Nursing REPLICA P - CASSINO - PONTECORVO

The Elective Educational Activities (ADE) include six seminars whose programs are described below. Thyroid pathologies (Teacher Prof. Salvatore Ulisse, 1 CFU - 12 hours) Overview of the pathophysiology of the thyroid gland and regulation of the hypothalamus-hypophysis-thyroid axis. Pathogenesis, diagnosis and therapy of hypothyroidism. Iodine deficiency disorders. Pathogenesis, diagnosis and therapy of hyperthyroidism. Risk factors associated with the onset of thyroid neoplasms (ionizing radiation, familiarity, iodine intake, etc.). Overview of the molecular pathogenesis of thyroid tumors. Main biochemical, genetic and instrumental diagnostic pathways used in the diagnosis of thyroid carcinomas. Staging systems and prognosis of patients affected by thyroid neoplasms. Infertility and assisted reproduction methods (Teacher Prof. Enke Baldini, 1 CFU - 12 hours) Basics of the hypothalamus-pituitary-gonadal axis. Reminders of the physiology of the male and female gonads. Infertility and sterility: definitions and epidemiology. Causes of male infertility. Causes of female infertility. Causes common to both sexes. PMA techniques. Artificial insemination. IVF. GIFT. Additional techniques (ICSI, PICSI, IMSI, pre-implantation diagnosis, fertility preservation). Sperm collection and preparation. Main diagnostic tests performed on sperm. Notes on PMA legislation. Genomics and the Nurse: Applications in Professional Practice (Teacher Prof. Samantha Cialfi, 1 CFU – 12 hours) Genes and the role of mutations in disease onset. Genetic screening for diagnosis and predisposition to disease. Personalized therapies: 1. Genomic editing: the CRISPR/Cas9 system and examples of beta-thalassemia and sickle cell anemia; 2. Correction of the basic defect: corrector drugs and modulators of protein functions and the example of cystic fibrosis. Oncological Surgery (Professor Mariarita Tarallo, 2 CFU, 24 hours) Approach to the oncologic surgical patient: preoperative evaluation and management of informed consent. Surgical and multidisciplinary management of colorectal, gastroesophageal, endocrine, and breast neoplasms. Postoperative care: monitoring, pain management, and prevention of complications. Minimally invasive and robotic surgery: innovations and clinical applications in oncologic surgery. Nursing Research Methodology (Professor Azzurra Massimi, 1 credit, 12 hours) Quantitative Research - Planning a research study; identifying the appropriate quantitative design; variables and hypotheses; sampling and data collection with questionnaires, scales, and measurement tools; validity and reliability, association and outcome measures. Qualitative Research - Qualitative designs and methods (phenomenology, grounded theory, ethnography, case studies); data collection techniques (interviews, focus groups, observation); data analysis and rigor criteria; integration of findings (mixed methods). Literature Reviews and Bibliographic Search - Types of Literature Reviews; defining the research question (PICO); constructing the search string; PubMed exercise for identifying and selecting evidence.

It is important that the student has knowledge of biology, genetics, histology, anatomy and physiology of the main organs and systems of the human body.

