Industrial pharmacy

General expected learning outcomes The student will acquire the tools and theoretical-practical strategies for the discovery and design of new active ingredients; in particular, the student will understand the necessary steps from the identification of a molecular prototype to the optimization of a molecule to the realization of a drug. He or she will, likewise, be able to apply the knowledge acquired in the professional field in the chemical-pharmaceutical industry. In addition, the student will be able to recognize the main chemical structures of drugs belonging to the classes covered in the "syllabus" and will have the ability to design the chemical synthesis of drugs and discuss their properties both qualitatively and quantitatively in terms of structure-activity relationships, physicochemical and pharmaco-toxicological properties. Specific expected learning outcomes 1. Knowledge and understanding The student will learn all aspects inherent in the history and molecular development of the classes of drugs with anti-infective activity (antibiotics, antivirals, antifungals, antiparasitics), gastro-intestinal dysfunctions (anti-ulcer, anti-diarrheals, antihistapsi, antacids) and antitumor, with particular reference to the molecular mechanisms of biochemical-biological action, their chemical-pharmaceutical, pharmacological and toxicological properties. Furthermore, the student will know the etiopathogenetic mechanisms that cause the various diseases object of therapeutic treatments with the studied drugs. 2. Applying knowledge and understanding At the end of the course, the student will be able to identify the different structures of drugs, analyze their biological, pharmacological and toxicological mechanisms of action, and most importantly, be able to adopt strategies for both structural and chemical synthesis design for the eventual development of new chemicals to be transformed into drugs. Knowledge of the methodologies for the identification and optimization of the parent compounds (lead compounds) will enable the student to be able to approach in academic and/or industrial settings the discovery and/or practical development of new chemical entities, to be able to improve both their pharmacological-therapeutic and toxicological profiles, which are important to achieve market introduction of new drugs. Knowledge of the most prevalent therapeutic problems and pharmaceutical solutions available in the treatment of the diseases discussed in the "syllabus" will make the student proficient and intuitive in the rational choice/consideration of such drugs in the field of human health. 3. Making judgements The lecturer will stimulate students to develop a logical-critical sense by asking frequent questions (brainstorming) during the lecture with the aim of inducing them to acquire skills in linking (correlative thinking) between the various concepts defined in the "syllabus," mastering the subject matter, but also to consider the study of pharmaceutical and toxicological chemistry I as an integral part and link with other disciplines already studied (anatomy, biology, organic chemistry, molecular biology, microbiology, biochemistry, physiology, pathology) and with others that will follow in future training (pharmaceutical and toxicological chemistry II, pharmacology, pharmacognosy, toxicology, pharmaceutical techniques and legislation, chemical and physical methods in organic chemistry). The instructor will periodically ask students to develop in-depth treatises/theses pertaining to key topics discussed in class, to habituate them to the design of chemical-pharmaceutical scientific research, will submit the students to learning tests to allow for their self-assessment and to have feedback on the teacher's teaching method. At the end of the course, students will be able to make analytical/critical judgment, interpret and correlate complex concepts, and design research inherent in the topics covered for the purpose of expanding scientific, ethical and social knowledge. 4. Communication skills Through the acquisition of knowledge and understanding, the ability to apply them and to propose a critical judgment on the topics covered, but also through the aid of the related scientific language used by the lecturer during the course and the frequent stimulation of communication of what has been learned in class, the student will be able to communicate with cognitive and linguistic-perceptual depth with figures who are his or her peers and/or who belong to an inherent scientific and social community or of a different cultural background. 5. Learning skills The student who has acquired the skills described above will be able to undertake future studies in the pharmaceutical field in a more autonomous, self-directed and rapid manner, but also to propose in social and/or work contexts issues useful to the scientific progress of society in the field of human health.