I contenuti del catalogo per l'a.a. 2022-2023 sono in corso di aggiornamento

Ritratto di Isabella.Saggio@uniroma1.it

Di seguito i link per accedere alla stanza meet per le lezioni dei corsi, secondo il relativo calendario didattico:

 

TERAPIA GENICA E NEUROSCIENZE: LM Neurobiologia - Neurobiology;
 

- GENE THERAPY: LM Genetica e Biologia Molecolare - Genetics and Molecular Biology;

 

- PROCESSI COMUNICATIVI SCIENZA E MEDICINA: LM Comunicazione scientifica biomedica.

 

 

Insegnamento Codice Anno Corso - Frequentare Bacheca
TERAPIA GENICA E NEUROSCIENZE 10592897 2021/2022
GENE THERAPY 1051858 2021/2022
PROCESSI COMUNICATIVI SCIENZA E MEDICINA 1041834 2021/2022
PROCESSI COMUNICATIVI SCIENZA E MEDICINA 1041834 2021/2022
GENE THERAPY 1051858 2020/2021
TERAPIA GENICA E NEUROSCIENZE 10592897 2020/2021
BIOLOGIA DELLE CELLULE STAMINALI E APPLICAZIONI 1056104 2020/2021
GENE THERAPY 1051858 2019/2020
TERAPIA GENICA E NEUROSCIENZE 10592897 2019/2020
BIOLOGIA DELLE CELLULE STAMINALI E APPLICAZIONI 1056104 2019/2020
LE NUOVE FRONTIERE DELLA BIOMEDICINA NELLA GENETICA E NELLE NEUROSCIENZE 1041407 2019/2020
GENE THERAPY 1051858 2018/2019
LE NUOVE FRONTIERE DELLA BIOMEDICINA NELLA GENETICA E NELLE NEUROSCIENZE 1041407 2018/2019
BIOLOGIA DELLE CELLULE STAMINALI E APPLICAZIONI 1056104 2018/2019
LE NUOVE FRONTIERE DELLA BIOMEDICINA NELLA GENETICA E NELLE NEUROSCIENZE 1041407 2017/2018
GENE THERAPY 1051858 2017/2018
BIOLOGIA DELLE CELLULE STAMINALI E APPLICAZIONI 1056104 2017/2018
LE NUOVE FRONTIERE DELLA BIOMEDICINA NELLA GENETICA E NELLE NEUROSCIENZE 1041407 2016/2017
GENE THERAPY 1051858 2016/2017

Contattare via email per un appuntamento.
Please send email for making an appointment.

Education
1993 PhD Genetics and Molecular Biology Sapienza University
1988 Laurea full marks cum laude Genetics Sapienza University

Academic appointments
2017 National scientific qualification Full Professor of Genetics 05/I1-BIO/18 (passed 3/3)
2017 to date Visiting Professor College of Science Nanyang Technological University of Singapore
2005 to date Associate Professor of Genetics BIO/18 Sapienza University
1996 2004 Assistant Professor of Genetics BIO/18 Sapienza University

Research appointments
2020 to date Associate scientist CNR Institute of molecular biology and pathology
2015 2017 Visiting scientist Nanyang Technological University of Singapore
2010 Jan Visiting scientist as CNR fellow Pasteur Institute Paris France
2008 Sept Visiting scientist as CNR fellow Salk Institute La Jolla CA USA
2004 Jan Feb Visiting scientist as CNR fellow Lyon Laennec University France
2003 2018 Associate scientist CNR Institute of molecular biology and pathology
2003 2010 Associate scientist and group leader San Raffaele Science Park Rome
1995 1996 EU postdoctoral fellow Gustave Roussy Institute Paris France
1991 1994 PhD fellow IRBM MSD Research Institute Rome Italy
1989 1990 Researcher (in 1990 with permanent position group B) National Institute of Health Rome Italy

Other appointments
2021 to date Selected member Sc MMFFNN Faculty outreaching committee Sapienza University
2021 to date Selected member Center for preclinical research and animal welfare Sapienza University
2019 to date Director International Winter School Genetics and Molecular Medicine 3CFU Sapienza University
2019 to date Selected member Strategic board Dept. Biology and Biotechnology Sapienza University
2019 to date Third mission delegate Dept. Biology and Biotechnology Sapienza University
2019 to date Vice president, delegate for internationalization Master degree of Genetics and
Molecular Biology Sapienza University
2017 2022 Founder and co-director Stem cell and genome editing in memoriam of Paolo Bianco
Master degree 60CFU (in English) Sapienza University
2016 to date Selected member Superior School of Advanced Studies Sapienza University
2016 to date Promoter and coordinator Sapienza University/Nanyang Technological University of Singapore agreements (for teacher
mobility, student mobility and framework agreement)
2015 2016 Selected member Sapienza committee for evaluation of scientific projects
2011 to date Promoter and coordinator Double Degree Sapienza University with Master en Génétique Université de Paris
2008 to date Board member PhD school in Genetics and Molecular Biology Sapienza University
2005 to date Director Master degree of Science Journalism 60CFU Sapienza University
2005 to date Erasmus project coordinator Sapienza University/Université de Paris, >100 outgoing and incoming students

