Ritratto di laura.stronati@uniroma1.it

Le lezioni di biologia cellulare per il CdL in Biotecnologie inizieranno il giorno 4 ottobre alle ore 14.00 presso l'aula C di Scienze Biochimiche e si terranno sia in presenza sia in remoto tramite link di accesso alla piattaforma zoom:  

 

https://uniroma1.zoom.us/j/84781919350?pwd=WjRiR3V0K3pBaFgwU29md2VCMTlNUT09

ID riunione: 847 8191 9350

Passcode: 720213

Name: Laura Stronati
E-mail: laura.stronati@uniroma1.it
Nationality: Italian

PRESENT POSITION
- Associate Professor at the Department of Molecular Medicine - Faculty of Pharmacy and Medicine Sapienza University of Rome
Scientific field BIO/13 Applied Biology
- Coordinator of PhD in Human Biology and Medical Genetics

WORK EXPERIENCE
-Associate Professor (BIO/13) at Sapienza University of Rome (30 october 2015 - today)
-Senior Researcher at ENEA (Italian agency for new technology, energy and sustainable economic development) (2011-2015)
-Researcher at ENEA (1990-2015)
-Consultant at ENEA (1989-1990)

EDUCATION AND TRAINING
-Postgraduate guest at ENEA (1986-1989)
-Degree in Life Sciences at Sapienza University of Rome (maximum cum laudem) (1986)

PERSONAL SKILLS
Teaching
-Teaching of genetics in the graduate program of Medicine HT at Sapienza University of Rome (2020-today)
-Teaching of cell biology in the graduate program of Biotechnology at Sapienza University of Rome (2016-today)
-Teaching of applied biology in the graduate program of Occupational Therapy at Sapienza University of Rome (2016-2017)
-Teaching of applied biology in the graduate program of Biomedical Laboratory Techniques at Sapienza University of Rome (2016-today)
-Teaching of cell biology in the graduate program of Biomedical Biotechnology at Sapienza University of Rome (2016-2019)
-Teaching of biochemistry in the graduate program of Pediatric Nursing at Sapienza University of Rome (2011-2015)
-Teaching of genetics in the graduate program of Technical Neurophysiopathology at Sapienza University of Rome (2012-2015)
-Teaching of molecular biology at Master of II level in Pediatric Gastroenterology, Hepatology and Digestive Endoscopy at Sapienza University of Rome (2005-today)
-Teaching of genetics in the graduate program of Techniques for the Prevention of Accidents in the Workplace at University of Rome Tor Vergata (2006-2008)
-Teaching of medical genetics in the graduate program of Physiotherapy at University of Rome Tor Vergata (2003-2005)

RESEARCH INTERESTS
- Immunopathogenesis of chronic inflammatory disorders
- Genetics of inflammatory bowel diseases
- Mechanisms of interaction between commensal microbiota and innate immune system
- Novel non-pharmacological therapies for the cure of inflammatory immune-mediated diseases
- Inflammatory processes in gut-liver axis and gut-brain axis

FUNDED PROJECTS
- Projects funded by TAKEDA Pharmaceutical Co "Effects of a RIP2 inhibitor on human colon tissue from patients with Crohn's disease and healthy controls" (2017-19)
-Projects funded by Ministry of Economic Development (MISE)
Messa a punto di una formulazione a base di acido glicirretico come strategia terapeutica innovativa per la cura di patologie intestinali immuno-mediate su base infiammatoria nell uomo - Research and development projects in technology areas identified by the Community framework program Horizon 2020 N. Prot. 37401 (2015-17)- Ministry of Economic Development
-Projects funded by Lazio Region (FILAS)
(Coordinator):
Studio, validazione e realizzazione di un nuovo kit per la diagnosi precoce delle infiammazioni intestinali tramite utilizzo della proteina HMGB1 come marcatore fecale . N. Prot. FILAS-CR-2011-1162 (2012-14)
-Projects funded by Ministry of Education, Research and University (MIUR)
- (Coordinator)-MIUR art.11 D.M. 593/2000 N.10/12 Studio e messa a punto di una nuova miscela di probiotici e molecole anti-infiammatorie da utilizzare nel trattamento delle malattie infiammatorie intestinali (2012-2015)
- Studio molecolare dei meccanismi patogenetici alla base dei meccanismi infiammatori intestinali RBAP104JYK_002 FIRB- (2011-2014)
- Nuove acquisizioni sui meccanismi delle malattie infiammatorie intestinali e identificazione di nuovi target terapeutici , Prot. 2010K34C45 -PRIN- (2010-2011)
- Relazioni genotipi-fenotipo e ruolo di nuovi geni di suscettibilità (ATG16L1 e IL23R) alle malattie infiammatorie intestinali in una popolazione pediatrica , prot. 2008X8NRH4 -PRIN- (2008)
- Immunita innata e malattia celiaca , Prot. 2006063485 (2006)
- Valutazione dei rischi mutageno/cancerogeni occupazionali in soggetti esposti a farmaci antiblastici , Prot. 2005062547 -PRIN- (2005)

