GENETICS

Course objectives

General skills The course provides students with a basic knowledge of Genetics aimed at understanding the rules of inheritance, their molecular bases, their main applications and their implications for variability and evolution. In addition, the course provides basic notions of how genetic information encoded in nucleic acids is converted into proteins and of the molecular mechanisms leading to development of mutations, genetic diseases or cancer progression. The course is focused on the analysis of the most significant experimental approaches in the history of genetics, with the aim of helping students developing problem solving skills. Dublin Descriptors A) Knowledge and understanding -Knowledge and understanding of the characteristics of the genetic material -Knowledge and understanding of the rules of genetic transmission -Knowledge and understanding of mutations and their implications -Basic knowledge on the dynamics of genes in populations as well as on the genetic mechanisms underlying evolution B) Applying knowledge and understanding - usage of a proper genetic terminology - identification of the right procedures to solve genetic problems - formulation of hypotheses on the hereditary transmission of characters - constructing and interpreting genetic maps and genealogical trees - acquisition of conceptual tools for the genetic dissection of biological systems - utilizing basic biostatistical methodologies for data analysis and hypothesis testing C) Making judgements - Acquisition of a critical judgment capacity on solving problems of formal genetics, through the study of the evolution of the gene concept from Mendel to the present day and the detailed analysis of some fundamental experiments. - Addressing questions for the elaboration and deepening of the gained information D) Communication skills - communicating the genetic concepts acquired during the course with appropriate terminology E) Learning skills - logically connecting the acquired knowledge - identification of the most relevant topics of the issues discussed during the course CFU CONTACT HOURS 6 Lectures Seminars Laboratory exercises Exercises Field work

Channel 1
GRAZIA DANIELA RAFFA Lecturers' profile

Program - Frequency - Exams

Course program
1. Biology of the cell: Structure of prokaryotic and eukaryotic cells; The chromosomal basis of Heredity: Structure of eukaryotic chromosomes; ploidy; Cell cycle; Mitosis; Meiosis; Sexual reproduction; alternation between Meiosis and Mitosis; Life cycles (in animals, plants, lower eukaryotes). 2. Mendel’ experiments; Purity of gametes; segregation; independence. Pedigree. Elements of statystical analysis: probability; chi-square test. Dominance. Multiple alleles. Genotype and environment; lethal genes; interactions between genes. 3. Sex-linked heredity: sex determination; dosage compensation. Concordance between mendelism and meiosis. Historical development of the chromosome theory. Non disjunction; aneuploydies. 4. Linkage and recombination; analysis of genetic maps; Three-point testcross; Deletion mapping and cytological maps. 5.Chromosome mutations: deletions; duplications; inversions; translocations. Position effect variegation. 6. Mechanisms of Gene Mutation: identification and analysis of mutations in viruses, bacteria, fungi, Drosophila, humans. Genetic basis of cancer. 7. Gene Transfer in Bacteria and Their Viruses: Bacterial conjugation; Bacterial transformation; Bacteriophage genetics; Transduction; Chromosome mapping 8. Genetic fine structure: Intragenic recombination; complementation. 9. DNA structure and replication; DNA repair. The genetic code; molecular mechanisms of mutation. Transcription; translation; protein synthesis. 10. Gene regulation in procaryotes: Lac Operon; Gene regulation in eukaryotes. 11. Genetic engineering tools. Development and analysis of transgenic plants.
Prerequisites
Chemistry Mathematics Zoology Botany
Books
Binelli-Ghisotti Genetica (EdiSES) Snustadt-Simmons Principi di Genetica (EdiSES) Pimpinelli GENETICA (Casa Editrice Ambrosiana) Ghisotti-Ferrari Eserciziario di Genetica (Piccin)
Teaching mode
5 CFU: frontal lectures 1 CFU: exercises
Frequency
Attendance is highly recommended
Exam mode
The final exam test is meant to verify the knowledge of the concepts acquired during the course and the ability in critical thinking and problem solving, developed by the student. The final exam consists of a written test and an oral exam The written exam (duration: 1 hour) consists of 5 numerical tests aimed at assessing the students’ problem solving skills on the following topics : - Rules of inheritance and pedigree analysis - construction of genetic maps - bacterial genetics Each test (correctly solved) will be given a score of 2 points. Minimal requirement for admission to the oral exam is to provide correct solutions to at least 3/5 tests (gaining a score of 6/10). A score equal to 5/10 grants admission to the oral exam but in any case, the final grade will result from an evaluation of both the written and oral tests. The oral exam consists of an interview (duration 20/30 minutes) in order to verify the achievement of the objectives in terms of knowledge and skills acquired, as well as communication skills, language property, clarity of exposition and critical ability to solve genetic problems. During the course, students will be offered the possibility to sustain a few tests for self-evaluation. For students who successfully pass these tests, the written exam will be waived.
Bibliography
Slides from lecture presentations are available on the e-learning platform
Lesson mode
5 CFU: frontal lectures 1 CFU: exercises
Channel 2
GRAZIA DANIELA RAFFA Lecturers' profile