Grants as PI -principal Investigator or I-investigator
2022-2026 PNRR Centro Nazionale Biodiversità, spoke co-coordinator;
first evaluation concluded, pending final evaluation 4100K
2022-2023 Pasteur Cenci Bolognetti 2020 Nuclear Envelope and Cancer, positive evaluation PI;
pending funding 40000
2021 2026 AIRC IG Nuclear Envelope and telomere stability in lymphomagenesis PI 432000
2017 2020 Progeria Research Foundation USA Progerias PI 150000$
2016 Telethon EG project AKTIP and progerias PI 45404
2015 2018 AIRC IG Telomeric genes I 446000
2013 2016 EU FP7 Marie Curie Industry-Academia IAPP Brainvectors - Gene therapy PI 38776
2007 2012 EU FP7 BrainCAV -Gene therapy PI and work-package leader 227376
2006 2018 Sponsoring MSD, Pfizer, Abbott, Novartis, Roche to Science communication initiatives PI avg5000 /year
2006 2007 MIUR PRIN Modeling and correcting organogenetic and pathogenetic
skeletal processes using stem cells I 25000
2004 2009 Telethon IG Stem cell disease fibrous dysplasia I 320000
2004 MIUR 6-2000 Science communication PI 20000
2004 2021 MIUR Sapienza internal annual funding PI avg 4000 /year
2002 MIUR 6-2000 Openlab PI 20milioni lire
2001 2002 Inter-University Biotechnology Consortium Phage vectors for gene transfer PI 200milioni lire
2000 2001 Pasteur Cenci Bolognetti Phage technology for the study of
Adenovirus-receptor interaction PI 20milioni lire
2000 2001 SIGMA TAU Adenoviral vectors for gene therapy PI 400milioni lire
2000 CNR Structure-function analysis of Adenovirus penton base PI 30milioni lire

Grants to I. Saggio lab members (selection)
2021 Be for ERC When Borders Lose integrity: study of the impact of Nuclear Envelope
and telomere fragility in lymphomagenesis (BLiNET) 50000
2019 Buzzati Traverso Foundation 2019 Nuclear envelope organization
and genome instability in cancer diffusion 20000
2019 Veronesi Foundation 2019 Nuclear envelope organization
and genome instability in cancer diffusion 15000
2019 FIRC Nuclear envelope organization and genome instability in cancer diffusion 25000
2012 Pasteur Cenci Bolognetti Telomeric genes 18600
2012 Inter-University Biotechnology Consortium Comparative investigation of
the toxicogenomic signature of adenovirus vectors 10000
2010 Sapienza AST Gene therapy of neurodegenerative disorders 19000

Revision of projects (selection)
2020 USA-Israel Binational Science Foundation
2019 Dutch Research council
2019 Medical Research Council UK
2019 to date Transnational research projects to accelerate diagnosis and/or explore
disease progression and mechanisms of rare diseases
2017 Leonardo da Vinci EU programme
2015 2016 Italian Ministry of University and Research MIUR
2014 INSERM-CNRS ATIP Avenir, France
2008 to date Association Nationale Recherche (ANR) France
2008 Université de Montpellier
2007 2009 Unity Through Knowledge Fund

Society memberships
2019 to date Elected counselor in the board of the Italian Association of Genetics (AGI)
2000 2014 Member European Association of Gene and Cell Therapy (ESGCT),
American Society of Gene Therapy (ASGT), American Society of Bone and Mineral Research (ASBMR)
2000 to date Member Italian Association of Genetics (AGI), Italian Federation of Life Sciences (FISV)

National teaching experience
2021 2022 Communication processes in science and medicine Sapienza University, BIO/18 (9CFU)
2018 to date Genetic medicine Superior School of Advanced studies Sapienza University, BIO/18 (3CFU)
2017 2018 Models in biology Superior School of Advanced studies Sapienza University (3CFU)
2017 2021 The biology of stem cells and their applications Sapienza University, BIO/18 (3CFU)
2013 to date Gene therapy and Neuroscience Sapienza University, BIO/18 (6CFU)
2001 to date Gene Therapy Sapienza University (in English), BIO/18 (6CFU)
2001 2013 Genetics Sapienza, University, BIO/18
2001 2005 Genetics University of Urbino, BIO/18
2001 to date Thesis tutoring > 20 graduate students, >15 PhD students and >100 Master students
2001 to date Young researcher mentoring (selection - name and current position) Y Martina Vice president Grünenthal Group London
UK, G Cherubini Permanent position Achilles Therapeutics London UK, R Burla CNR permanent position Rome Italy, E Di
Matteo permanent position Nuscom Rome Italy, S Del Giudice fellow CNR Naples Italy, L Astrologo Research associate
University of Bern Switzerland, P Caruso Research associate University of Cambridge UK

International teaching experience
2021 Lecture 3D structured illumination microscopy for studies on nuclear integrity and cancer invasion CIVIS - Project for
a European Civic University
2017 to date Visiting professor Nanyang Technological University of Singapore College of Science (6-8 weeks per year)
2011 to date Gene Therapy Université de Paris France (1CFU per year)
2011 to date Stage and thesis tutoring of >20 foreign students
2011 to date Member of thesis committees at Master Génétique Université de Paris France

