FRANCESCA MEGIORNI

Il ricevimento di tutti gli studenti sarà concordato previo appuntamento mediante email istituzionale: francesca.megiorni@uniroma1.it

Per i singoli moduli dei diversi Corsi di Laurea verrà istituita una Classroom specifica. Gli studenti saranno aggiunti direttamente dal docente (inserimento delle email) e dovranno aderire alla richiesta di partecipazione. Nella Classroom saranno caricati i pdf delle lezioni, il materiale di approfondimento, il link del Meet (ove richiesto per emergenza Covid-19) ed eventuali notizie relative alle lezioni e ai diversi CdL/CLM. 

CURRENT POSITION
Associate Professor MEDS-26/A Technical Sciences of Laboratory Medicine
Specialist in Medical Genetics
Interdisciplinary Department of Well-being, Health and Environmental Sustainability (BeSSA) - Rieti Campus
Faculty of Medicine and Dentistry, Sapienza University of Rome

EDUCATION AND TRAINING
21-10-1998 Degree in Biological Sciences - Biomolecular field. University SAPIENZA of Rome with vote of 110/110 cum laude
May 2000 License in Biologist Profession. University SAPIENZA of Rome with vote of 140/150
04-06-2005 Ph.D in Medical Genetics. University SAPIENZA of Rome
04-12-2007 Postgraduate Specialization in Medical Genetics – Technical field. University SAPIENZA of Rome with vote of 70/70 cum laude
31-03-2017 National Scientific Habilitation for Associate Professor, Sector 06/A1 – Medical Genetics MIUR
31-03-2017 National Scientific Habilitation for Associate Professor, Sector 06/N1 – Sciences of Health Care Professions and Applied Medical Technologies MIUR

EDITORIAL ACTIVITY
- Associate Editor, Frontiers in Molecular Biosciences – section of Molecular Diagnostics and Therapeutics
- Academic Editor, PLOS ONE
- Guest Editor, Medical Sciences 2016 – Special Issue: "Genetics of Celiac Disease"
- Guest Editor, Cells 2021 – Special Issue "Advances in Rhabdomyosarcoma"

COMMITEE RESPONSABILITY
- REPRISE (register of scientific experts established at MIUR) for “basic research”
- GEV – ANVUR. External reviewer for VQR 2015-2019

MEMBERSHIP TO SCIENTIFIC SOCIETIES
- Ordine Nazionale dei Biologi – Sezione A dal 26-01-2005 con n° 054772
- Società Italiana di Genetica Umana – SIGU
- Società Italiana Ricerca Traslazionale e Professioni Sanitarie – SIRTEPS

PATENTS
Title: “Diagnosi e trattamento dei tumori”. Inventori: Bozzoni Irene, Legnini Ivano, Di Timoteo Gaia, Rossi Francesca, Dominici Carlo, Megiorni Francesca. Portafoglio brevettuale della SAPIENZA – Application number: 102016000124288; Priority date: 07/12/2016 (https://www.uniroma1.it/en/brevetto/102016000124288)

PUBLICATIONS (ORCID: 0000-0003-3705-3248)
Mattei V, Santilli F, Pulcini F, Fabrizi J, Lancia L, Santacroce C, Megiorni F, Ceccarelli S, Paldino E, Gramignoli R, Roubelakis MG, Bahareh S, Vosough M, Bollini S, Galderisi U, Salgado AJ, Angeloni A, Marchese C, Delle Monache S. Validated methods for isolation and qualification of mesenchymal stromal/stem cells from different sources. J Transl Med. 2025;23(1):975. doi: 10.1186/s12967-025-06972-8. IF 7.5

Maiullari F, Ceraolo MG, Presutti D, Fratini N, Galbiati M, Fasciani A, Giżyński K, Bousselmi S, Megiorni F, Marchese C, Kasprzycki P, Karnowski K, Talone A, Varvaro G, Peddis D, Costantini M, Bearzi C, Rizzi R. Modeling breast cancer dynamics through modulable small Vessel Environment Bioreactor (sVEB). Biomaterials. 2025;323:123441. doi: 10.1016/j.biomaterials.2025.123441. IF 12.479