Program - Frequency - Exams

Course program
1. Biology of the cell: Structure of prokaryotic and eukaryotic cells; The chromosomal basis of Heredity: Structure of eukaryotic chromosomes; ploidy; Cell cycle; Mitosis; Meiosis; Sexual reproduction; alternation between Meiosis and Mitosis; Life cycles (in animals, plants, lower eukaryotes). 2. Mendel’ experiments; Purity of gametes; segregation; independence. Pedigree. Elements of statystical analysis: probability; chi-square test. Dominance. Multiple alleles. Genotype and environment; lethal genes; interactions between genes. 3. Sex-linked heredity: sex determination; dosage compensation. Concordance between mendelism and meiosis. Historical development of the chromosome theory. Non disjunction; aneuploydies. 4. Linkage and recombination; analysis of genetic maps; Three-point testcross; Deletion mapping and cytological maps. 5.Chromosome mutations: deletions; duplications; inversions; translocations. Position effect variegation. 6. Mechanisms of Gene Mutation: identification and analysis of mutations in viruses, bacteria, fungi, Drosophila, humans. Genetic basis of cancer. 7. Gene Transfer in Bacteria and Their Viruses: Bacterial conjugation; Bacterial transformation; Bacteriophage genetics; Transduction; Chromosome mapping 8. Genetic fine structure: Intragenic recombination; complementation. 9. DNA structure and replication; DNA repair. The genetic code; molecular mechanisms of mutation. Transcription; translation; protein synthesis. 10. Gene regulation in procaryotes: Lac Operon; Gene regulation in eukaryotes. 11. Genetic engineering tools. Development and analysis of transgenic plants.
Prerequisites
Chemistry Mathematics Zoology Botany
Books
Binelli-Ghisotti Genetica (EdiSES) Snustadt-Simmons Principi di Genetica (EdiSES) Pimpinelli GENETICA (Casa Editrice Ambrosiana) Ghisotti-Ferrari Eserciziario di Genetica (Piccin)
Teaching mode
5 CFU: frontal lectures 1 CFU: exercises
Frequency
Attendance is highly recommended
Exam mode
The final exam test is meant to verify the knowledge of the concepts acquired during the course and the ability in critical thinking and problem solving, developed by the student. The final exam consists of a written test and an oral exam The written exam (duration: 1 hour) consists of 5 numerical tests aimed at assessing the students’ problem solving skills on the following topics : - Rules of inheritance and pedigree analysis - construction of genetic maps - bacterial genetics Each test (correctly solved) will be given a score of 2 points. Minimal requirement for admission to the oral exam is to provide correct solutions to at least 3/5 tests (gaining a score of 6/10). A score equal to 5/10 grants admission to the oral exam but in any case, the final grade will result from an evaluation of both the written and oral tests. The oral exam consists of an interview (duration 20/30 minutes) in order to verify the achievement of the objectives in terms of knowledge and skills acquired, as well as communication skills, language property, clarity of exposition and critical ability to solve genetic problems. During the course, students will be offered the possibility to sustain a few tests for self-evaluation. For students who successfully pass these tests, the written exam will be waived.
Bibliography
Slides from lecture presentations are available on the e-learning platform
Lesson mode
5 CFU: frontal lectures 1 CFU: exercises
  • Lesson code1016316
  • Academic year2024/2025
  • CourseNatural Sciences
  • CurriculumSingle curriculum
  • Year2nd year
  • Semester1st semester
  • SSDAGR/07
  • CFU6
  • Subject areaDiscipline agrarie, chimiche, fisiche, giuridiche, economiche e di contesto