Science communication, outreaching and public engagement
2022 Founder and Director STAR, Sapienza magazine for scientific culture ISSN 2785-5058
2021 Director Public speaking Advanced training course, 1CFU Sapienza University
2021 Director Science and Democracy 3CFU Advanced training course Sapienza University
2021 La scienza nella pratica giornalistica. 2015-2019 case study for Sapienza University
2021 Registered Journalist at the Italian Bar Association of Journalists
2021 Director Creating a journal, Advanced training course 3CFU Sapienza University of Rome
2018 to date Organizer Public speaking course PhD School Genetics and Molecular Biology Sapienza University
2016 to date Organizer of >30 meetings for >800 journalists, recognized as educational CFPs
by the National association of journalism (ODG)
2015 to date Founder and Director online journal Stoccolmaaroma (40,000 visitors/year)
2012 to date Media (selection) Saggio I. Quante Storie RAI TV (2022); Saggio I. Le parole per dirlo RAI TV (2021); Saggio I. Genetics in
the history of science RAI TV (2021); Saggio I. Intimations of immortality (2016) Longitude Italian Monthly on World Affairs.
#63; Saggio I. Ebola: What is to be done? (2014) Longitude Italian Monthly on World Affairs. #43; Saggio I. Keeping
resistance at bay. (2013) Longitude Italian Monthly on World Affairs. #27; Saggio I. Deadly friends. (2012) Longitude Italian
Monthly on World Affairs. #06; Saggio I. Ce l ho nel Dna (2012) La Stampa
2006 to date Promoter and coordinator of student training agreements between Sapienza Job soul and (selection) CNR, RAI, IFO, INFN,
Telethon, APRE, IGMM CNRS (Montpellier), Institut Pasteur (Paris), IFOM Cogentech (Milan), IEO (Milan), NIH (Bethesda, US)
2005 to date Founder (and Director) Master degree of Science Journalism Sapienza University

Transfer of technology, patents
Saggio I, Di Giovine M, Salone B, Martina Y. Chimeric vectors and their use for gene transfer. Granted Italian and international patent (2002; WO 02/24934)

Laufer R, Saggio I, Gloaguen I, Di Marco A, Demartis A. Variants of human ciliary neurotrophic factor (hCNTF) with improved receptor-selectivity, and methodology for their selection. Granted Italian and international patent. (1998; WO 98/41625)
Ciliberto G, Saggio I, Savino R, Perricaudet M. Adenoviral vectors for mutants of human interleukin 6 (hIL-6) with hIL-6 antagonist activity over hIL-6. Pharmaceutical compositions there with and their uses. Granted Italian and international patent. (1998; WO 98/13383)

Laufer R, Saggio I. Variants of human ciliary neurotrophic factor (hCNTF) with improved receptor binding affinity. Granted Italian patent. (1994; n. 012878094)

Laufer R, Saggio I. Method for production of Filamentous phages displaying on the surface of the capsids peptides capable of binding biotin, and Filamentous phages and peptides thus obtained. Granted Italian patent. (1993; n. 1261693)

Research activities and publications
Activity I: Telomeres and genome integrity in aging and cancer.

I. Saggio identified the first human telomere-associated factor linked with the nuclear envelope. Telomere dysfunction causes genome instability and is a driver of cancer and premature aging (Burla et al Plos Genetics 2015; Cenci et al Plos Genetics 2015; Burla et al Open Biology 2016; La Torre et al Aging Cell 2018, Chen et al. Cell Reports 2019). More recently, building on the link between telomeres and the nuclear envelope, I. Saggio developed new research focusing on the implication of nuclear integrity in aging and cancer. The model systems used by I. Saggio are primarily mammalian cells and mice. In addition, comparative studies were performed in D. melanogaster. Research by I. Saggio and the work of her group have been recognized internationally and she has been funded, as PI, based on open competition and peer reviewing, by national and international agencies, including, in the last 5 years, Telethon, the Progeria Research Foundation USA and AIRC.

1. Mitra A, Burla R, Zeng Y, Hoon NM, Lim CT, Saggio I and Zhao W. (2022) Acute Chromatin Decompaction leads to Stiffening of Nuclear-
Lamina as revealed by Nanoscale Nuclear Deformation. Bio-archives, https://doi.org/10.1101/2022.01.30.478168

2. Merigliano C, Burla R, La Torre M, Del Giudice S, Teo Hsiang L, Chong Wai L, Chojnowski A, Goh WI, Olmos Y, Maccaroni K, Giubettini M,
Chiolo I, Carlton J, Raimondo D, Verni F, Stewart CL, Rhodes D, Wright G, Burke B and Saggio I (2021) Human AKTIP interacts with ESCRT
proteins and functions at the midbody in cytokinesis. Plos Genetics. 17(8):e1009757. IF: 5.917

4. Burla R, La Torre M, Maccaroni K, Verni F, Giunta S and Saggio I (2020). Interplay of the nuclear envelope ith chromatin in physiology and
pathology. Nucleus. Dec11(1):205-218. IF: 2.792

5. Chen L, Roakel CM, Galati A, Bavasso F, Saggio I, Schoeftner S, Cacchione S, Gatti M, Artandi SE, Raffa GD (2020) Loss of human TGS1
hypermethylase promotes increased telomerase RNA and telomere elongation. Cell Reports. 30(5):1358-1372.e5. IF: 8.109

