DESIGN SYNTHESIS PURIFICATION AND STRUCTURAL CHARACTERIZATION OF A HETEROCYCLIC COMPOUND

Course objectives

General expected learning outcomes The module aims to initiate students to experimental research work in organic chemistry, consisting in the design, synthesis, purification and structural characterization of a heterocyclic compound. The module is closely linked to the knowledge imparted in the Advanced Synthesis course in Organic Chemistry, in which all the necessary knowledge is provided to deal competently with the related activities and which represents, albeit not exclusively, the cultural prerequisite for being able to follow it profitably. Specific expected learning outcomes The module is divided into the following two sections: 1. 0.5 credits of lectures during which the problem relating to the design of a molecule belonging to the class of heterocyclic compounds will be addressed. The problem will be examined in the light of the main synthetic methodologies, classic and innovative, of the organometallic and organocatalytic type, with particular attention to the stereochemical aspects. 2. 1.5 CFU of experimental activities during which the designed molecule will be synthesized, purified and structurally characterized. Syntheses will be performed using both classical and innovative methodologies, such as solid phase synthesis, microwave assisted synthesis or flow chemistry. Purification activities will be carried out using standard systems, such as flash chromatography, or advanced ones, such as semi-preparative HPLC, both in direct and reverse phase. Structural characterization will be performed by one- and two-dimensional NMR analysis and GC-MS or LC-MS.

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ANTONELLA GOGGIAMANI Lecturers' profile

Program - Frequency - Exams

Course program
1. Design the synthesis of a heterocyclic derivative 2. Perform the synthesis at the laboratory scale level 3. Purify the obtained products, reaction intermediates and final products 4. Attribute the structure of the obtained products by suitable spectroscopic techniques
Prerequisites
StudeTo effectively understand the SACO lectures, students must possess the knowledge acquired in the courses Organic Chemistry I and II, and Physical Methods in Organic Chemistry. This includes: basic and advanced stereochemistry, reactivity of organic functional groups, main reaction mechanisms, acid and nucleophilic catalysis (both inter- and intramolecular), and interpretation of 1D-NMR spectra (¹H and ¹³C).
Books
Any teaching materials will be provided by the professor
Frequency
Compulsory attendance
Exam mode
The acquisition of course credits (CFU) is subject to passing the final examination, which takes place starting from the end of the course, during the exam periods established by the Degree Program Council. The instructor is also available to examine students in small groups within the official exam session period, to facilitate study planning. No midterm tests or partial exemption exams are foreseen. The objective of the final examination is to certify the student’s knowledge of the laboratory activities carried out. The final exam consists of the preparation and presentation of a report concerning the design, synthesis, and spectroscopic characterization of the heterocyclic derivatives obtained during the laboratory period. The evaluation, graded out of thirty, reflects: 1. The level of understanding of the activities carried out; 2. The ability and clarity in presenting the content. Passing the exam with the minimum grade requires a sufficient understanding of the topics covered. To achieve a score of 30/30 with honors, the student must demonstrate an excellent understanding of the laboratory activities conducted and be able to explain the procedures theoretically.
Lesson mode
The teaching activity is structured in two parts: 1. 0.5 CFU of classroom lectures, during which issues related to the design of a molecule belonging to the class of heterocyclic compounds will be addressed. 2. 1.5 CFU of experimental activities, during which the designed molecule will be synthesized, purified, and structurally characterized.
ANTONELLA GOGGIAMANI Lecturers' profile

Program - Frequency - Exams

Course program
1. Design the synthesis of a heterocyclic derivative 2. Perform the synthesis at the laboratory scale level 3. Purify the obtained products, reaction intermediates and final products 4. Attribute the structure of the obtained products by suitable spectroscopic techniques
Prerequisites
StudeTo effectively understand the SACO lectures, students must possess the knowledge acquired in the courses Organic Chemistry I and II, and Physical Methods in Organic Chemistry. This includes: basic and advanced stereochemistry, reactivity of organic functional groups, main reaction mechanisms, acid and nucleophilic catalysis (both inter- and intramolecular), and interpretation of 1D-NMR spectra (¹H and ¹³C).
Books
Any teaching materials will be provided by the professor
Frequency
Compulsory attendance
Exam mode
The acquisition of course credits (CFU) is subject to passing the final examination, which takes place starting from the end of the course, during the exam periods established by the Degree Program Council. The instructor is also available to examine students in small groups within the official exam session period, to facilitate study planning. No midterm tests or partial exemption exams are foreseen. The objective of the final examination is to certify the student’s knowledge of the laboratory activities carried out. The final exam consists of the preparation and presentation of a report concerning the design, synthesis, and spectroscopic characterization of the heterocyclic derivatives obtained during the laboratory period. The evaluation, graded out of thirty, reflects: 1. The level of understanding of the activities carried out; 2. The ability and clarity in presenting the content. Passing the exam with the minimum grade requires a sufficient understanding of the topics covered. To achieve a score of 30/30 with honors, the student must demonstrate an excellent understanding of the laboratory activities conducted and be able to explain the procedures theoretically.
Lesson mode
The teaching activity is structured in two parts: 1. 0.5 CFU of classroom lectures, during which issues related to the design of a molecule belonging to the class of heterocyclic compounds will be addressed. 2. 1.5 CFU of experimental activities, during which the designed molecule will be synthesized, purified, and structurally characterized.
  • Lesson codeAAF2375
  • Academic year2025/2026
  • CourseIndustrial pharmacy
  • CurriculumSingle curriculum
  • Year5th year
  • Semester1st semester
  • CFU2