Projects funded by Sapienza University of Rome
- Characterization of the esophageal tissue by single cell rna sequencing in pediatric patients with eosinophilic esophagitis and identification of novel biomarkers to predict the early relapse to the disease - (Progetti medi Ateneo-2020)
- "Transcription factor ZNF281: a potential new player un gut and liver fibrosis" (Progetti medi Ateneo-2019)
- Gut-brain axis in autism spectrum disorders: novelties in pathogenetic mechanisms and therapeutic approaches aiming at modulating intestinal microbioma , DR. n. 2767/2016
(Grandi Progetti - Ateneo) (2016)
- "Identification of Escherichia coli strains with adherent/invasive phenotype in inflamed tissues of pediatric patients with Inflammatory Bowel Disease (IBD) and their interactions with autophagy proteins" C26A1245ZC (Ricerca Universitaria) (2012)
- High-mobility-group box-1 (HMGB1) protein plays a role in mediating mucosal inflammation and is a novel fecal marker in pediatric Inflammatory Bowel Diseases", C26A118C7Z (Ricerca Universitaria) (2011)
- "New insights into mechanisms of pediatric Inflammatory Bowel Disease and identification of potential therapeutic targets", C26A10MHRA (Ricerca Universitaria) (2010)
- Identificazione di nuovi fattori di trascrizione potenzialmente implicati nella patogenesi della malattia di Crohn pediatrica", C26A098MXT (Ricerca Universitaria) (2009)
- Studio di fattori genetici di suscettibilità alla malattia di Crohn del colon in eta pediatrica", C26F095M4H (Ricerca dell'Ateneo Federato, delle Scienze delle Politiche Pubbliche e Sanitarie SPPS, Progetto di Ricerca di Facoltà) (2009)
- Studio dell espressione di geni dell immunità innata mucosale e di proteine batteriche del microbiota intestinale in bambini con malattia di Crohn in trattamento con anticorpo monoclonale anti-TNF-alfa e con terapia nutrizionale", C26A084AX7 (Ricerca Universitaria) (2008)
- Relazioni genotipo-fenotipo e ruolo di nuovi geni di suscettibilità nelle malattie infiammatorie intestinali in eta' pediatrica , C26F08W9MN (Ricerca dell'Ateneo Federato, delle Scienze delle Politiche Pubbliche e Sanitarie SPPS, Progetto di ricerca di Facoltà) (2008)
- Attivazione della via di segnale di NF-kB indotta dai recettori batterici citoplasmatici e transmembranici (NODs-TLRs) dell'immunita' innata e ruolo della microflora associata all'epitelio intestinale in bambini con malattia di Crohn", C26A079CNN (Ricerca Universitaria) (2007)
- Immunita' innata e malattia celiaca nel bambino: caratterizzazione molecolare della flora batterica associata alla mucosa intestinale e espressione dei recettori Toll-like nella mucosa intestinale", C26A06FPZ9 (Ricerca Universitaria) (2006)

-Projects funded by GlaxoSmithKline (GSK)
Pattern Recognition Receptor DPU, Immuno-inflammation CEDD, GlaxoSmithKline: Small Molecule Inhibitors of Rip2 Kinase Reduce Inflammatory Responses in Human And Murine IBD (2011-12)

-Projects funded by Italian Medicines Agency (AIFA)
Multicenter comparative study between nutritional therapy alone and anti-TNFalfa monoclonal antibody in inducing and maintaining remission in pediatric Crohn s disease. A randomized controlled trial , FARM79YXLN (2008-2010)