6. Sechi S, Frappaolo A, Karimpour-Ghahnavieh A, Gottardo M, Burla R, Di Francesco L, Szafer-Glusman E, Schininà E, Fuller M T, Saggio I,
Riparbelli M G, Callaini G, and Giansanti MG (2019) Drosophila Doublefault protein coordinates multiple events during male meiosis by
controlling mRNA translation. Development. 146(22) dev182053. IF: 5.611

7. Mascolo E, Barile A, Stufera Mecarelli L, Amoroso N, Merigliano C, Massimi A, Saggio I Hansen T, Tramonti A, Di Salvo ML, Barbetti F,
Contestabile R and Vernì F (2019) The expression of four pyridoxal kinase (PDXK) human variants in Drosophila impacts on genome
integrity. Scientific Reports. 9(1):14188. IF: 3.998

8. Mascolo E, Amoroso N, Saggio I, Merigliano C, Vernì F (2019) Pyridoxine/pyridoxamine 5 -phosphate oxidase (Sgll/PNPO) is important for
DNA integrity and glucose homeostasis maintenance in Drosophila. J. Cell. Physiology. 235(1):504-512. IF: 5.546

9. Merigliano C, Mascolo E, Cesta A, Saggio I, Vernì F (2019) A new role for Drosophila Aurora-A in maintaining chromosome integrity.
Chromosoma, 128(1):41-52. IF: 3.442

10. Burla R, La Torre M, Zanetti G, Bastianelli A, Merigliano C, Del Giudice S, Vercelli A, Di Cunto F, Boido M, Vernì F and Saggio I (2018) p53-
sensitive epileptic behavior and inflammation in Ft1 hypomorphic mice. Frontiers in Genetics 9:581. IF: 3.517

11. Merigliano C, Mascolo E, Burla R, Saggio I and Vernì F (2018) The relationship between Vitamin B6, diabetes and cancer. Frontiers in
Genetics 9(SEP):388. IF: 3.517

12. Merigliano C, Mascolo E, La Torre M, Saggio I and Vernì F (2018) Protective role of vitamin B6 (PLP) against DNA damage in Drosophila
models of type 2 diabetes. Scientific Reports 8(1):11432. IF: 4.011

13. Burla R, La Torre M, Merigliano C, Verni F and Saggio I (2018) Genomic instability and DNA replication defects in progeroid syndromes.
Nucleus 9(1):368-379. IF: 2.157

14. La Torre M, Burla R, Merigliano C et al. (2018) Mice with reduced expression of the telomere-associated protein Ft1 develop p53-sensitive
progeroid traits. Aging cell 17(4):e12730. IF: 7.346

15. Burla R, La Torre M, Saggio I (2016) Mammalian telomeres and their partnership with lamins. Nucleus 7(2):187-202. IF: 2.387

16. Burla R, Carcuro MT, La Torre M, Fratini F, Crescenzi M, D Apice MR, Spitalieri P, Raffa GD, Astrologo L, Lattanzi G, Cundari E, Raimondo D,
Biroccio AM, Gatti M, Saggio I (2016) The telomeric protein AKTIP interacts with A- and B-type lamins and is involved in regulation of
cellular senescence. Open Biology 6(8):160103. IF: 3.481

17. Cenci G, Ciapponi L, Marzullo M, Raffa GD, Morciano P, Raimondo D, Burla R, Saggio I and Gatti M (2015) The analysis of pendolino (peo)
mutants reveals differences in the fusigenic potential among Drosophila telomeres. Plos Genetics 11(6):e1005260. IF: 6.661

18. Burla R, Carcuro M, Raffa GD, Galati A, Raimondo D, Rizzo A, la Torre M, Micheli M, Ciapponi L, Cenci G, Cundari E, Musio A, Biroccio A,
Cacchione S, Gatti M and Saggio I (2015) AKTIP/Ft1, a new shelterin-interacting factor required for telomere maintenance. Plos Genetics
11(6):e1005167. IF: 6.661

19. Cossetti C, Lugini L, Astrologo L, Saggio I, Fais S and Spadafora C (2014) Soma-to-germline transmission of RNA in mice xenografted with
human tumour cells: possible transport by exosomes. Plos One 9(7):e101629. IF: 3.234

Activity II: Gene and stem cell therapy.
During the association with the laboratories of San Raffaele Science Park, I. Saggio has been involved in the study of stem cells and contributed to unravel the characterization of stem cell progenitors as organizers of the hematopoietic microenvironment (Sacchetti et al Cell 2007; Sacchetti et al Stem cell reports 2016). In addition, I. Saggio laboratory has experience in vectors for gene and cell therapies, including lentiviral, adenoviral and humanized phages (patented WO 02/24934). I. Saggio developed growth factor antagonists and expressed them with adenoviral vectors as proof of principle studies of disease customized gene therapy (Saggio et al Gene therapy 1997; Di Marco et al PNAS 1996; and patent on viral vectors WO 98/13383).

