INTERPRETATION OF MASS SPECTRA OF MODEL DRUGS

Course objectives

General expected learning outcomes The general expected learning outcome of this 2 CFU course is to provide a thorough knowledge of the ChemDraw software for the design of organic molecules and the prediction of the most frequent molecular fragmentations that occur in a mass spectrometer (use of the ChemDraw "mass fragmentation" command). The acquired knowledge will be applied by the students to interpret the ESI mass spectra of model drugs (offered by the teacher), by attributing the different peaks in the spectrum to specific fragments produced within the ionization source. Specific expected learning outcomes 1. Knowledge and understanding At the end of the course the student has a thorough knowledge of the ChemDraw software for the design of organic molecules and the prediction of the most frequent molecular fragmentations that occur in a mass spectrometer (use of the ChemDraw "mass fragmentation" command). 2. Applying knowledge and understanding At the end of the course the student is able to interpret an ESI mass spectrum of a model drug and to attribute the different peaks present in the spectrum to specific fragments produced within the ionization source. 3. Making judgements At the end of the course the student is able to independently decide which analytical method is more useful to solve a particular trouble he may meet in the working field, from the characterization of new active ingredients of therapeutic interest to the production and quality control of the drug. 4. Communication skills At the end of the course the student has the ability to communicate the knowledge he has learned during the course to the outside world, both with regard to the scientific community and the world of work. In particular, he/she must be able to present information relating to mass spectrometry and its possible application to the field of drugs in a clear and straight way. 5. Learning skills The student who has passed the exam is able to continue the study by reading the most recent articles published in the literature that the teacher makes available to him/her on the e-learning platform. He/she is also able to check specific databases in the field of drugs.

Channel 1
CLAUDIO VILLANI Lecturers' profile

Program - Frequency - Exams

Prerequisites
Having passed the exam in Physical Methods in Organic Chemistry
Frequency
Attendance at classroom lectures is optional, although strongly recommended.
Exam mode
The assessment methods are characterized by an oral exam session scheduled for each month of the year, except for the month of August. The elements taken into consideration for the assessment are: knowledge of the subject in all the parts described in the program, the use of appropriate scientific language, the ability to reason demonstrated during the exam interview, the ability to study independently on the indicated texts. A sufficient knowledge of the topics covered, in the various parts of the program, is required to pass the exam with the minimum grade (18/30). To achieve a score of 30/30 with honors, the student must, instead, demonstrate that he has acquired an excellent knowledge of all the topics covered during the course, being able to connect them in a logical and coherent way. He must also demonstrate that he has acquired mastery of the subject, moving within it with confidence, appropriateness and naturalness.
Lesson mode
The course consists of classroom lectures The classroom lectures are held by the teacher in an interactive way, during which the student's attention is continuously stimulated with questions related to what was previously acquired in other courses and/or presented in the classroom. This allows the teacher to make evident the connections between the current course and some previous courses (Organic Chemistry 1 and 2, physical chemistry, physical methods in organic chemistry), whose notions have a key role in understanding what was presented during the lesson. The continuous references/connections to notions already covered have the purpose of strengthening the student's learning; furthermore, the continuous correlations with notions studied in previous courses have the purpose of accustoming the student to learning the proposed subject as something aimed at a multidisciplinary study, useful for his cognitive growth in all disciplines
CLAUDIO VILLANI Lecturers' profile

Program - Frequency - Exams

Prerequisites
Having passed the exam in Physical Methods in Organic Chemistry
Frequency
Attendance at classroom lectures is optional, although strongly recommended.
Exam mode
The assessment methods are characterized by an oral exam session scheduled for each month of the year, except for the month of August. The elements taken into consideration for the assessment are: knowledge of the subject in all the parts described in the program, the use of appropriate scientific language, the ability to reason demonstrated during the exam interview, the ability to study independently on the indicated texts. A sufficient knowledge of the topics covered, in the various parts of the program, is required to pass the exam with the minimum grade (18/30). To achieve a score of 30/30 with honors, the student must, instead, demonstrate that he has acquired an excellent knowledge of all the topics covered during the course, being able to connect them in a logical and coherent way. He must also demonstrate that he has acquired mastery of the subject, moving within it with confidence, appropriateness and naturalness.
Lesson mode
The course consists of classroom lectures The classroom lectures are held by the teacher in an interactive way, during which the student's attention is continuously stimulated with questions related to what was previously acquired in other courses and/or presented in the classroom. This allows the teacher to make evident the connections between the current course and some previous courses (Organic Chemistry 1 and 2, physical chemistry, physical methods in organic chemistry), whose notions have a key role in understanding what was presented during the lesson. The continuous references/connections to notions already covered have the purpose of strengthening the student's learning; furthermore, the continuous correlations with notions studied in previous courses have the purpose of accustoming the student to learning the proposed subject as something aimed at a multidisciplinary study, useful for his cognitive growth in all disciplines
  • Lesson codeAAF2376
  • Academic year2025/2026
  • CourseIndustrial pharmacy
  • CurriculumSingle curriculum
  • Year5th year
  • Semester1st semester
  • CFU2