-Projects funded USA, Broad Medical Research Project (BMPR) (Coordinator):
Molecular characterization of mucosa-associated intestinal microbiota and intestinal innate immune response: searching for novel risk factors for pediatric inflammatory bowel disease Proposal N. IBD-0225R (2009-2011)

-Projects funded by European Community (EU)
Protection of the European Population From the Aneugenic Chemicals (PEPFAC) Contract Number QLK4-CT-2000-00058 (2001-2004)

-Projects funded by Research Toxicology Centre S.p.A
"Standardization and evaluation of alternative test for the definition of carcinogenic risk in humans" carried out within the National Program of Research and Training for Technologies in Oncology "Development of innovative methodologies for prevention (primary and secondary) of cancer "(DM July 22, 1998) (1999-2002)

PATENT
-National and international patent (publication number: WO 2014/017466 A1) titled Use of HMGB1 as a biological marker of bowel inflammatory conditions, non-invasive method for its detection in fecal samples and kit thereof , filed 28/08/2014
-National and international patent (publication number: WO 2019/016719 A)

SPIN-OFF
Member of the Spin-off FARMA ID Tax code and Registration Number: 12692381002

PUBBLICATIONS
Author of 73 peer-reviewed scientific pubblications in international journals (http://www.ncbi.nlm.nih.gov/pubmed)

EDITORIAL BOARD
Associate editor of Digestive and Liver Disease (Elsevier)

BOOKS
Cucchiara S and Stronati L. Crohn s disease in children: a multidisciplinary approach. Eds Roberto Tersigni and Cosimo Prantera, Springer 2009, Vol. unico, chp 15, 169-186. ISBN: 8847014719 |

DIGITAL COMPETENCE
Excellent knowledge of computers and the major operating systems
Apple, Windows)

MOTHRE TONGUE
Italian

OTHER LANGUAGE(S)
English (fluent)