1. Raimondo D, Remoli C, Astrologo L, Burla R, La Torre M, Vernì F, Tagliafico E, Corsi A, Del Giudice S, Persichetti A, Giannicola G, Robey PG,
Riminucci R and Saggio I (2020) Changes in gene expression in human skeletal stem cells transduced with constitutively active Gs
correlates with hallmark histopathological changes seen in fibrous dysplastic bone. Plos One. 15(1):e0227279. IF: 2.740

2. del Rio D, Beucher B, Lavigne M, Wehbi A, Saggio I & Kremer EJ (2019) CAV-2 Vector Development and Gene Transfer in the Central and
Peripheral Nervous Systems. Frontiers in molecular neuroscience, 12:71. IF: 4.057

3. Saggio I (2019) Perils and Promises of Therapeutic Approaches for the Stem Cell Disease Fibrous Dysplasia. Stem cells translational
medicine 8(2):110-111. IF: 6.429

4. Mestre-Francés N , Serratrice N, Gennetier A, Devau G, Cobo S, Trouche S, Fontes P, Zussy C, De Deurwaerdere P, Salinas S, Mennechet
FKJD, Dusonchet J, Schneider B, Saggio I, Kalatzis V, Luquin-Piudo MRJ, Verdier M, and Kremer EJ (2018) Exogenous LRRK2G2019S induces
parkinsonian-like pathology in a nonhuman primate. JCI Insight 3(14):98202. IF: 6.014

5. Sacchetti B, Funari A, Remoli C, Giannicola G, Robey PG, Kogler G, Liedtke S, Cossu G, Serafini M, Sampaolesi M, Tagliafico E, Tenedini E,
Saggio I, Riminucci M, Bianco P (2016) No identical "mesenchymal stem cells" at different times and sites: Human committed progenitors
of distinct origin and differentiation potential are incorporated as adventitial cells in microvessels. Stem cell reports 6(6):897-913. IF:
7.338

6. Simão D, Pinto C, Fernandes P, Peddie CJ, Piersanti S, Collinson LM, Salinas S, Saggio I, Schiavo G, Kremer EJ, Brito C, Alves PM (2016)
Evaluation of helper-dependent canine adenovirus vectors in a 3D human CNS model. Gene therapy 23(1):86 94. IF: 3.11

7. Piersanti S, Burla R, Licursi V, Brito C, la Torre, M, Alves P, Simao D, Mottini C, Salinas S, Negri R, Tagliafico E, Kremer EJ and Saggio I
(2015) Transcriptional response of human neurospheres to helper-dependent CAV-2 vectors: activation of DNA damage response,
modulation of microtubule motors and centromeric proteins. Plos One 10(7):e0133607. IF: 3.057

8. Remoli C, Michienzi S, Sacchetti B, Di Consiglio A, Cersosimo S, Spica S, Robey PG, Holmbeck K, Cumano A, Boyde A, Davis G, Saggio I,
Riminucci M, and Bianco P (2015) Osteoblast-specific expression of the fibrous dysplasia (FD)-causing mutation Gs (R201C) produces a
high bone mass phenotype but does not reproduce FD in the mouse. Journal of Bone and Mineral Research 30(6):1030-1043. IF: 5.622

9. Simão D, Pinto C, Piersanti S, Weston A, Peddie CJ, Bastos AEP, Licursi V, Schwarz SC, Collinson LM, Salinas S, Serra M, Teixeira AP, Saggio I,
Lima PA, Kremer EJ, Schiavo G, Brito C, Alves PM (2015) Modeling human neural functionality in vitro: 3D culture for dopaminergic
differentiation. Tissue Engineering-Part A 21(3-4):654-668. IF: 3.892

10. Saggio I, Remoli C, Spica E, Cersosimo S, Sacchetti B, Robey PJ, Holmbeck K, Cumano A, Boyde A, Bianco P, Riminucci M (2014)
Constitutive Expression of Gs R201C in Mice Produces a Heritable, Direct Replica of Human Fibrous Dysplasia Bone Pathology and
Demonstrates Its Natural History. Journal of Bone and Mineral Research 29(11S1):2357-2368. IF: 6.832

11. Piersanti S, Tagliafico E, Saggio I (2014) DNA microarray to analyze Adenovirus-host interactions. Methods in Molecular Biology Humana
Press 1089:89-104. IF: n/a

12. Piersanti S, Astrologo L, Licursi V, Costa R, Roncaglia E, Gennetier A, Ibanes S, Chillon M, Negri R, Tagliafico, Kremer EJ, Saggio I (2013)
Differentiated neuroprogenitor cells incubated with human or canine adenovirus, or lentiviral vectors have distinct transcriptome profiles.
Plos One 8(7):e69808. IF: 3.534

13. Soldati C, Cacci E, Biagioni S, Carucci N, Lupo G, Perrone-Capano C, Saggio I, Augusti-Tocco G (2012) Restriction of neural precursor ability
to respond to Nurr1 by early regional specification. Plos One 7(12):e51798. IF: 3.73

14. Khalaj-Kondori M, Sadeghizadeh M, Behmanesh M, Saggio I, Monaci P (2011) Chemical coupling as a potent strategy for preparation of
targeted bacteriophage-derived gene nanocarriers into eukaryotic cells. Journal of Gene Medicine 13(11):622-631. IF: 2.483