Giovannetti F, Pontecorvi P, Megiorni F, Armentano M, Alisi L, Romano E, Marchese C, Lambiase A, Bruscolini A. Conjunctival MicroRNA Expression Signature in Primary Sjögren's Syndrome Dry Eye: A NanoString-Based Bioinformatic Analysis. Investigative Ophthalmology and Visual Science. 2025;66(4):80. doi: 10.1167/iovs.66.4.80. IF 4.7

Gerini G, Mari E, Pontecorvi P, Camero S, Romano E, Ranieri D, Megiorni F, Fioramonti P, Angeloni A, Marchese C, Ceccarelli S. 3D culturing as a promising strategy to enhance the angiogenic potential of adipose stem cell-derived secretome: insights into the role of miR-145-5p/ANGPT2 axis. Stem Cell Research & Therapy. 2025;16(1):153. doi: 10.1186/s13287-025-04277-7. IF 7.3

Gerini G, Traversa A, Cece F, Cassandri M, Pontecorvi P, Camero S, Nannini G, Romano E, Marampon F, Venneri MA, Ceccarelli S, Angeloni A, Amedei A, Marchese C, Megiorni F. Deciphering the Transcriptional Metabolic Profile of Adipose-Derived Stem Cells During Osteogenic Differentiation and Epigenetic Drug Treatment. Cells. 2025;14(2):135. doi: 10.3390/cells14020135. IF 5.2

Traversa A, Mari E, Pontecorvi P, Gerini G, Romano E, Megiorni F, Amedei A, Marchese C, Ranieri D, Ceccarelli S. Polyethylene Micro/Nanoplastics Exposure Induces Epithelial–Mesenchymal Transition in Human Bronchial and Alveolar Epithelial Cells. International Journal of Molecular Sciences. 2024;25(18):10168. doi: 10.3390/ijms251810168 IF 4.9

Cassandri M, Porrazzo A, Pomella S, Noce B, Zwergel C, Aiello FA, Vulcano F, Milazzo L, Camero S, Pajalunga D, Spada M, Manzi V, Gravina GL, Codenotti S, Piccione M, Tomaciello M, Signore M, Barillari G, Marchese C, Fanzani A, De Angelis B, Quintarelli C, Vakoc CR, Chen EY, Megiorni F, Locatelli F, Valente S, Mai A, Rota R, Marampon F. HDAC3 genetic and pharmacologic inhibition radiosensitizes fusion positive rhabdomyosarcoma by promoting DNA double-strand breaks. Cell Death Discov. 2024;10(1):351. doi: 10.1038/s41420-024-02115-y. IF 6.122

Camero S, Milazzo L, Vulcano F, Ceccarelli F, Pontecorvi P, Pedini F, Rossetti A, Scialis ES, Gerini G, Cece F, Pomella S, Cassandri M, Porrazzo A, Romano E, Festuccia C, Gravina GL, Ceccarelli S, Rota R, Lotti LV, Midulla F, Angeloni A, Marchese C, Marampon F, Megiorni F. Antitumour effects of SFX-01 molecule in combination with ionizing radiation in preclinical and in vivo models of rhabdomyosarcoma. BMC Cancer. 2024;24(1):814. doi: 10.1186/s12885-024- 12536-8. IF 3.4

Pace A, Scirocchi F, Napoletano C, Zizzari IG, Po A, Megiorni F, Asquino A, Pontecorvi P, Rahimi H, Marchese C, Ferretti E, Nuti M, Rughetti A. Targeting FGFRs by pemigatinib induces G1 phase cell cycle arrest, cellular stress and upregulation of tumor suppressor microRNAs. Journal of Translational Medicine. 2023;21(1):626. doi: 10.1186/s12967-023-04450-7. IF 8.45

Pontecorvi P, Ceccarelli S, Cece F, Camero S, Lotti VV, Niccolai G, Nannini G, Gerini G, Anastasiadou E, Scialis ES, Romano E, Venneri MA, Amedei A, Angeloni A, *Megiorni F, Marchese C. Assessing the Impact of Polyethylene Nano/Microplastic Exposure on Human Vaginal Keratinocytes. Int J Mol Sci. 2023;24(14):11379. doi: 10.3390/ijms241411379. IF 5.6

