molecolare" si terranno sulla piattaforma Zoom al seguente link:

https://uniroma1.zoom.us/j/86026596241?pwd=VGZaTWNxWHdCNkhQazdTMWdqTnNjdz09

 

 

Si consiglia l'uso del browser Chrome

Lun e Ven 11-13 - Mar 15-17
Altri giorni su appuntamento
Dipartimento Scienze Biochimiche (Edificio CU027) piano 2, stanza 202

Dr. Fabio Altieri got on 1981 his Master degree in Biology with honors from the University of Rome Sapienza. On 1986 he got the Ph.D. in Biochemistry, Department of Biochemical Sciences, University of Rome Sapienza. From 1987 to 1989 he worked for two years as Researcher at the School of Basic Life Sciences, University of Missouri-Kansas City USA. On 1991 he was appointed as Researcher, working at the Department of Biochemical Sciences, Sapienza University of Rome and in 2000 was promoted to Associate Professor in Biochemistry, Faculty of Pharmacy, Sapienza University of Rome. Since 2006 is Full Professor in Biochemistry, Faculty of Pharmacy and Medicine, Department of Biochemical Sciences, Sapienza University of Rome. He conducted his research working initially on the characterization of non-histone chromosomal proteins. After that he focused the attention on nuclear protein purification and characterization, protein-protein and protein-DNA interactions. Current research cover the analysis of protein involved in signal transduction, cancer onset and progression, and oxidative stress response, as well as the screening of bioactive compounds and their impact on protein functionality.
Keywords: oxidative stress, cellular biochemistry, signal transduction, protein-ligand interaction, bioactive compounds

ORCID: 000-0002-6546-2738

Selected publications:

Giamogante F, Marrocco I, Cervoni L, Eufemi M, Chichiarelli S, Altieri F.
Punicalagin, an active pomegranate component, is a new inhibitor of PDIA3 reductase activity.
Biochimie. 2018 Feb 6. pii: S0300-9084(18)30034-8. doi: 10.1016/j.biochi.2018.01.008.

Battisti F, Napoletano C, Rahimi Koshkaki H, Belleudi F, Zizzari IG, Ruscito I, Palchetti S, Bellati F, Benedetti Panici P, Torrisi MR, Caracciolo G, Altieri F, Nuti M, Rughetti A.
Tumor-Derived Microvesicles Modulate Antigen Cross-Processing via Reactive Oxygen Species-Mediated Alkalinization of Phagosomal Compartment in Dendritic Cells.
Front Immunol. 2017 Sep 25;8:1179. doi: 10.3389/fimmu.2017.01179. eCollection 2017.

Marrocco I, Altieri F, Peluso I.
Measurement and Clinical Significance of Biomarkers of Oxidative Stress in Humans.
Oxid Med Cell Longev. 2017;2017:6501046. doi: 10.1155/2017/6501046. Epub 2017 Jun 18. Review.

Cocchiola R, Romaniello D, Grillo C, Altieri F, Liberti M, Magliocca FM, Chichiarelli S, Marrocco I, Borgoni G, Perugia G, Eufemi M.
Analysis of STAT3 post-translational modifications (PTMs) in human prostate cancer with different Gleason Score.
Oncotarget. 2017 Jun 27;8(26):42560-42570. doi: 10.18632/oncotarget.17245.

Coccurello R, Romano A, Giacovazzo G, Tempesta B, Fiore M, Giudetti AM, Marrocco I, Altieri F, Moles A, Gaetani S.
Increased intake of energy-dense diet and negative energy balance in a mouse model of chronic psychosocial defeat.
Eur J Nutr. 2017 Mar 17. doi: 10.1007/s00394-017-1434-y.

Giamogante F, Marrocco I, Romaniello D, Eufemi M, Chichiarelli S, Altieri F
Comparative Analysis of the Interaction between Different Flavonoids and PDIA3
Oxidative Medicine and Cellular Longevity, vol. 2016, Article ID 4518281, 12 pages, 2016.
doi:10.1155/2016/4518281

Gaucci E, Raimondo D, Grillo C, Cervoni L, Altieri F, Nittari G, Eufemi M, Chichiarelli S.
Analysis of the interaction of calcitriol with the disulfide isomerase ERp57.
Sci Rep. 2016 Nov 29;6:37957.
doi: 10.1038/srep37957. PubMed PMID: 27897272.