15. Cherubini G, Naim V, Caruso P, Burla R, Bogliolo M, et al. (2011) The FANC pathway is activated by adenovirus infection and promotes viral
replication-dependent recombination. Nucleic Acids Research 39(13):5459-5473. IF:8.026

16. Riminucci M, Robey PG, Saggio I, Bianco P (2010) Skeletal progenitors and the GNAS gene: fibrous dysplasia of bone read through stem
cells. Journal of Molecular Endocrinology 45(6):355-364. IF: 3.628

17. Piersanti S, Remoli C, Saggio I, Funari A, Michienzi S, et al. (2010) Transfer, Analysis, and Reversion of the Fibrous Dysplasia Cellular
Phenotype in Human Skeletal Progenitors. Journal of Bone and Mineral Research 25(5):1103-1116 IF: 7.059

18. Bianco P, Robey PG, Saggio I, Riminucci M (2010) "Mesenchymal'' Stem Cells in Human Bone Marrow (Skeletal Stem Cells): A Critical
Discussion of Their Nature, Identity, and Significance in Incurable Skeletal Disease. Human Gene Therapy 21(9):1057-1066. IF: 4.829

19. Caruso P, Burla R, Piersanti S, Cherubini G, Remoli C, et al. (2009) Prion expression is activated by Adenovirus 5 infection and affects the
adenoviral cycle in human cells. Virology 385(2):343-350 IF: 3.042

20. Sacchetti B, Funari A, Michienzi S, Di Cesare S, Piersanti S, et al. (2007) Self-renewing osteoprogenitors in bone marrow sinusoids can
organize a hematopoietic microenvironment. Cell 131(2):324-336. IF: 29.887

21. Martina Y, Avitabile D, Piersanti S, Cherubini G, Saggio I (2007) Different modulation of cellular transcription by adenovirus 5, Delta E1/E3
adenovirus and helper-dependent vectors. Virus Research 130(1-2):71-84. IF: 2.81

22. Benihoud K, Esselin S, Descamps D, Jullienne B, Salone B, et al. (2007) Respective roles of TNF-alpha and IL-6 in the immune response-
elicited by adenovirus-mediated gene transfer in mice. Gene Therapy 14(16):533-544. IF: 4.812

23. Riminucci M, Saggio I, Robey PG, Bianco P (2006) Fibrous dysplasia as a stem cell disease. Journal of Bone and Mineral Research
22(SUPPL.2): 125-131. IF: 6.635

24. Piersanti S, Sacchetti B, Funari A, Di Cesare S, Bonci D, et al. (2006) Lentiviral transduction of human postnatal skeletal (stromal,
mesenchymal) stem cells: In vivo transplantation and gene silencing. Calcified Tissue International 78(6):372-384. IF: 2.483

25. Cherubini G, Petouchoff T, Grossi M, Piersanti S, Cundari E, et al. (2006) E1B55K-deleted adenovirus (ONYX-015) overrides G(1)/S and
G(2)/M checkpoints and causes mitotic catastrophe and endoreduplication in p53-proficient normal cells. Cell Cycle 5(19):2244-2252. IF:
3.214

26. Campo S, Serlupi-Crescenzi O, Arseni B, Rossi S, Saggio I, et al. (2005) Comparative activity of Sant7 and anti-IL-6, IL-6R monoclonal
antibodies in a murine model of B-cell lymphoma. Cytokine 31(5):368-374. IF: 2.012

27. Piersanti S, Martina Y, Cherubini G, Avitabile D, Saggio I (2004) Use of DNA microarrays to monitor host response to virus and virus-derived
gene therapy vectors. Am J Pharmacogenomics 4(6):345-356. IF: n/a

28. Piersanti S, Cherubini G, Martina Y, Salone B, Avitabile D, et al. (2004) Mammalian cell transduction and internalization properties of
lambda phages displaying the full-length adenoviral penton base or its central domain. Journal of Molecular Medicine 82(7):467-476. IF:
4.256

29. Salone B, Martina Y, Piersanti S, Cundari E, Cherubini G, et al. (2003) Integrin alpha 3 beta 1 is an alternative cellular
receptor for adenovirus serotype 5. Journal of Virology 77(24):13448-13454. IF: 5.225

30. Di Giovine M, Salone B, Martina Y, Amati V, Zambruno G, et al. (2001) Binding properties, cell delivery, and gene transfer of adenoviral
penton base displaying bacteriophage. Virology 282(1):102-112. IF: 3.27

31. Benihoud K, Salone B, Esselin S, Opolon P, Poli V, et al. (2000) The role of IL-6 in the inflammatory and humoral response to adenoviral
vectors. Journal of Gene Medicine 2(3):194-203. IF: 3.103

32. Benihoud K, Saggio I, Opolon P, Salone B, Amiot F, et al. (1998) Efficient, repeated adenovirus-mediated gene transfer in mice lacking
both tumor necrosis factor alpha and lymphotoxin alpha. Journal of Virology 72(12):9514-9525. IF: 5.828

33. Saggio I, Ciapponi L, Savino R, Ciliberto G, Perricaudet M (1997) Adenovirus-mediated gene transfer of a human IL-6 antagonist. Gene
Therapy 4(8):839-845. IF: 5.996