Raparelli V, Romiti GF, Di Teodoro G, Seccia R, Tanzilli G, Viceconte N, Marrapodi R, Flego D, Corica B, Cangemi R, Pilote L, Basili S, Proietti M, Palagi L, Stefanini L; EVA Investigators (Megiorni F among the collaborators). A machine-learning based bio-psycho-social model for the prediction of non-obstructive and obstructive coronary artery disease. Clin Res Cardiol. 2023 Apr 1. doi: 10.1007/s00392-023-02193-5. IF 4.6

Vaccaro S, Rossetti A, Porrazzo A, Camero S, Cassandri M, Pomella S, Tomaciello M, Macioce G, Pedini F, Barillari G, Marchese C, Rota R, Cenci G, Tombolini M, Newman RA, Yang P, Codenotti S, Fanzani A, Megiorni F, Festuccia C, Minniti G, Gravina GL, Vulcano F, Milazzo L, Marampon F. The botanical drug PBI-05204, a supercritical CO2 extract of Nerium oleander, sensitizes alveolar and embryonal rhabdomyosarcoma to radiotherapy in vitro and in vivo. Front Pharmacol. 2022;13:1071176. doi: 10.3389/fphar.2022.1071176. IF 5.6

Camero S, Cassandri M, Pomella S, Milazzo L, Vulcano F, Porrazzo A, Barillari G, Marchese C, Codenotti S, Tomaciello M, Rota R, Fanzani A, * Megiorni F, Marampon F. Radioresistance in rhabdomyosarcomas: Much more than a question of dose. Front Oncol. 2022;12:1016894. doi: 10.3389/fonc.2022.1016894. IF 5.783

Ceccarelli S, Gerini G, Megiorni F, Pontecorvi P, Messina E, Camero S, Anastasiadou E, Romano E, Onesti MG, Napoli C, Marchese C. Inhibiting DNA methylation as a strategy to enhance adipose-derived stem cells differentiation: Focus on the role of Akt/mTOR and Wnt/β-catenin pathways on adipogenesis. Front Cell Dev Biol. 2022;10:926180. doi: 10.3389/fcell.2022.926180. IF 6.081

Pomella S, Porrazzo A, Cassandri M, Camero S, Codenotti S, Milazzo L, Vulcano F, Barillari G, Cenci G, Marchese C, Fanzani A, Megiorni F, Rota R, Marampon F. Translational Implications for Radiosensitizing Strategies in Rhabdomyosarcoma. Int J Mol Sci. 2022;23(21):13281. doi: 10.3390/ijms232113281. IF 6.208

Di Rocco A, Camero S, Benedetti A, Lozanoska-Ochser B, Megiorni F, Marchese C, Stramucci L, Ciccarelli C, Bouché M, Bossi G, Marampon F, Zani BM. Anti‑oncogenic and pro‑myogenic action of the MKK6/p38/AKT axis induced by targeting MEK/ERK in embryonal rhabdomyosarcoma. Oncol Rep. 2022 Sep;48(3):151. doi: 10.3892/or.2022.8363. IF 4.136

Conteduca G, Rossi A, Megiorni F, Parodi A, Ferrera F, Tardito S, Altosole T, Fausti V, Occella C, Kalli F, Negrini S, Pizzuti A, Marchese C, Rizza E, Indiveri F, Coviello D, Fenoglio D, Filaci G. Single-nucleotide polymorphisms in 3'-untranslated region inducible costimulator gene and the important roles of miRNA in alopecia areata. Skin Health Dis. 2021; 1(2):e34. doi: 10.1002/ski2.34. IF 1.347

Raparelli V, Nocella C, Proietti M, Romiti GF, Corica B, Bartimoccia S, Stefanini L, Lenzi A, Viceconte N, Tanzilli G, Cammisotto V, Pilote L, Cangemi R, Basili S, Carnevale R; EVA Collaborators (Megiorni F among the collaborators). Testosterone-to-estradiol ratio and platelet thromboxane release in ischemic heart disease: the EVA project. J Endocrinol Invest. 2022 Mar 9. doi: 10.1007/s40618-022-01771-0. IF 4.256

