POPULATION GENETICS

Course objectives

General skills The course deals with the extension of mendelian genetics to groups of individuals (populations). The main goal of the course is to provide students with an in-depth knowledge of within- and between-population genetic diversity and how it changes as a consequence of different evolutionary factors. The course requires knowledge of mendelian genetics, and basic knowledge of statistics and probability theory. The course includes both theoretical population genetics, based on simple mathematical models, and applied population genetics, where several case studies will be analyzed. During the course students will learn to use software for the simulation of evolutionary processes and for the calculation of population genetics parameters. Specific skills A) Knowledge and understanding - Knowledge of human, animal and plant genetic diversity - Knowledge and understanding of evolutionary factors - Knowledge and understanding of the main methods used to reconstruct the micro-evolutionary history of the populations - Knowledge and understanding of the main methods for the estimation of population genetics parameters B) Ability to apply knowledge and understanding - Be able to use specific terminology - Be able to adequately describe the genetic composition of individuals, populations and group of populations - Be able to give a statistical weight to the observations - Be able to recognize the evolutionary factors that shaped the genetic make-up of a population C) Making judgements Through the in-depth analysis of many case studies, the student will acquire critical judgement skills D) Communication skills -During the lessons, students will be encouraged to communicate and interact with the teacher and other students on different population genetic topics E) Learning ability -Learning the specific terminology -Be able to make the logical connections between the topics covered -Be able to identify the most relevant topics and to independently pursue the study of advanced topics in population genetics

Channel 1
FULVIO CRUCIANI Lecturers' profile

Program - Frequency - Exams

Course program
The course consists of 20 theoretical lessons of two hours each, and 4 lessons of applied human genetics of three hours each, for a total of 52 hours of lessons. The Professor can organize seminars held by external expert Human genome structure (8 ore): Human genetic diversity (6 ore): Multifactorial inheritance and complex diseases (6 ore): Genetic counseling (8 ore) Genetics of human populations (6 ore) Human gene mapping (6 ore) Applied human genetics (12 ore)
Prerequisites
The course requires knowledge of mendelian genetics and population genetics, and basic knowledge of statistics and probability theory.
Books
1) Powerpoint slides (available at https://elearning2.uniroma1.it) 2) "Human Molecular Genetics" (Strachan & Read, anno 2012, Zanichelli) 3) "Genetica" (Sergio Pimpinelli, anno 2014, CEA) Chapter 13.3 (genetics of the hemoglobins). 4) Book "Genetica clinica" (Read & Donnai, anno 2007, Zanichelli), Chapter 10 For news on textbooks and teaching materials see: https://elearning2.uniroma1.it
Teaching mode
Learning methods include theoretical and applied classroom lessons. Theoretical lectures will give students a comprehensive understanding of the main topics concerned with human genetics. Lessons on applied human genetics will mainly concern the evaluation of genetic counseling cases and calculations of different genetic indices. Students will also learn how to retrieve information from human genetics databases and genomic browsers available online.
Frequency
Attendance is not mandatory but strongly recommended
Exam mode
The final evaluation consists of an oral examination on the course topics and includes the interpretation of a challenging genetic counseling case
Bibliography
- Schon et al. (2012) Human mitochondrial DNA: roles of inherited and somatic mutations. Nat Rev Genet 13: 878-888 - Cordeaux and Batzer (2009) The impact of retrotransposons on human genome evolution. Nat Rev Genet 10: 691-703 - Campbell and Eichler (2013) Properties and rates of germline mutations in humans. Trends Genet 29: 575-583
Lesson mode
Learning methods include theoretical and applied classroom lessons. Theoretical lectures will give students a comprehensive understanding of the main topics concerned with human genetics. Lessons on applied human genetics will mainly concern the evaluation of genetic counseling cases and calculations of different genetic indices. Students will also learn how to retrieve information from human genetics databases and genomic browsers available online.
  • Lesson code1019210
  • Academic year2025/2026
  • CourseBiology
  • CurriculumGenerale
  • Year3rd year
  • Semester1st semester
  • SSDBIO/18
  • CFU6