Cocchiola R, Grillo C, Altieri F, Chichiarelli S, Turano C, Eufemi M.
Upregulation of TPX2 by STAT3: identification of a novel STAT3 binding site.
PLoS One. 2014 Nov 17;9(11):e113096.
doi: 10.1371/journal.pone.0113096. PubMed PMID:25401333; PubMed Central PMCID: PMC4234655.

Peluso I, Manafikhi H, Altieri F, Zanza C, Palmery M.
The effect of sample storage on the Peroxidation of Leukocytes Index Ratio (PLIR) measure.
Sci Rep. 2014 Oct 7;4:6539.
doi: 10.1038/srep06539. PubMed PMID: 25290094.

Bedse G, Colangeli R, Lavecchia AM, Romano A, Altieri F, Cifani C, Cassano T, Gaetani S.
Role of the basolateral amygdala in mediating the effects of the fatty acid amide hydrolase inhibitor URB597 on HPA axis response to stress. Eur
Neuropsychopharmacol. 2014 Sep;24(9):1511-23.
doi:10.1016/j.euroneuro.2014.07.005. PubMed PMID: 25106694.

Grillo C, Chichiarelli S, Gaucci E, Altieri F, Turano C, Cervoni L.
The binding of silibinin to ERp57.
Chem Biol Interact. 2014 Apr 25;213:37-43.
doi:10.1016/j.cbi.2014.02.005. PubMed PMID: 24530445.

Bedse G, Romano A, Cianci S, Lavecchia AM, Lorenzo P, Elphick MR, Laferla FM, Vendemiale G, Grillo C, Altieri F, Cassano T, Gaetani S.
Altered expression of the CB1 cannabinoid receptor in the triple transgenic mouse model of Alzheimer's disease.
J Alzheimers Dis. 2014;40(3):701-12.
doi: 10.3233/JAD-131910. PubMed PMID: 24496074.

Cocchiola R, Grillo C, Altieri F, Chichiarelli S, Turano C, Eufemi M.
Upregulation of TPX2 by STAT3: identification of a novel STAT3 binding site.
PLoS One. 2014, 9(11):e113096. doi: 10.1371/journal.pone.0113096.

Grillo C, Chichiarelli S, Gaucci E, Altieri F, Turano C, Cervoni L.
The binding of silibinin to ERp57.
Chem Biol Interact. 2014, 213:37-43. doi: 10.1016/j.cbi.2014.02.005.

Gaucci E, Altieri F, Turano C, Chichiarelli S.
The protein ERp57 contributes to EGF receptor signaling and internalization in MDA-MB-468 breast cancer cells.
J Cell Biochem. 2013, 114(11):2461-70. doi: 10.1002/jcb.24590.

Trnková L, Ricci D, Grillo C, Colotti G, Altieri F.
Green tea catechins can bind and modify ERp57/PDIA3 activity.
Biochim Biophys Acta 2013, 1830:2671-2682.

Sciandra F, Angelucci E, Altieri F, Ricci D, Hübner W, Petrucci TC, Giardina B, Brancaccio A, Bozzi M.
Dystroglycan is associated to the disulfide isomerase ERp57.
Exp Cell Res. 2012, 318: 2460-2469.

Frasconi M, Chichiarelli S, Gaucci E, Mazzei F, Grillo C, Chinazzi A, Altieri F.
Interaction of ERp57 with calreticulin: Analysis of complex formation and effects of vancomycin.
Biophys Chem. 2012, 160(1):46-53. doi: 10.1016/j.bpc.2011.09.003.

Vascotto C, Bisetto E, Li M, Zeef LA, D'Ambrosio C, Domenis R, Comelli M, Delneri D, Scaloni A, Altieri F, Mavelli I, Quadrifoglio F, Kelley MR, Tell G.
Knock-in reconstitution studies reveal an unexpected role of Cys-65 in regulating APE1/Ref-1 subcellular trafficking and function.
Mol Biol Cell. 2011, 22: 3887-3901.

