LABORATORY OF ANCIENT DNA AND RECONSTRUCTIONS OF THE PAST

Course objectives

The course consists of two parts: 1. Ancient DNA - theory and study, discussion and oral presentation of recent case studies. 2. Ancient DNA - practice with visits to modern DNA laboratories in Sapienza and virtual visits to ancient DNA laboratories in Italy and other European countries. OBJECTIVES and LEARNING OUTCOMES of the COURSE. After completing the first part, students are expected to be able to: - explain the peculiarities of ancient DNA and its importance in reconstructions of the past - provide an overview of laboratory and genetic analysis methodologies used in the study of ancient material - present basic theoretical knowledge of the evolutionary and ecological processes that occurred during the last ice age - explain how environments have changed over the past 2.6 million years - relate chronologically the events that occurred during the last 2.6 million years - provide an overview of the processes that have changed environments over the past 2.6 million years - contextualize the evolutionary processes that have occurred in plants and animals through a synthesis of knowledge from the different areas of research covered in the course. After completing the second part, students are expected to be able to: - explain how to extract DNA from ancient fossil specimens and sediments and perform analyses on ancient DNA - explain the peculiarities of an ancient DNA laboratory versus a modern one and how to work in this environment.

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LAURA PARDUCCI Lecturers' profile

Program - Frequency - Exams

Course program
This course aims to provide the latest knowledge on how DNA extracted from fossil remains and ancient sediments is used to study the processes that have shaped the evolution and distribution of plant and animal species over the last 2.6 million years. These processes include both climate and sea level changes and biological changes such as speciation and species extinction. The course analyzes recent case studies such as the reconstruction of paleoenvironments, hybridization between human species, migration, demographic expansions after the glaciations and the extinction of plant and animal species. An overview of other biomolecular methods currently used on ancient remains will also be provided. The course has a practical component in which students will visit laboratories and watch videos shot in ancient DNA laboratories and will learn how DNA is extracted and analyzed from fossil remains and how to use computational tools to analyze the resulting sequence data. The course consists of two parts: 1. Ancient DNA – theory and study, discussion and oral presentation of recent case studies. 2. Ancient DNA – practice with visits to modern DNA laboratories in Sapienza and virtual visits to ancient DNA laboratories in Italy and other European countries.
Prerequisites
Access to the course requires basic school knowledge in Archaeology, Geography, Genetic Geology and Biology.
Books
Recommended TEXTBOOKS Lindqvist, Charlotte, and Om P. Rajora, eds. Paleogenomics: Genome-Scale Analysis of Ancient DNA. Springer, 2019. ISBN 978-3-030-04753-5 (Available as E-book Stockholm University). Eric Capo, Cecilia Barouillet, and John Smol. eds Tracking Environmental Change Using Lake Sediments. Springer, 2024 ISBN
Frequency
The lessons provide an overview of the main topics. Attendance at lessons is not compulsory but it is desirable: frequent absences result in a reduced ability to answer the exam questions.
Exam mode
An intermediate project with a short (15 min) oral presentation of a selected topic (25%) and a final oral examination (75%) verify the student's understanding of the course topics.
Lesson mode
6 credits Lectures approximately 32 hours, 16-18 two-hour lectures and practical exercises to be carried out in class and in the laboratory, approximately 24 hours
LAURA PARDUCCI Lecturers' profile

Program - Frequency - Exams

Course program
This course aims to provide the latest knowledge on how DNA extracted from fossil remains and ancient sediments is used to study the processes that have shaped the evolution and distribution of plant and animal species over the last 2.6 million years. These processes include both climate and sea level changes and biological changes such as speciation and species extinction. The course analyzes recent case studies such as the reconstruction of paleoenvironments, hybridization between human species, migration, demographic expansions after the glaciations and the extinction of plant and animal species. An overview of other biomolecular methods currently used on ancient remains will also be provided. The course has a practical component in which students will visit laboratories and watch videos shot in ancient DNA laboratories and will learn how DNA is extracted and analyzed from fossil remains and how to use computational tools to analyze the resulting sequence data. The course consists of two parts: 1. Ancient DNA – theory and study, discussion and oral presentation of recent case studies. 2. Ancient DNA – practice with visits to modern DNA laboratories in Sapienza and virtual visits to ancient DNA laboratories in Italy and other European countries.
Prerequisites
Access to the course requires basic school knowledge in Archaeology, Geography, Genetic Geology and Biology.
Books
Recommended TEXTBOOKS Lindqvist, Charlotte, and Om P. Rajora, eds. Paleogenomics: Genome-Scale Analysis of Ancient DNA. Springer, 2019. ISBN 978-3-030-04753-5 (Available as E-book Stockholm University). Eric Capo, Cecilia Barouillet, and John Smol. eds Tracking Environmental Change Using Lake Sediments. Springer, 2024 ISBN
Frequency
The lessons provide an overview of the main topics. Attendance at lessons is not compulsory but it is desirable: frequent absences result in a reduced ability to answer the exam questions.
Exam mode
An intermediate project with a short (15 min) oral presentation of a selected topic (25%) and a final oral examination (75%) verify the student's understanding of the course topics.
Lesson mode
6 credits Lectures approximately 32 hours, 16-18 two-hour lectures and practical exercises to be carried out in class and in the laboratory, approximately 24 hours
  • Lesson code10616596
  • Academic year2025/2026
  • CourseSciences and Teaching of Natural Systems
  • CurriculumClima ambiente ed energia - Percorso valido anche per coloro che partecipano al percorso internazionale di titolo multiplo italo-svizzero-svedese-francese con prima iscrizione presso l'Università di Stoccolma)
  • Year1st year
  • Semester2nd semester
  • SSDBIO/02
  • CFU6