PRECISION ONCOLOGY

Course objectives

General expected learning outcomes The course is aimed to provide knowledge concerning the main molecular mechanisms implied in the pathogenesis of cancer, in order to give the theoretical basis for the development of new diagnostic, prognostic and therapeutic procedures in oncology. Specific expected learning outcomes 1. Knowledge and understanding During the course the student will acquire knowledge about causes and pathogenic mechanisms of cancer, specifically referring to genetic and epigenetic alterations, altered pathways in cancer, therapeutic targets and molecular mechanisms of drug resistance in cancer therapy. This knowledge will be applied in the development of new targeted therapies in cancer. A further objective of the course is to equip the figure of the graduate in CTF with the basic theoretical tools for the understanding of clinical trials in oncology, of the research methodology, of the national legislation that governs its management . 2. Applying knowledge and understanding The knowledge of the molecular mechanisms involved in cancer progression will make the student: -able to link the alterations at the molecular level with the identification of new therapeutic targets - possessing the appropriate skills to carry out both activities within the NHS's local pharmaceutical services and research activities; - capable of independent judgment with reference to the evaluation, interpretation and reprocessing of literature data; - able to elaborate in a critical and autonomous way original ideas in a biomedical research context; - able to communicate the acquired information to specialists and non-specialists in the field of oncology. 3. Making judgements The student will be able to independently collect and interpret data derived from scientific studies in oncology by reading scientific articles in English as well as to communicate information and knowledge to specialists in the field of oncology. The student will also be able to critically and autonomously elaborate original ideas in a clinical research context and to interpret and formulate judgments on current clinical trials in oncology. 4. Communication skills The modality of interactive lessons with seminars held by specialists in oncology (from diagnostics to therapy) will allow students to stimulate their critical and communicative skills. In the view of transformation of pharma companies, with the exponential growth of molecularly targeted drugs, a thorough knowledge of precision medicine in oncology will be extremely useful . 5. Learning skills In the age of precision medicine the student will become aware of how indispensable for professional purposes is a continuous updating in a field, such as oncology, in which innovation in the pharmacological research it is in continuous evolution, with the development of always new targeted agents in the view of a more and more precise personalization of the treatments in oncology.

Channel 1
PAOLA GAZZANIGA Lecturers' profile

Program - Frequency - Exams

Course program
Precision oncology: introduction. Hallmarks of cancer. Biomarkers in precision oncology. Biomarker based trials. Cancer as an ecosystem. Angiogenesis. Cancer and the immune system. The immunotherapy of cancer. Cancer heterogeneity. Cancer clonal evolution. Liquid biopsies in precision oncology. Circulating tumor cells and ctDNA. The molecular basis of drug resistance in oncology. Clinical trials in oncology: toward molecular-based clinical trials. The future perspectives of precision medicine in oncology. Students meet pharma companies leader in oncology
Prerequisites
Notions in general pathology and biochemistry are necessary .
Books
Since molecular oncology texts are not available on the market, the teaching material consists of scientific articles and teacher slides that will be made available to the student during the course and on the e-learning Platform.Supplementaries deemed necessary will be conveyed through scientific articles, previously illustrated during the lectures, made available to students on the e-learning platform
Teaching mode
classroom frontal lessons
Frequency
strongly recommended
Exam mode
the exam consists in the preparation of a scientific article on the topics covered in class
Lesson mode
classroom lessons
PAOLA GAZZANIGA Lecturers' profile

Program - Frequency - Exams

Course program
Precision oncology: introduction. Hallmarks of cancer. Biomarkers in precision oncology. Biomarker based trials. Cancer as an ecosystem. Angiogenesis. Cancer and the immune system. The immunotherapy of cancer. Cancer heterogeneity. Cancer clonal evolution. Liquid biopsies in precision oncology. Circulating tumor cells and ctDNA. The molecular basis of drug resistance in oncology. Clinical trials in oncology: toward molecular-based clinical trials. The future perspectives of precision medicine in oncology. Students meet pharma companies leader in oncology
Prerequisites
Notions in general pathology and biochemistry are necessary .
Books
Since molecular oncology texts are not available on the market, the teaching material consists of scientific articles and teacher slides that will be made available to the student during the course and on the e-learning Platform.Supplementaries deemed necessary will be conveyed through scientific articles, previously illustrated during the lectures, made available to students on the e-learning platform
Teaching mode
classroom frontal lessons
Frequency
strongly recommended
Exam mode
the exam consists in the preparation of a scientific article on the topics covered in class
Lesson mode
classroom lessons
  • Lesson code10612246
  • Academic year2025/2026
  • CourseIndustrial pharmacy
  • CurriculumSingle curriculum
  • Year5th year
  • Semester1st semester
  • SSDMED/46
  • CFU6