Medicine and Surgery HT

GENERAL VIROLOGY General properties and structure of viruses Replication of viruses Effects of the virus on the host cell Viral oncogenesis Pathogenesis of viral infections Antiviral drugs Principles of virological diagnosis MEDICAL VIROLOGY Structure, morphological features, pathogenesis, control, epidemiology, and diagnosis of all viruses and viral infections important in human pathology with special reference to: RNA viruses: Picornaviridae, Togaviridae, Flaviviridae, Orthomixoviridae, Paramyxoviridae, Rhabdoviridae, Retroviridae, Reoviridae, Astroviridae, Coronaviridae, Bunyaviridae (hint), Hepeviridae, Philoviridae DNA viruses: Adenoviridae, Papillomaviridae, Polyomaviridae, Herpesviridae, Hepadnaviridae, Parvoviridae, Poxviridae Viral zoonoses Diseases transmitted by arthropods

Prerequisites: There are no specific essential prerequisites. However, a good basic knowledge of molecular and cellular biology is very helpful.

TESTI CONSIGLIATI Principi di Microbiologia Medica (III EDIZIONE; G.Antonelli, M. Clementi, G.Pozzi, G.M. Rossolini) Microbiologia Medica (Murray, Rosenthal, Pfaller) Microbiologia Medica (Jawets, Melnick &Adelberg’s) TESTI SPECIALIZZATI Virology vol. 1-2 (B.N. Fields et al. – Lippincott- Raven Publishers) Viral Pathogenesis (N. Nathanson et al. – Lippincott – Raven) RECOMMENDED TEXTS Principles of Medical Microbiology (III EDITION; G. Antonelli, M. Clementi, G.Pozzi, G.M. Rossolini) Medical Microbiology (Murray, Rosenthal, Pfaller) Medical Microbiology (Jawets, Melnick & Adelberg's) SPECIALIZED TEXTS Virology vol. 1-2 (B.N. Fields et al. - Lippincott- Raven Publishers) Viral Pathogenesis (N. Nathanson et al. - Lippincott - Raven)

The teacher delivers lectures with traditional methods with power point presentation and scheduling of lessons as reported on GOMP Aure/Orari system, published on the website of CdS.

Mandatory attendance

Written exam

Virology papers selected from PUBMED

Classification and structure of the bacterial cell The bacterial spore: structure, sporogenesis, germination. Bacterial genetics bacterial metabolism. The cultivation of bacteria: culture media; Bacterial growth (growth curve). Bacterial pathogenic action; dynamics of pathogenicity; virulence factors bacterial toxins Notes on the innate and acquired immunity of the host towards infections The mechanisms of antibiotic resistance. The mechanism of action of antibiotics and chemotherapy. Vaccines and serums. The human microbiota, state of health and disease. Bacteriology: Clostridium, Corynebacterium , Listeria, Staphylococci, Streptococci, Enterococci, Enterobacteriaceae; Vibrionceae, Campylobacter, Helicobacter; Haemophilus, Bordetella, Brucella; Francisiella; Yersinia; Neisseria; Legionella Pseudomonas, Acinetobacter, Mycobacteria, Spirochetes, Mycoplasmas, Rickettsia, Chlamydia Mycology: The fungal cell structure. The methods of reproduction and classification of fungi Superficial mycoses; Cutaneous mycoses, subcutaneous mycoses, systemic mycoses, opportunistic mycoses. Candida, Aspergillus, Cryptococcus neoformans

Principi di Microbiologia Medica (G.Antonelli, M. Clementi, G.Pozzi, G.M. Rossolini) Virology vol. 1-2 (B.N. Fields et al. – Lippincott- Raven Publishers) Viral Pathogenesis (N. Nathanson et al. – Lippincott – Raven) Cancrini G. Parassitologia medica illustrata Ed. EDRA terza edizione et al. – Lippincott – Raven)

Mandatory attendance in attendance

The exam will be written in presence, the written exam will be followed by an oral exam at the discretion of the teacher, or at the request of the student

Lectures in presence with the aid of power point presentations