THREE-DIMENSIONAL MODELING

Course objectives

General expected learning outcomes This course completes the basic knowledge of the general chemistry acquired during the first year highlighting the interconnections and introduces students to some fundamental analytical disciplines/procedures that will be developed in detail in the following years according to the specific addresses of the degree course. Specific expected learning outcomes 1. Knowledge and understanding The student becomes aware of the interconnections between the different chemical and physical properties of the molecules and of the conditions in which these properties occur, or are inhibited, from the point of view of the regulation / control mechanisms of these properties. Particular attention is paid to the fundamental topics of chemistry (salts, acids and bases, solubility, redox processes, complexes), which having been the subject of the teaching of General Chemistry in the first year of the CdL in CTF, they are now shown in the optics of their application in laboratory activities. The course includes the theoretical and applicative treatment of coordination compounds and the basics of nuclear chemistry, with particular reference to the production of artificial radioisotopes used in diagnostic and therapeutic nuclear medicine (radiopharmaceuticals). Other knowledge acquired concern the statistical foundations of Analytical Chemistry for the treatment of measures and errors, and the criteria for the graphic representation of chemical-physical processes and phenomena, useful in the laboratory activities. Finally, students receive basic training for the principles of chromatography and mass spectrometric methodologies. 2. Applying knowledge and understanding At the end of the course the student will develop towards the fundamental aspects of chemical reactions and analytical chemistry, enough sensitivity to allow him to consciously deal with the subsequent courses of preparatory laboratory, quantitative analysis and separation of substances. 3. Making judgements During the lessons, the critical and judgmental skills of the students are stimulated by their active participation, both through questions by the teacher, and through the collective solution of exercises representing real cases of problems that may occur in laboratory practice. 4. Communication skills This ability emerges during the lessons, when the collective participation of the students is needed and finds the upper level during the examination, in which the student explains the logical motivations of the answers, also through the use of visual tools such as functional charts and histograms. 5. Learning skills The student is induced to study autonomously not only by reading the recommended texts, but also by researching information through computer tools, especially for those topics treated only at an introductory level during the course, but that being historically consolidated they are described more in depth on specialized websites accessible through search engines.

Channel 1
CATERINA FRASCHETTI Lecturers' profile

Program - Frequency - Exams

Course program
- Coordination compounds: nomenclature, mono- and polydentate ligands (chelate effect and macrocyclic effect), partial and overall formation constants of complexes, distribution ratios, polynuclear complexes, polyaminocarboxylic acids, conditional constants, effect of pH on the formation of metal cation complexes with varying acidity, speciation model, complexometric titrations and indicators, effect of complex formation on redox potentials, effect of complex formation on the solubility of ionic solids. - Theory of coordination compounds: chemical and physical properties, simple electrostatic theory (ionic complexes), valence bond (VB) theory, crystal field theory (complexes with coordination numbers 4, 5, and 6), ligand field theory, stability and reactivity of complexes in light of crystal field theory. - HSAB principles: fundamentals and applications - Elements of Nuclear Chemistry: properties of the atomic nucleus, nuclear energy as a function of A, nuclear energy per nucleon, natural radioelements, stability of nuclei as a function of A and Z, factors of instability, types of nuclear decay, excited nuclear states, nuclear isomerism, Auger effect, kinetic law of decay, decay constant, half-life, activity, specific activity (units of measurement), nuclide mixtures, chain decay, radioactive equilibrium, interaction of radiation with matter, artificial radioelements, nuclear fission and fusion, nuclear reactions, notation and energy of nuclear reactions, reactions induced by protons, alpha particles, deuterons, and neutrons, detectors (gas ionization, scintillation, semiconductor), radiocarbon dating, radiometric analysis, activation analysis, isotopic dilution analysis, general use of short-lived radioisotopes in nuclear medicine, fast synthesis, radiopharmaceuticals used in diagnostics (PET) and therapy (anticancer agents).
Prerequisites
The student must have acquired the knowledge provided in the first-year foundamental courses: General and Inorganic Chemistry, Physics with Elements of Statistics, and Mathematics with Elements of Computer Science.
Books
Skoog, West, Holler: “Chimica Analitica. Una introduzione” - EdiSES S.r.l. – Napoli - A.Liberti, A. Napoli: “Lezioni di Chimica Analitica” - EUROMA - Ed. Univ. Di Roma – La Goliardica - A.Liberti: “Lezioni di Chimica Analitica” - EDIZIONI RICERCHE – Roma - G. Wulfsberg: “La Moderna Chimica Inorganica: Previsioni di reattività” - EDIZIONI LA SORBONA - Milano. - M. Speranza et al: “Le Basi della Chimica” – Edizioni A.L.E.- Roma (comprende materiale didattico online)
Frequency
Attendance to the course is not mandatory but strongly recommended.
Exam mode
A set of five questions will be provided to the students, who will have 20 minutes to organize their thoughts and prepare for the actual oral examination. The exam is considered passed if the student is able to orally discuss at least three out of the five answers with accuracy and mastery of technical language.
Lesson mode
The course is delivered through traditional lectures. With the aid of slides and an interactive whiteboard, the instructor will present to the audience the fundamental concepts that students are expected to reflect upon, study, and later discuss during the exam. For each topic, numerical exercises will be proposed to deepen understanding through the simulation of real-world problems. In several cases, students will be invited to solve the problem independently and then present their solution to the class.
Channel 2
ANTONELLO FILIPPI Lecturers' profile
  • Academic year2025/2026
  • CourseIndustrial pharmacy
  • CurriculumSingle curriculum
  • Year2nd year
  • Semester1st semester
  • SSDCHIM/03
  • CFU4