ADE Prof. Ulisse F. Monaco: “Endocrinology for Degree Courses in the Health Professions. Società Editrice Universo, 1st Edition 2008. Students will also be provided with slides and other in-depth material. ADE Prof. Baldini L. Gandini, A. Lenzi: "Biotechnologies of human reproduction", Carocci Faber, Edition: 2013. Series: The Manuals. Students will also be provided with slides and other in-depth material. ADE Prof. Cialfi Talesa, Giovannini, Antogneli " Elements of Biology and Genetics " ed. Mc Graw Hil ISBN 978-88-386-188-4. Gostimskaya, I. CRISPR–Cas9: A History of Its Discovery and Ethical Considerations of Its Use in Genome Editing. Biochemistry Moscow 87, 777–788 (2022). https://doi.org/10.1134/S0006297922080090 Charpentier E, Doudna JA. Biotechnology: Rewriting a genome. Nature. 2013 Mar 7;495(7439):50-1. doi: 10.1038/495050a. PMID: 23467164. Cai L, Fisher AL, Huang H, Xie Z. CRISPR-mediated genome editing and human diseases. Genes Dis. 2016 Aug 30;3(4):244-251. doi: 10.1016/j.gendis.2016.07.003. PMID: 30258895; PMCID: PMC6150104. Khan S, Mahmood MS, Rahman SU, Zafar H, Habibullah S, Khan Z, Ahmad A. CRISPR/Cas9: the Jedi against the dark empire of diseases. J Biomed Sci. 2018 Mar 28;25(1):29. doi: 10.1186/s12929-018-0425-5. PMID: 29592810; PMCID: PMC5875004. Zang SS, Zhang R, Zhang JR, Zhang X, Li J. Progress, Applications and Prospects of CRISPR-Based Genome Editing Technology in Gene Therapy for Cancer and Sickle Cell Disease. Hum Gene Ther. 2025 Jun;36(11-12):858-869. doi: 10.1089/hum.2024.262. Epub 2025 May 12. PMID: 40351170. Wainwright CE. Ivacaftor for patients with cystic fibrosis. Expert Rev Respir Med. 2014 Oct;8(5):533-8. doi: 10.1586/17476348.2014.951333. Epub 2014 Aug 22. PMID: 25148205. Wainwright CE, Elborn JS, Ramsey BW. Lumacaftor-Ivacaftor in Patients with Cystic Fibrosis Homozygous for Phe508del CFTR. N Engl J Med. 2015 Oct 29;373(18):1783-4. doi: 10.1056/NEJMc1510466. PMID: 26510034. Bear CE. A Therapy for Most with Cystic Fibrosis. Cell. 2020 Jan 23;180(2):211. doi: 10.1016/j.cell.2019.12.032. PMID: 31978337. Ong T, Ramsey BW. Cystic Fibrosis: A Review. JAMA. 2023 Jun 6;329(21):1859-1871. doi: 10.1001/jama.2023.8120. PMID: 37278811 ADE Prof. Tarallo Any textbook of general and oncologic surgery for nurses.

In order to be able to take the exam related to the specific integrated course it is necessary to have documented the presence in the classroom of at least 67% of the hours corresponding to the credits assigned to the integrated course.

To pass an ADE the student need to obtain a qualification. The student must demonstrate to have acquired sufficient knowledge of the topics covered in class, and to be able to expose them in a clear way with language property.

Lectures with the aid of "PowerPoint" presentations that will be made available to students.

Basics of the hypothalamus-pituitary-gonadal axis. Reminders of the physiology of the male and female gonads. Infertility and sterility: definitions and epidemiology. Causes of male infertility. Causes of female infertility. Causes common to both sexes. PMA techniques. Artificial insemination. IVF. GIFT. Additional techniques (ICSI, PICSI, IMSI, pre-implantation diagnosis, fertility preservation). Sperm collection and preparation. Main diagnostic tests performed on sperm. Notes on PMA legislation.

Basics of the reproductive system and sexual hormones.

L. Gandini, A. Lenzi: "Biotecnologie della riproduzione umana", Carocci Faber, Edizione: 2013. Collana: I Manuali.

Students are required to attend at least 2/3 of the lessons.

To pass the exam, the student must demonstrate to have acquired sufficient knowledge of the topics covered in class, and to be able to expose them in a clear way with language property.

Frontal teaching lessons including slide projection and videos.

Genes and the role of mutations in the onset of diseases Genetic tests and screening for disease diagnosis and predisposition to disease development Personalized therapies - Genome editing: the CRISPR/Cas9 system and examples of beta-thalassemia and sickle cell anemia - Correction of the basic defect: drug correctors and modulators of protein functions and the example of cystic fibrosis

Basis Knowledge of biology, genetics and general pathology

Recommended genetics textbooks for healthcare professions

Lectures with the aid of ppt slide projections that will be made available to students.

To pass the exam, the student must demonstrate to have acquired sufficient knowledge of the topics covered in class and to be able to expose them in a clear way with language property.

Principal study designs in epidemiology. Bibliographical search. Systematic reviews of the literature. Introduction to qualitative and mixed-methods research. Sampling and data collection in quantitative and qualitative research. Application fields in nursing research.

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Denise F. Polit, Cheryl Tatano Beck. Fondamenti di Ricerca Infermieristica. Seconda edizione. MacGraw-Hill

The course will cover the following main topics: Approach to the surgical patient: preoperative evaluation and management of informed consent. Major surgeries: appendectomy, cholecystectomy, hernioplasty, etc. Postoperative management: monitoring, pain management and complication prevention. Emergency surgery: immediate approaches and trauma management. Oncologic surgery: principles and major treatments. Minimally invasive and robotic surgery: innovations and clinical applications.

Basic knowledge of human anatomy and physiology. Skills in general pathology and pharmacology. Ability to work in a team and follow clinical protocols.

general and emergency surgery textbooks for health professions

Attendance at theoretical and practical classes is mandatory. Students must attend at least 75% of the activities in order to take the final exam.

Student assessment will be based on: Final written examination with multiple-choice and open-ended questions. Oral examination.