Megiorni F, Pontecorvi P, Gerini G, Anastasiadou E, Marchese C, Ceccarelli S. Sex-Related Factors in Cardiovascular Complications Associated to COVID-19. Biomolecules. 2021 Dec 24;12(1):21. doi: 10.3390/biom12010021. IF 4.879

Camero S, Vitali G, Pontecorvi P, Ceccarelli S, Anastasiadou E, Cicchetti F, Flex E, Pomella S, Cassandri M, Rota R, Marampon F, Marchese C, Schiavetti A, Megiorni F. DNMT3A and DNMT3B Targeting as an Effective Radiosensitizing Strategy in Embryonal Rhabdomyosarcoma. Cells. 2021 Oct 30;10(11):2956. doi: 10.3390/cells10112956. IF 6.600

Cassandri M, Pomella S, Rossetti A, Petragnano F, Milazzo L, Vulcano F, Camero S, Codenotti S, Cicchetti F, Maggio R, Festuccia C, Gravina GL, Fanzani A, Megiorni F, Catanoso M, Marchese C, Tombolini V, Locatelli F, Rota R, Marampon F. MS-275 (Entinostat) Promotes Radio-Sensitivity in PAX3-FOXO1 Rhabdomyosarcoma Cells. Int J Mol Sci. 2021 Oct 1;22(19):10671. doi: 10.3390/ijms221910671. IF 5.924

Anastasiadou E, Ceccarelli S, Messina E, Gerini G, Megiorni F, Pontecorvi P, Camero S, Onesti MG, Trivedi P, Faenza M, Coscioni E, Nicoletti GF, Napoli C, Marchese C (2021). MiR-200c-3p maintains stemness and proliferative potential in adipose-derived stem cells by counteracting senescence mechanisms. PLOS ONE, 16(9):e0257070. doi: 10.1371/journal.pone.0257070. IF 3.24

Anastasiadou E, Messina E, Sanavia T, Labruna V, Ceccarelli S, Megiorni F, Gerini G, Pontecorvi P, Camero S, Perniola G, Venneri MA, Trivedi P, Lenzi A, Marchese C (2021). Calcineurin Gamma Catalytic Subunit PPP3CC Inhibition by miR-200c-3p Affects Apoptosis in Epithelial Ovarian Cancer. GENES, 12(9):1400. doi: 10.3390/genes12091400. IF 4.096

Carpentieri G, Leoni C, Pietraforte D, Cecchetti S, Iorio E, Belardo A, Pietrucci D, Di Nottia M, Pajalunga D, Megiorni F, Mercurio L, Tatti M, Camero S, Marchese C, Rizza T, Tirelli V, Onesimo R, Carrozzo R, Rinalducci S, Chillemi G, Zampino G, Tartaglia M, Flex E. Hyperactive HRAS dysregulates energetic metabolism in fibroblasts from patients with Costello syndrome via enhanced production of reactive oxidizing species. Hum Mol Genet. 2021 Sep 11:ddab270. doi: 10.1093/hmg/ddab270. IF 6.150

Pontecorvi P, Megiorni F, Camero S, Ceccarelli S, Bernardini L, Capalbo A, Anastasiadou E, Gerini G, Messina E, Perniola G, Benedetti Panici P, Grammatico P, Pizzuti A, Marchese C (2021). Altered expression of candidate genes in Mayer-Rokitansky-Küster-Hauser syndrome may influence vaginal keratinocytes biology: a focus on Protein Kinase X. BIOLOGY, 10(6):450. doi: 10.3390/biology10060450. IF 5.079

#Megiorni F, Camero S, Pontecorvi P, Camicia L, Marampon F, Ceccarelli S, Anastasiadou E, Bernabò N, Perniola G, Pizzuti A, Benedetti Panici P, Tombolini V, Marchese C. OTX015 Epi-Drug Exerts Antitumor Effects in Ovarian Cancer Cells by Blocking GNL3-Mediated Radioresistance Mechanisms: Cellular, Molecular and Computational Evidence. Cancers 2021; 13(7), 1519; doi: 10.3390/cancers13071519. IF 6.639

