THREE-DIMENSIONAL MODELING

Course objectives

The Animal Physiology module aims to provide cellular and molecular bases to understand physiological mechanisms governing the function of animals’ major tissues and organs. Program will focus particularly on the relationship between structure and function and on the evolutional and physiological adaptations of the major organs. Specific learning objectives are: - knowledge of the organization and structure of the animal cell; - understanding the functions of the major classes of biomolecules (lipids, proteins, carbohydrates); - study of the processes involved in the transport and exchange of the major solutes and organic molecules between the animal cells and the environment; - study of the mechanisms behind the regulation and maintenance of tissue and cell homeostasis; - study of the mechanisms governing inter-cellular communications (chemical and electrical) - studio dei meccanismi di comunicazione (chimica e elettrica) inter-cellulare; - understanding the function and organization of the major animals’ tissues and organs. A) Knowledge and ability to understand Students who have passed the exam will be able to know and understand: - the structure of the animal cell and the function of the major biomolecules; - the chemical-physical bases of the transports’ mechanisms of the major organic solutes and molecules across the plasma membrane and the processes to maintain cell homeostasis; - the electric properties of excitable cells’ plasma membrane and the mechanisms of electric stimuli propagation and transmission; - the cellular and molecular processes at the basis of muscle tissues physiology; - the physical properties of the heart and circulatory system; - the chemical-physical bases of respiratory physiology; - kydney’s functions and their role in the maintenance of systemic homeostasis; - biochemical bases of major biomolecules metabolism and adsorption. B) Ability to apply knowledge and understanding Students who have passed the exam will have adequate skills to: - describe the main features of an animal and the functions of bio-molecules; - critically discuss the chemical-physical principles underlying transports’ mechanisms of the major organic solutes and molecules across the plasma membrane and their importance to maintain cell homeostasis; - understand and critically discuss the cellular mechanisms behind the function of the major organic systems described; - describe and critically discuss the regulatory mechanisms to maintain organismal homeostasis; - describe and critically discuss the environmental factors influencing the major physiological processes in animals. C) Making judgments (making judgments) - At the end of the course the students will acquire critical judgment skills on key aspects in the field of animal physiology. This would be done following the lessons, through the study of scientific texts and by performing small laboratory’s experiences. D) Communication skills - At the end of the course students will be able to communicate, even to non-specialists’ audience, acquired knowledges through the use of technical and scientific languages, also by the use of graphic elements. E) Learning skills (learning skills) - Students will be able to critically interpret and deepen basic physiological issues also through the use of bibliographic databases and attending seminars and work’s groups.

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CHIARA MOZZETTA Lecturers' profile

Program - Frequency - Exams

Course program
ANIMAL PHYSIOLOGY module will be developed in 40 hours of frontal teaching, divided into the following didactic modules, and implemented by 12 hours of laboratory activities. The animal cell. 6 hours Chemical composition, structure and function of carbohydrates, lipids and proteins. Function of subcellular organelles. Cellular energetics. Plasma membrane: structure, specialized domains. Transport across membranes: simple diffusion, facilitated diffusion, active transport. Endocytosis and exocytosis. Trans-epithelial transport. Surface receptors. Electrophysiology. 8 hours Electric properties of the plasma membrane. Ionic basis of membrane potential. The action potential and conductance of electric impulses. Nerve cell organization. Synapses and impulse transmission. Spinal and autonomous neural circuits. Sensory transduction. Physiology of movement. 4 hours Skeletal muscle: excitability, molecular basis of muscle contraction, excitation – contraction coupling. Smooth muscle. Cardiovascular system. 6 hours Electrical activity of the heart, contractility, excitability, refractory period. Regulation of cardiac output. Circulatory system: hemodynamics, arteries, capillaries, veins, flux and pressure, transcapillary exchange. Arterial pressure regulation. Respiratory system. 5 hours Mechanical aspects. Blood gas transport and tissue gas exchange. Central organization of breathing. Mechanical and chemical control of breathing. Renal function. 6 hours Functional anatomy of the kidney. Ultrastructure and function of the nephron: glomerular filtration, tubular reabsorption and secretion. Medullary osmotic gradient. Urine concentration. Ionic and volume regulation. Osmotic regulation. Hormonal control. 5 hours General principles of endocrine physiology. Chemical classification of hormones. Regulation of hormone secretion. Hypothalamus and pituitary gland. Mechanism of action of peptidic and steroid hormones. Surface and intracellular receptors. Signal transduction: second messengers. Glycemia regulation. Reproduction regulation.
Prerequisites
The student must have at the beginning of the teaching activities basic knowledge of the following subjects, to understand the contents of the same and to achieve the learning objectives: - mathematics: algebra and mathematical analysis: linear, exponential, derivative, integral functions (indispensable) - physics: fluid physics (indispensable); gas physics (indispensable); thermodynamics (important); optic (important); - general and inorganic chemistry: description of the atom and the electronic orbitals (important); main chemical elements (important); reductions and redox potential (important); osmotic pressure (indispensable); the concept of pH and buffer solutions (indispensable); - organic chemistry: main classes of organic compounds and biological macromolecules (indispensable); - biochemistry: enzymes, enzymatic kinetics and activation energy (indispensable); phosphorylation reactions (important); main cofactors of the biological redox reactions (important); mitochondrial respiration (important); - cell biology: main eukaryotic cell structures (indispensable); cell division (useful); transcription (useful); protein synthesis (useful)
Books
- Silverthorn: Fisiologia una visione integrata – Casa Editrice Pearson - Sherwood: Fisiologia degli animali. Dai geni agli organismi - Casa Editrice Zanichelli Additional online material on the Moodle teaching platform (only for course participants)
Frequency
In person lessons 2 times a week. Attendance is not obligatory but strongly recommended
Exam mode
The exam is aimed at verifying the level of knowledge and in-depth examination of the topics of the teaching program and the reasoning skills developed by the student. The evaluation is expressed in thirtieths (minimum grade 18/30, maximum mark 30/30 with honors). The final grade will be a pondered mean between the grade of animal (2/3) and plant (1/3) physiology modules
Lesson mode
The Animal Physiology module includes 40 hours of frontal teaching, divided into the teaching modules indicated in the program, and 12 hours of laboratory activities.
  • Academic year2025/2026
  • CourseEnvironmental Sciences
  • CurriculumSingle curriculum
  • Year3rd year
  • Semester1st semester
  • SSDBIO/09
  • CFU6