Titolo Rivista Anno
Potentiation of low-dose doxorubicin cytotoxicity by affecting p-glycoprotein through caryophyllane sesquiterpenes in hepg2 cells: an in vitro and in silico study INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 2020
Discovery of the first human arylsulfatase a reversible inhibitor impairing mouse oocyte fertilization ACS CHEMICAL BIOLOGY 2020
Oleoylethanolamide decreases frustration stress-induced binge-like eating in female rats: a novel potential treatment for binge eating disorder NEUROPSYCHOPHARMACOLOGY 2020
Insights into ppar?phosphorylation and its inhibition mechanism JOURNAL OF MEDICINAL CHEMISTRY 2020
Pdia3 expression in glioblastoma modulates macrophage/microglia pro-tumor activation INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 2020
Influence of ellagitannins extracted by pomegranate fruit on disulfide isomerase PDIA3 activity NUTRIENTS 2019
STAT3 post-translational modifications drive cellular signaling pathways in prostate cancer cells INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 2019
Shmt2: a stat3 signaling new player in prostate cancer energy metabolism CELLS 2019
beta-HEXACHLOROCYCLOHEXANE MAY INDUCE HORMONE RESISTANCE IN PROSTATE CANCER 2019
Increased intake of energy-dense diet and negative energy balance in a mouse model of chronic psychosocial defeat EUROPEAN JOURNAL OF NUTRITION 2018
New insights in the antitumor effects of ?-caryophyllene in breast cancer cells: The role of cannabinoid and adrenergic systems ANNALS OF ONCOLOGY 2018
Punicalagin, an active pomegranate component, is a new inhibitor of pdia3 reductase activity BIOCHIMIE 2018
STAT3, a hub protein of cellular signaling pathways, is triggered by ?-hexaclorocyclohexane INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 2018
STAT3 is a hub protein of cellular signalling pathways triggered by persistent organochlorine pollutants (POPs) 2018
The role of AhR signalling pathways triggered by ?-HCH in the progression of prostate cancer 2018
The natural sesquiterpene ?- caryophyllene acts as an enviromental decontaminant through the interference with the STAT3 signalling pathway 2018
Punica granatum L.: colorimetric CIEL*a*b* analysis, HPLC-DAD analysis and bioactivity on PDIA3 evaluation of phytocomplex components 2018
Analysis of stat3 post-translational modifications (ptms) in human prostate cancer with different gleason scores ONCOTARGET 2017
Tumor-derived microvesicles modulate antigen cross-processing via reactive oxygen species-mediated alkalinization of phagosomal compartment in dendritic cells FRONTIERS IN IMMUNOLOGY 2017
Measurement and clinical significance of biomarkers of oxidative stress in humans OXIDATIVE MEDICINE AND CELLULAR LONGEVITY 2017
Insegnamento Codice Anno Corso - Frequentare
BIOLOGIA MOLECOLARE 1011772 2020/2021 Chimica e tecnologia farmaceutiche
BIOCHIMICA 1022436 2020/2021 Farmacia
BIOTECNOLOGIE BIOCHIMICHE E FARMACEUTICHE 10589767 2020/2021 Biotecnologie Farmaceutiche
BIOLOGIA MOLECOLARE 1011772 2019/2020 Chimica e tecnologia farmaceutiche
BIOCHIMICA 1022436 2019/2020 Farmacia
BIOTECNOLOGIE BIOCHIMICHE E FARMACEUTICHE 10589767 2019/2020 Biotecnologie Farmaceutiche
BIOLOGIA MOLECOLARE 1011772 2018/2019 Chimica e tecnologia farmaceutiche
BIOCHIMICA 1022436 2018/2019 Farmacia
BIOTECNOLOGIE BIOCHIMICHE E FARMACEUTICHE 10589767 2018/2019 Biotecnologie Farmaceutiche
BIOLOGIA MOLECOLARE 1011772 2017/2018 Chimica e tecnologia farmaceutiche
BIOCHIMICA 1022436 2017/2018 Farmacia
ENZIMOLOGIA E BIOCHIMICA INDUSTRIALE 1022406 2017/2018 Biotecnologie Farmaceutiche
BIOCHIMICA CELLULARE E FUNZIONALE 1026262 2017/2018 Biotecnologie Farmaceutiche
ENZIMOLOGIA E BIOCHIMICA INDUSTRIALE 1022406 2016/2017 Biotecnologie Farmaceutiche
BIOCHIMICA 1022436 2016/2017 Farmacia
BIOLOGIA MOLECOLARE 1011772 2016/2017 Chimica e tecnologia farmaceutiche
BIOCHIMICA CELLULARE E FUNZIONALE 1026262 2016/2017 Biotecnologie Farmaceutiche
Facoltà
Farmacia e Medicina
Dipartimento
SCIENZE BIOCHIMICHE "ALESSANDRO ROSSI FANELLI"
SSD

BIO/10