Anastasiadou E, Messina E, Sanavia T, Mundo L, Farinella F, Lazzi S, Megiorni F, Ceccarelli S, Pontecorvi P, Marampon F, Di Gioia CRT, Perniola G, Benedetti Panici P, Leoncini L, Trivedi P, Lenzi A, Marchese C. MiR-200c-3p contrasts PD-L1 induction by combinatorial therapies and slows proliferation of epithelial ovarian cancer through downregulation of β-catenin and c-Myc. Cells 2021; 10(3), 519; doi: 10.3390/cells10030519. IF 6.600

Pontecorvi P, Bernardini L, Capalbo A, Ceccarelli S, Megiorni F, Vescarelli E, Bottillo I, Preziosi N, Fabbretti M, Perniola G, Benedetti Panici P, Pizzuti A, Grammatico P, Marchese C. Protein-protein interaction network analysis applied to DNA copy number profiling suggests new perspectives on the aetiology of Mayer-Rokitansky-Küster-Hauser syndrome. Sci Rep. 2021 Jan 11;11(1):448. doi: 10.1038/s41598-020-79827-5. IF 3.998

Petragnano F, Pietrantoni I, Camero S, Codenotti S, Milazzo L, Vulcano F, Macioce G, Giordani I, Tini P, Cheleschi S, Gravina GL, Festuccia C, Rossetti A, Delle Monache S, Ordinelli A, Ciccarelli C, Mauro A, Barbara B, Antinozzi C, Schiavetti A, Maggio R, Di Luigi L, Polimeni A, Marchese C, Tombolini V, Fanzani A, Bernabò N, *Megiorni F, Marampon F. Clinically relevant radioresistant rhabdomyosarcoma cell lines: functional, molecular and immune-related characterization. J Biomed Sci. 2020 Aug 27;27(1):90. doi: 10.1186/s12929-020-00683-6. IF 5.762

Marchionni E, Porpora MG, Megiorni F, Piacenti I, Giovannetti A, Marchese C, Benedetti Panici P, Pizzuti A. TLR4 T399I Polymorphism and Endometriosis in a Cohort of Italian Women. Diagnostics (Basel). 2020 Apr 27;10(5):255. doi: 10.3390/diagnostics10050255. IF 2.489

Pepin ME, Infante T, Benincasa G, Schiano C, Miceli M, Ceccarelli S, Megiorni F, Anastasiadou E, Della Valle G, Fatone G, Faenza M, Docimo L, Nicoletti GF, Marchese C, Wende AR, Napoli C. Differential DNA Methylation Encodes Proliferation and Senescence Programs in Human Adipose-Derived Mesenchymal Stem Cells. Front Genet. 2020 Apr 15;11:346. doi: 10.3389/fgene.2020.00346. eCollection 2020. IF 3.517

Camero S, Camicia L, Marampon F, Ceccarelli S, Shukla R, Mannarino O, Pizer B, Schiavetti A, Pizzuti A, Tombolini V, Marchese C, Dominici C, # Megiorni F. BET inhibition therapy counteracts cancer cell survival, clonogenic potential and radioresistance mechanisms in rhabdomyosarcoma cells. Cancer Lett. 2020 Mar 18. pii: S0304-3835(20)30130-0. doi: 10.1016/j.canlet.2020.03.011. IF 6.491

Raparelli V, Romiti GF, Spugnardi V, Borgi M, Cangemi R, Basili S, Proietti M; The Eva Collaborative Group (Megiorni F among the collaborators). Gender-Related Determinants of Adherence to the Mediterranean Diet in Adults with Ischemic Heart Disease. Nutrients. 2020 Mar 13;12(3). pii: E759. doi: 10.3390/nu12030759. PubMed PMID: 32183044; PubMed Central PMCID: PMC7146303. IF 4.171

#Megiorni F. Epigenetics in rhabdomyosarcoma: cues to new biomarkers and targeted therapies. EBioMedicine. 2020 Feb;52:102673. doi: 10.1016/j.ebiom.2020.102673. IF 6.680

Vescarelli E, Gerini G, Megiorni F, Anastasiadou E, Pontecorvi P, Solito L, De Vitis C, Camero S, Marchetti C, Mancini R, Benedetti Panici P, Dominici C, Romano F, Angeloni A, Marchese C, Ceccarelli S. MiR-200c sensitizes Olaparib-resistant ovarian cancer cells by targeting Neuropilin 1. J Exp Clin Cancer Res. 2020 Jan 2;39(1):3. doi: 10.1186/s13046-019-1490-7. IF 5.646

