Medicine and Surgery

To illustrate the concepts of homeostasis, functional reserve and decompensation Understanding the concept of antigen and immunogenicity, self and non-self. Know and describe the immune system: organs, cells and molecules Describe the involvement of immune defense against infections describe the effectors of innate immunity and their functional mechanisms: adhesion, chemotaxis, phagocytosis Describe the main molecular and cellular aspects of the early phases of inflammation To know the receptor mechanisms of innate immunity, signal transduction and proinflammatory cytokines Describe the main molecular and functional aspects of the complement system To illustrate the vascular phenomena and to describe the actions performed by the mediators involved in the different phases of acute inflammation To illustrate the systemic phenomena associated with acute inflammation Understanding the pleiotropic role of the macrophage in response to persistent damage Describe the mechanisms that underlie intercellular communication, the formation and functions of cytokines and their receptors To know the interaction between Innate and Acquired Immunity Correlate the structure and function of MHC with antigen processing and presentation Know and describe the maturation and activation of T lymphocytes. Explain the functional role of T lymphocyte receptor (TCR) Know and describe the maturation and activation of B lymphocytes Knowing how to describe the organization of genes and the formation of Immunoglobulins. Know the differences between the different classes of Ig Describe the mechanisms that underlie the humoral immune response Describe the mechanisms that cause the various hypersensitivity reactions: classification and immunological basis To know the pathogenetic mechanism and to be able to illustrate the main clinical manifestations of the hypersensitivity reactions of the type Describe the mechanisms that underlie autoimmunity. To illustrate the relationship between autoimmunity and immunological tolerance Knowing how to indicate the pathogenetic mechanisms of the main autoimmune diseases Explain the general principles that regulate the immune response in transplantation Know the immunodeficiencies, congenital and acquired, as a consequence of the reduced or failed functioning of the immune system Describe the role of the immune system on the development of tumors Know the main laboratory techniques in immunological and serological diagnostics

First year exams plus Biochemistry

Lezioni di Immunologia e Immunopatologia A.Amadorie P.Zanovello Ed. PICCIN 2021 Immunologia Cellulare e Molecolare ABBAS Slides and papers from Classroom https://classroom.google.com/c/NjI3MzcyMjE1OTQ3

The teaching activity will take place through lectures, classroom seminars, small group exercises in the laboratory and ADE. The following platforms are used for remote learning: Zoom; Google Meet and Moodle

In presence

Written test consisting of 40 multiple choice quiz Oral examination to be sustained if you pass the written test with sufficiency (18/30)

The teaching activity will take place through lectures, classroom seminars, small group exercises in the laboratory and ADE. The following platforms are used for remote learning: Zoom; Google Meet and Moodle

Illustrate the concepts of homeostasis, functional reserve and decompensation. Understand the concept of antigen and immunogenicity, self and non-self. Know and describe the immune system: organs, cells and molecules Describe the involvement of the immune defense against infections describe the effectors of innate immunity and their functional mechanisms: adhesion, chemotaxis, phagocytosis Describe the main molecular and cellular aspects of the early phases of inflammationKnow the receptor mechanisms of innate immunity, signal transduction and proinflammatory cytokinesDescribe the main molecular and functional aspects of the complement systemIllustrate the vascular phenomena and describe the actions carried out by the mediators involved in the different phases of acute inflammation Illustrate the systemic phenomena associated with acute inflammation Understand the pleiotropic role of the macrophage in response to persistent damage Describe the mechanisms underlying intercellular communication, of the formation and functions of cytokines and their receptorsKnow the interaction between Innate and Acquired ImmunityCorrelate the structure and function of the MHC with antigen processing and presentationKnow and describe the maturation and activation of T lymphocytes. Illustrate the functional role of the T lymphocyte receptor (TCR). Know and describe the maturation and activation of lymphocytes. Know how to describe the organization of genes and the formation of immunoglobulins. Know the differences between the different classes of IgDescribe the mechanisms underlying the humoral immune response. Describe the characteristics and uses of monoclonal antibodies. Know the mechanisms of action of vaccines and their characteristics. Describe the mechanisms that cause the different hypersensitivity reactions: classification and immunological bases Know the pathogenetic mechanism and be able to illustrate the main clinical manifestations of type I hypersensitivity reactions Describe the mechanisms that underlie autoimmunity. Illustrate the relationship between autoimmunity and immunological tolerance. Know how to indicate the pathogenetic mechanisms of the main autoimmune diseases. Illustrate the general principles that regulate the immune response in transplants. Learn about immunodeficiencies, congenital and acquired, as a consequence of the reduced or failed functioning of the immune system. Describe the role of the immune system on the development of tumors. Know the main laboratory techniques in immunological and serological diagnostics.

