Laboratory Medicine I - Clinical Biochemistry and Clinical Molecular Biology

Course objectives

Essential objectives of the integrated course Upon completion of the integrated course, the student must: - know the structure and function of the major classes of biomolecules with emphasis on macromolecules and supramolecular structures and the main biochemical methodologies used in their study; - be able to recognize the principles underlying the structure-function relationships of biological macromolecules; - be aware that the study of molecular structures forms the conceptual basis for understanding metabolic processes and cellular pathophysiology. - know the major metabolic pathways, their regulation at the molecular and cellular levels, and their integration; - be able to recognize the logic that regulates the fluxes of intermediate metabolites; - be aware of how alterations in the structure of biological macromolecules responsible for reactions and regulation of metabolic pathways are reflected in cellular and systemic pathological conditions.

Channel 1
GIAMPIERO FERRAGUTI Lecturers' profile

Program - Frequency - Exams

Course program
Variability in laboratory medicine and quality controls. How to analyze a sample. Main analytical methods. Calibration curve and calibration materials. Appropriateness in Laboratory Medicine. Correct diagnostic procedure. Knowing how to request a laboratory investigation: Why request a laboratory exam: paper request; LIS (Laboratory Information System). Variability in Laboratory Medicine: Analytical and Biological variability. Sample collection. Peripheral venous blood drawing. Choice and use of the test tubes. Criteria for sample acceptability. Reliability criteria of a laboratory survey. Precision, accuracy, sensitivity and analytical specificity. Errors in Laboratory Medicine. The intra and inter laboratory quality checks. Knowing how to interpret a laboratory survey: Chronobiological variability; Index of individuality; Reference intervals, critical values and decision limits; Longitudinal and transversal comparison and critical difference. How to evaluate a diagnostic test: Prevalence, sensitivity and diagnostic specificity; Diagnostic efficacy and positive and negative predictive values; ROC Curves.
Books
Ciaccio. Trattatato di Biochimica Clinica e Medicina di Laboratorio. Edizioni Edises.
  • Academic year2025/2026
  • CourseMedicine and Surgery
  • CurriculumSingle curriculum
  • Year3rd year
  • Semester1st semester
  • SSDBIO/12
  • CFU2