Raparelli V, Proietti M, Romiti GF, Lenzi A, Basili S; EVA Collaborative Group (Megiorni F among collaborators). The Sex-Specific Detrimental Effect of Diabetes and Gender-Related Factors on Pre-admission Medication Adherence Among Patients Hospitalized for Ischemic Heart Disease: Insights From EVA Study. Front Endocrinol (Lausanne). 2019 Feb 25;10:107. doi: 10.3389/fendo.2019.00107. IF 3.519

De Felice F, *Megiorni F, Pietrantoni I, Tini P, Lessiani G, Mastroiacovo D, Mattana P, Antinozzi C, Di Luigi L, Delle Monache S, Angelucci A, Festuccia C, Fanzani A, Maggio R, Tombolini V, Gravina GL, Marampon F. Sulodexide counteracts endothelial dysfunction induced by metabolic or non-metabolic stresses through activation of the autophagic program. Eur Rev Med Pharmacol Sci. 2019 Mar;23(6):2669-2680. doi: 10.26355/eurrev_201903_17415. IF 2.727

Codenotti S, Faggi F, Ronca R, Chiodelli P, Grillo E, Guescini M, Megiorni F, Marampon F, Fanzani A. Caveolin-1 enhances metastasis formation in a human model of embryonal rhabdomyosarcoma through Erk signaling cooperation. Cancer Lett. 2019 Feb 13. pii: S0304-3835(19)30085-0. doi: 10.1016/j.canlet.2019.02.013. IF: 6.491

Ceccarelli S, Megiorni F, Bellavia D, Marchese C, Screpanti I, Checquolo S. Notch3 Targeting: A Novel Weapon against Ovarian Cancer Stem Cells. Stem Cells Int. 2019 Jan 6;2019:6264931. doi: 10.1155/2019/6264931. eCollection 2019. Review. IF: 3.989

Marampon F, Codenotti S, Megiorni F, Del Fattore A, Camero S, Gravina GL, Festuccia C, Musio D, De Felice F, Nardone V, Santoro AN, Dominici C, Fanzani A, Pirtoli L, Fioravanti A, Tombolini V, Cheleschi S, Tini P. NRF2 orchestrates the redox regulation induced by radiation therapy, sustaining embryonal and alveolar rhabdomyosarcoma cells radioresistance. J Cancer Res Clin Oncol. 2019 Jan 30. doi: 10.1007/s00432-019-02851-0. IF: 3.081

Rossi F, Legnini I, Megiorni F, Colantoni A, Santini T, Morlando M, Di Timoteo G, Dattilo D, Dominici C, Bozzoni I. Circ-ZNF609 regulates G1-S progression in rhabdomyosarcoma. Oncogene. 2019 Jan 22. doi: 10.1038/s41388-019-0699-4. IF: 6.854

Marampon F, Leoni F, Mancini A, Pietrantoni I, Codenotti S, Letizia F, Megiorni F, Porro G, Galbiati E, Pozzi P, Mascagni P, Budillon A, Maggio R, Tombolini V, Fanzani A, Gravina GL, Festuccia C. Marampon F, Histone deacetylase inhibitor ITF2357 (givinostat) reverts transformed phenotype and counteracts stemness in in vitro and in vivo models of human glioblastoma. J Cancer Res Clin Oncol. 2019 Feb;145(2):393-409. IF: 3.081

Camero S, Ceccarelli S, De Felice F, Marampon F, Mannarino O, Camicia L, Vescarelli E, Pontecorvi P, Pizer B, Shukla R, Schiavetti A, Mollace MG, Pizzuti A, Tombolini V, Marchese C, *#Megiorni F, Dominici C. PARP inhibitors affect growth, survival and radiation susceptibility of human alveolar and embryonal rhabdomyosarcoma cell lines. J Cancer Res Clin Oncol. 2019 Jan;145(1):137-152. IF: 3.081