To tackle the Immunology and Immunopathology course the student must have the basics of Biology and Genetics, Physiology, Biochemistry and have passed the related exams

Abbas AK, casa ed. Elsevier Immunologia Cellulare e molecolare Patologia generale, Piccin

During the academic year, the students have eight dates available to be assessed, distributed so as not to be superimposed on the performance of the lessons. Oral exam

questions on treated lessons

During the academic year, the students have eight dates available to be assessed, distributed so as not to be superimposed on the performance of the lessons. Oral exam

Introduzione allo studio del sistemaimmunitario Immunità anti-infettiva: aspetti generali Risposta Innata Organi linfoidi primari e secondari Sistemidi comunicazíone Homing Citochine p roin fiammatorie Antigeni. Antigenicità, lmmunogenicità Sistemadel complemento Matuazione dei linfociti B e recettore per I'antigene Meccanismi molecolari dell' angioflogosi Fasi e mediatori dell' angioflogosi Chemiotassie fagocitosi Meccanismidelf istoflogosi Matunzíone dei linfociti T recettore per I' antigene ComplessoMaggioredi Istocompatibilità Processazionee presentazionedell' antigene Atavazione linfociti T Citochine Attivazione dei linfociti B Anticorpi .n., , ..r, ,., , ._ r, Intenzione Lin fociti B /Linfo citi T Anticorpi monoclonal-i Citotossicità Immunità antineoplastica Vaccini Reazioni immunopatogene di I tipo Reazioni immunopatogene (clinica) Reazioni immunopatogene di II, III e [V tipo TolTeranza Autoimmunità Autoimmunità" clinica Immunodeficienze Immunod eftcienze e trapranti

Abbas Immunologia cellulare e Molecolare Patologia Generale Piccin

In aula obbligatoria

Prova orale

Diapositive su Classroom

Introduction to the study of the immune system. Anti-infective immunity: general aspects Innate Response Primary and secondary lymphoid organs Communication systems Homing Proinflammatory cytokines Antigens. antigenicity, Immunogenicity Complement system Maturation of B lymphocytes and antigen receptor Molecular mechanisms of angioflogosis Stages and mediators of angioflogosis Chemotaxis and phagocytosis Mechanisms of histoplogosis Maturation of T lymphocytes receptor for antigen Antigen processing and presentation Major Histocompatibility Complex T lymphocyte activation cytokines Activation of B lymphocytes Antibodies Interaction Lymphocytes B / T lymphocytes Monoclonal antibodies cytotoxicity Antineoplastic immunity vaccines Practical activities Immunopathogenic reactions of type I Immunopathogenic reactions clinic Immunopathogenic reactions of II, III and IV type Practical activities Tolerance Autoimmunity Clinical autoimmunity Immunodeficiencies Immunodeficiencies and transplants

Immunologia cellulare e molecolare, Abul Abbas casa editrice EDRA Patologia e Fisiopatologia Generale, casa editrice Piccin Lezioni di Immunologia e Immunopatologia, Alberto Amadori-Paola Zanovello, casa editrice Piccin

Practical laboratory lessons

Students are required to participate in small group teaching in the Immunology Research Laboratory. In this way, students have the opportunity to approach the world of research.

The written exam includes forty multiple choice questions, of which only one will be the correct answer. The oral exam will be supported only by the sudent who have passed the written test, it will be necessary to have answered correctly at least 24 questions, to get 18/30 to access the oral exam.

Practical laboratory lessons