34. Di Marco A, Gloaguen I, Demartis A, Saggio I, Graziani R, et al. (1997) Agonistic and antagonistic variants of ciliary neurotrophic factor
(CNTF) reveal functional differences between membrane-bound and soluble CNTF alpha-receptor. Journal of Biological Chemistry
272(37):23069-23075. IF: 6.963

35. Di Marco A, Gloaguen I, Graziani R, Paonessa G, Saggio I, et al. (1996) Identification of ciliary neurotrophic factor (CNTF) residues
essential for leukemia inhibitory factor receptor binding and generation of CNTF receptor antagonists. Proc Natl Acad Sci U S A
97(17):9247-9252. IF: 10.244

36. Saggio I, Gloaguen I, Poiana G, Laufer R (1995) CNTF variants with increased biological potency and receptor selectivity define a
functional site of receptor interaction. Embo Journal 14(13):3045-3054. IF: 13.505

37. Saggio I, Gloaguen I, Laufer R (1995) Functional phage display of ciliary neurotrophic factor. Gene 152(1):35-39. IF: 2.16

38. Saggio I, Paonessa G, Gloaguen I, Graziani R, Deserio A, et al. (1994) Nonradioactive receptor binding assay for ciliary neurotrophic factor.
Analytical Biochemistry 221(2):387-391. IF: 2.313

39. Saggio I, Laufer R (1993) Biotin binders selected from a random peptide library expressed on phage.
Biochemical Journal 293(3):613-616. IF: 3.579

40. Saggio I, Laufer R (1993) Detection of biotinylated molecules in solid-phase assays using a recombinant biotin-binding bacteriophage.
Analytical Biochemistry 214(1):352-355. IF: 2.313

Books and book chapters
Saggio I. L'eta' se esiste (2022). Editor Il Mulino ISBN 978 88 15 29563 7
Saggio I. In Genetica, Terapia genica (2014) Casa Editrice Ambrosiana Rozzano (Mi) 550-559
Saggio I. Terapia genica. I virus usati per curare (2008) Enciclopedia medica 52-58.
Saggio I. Targeting bacteriophage vectors. (2002) In Vector targeting for therapeutic gene delivery. Edited by Curiel DT and Douglas JT Published by Wiley, New York. 20: 429-456.

Board of editors/ reviewer in scientific journals
2020 to date Cells, editor
2018 to date PLOS One, editor
2018 to date Nucleus, reviewer
2018 Stem cell translational medicine, reviewer
2017 Molecular therapy, reviewer
2016 to date BMC Medical Genomics, reviewer
2014 to date Stem Cell Research, reviewer
2009 Experimental Cell Research, reviewer

Speaker at conferences and invited seminars (selection)
2019 Talk Science communication TIGEM Naples It
2019 Talk Laminopathy meeting London UK
2019 Seminar Mechanobiology Institute NUS Singapore
2019 Seminar Nanyang Technological University College of Science Singapore
2018 Talk Progeria research Foundation Boston USA
2018 Talk Italian laminopathy meeting Bologna It
2018 Talk Telomere Embo meeting Singapore
2018 Seminar Nanyang Technological University College of Science Singapore
2017 Talk Telomere CSH Cold Spring Harbor NY USA
2017 Talk FISV Rome It
2017 Talk Italian laminopathy meeting Bologna It
2017 Talk p53 international meeting Singapore
2016 Talk Nuclear organization and function CSH Cold Spring Harbor NY USA
2016 Talk Telethon Skelethon convention Rome It

Last 5year publications (IF publication year)
1. Merigliano C, Burla R, La Torre M, Del Giudice S, Teo Hsiang L, Chong Wai L, Chojnowski A, Goh WI, Olmos Y, Maccaroni K, Giubettini M,
Chiolo I, Carlton J, Raimondo D, Verni F, Stewart CL, Rhodes D, Wright G, Burke B and Saggio I (2021) Human AKTIP interacts with ESCRT
proteins and functions at the midbody in cytokinesis. Plos Genetics. 17(8):e1009757. IF: 5.917

2. Burla R, La Torre M, Maccaroni K, Verni F, Giunta S and Saggio I (2020). Interplay of the nuclear envelope with chromatin in physiology and
pathology. Nucleus. Dec11(1):205-218. IF:2.792

3. Chen L, Roakel CM, Galati A, Bavasso F, Saggio I, Schoeftner S, Cacchione S, Gatti M, Artandi SE, Raffa GD (2020) Loss of human TGS1
hypermethylase promotes increased telomerase RNA and telomere elongation. Cell Reports. 30(5):1358-1372. IF: 8.109

4. Raimondo D, Remoli C, Astrologo L, Burla R, La Torre M, Vernì F, Tagliafico E, Corsi A, Del Giudice S, Persichetti A, Giannicola G, Robey PG,
Riminucci R and Saggio I (2020) Changes in gene expression in human skeletal stem cells transduced with constitutively active Gs
correlates with hallmark histopathological changes seen in fibrous dysplastic bone. Plos One. 15(1):e0227279. IF:2.74

