Medicine and Surgery

Oncology General concepts, introduction and classification. Definition of cancer. Morphological and biochemical features of the neoplastic cell. Histogenetic classification of tumors. Clinical criteria for the classification of tumors: grading and staging. Pathophysiology of replication and of cell differentiation and growth factors. Chemical, physical, biological and hormonal carcinogenesis. Stages of the neoplastic process: initiation, promotion and progression (invasion, metastasis, angiogenesis). Multi-step tumorigenesis. Oncogenes and Tumor suppressor genes: mechanisms of action. Main examples of some tumors. Genomic instability. Cancer Stem Cells. Cancer cell metabolism. Immunity and tumors. Molecular diagnostics. Biological basis of antineoplastic therapy General Pathophysiology Pathophysiology of endothelial cells. Atherosclerosis. Pathophysiology of the Heart. General Pathophysiology of Hydro-electrolytic and acid-base balance. General Pathophysiology of blood, haematopoietic organs and Hemostasis. General Pathophysiology of renal, respiratory, cardiovascular, gastro-intestinal systems. General pathophysiology of the endocrine system. Pathophysiology of hypothalamic–pituitary system. Pathophysiology of the thyroid gland. Pathophysiology of Surrene Pathophysiology of Diabetes Obesity

Patologia generale e Fisiopatologia generale VI Edizione G.M. Pontieri Piccin Editore Educational material provided during the course (including scientific papers available on PubMed platform) and uploaded as PDF files on the E-learning platform.

Cardiac, vascular, pulmonary, renal, coagulative, metabolic pathophysiology

Knowledge of physiology

Pontieri. Lesson slide sets

Mandatory

Oral exam