Laboratory Medicine II - Clinical Biochemistry and Clinical Molecular Biology

Course objectives

Essential objectives of the integrated course Upon completion of the integrated course, the student must: - know the structure and function of the major classes of biomolecules with emphasis on macromolecules and supramolecular structures and the main biochemical methodologies used in their study; - be able to recognize the principles underlying the structure-function relationships of biological macromolecules; - be aware that the study of molecular structures forms the conceptual basis for understanding metabolic processes and cellular pathophysiology. - know the major metabolic pathways, their regulation at the molecular and cellular levels, and their integration; - be able to recognize the logic that regulates the fluxes of intermediate metabolites; - be aware of how alterations in the structure of biological macromolecules responsible for reactions and regulation of metabolic pathways are reflected in cellular and systemic pathological conditions.

Channel 1
ANDREA FUSO Lecturers' profile

Program - Frequency - Exams

Course program
Main lipoprotein classes, enzymatic activities, receptors and apoproteins involved in lipid metabolism. Intracellular and systemic regulation of cholesterol. Classification of dyslipidemias. Reference values ​​for cholesterol and triglycerides, concept of cardiovascular risk, atherosclerotic disease. Laboratory diagnostics of dyslipidemia. Main cardiovascular risk factors. Laboratory diagnostics of myocardial infarction: creatine kinase, creatine kinase MB fraction, myoglobin, troponins, aspartate aminotransferase, lactic dehydrogenase. Iron, protoporphyrin and globins: pathophysiology, clinical biochemistry and laboratory diagnostics. Iron deficiency anemias, porphyrias, thalassemias and hemoglobinopathies. Automated blood count: operating principles, examples of equipment, main parameters relating to erythrocytes, leukocytes and platelets. Examples of changes in the blood count. Classification of anemia and relationship with the parameters of the blood count. Pathophysiology, Clinical Biochemistry and laboratory diagnostics of hemostasis. Review of the vascular and platelet phases; the coagulation system and the fibrinolytic system: main plasma factors involved and their alterations. Laboratory diagnostics in the exploration of the platelet phase and the coagulation and fibrinolytic system, also in relation to thrombotic and hemorrhagic states.
Prerequisites
Knowledge on chemistry, biochemistry, molecular biology and human phisiology
Books
Antonozzi I., Gulletta E.: Medicina di Laboratorio Logica e Patologia clinica. Editore Piccin Nuova Libreria S.p.A. Ciaccio M., Lippi G.: Biochimica clinica e Medicina di Laboratorio. EdiSES II edizione Roberto Cevenini: Microbiologia Clinica (seconda edizione )- Piccin Bizzarri M.: Interpretazione clinica degli esami di laboratorio. Piccin.
Teaching mode
Frontal Lessons. Remote lessons due to Coviud-19 restrictions
Frequency
70% attendance to access the exams
Exam mode
Oral exam
Lesson mode
Frontal Lessons. Remote lessons due to Coviud-19 restrictions
GIAMPIERO FERRAGUTI Lecturers' profile
  • Academic year2025/2026
  • CourseMedicine and Surgery
  • CurriculumSingle curriculum
  • Year3rd year
  • Semester2nd semester
  • SSDBIO/12
  • CFU4