5. Sechi S, Frappaolo A, Karimpour-Ghahnavieh A, Gottardo M, Burla R, Di Francesco L, Szafer-Glusman E, Schininà E, Fuller M T, Saggio I,
Riparbelli M G, Callaini G, and Giansanti M G (2019) Drosophila Doublefault protein coordinates multiple events during male meiosis by
controlling mRNA translation. Development. 146(22). IF: 5.611

6. Mascolo E, Barile A, Stufera Mecarelli L, Amoroso N, Merigliano C, Massimi A, Saggio I Hansen T, Tramonti A, Di Salvo ML, Barbetti F,
Contestabile R and Vernì F (2019) The expression of four pyridoxal kinase (PDXK) human variants in Drosophila impacts on genome
integrity. Scientific Reports. 9(1):14188. IF: 3.998

7. Mascolo E, Amoroso N, Saggio I, Merigliano C, Vernì F (2019) Pyridoxine/pyridoxamine 5 -phosphate oxidase (Sgll/PNPO) is important for
DNA integrity and glucose homeostasis maintenance in Drosophila. J. Cell. Physiology. 235(1):504-512. IF: 5.546

8. Merigliano C, Mascolo E, Cesta A, Saggio I, Vernì F (2019) A new role for Drosophila Aurora-A in maintaining chromosome integrity.
Chromosoma, 128(1):41-52. IF: 3.442

9. del Rio D, Beucher B, Lavigne M, Wehbi A, Saggio I & Kremer EJ (2019) CAV-2 Vector Development and Gene Transfer in the Central and
Peripheral Nervous Systems. Frontiers in molecular neuroscience, 12:71. IF: 4.057

10. Saggio I (2019) Perils and Promises of Therapeutic Approaches for the Stem Cell Disease Fibrous Dysplasia. Stem cells translational
medicine 8(2):110-111. IF: 6.429

11. Burla R, La Torre M, Zanetti G, Bastianelli A, Merigliano C, Del Giudice S, Vercelli A, Di Cunto F, Boido M, Vernì F and Saggio I (2018) p53-
sensitive epileptic behavior and inflammation in Ft1 hypomorphic mice. Frontiers in Genetics 9:581. IF: 3.517

12. Merigliano C, Mascolo E, Burla R, Saggio I and Vernì F (2018) The relationship between Vitamin B6, diabetes and cancer. Frontiers in
Genetics 9(SEP):388. IF: 3.517

13. Merigliano C, Mascolo E, La Torre M, Saggio I and Vernì F (2018) Protective role of vitamin B6 (PLP) against DNA damage i in Drosophila
models of type 2 diabetes. Scientific Reports 8(1):11432. IF: 4.011

14. Burla R, La Torre M, Merigliano C, Verni F and Saggio I (2018). Genomic instability and DNA replication defects in progeroid syndromes.
Nucleus 9(1):368-379. IF: 2.157

15. La Torre M, Burla R, Merigliano C et al. (2018). Mice with reduced expression of the telomere-associated protein Ft1 develop p53-sensitive
progeroid traits. Aging cell 17(4):e12730. IF: 7.346

16. Mestre-Francés N, Serratrice N, Gennetier A, Devau G, Cobo S, Trouche S, Fontes P, Zussy C, De Deurwaerdere P, Salinas S, Mennechet
FKJD, Dusonchet J, Schneider B, Saggio I, Kalatzis V, Luquin-Piudo MRJ, Verdier M, and Kremer EJ (2018) Exogenous LRRK2G2019S induces
parkinsonian-like pathology in a nonhuman primate. JCI Insight 3(14):98202. IF: 6.014

17. Burla R, La Torre M, Saggio I (2016) Mammalian telomeres and their partnership with lamins. Nucleus 7(2):187-202. IF: 2.387

18. Burla R, Carcuro MT, La Torre M, Fratini F, Crescenzi M, D Apice MR, Spitalieri P, Raffa GD, Astrologo L, Lattanzi G, Cundari E, Raimondo D,
Biroccio AM, Gatti M, Saggio I (2016) The telomeric protein AKTIP interacts with A- and B-type lamins and is involved in regulation of
cellular senescence. Open Biology 6(8):160103. IF: 3.481

19. Sacchetti B, Funari A, Remoli C, Giannicola G, Robey PG, Kogler G, Liedtke S, Cossu G, Serafini M, Sampaolesi M, Tagliafico E, Tenedini E,
Saggio I, Riminucci M, Bianco P. (2016) No identical "mesenchymal stem cells" at different times and sites: Human committed progenitors
of distinct origin and differentiation potential are incorporated as adventitial cells in microvessels. Stem cell reports 6(6):897-913. IF:
7.338

20. Simão D, Pinto C, Fernandes P, Peddie CJ, Piersanti S, Collinson LM, Salinas S, Saggio I, Schiavo G, Kremer EJ, Brito C, Alves PM. (2016)
Evaluation of helper-dependent canine adenovirus vectors in a 3D human CNS model. Gene therapy 23(1):86 94. IF: 3.11

Bibliometrics (Scopus)
Total scientific articles 57
Total citations 3234
Total H index 23

Articles 2012-2022 30 (threshold ASN commissario SSD BIO/18 =24)
Citations 2007-2022 2726 (threshold ASN commissario SSD BIO/18 = 866)
H index 2007-2022 17 (threshold ASN commissario SSD BIO/18 =15)