IMMUNOLOGY

Course objectives

General skills The aim of this course is to guide the student in understanding the mechanisms by which the immune system protects the individual from the aggression of potentially harmful microbes with whom he comes into contact during his life. The student will receive the conceptual bases to know the cells, tissues and molecules of the immune system and the mechanisms responsible for the activation and maturation of immune responses following the encounter of immune cell receptors with the molecular components of the microbes. Moreover, the mechanisms of innate and adaptive immune responses in the various districts and tissues of the organism and in response to the different pathogens will be investigated. The course includes lectures and classroom teaching sessions, with a description of the experimental techniques used today for the analysis of the functioning of the immune system and learning assessment activities through written exam simulation tests. Specific skills 1.Knowledge and understanding skills - Knowledge and understanding of the functioning of the molecules and cell types of the innate and adaptive immune system - Knowledge of the mechanisms of cooperation and integration of innate and adaptive immune responses and theirs - Knowledge and understanding of innate and adaptive immune responses in the different districts and tissues of the organism and in response to the different pathogens - Knowledge and understanding of the experimental techniques used today for the analysis of the functioning of the immune system 2. Ability to apply knowledge and understanding Be able to use the specific terminology of the discipline Be able to identify the right procedures to solve the questions of Immunology Apply the knowledge of the specific topics covered in class and the techniques used in immunology 3. Making judgmental The student will learn to discuss and critically evaluate the progress achieved in the immunological field and to ask questions for the elaboration and deepening of the knowledge learned 4. Ability to communicate what has been learned The student will be able to communicate what has been learned during the written exam 5. Ability to continue the study independently in the course of life The student will acquire not only basic knowledge, but also the methodologies and terminology specific to the field of Immunology. This knowledge will allow the student to continue his / her study independently, even after the end of the course and passing the exam.

Channel 1
LORETTA TUOSTO Lecturers' profile

Program - Frequency - Exams

Course program
The course is aimed to clarify the cellular and molecular mechanisms underlying the proper functioning of the immune system. The main objectives of the course will be aimed at knowledge: the general characteristics of the antigens; of molecular structures (antibodies, receptors, cytokines) of the cells, tissues and organs that make up the immune system, the mechanisms of maturation of T and B lymphocytes and the regulation of central and peripheral tolerance: the components and molecular mechanisms of innate and adaptive immune responses and their cooperation and integration. The mechanisms of the innate and adaptive immune responses in the various districts and tissues and in response to different pathogens will also be in-depth. To this aim, the course will be structured as follows: - Introduction to the Immune system - Cells and tissues of the immune system - Mechanisms of leucocyte recruitment - Innate immunity - Natural killer cells (NK) - Structure of antigens ad antibodies (Ig) - The major complex of hystocompatibility (MHC) - Antigen uptake, processing and presentation - The T cell receptor (TCR) and signal transduction - The B cell receptor (BCR) and signal transduction - T cell maturation - B cell maturation - The immune tolerance - Cell-mediated immune responses - B cell activation - Humoral immune responses - Regional and mucosal immune responses - Immunity to pathogens - Type I hypersensitivity: allergy The topics described above will be covered in the 40 hours of the course. 8 hours will be reserved to the evaluation of learning activities through written exam simulation tests. These tests will be aimed to evaluate the knowledge acquired by the student. At the end of the course students will have acquired knowledge of the specific topics covered in class, the ability to identify the links between the different parts of the course and the mastery of the specific language of the discipline.
Prerequisites
Although no prerequisites are required, the student must possess an adequate knowledge of cell and molecular biology, biochemistry and physiology is required.
Books
Abbas, Lichtman, Pillai. "Molecular and cellular immunology". Edra IX or X Edition
Frequency
Attendance at lessons is not required but the student is encouraged to attend classes as well as to participate to the evaluation tests
Exam mode
Assessment of learning outcomes will be assessed through a written exam at the end of the course. The exam will consist of 23 directly-answer questions on the entire program to be completed in 1 hour and 30 minutes. In the evaluation of the tests and in the assignment of the final mark, the following will be taken into account: the level of knowledge of the demonstrated contents (superficial, precise and complete, complete and in-depth), the ability to apply the theoretical concepts (errors in applying the concepts, discrete , good, well established), the capacity for analysis, synthesis and interdisciplinary links (sufficient, good, excellent), the capacity for critical sense and the formulation of judgments (sufficient, good, excellent).
  • Lesson code1019010
  • Academic year2024/2025
  • CourseBiology
  • CurriculumBiosanitario
  • Year3rd year
  • Semester2nd semester
  • SSDMED/04
  • CFU6
  • Subject areaAttività formative affini o integrative