Insegnamento Codice Anno Corso - Frequentare
BASI CELLULARI E MOLECOLARI DELLA VITA 1035043 2021/2022 Dietistica (abilitante alla professione sanitaria di Dietista) - Roma Azienda Policlinico Umberto I
BASI CELLULARI E MOLECOLARI DELLA VITA 1035043 2021/2022 Tecniche di laboratorio biomedico (abilitante alla professione sanitaria di Tecnico di laboratorio biomedico) - Corso di laurea B - Roma Azienda S.Camillo Forlanini
BIOLOGIA CELLULARE 1038524 2021/2022 Biotecnologie
BIOLOGIA GENETICA E PRINCIPI DI OTTIMIZZAZIONE 10595355 2021/2022 Medicina e chirurgia HT (abilitante all'esercizio della professione di Medico Chirurgo)
BIOLOGIA E GENETICA 1026208 2021/2022 Medicina e chirurgia "B" (abilitante all'esercizio della professione di Medico Chirurgo) - Roma Azienda Policlinico Umberto I
BIOLOGIA GENETICA E PRINCIPI DI OTTIMIZZAZIONE 10595355 2020/2021 Medicina e chirurgia HT
BIOLOGIA CELLULARE 1038524 2020/2021 Biotecnologie
BASI CELLULARI E MOLECOLARI DELLA VITA 1035043 2020/2021 Tecniche di laboratorio biomedico (abilitante alla professione sanitaria di Tecnico di laboratorio biomedico) - Corso di laurea B - Roma Azienda S.Camillo Forlanini
BIOLOGIA E GENETICA 1026208 2020/2021 Medicina e chirurgia "B" - Roma Azienda Policlinico Umberto I
BASI CELLULARI E MOLECOLARI DELLA VITA 1035043 2019/2020 Tecniche di laboratorio biomedico (abilitante alla professione sanitaria di Tecnico di laboratorio biomedico) ROMA - Corso di laurea B - Roma Azienda S.Camillo Forlani
BASI MOLECOLARI DELLE FUNZIONI CELLULARI 1025448 2019/2020 Biotecnologie mediche
BIOLOGIA CELLULARE 1038524 2019/2020 Biotecnologie
BASI MOLECOLARI DELLE FUNZIONI CELLULARI 1025448 2018/2019 Biotecnologie mediche
BASI CELLULARI E MOLECOLARI DELLA VITA 1035043 2018/2019 Tecniche di laboratorio biomedico (abilitante alla professione sanitaria di Tecnico di laboratorio biomedico) ROMA - Corso di laurea B - Roma Azienda S.Camillo Forlani
BIOLOGIA CELLULARE 1038524 2018/2019 Biotecnologie
BIOLOGIA E GENETICA 1026208 2018/2019 Medicina e chirurgia 'B'
BASI MOLECOLARI DELLE FUNZIONI CELLULARI 1025448 2017/2018 Biotecnologie mediche
BASI CELLULARI E MOLECOLARI DELLA VITA 1035043 2017/2018 Tecniche di laboratorio biomedico (abilitante alla professione sanitaria di Tecnico di laboratorio biomedico) ROMA - Corso di laurea B - Roma Azienda S.Camillo Forlani
BIOLOGIA CELLULARE 1038524 2017/2018 Biotecnologie
BASI MOLECOLARI DELLA VITA 1034829 2016/2017 Terapia occupazionale (abilitante alla professione sanitaria di Terapista occupazionale) ASL Viterbo - Montefiascone (Corso di laurea B)
BASI MOLECOLARI DELLE FUNZIONI CELLULARI 1025448 2016/2017 Biotecnologie mediche
BIOLOGIA CELLULARE 1038524 2016/2017 Biotecnologie
BASI CELLULARI E MOLECOLARI DELLA VITA 1035043 2016/2017 Tecniche di laboratorio biomedico (abilitante alla professione sanitaria di Tecnico di laboratorio biomedico) ROMA - Corso di laurea B - Roma Azienda S.Camillo Forlani
Titolo Rivista Anno
Fecal and mucosal microbiota profiling in pediatric inflammatory bowel diseases EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY 2021
Emerging Roles of Gut Virome in Pediatric Diseases INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 2021
Intestinal Inflammation Alters the Expression of Hepatic Bile Acid Receptors Causing Liver Impairment JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION 2020
Mucosal healing in Crohn's disease: new insights EXPERT REVIEW OF GASTROENTEROLOGY & HEPATOLOGY 2020
Recent advances in potential targets for eosinophilic esophagitis treatments EXPERT REVIEW OF CLINICAL IMMUNOLOGY 2020
Necroptosis in intestinal inflammation and cancer: New concepts and therapeutic perspectives BIOMOLECULES 2020
Sa1295 – Serpinb12 As a Possible Marker of Steroid Dependency in Children with Eosinophilic Esophagitis: A Pilot Study GASTROENTEROLOGY 2019
Next Generation Metagenomics: Methodological Challenges and Opportunities OMICS 2019
Dipotassium Glycyrrhizate Improves Intestinal Mucosal Healing by Modulating Extracellular Matrix Remodeling Genes and Restoring Epithelial Barrier Functions FRONTIERS IN IMMUNOLOGY 2019
Functional analysis of gut microbiota and immunoinflammation in children with autism spectrum disorders DIGESTIVE AND LIVER DISEASE 2019
SERBINB12 as a possible marker of steroid dependency in children with eosinophilic esophagitis: a pilot study DIGESTIVE AND LIVER DISEASE 2019
Low Dose of Dipotassium Glycyrrhizate Counteracts Atherosclerosis Progression in Apoe-/- Female Mice JOURNAL OF VASCULAR RESEARCH 2019
Comparative performances of machine learning methods for classifying Crohn Disease patients using genome-wide genotyping data SCIENTIFIC REPORTS 2019
NOD2 and inflammation: current insights JOURNAL OF INFLAMMATION RESEARCH 2018
Quantitative assessment of shotgun metagenomics and 16S rDNA amplicon sequencing in the study of Human Gut Microbiome OMICS 2018
Faecal high mobility group box 1 in children with celiac disease: A pilot study DIGESTIVE AND LIVER DISEASE 2018
Krill oil, vitamin D and Lactobacillus reuteri cooperate to reduce gut inflammation BENEFICIAL MICROBES 2018
Bifidobacteria and lactobacilli in the gut microbiome of children with non-alcoholic fatty liver disease: which strains act as health players? ARCHIVES OF MEDICAL SCIENCE 2018
Transcription factor ZNF281: a novel player in intestinal inflammation and fibrosis FRONTIERS IN IMMUNOLOGY 2018
DIET, MICROBIOTA AND GUT-LIVER AXIS 2018
Dipartimento
MEDICINA MOLECOLARE
SSD

BIO/13