Giannattasio S, *Megiorni F, Di Nisio V, Del Fattore A, Fontanella R, Camero S, Antinozzi C, Festuccia C, Gravina GL, Cecconi S, Dominici C, Di Luigi L, Ciccarelli C, De Cesaris P, Riccioli A, Zani BM, Lenzi A, Pestell RG, Filippini A, Crescioli C, Tombolini V, Marampon F. Testosterone-mediated activation of androgenic signalling sustains in vitro the transformed and radioresistant phenotype of rhabdomyosarcoma cell lines. J Endocrinol Invest. 2019 Feb;42(2):183-197. IF: 3.166

#Megiorni F, Gravina GL, Camero S, Ceccarelli S, Del Fattore A, Desiderio V, Papaccio F, McDowell HP, Shukla R, Pizzuti A, Beirinckx F, Pujuguet P, Saniere L, der Aar EV, Maggio R, De Felice F, Marchese C, Dominici C, Tombolini V, Festuccia C, Marampon F. Pharmacological targeting of the ephrin receptor kinase signalling by GLPG1790 in vitro and in vivo reverts oncophenotype, induces myogenic differentiation and radiosensitizes embryonal rhabdomyosarcoma cells. J Hematol Oncol. 2017 Oct 6;10(1):161. IF: 7.333

#Megiorni F, Colaiacovo M, Cialfi S, McDowell HP, Guffanti A, Camero S, Felsani A, Losty PD, Pizer B, Shukla R, Cappelli C, Ferrara E, Pizzuti A, Moles A, Dominici C. A sketch of known and novel MYCN-associated miRNA networks in neuroblastoma. Oncol Rep. 2017 Jul;38(1):3-20. IF: 2.976

Marampon F, *Megiorni F, Camero S, Crescioli C, McDowell HP, Sferra R, Vetuschi A, Pompili S, Ventura L, De Felice F, Tombolini V, Dominici C, Maggio R, Festuccia C, Gravina GL. HDAC4 and HDAC6 sustain DNA double strand break repair and stem-like phenotype by promoting radioresistance in glioblastoma cells. Cancer Lett. 2017 Jul 1;397:1-11. IF: 6.491

#Megiorni F, Camero S, Ceccarelli S, McDowell HP, Mannarino O, Marampon F, Pizer B, Shukla R, Pizzuti A, Marchese C, Clerico A, Dominici C. DNMT3B in vitro knocking-down is able to reverse embryonal rhabdomyosarcoma cell phenotype through inhibition of proliferation and induction of myogenic differentiation. Oncotarget. 2016 Nov 29;7(48):79342-79356. IF: 5.168

#Megiorni F, McDowell HP, Camero S, Mannarino O, Ceccarelli S, Paiano M, Losty PD, Pizer B, Shukla R, Pizzuti A, Clerico A, Dominici C. Crizotinib-induced antitumour activity in human alveolar rhabdomyosarcoma cells is not solely dependent on ALK and MET inhibition. J Exp Clin Cancer Res. 2015 Oct 6;34:112. IF: 4.357

Nardella M, Guglielmi L, Musa C, Iannetti I, Maresca G, Amendola D, Porru M, Carico E, Sessa G, Camerlingo R, Dominici C, Megiorni F, Milan M, Bearzi C, Rizzi R, Pirozzi G, Leonetti C, Bucci B, Mercanti D, Felsani A, D'Agnano I. Down-regulation of the Lamin A/C in neuroblastoma triggers the expansion of tumor initiating cells. Oncotarget. 2015 Oct 20;6(32):32821-40. IF: 5.008

#Megiorni F, Cialfi S, McDowell HP, Felsani A, Camero S, Guffanti A, Pizer B, Clerico A, De Grazia A, Pizzuti A, Moles A, Dominici C. Deep Sequencing the microRNA profile in rhabdomyosarcoma reveals down-regulation of miR-378 family members. BMC Cancer. 2014 Nov 25;14:880. IF: 3.362.

Cavaggioni G, Lia C, Resta S, Antonielli T, Benedetti Panici P, Megiorni F, Porpora MG. Are mood and anxiety disorders and alexithymia associated with endometriosis? A preliminary study. Biomed Res Int. 2014;2014:786830. IF: 1.579

#Megiorni F, Resta S, Yazdanian D, Cavaggioni G, Lia C, Benedetti Panici P, Pizzuti A, Porpora MG. Lack of association between serotonin transporter 5-HTT gene polymorphism and endometriosis in an Italian patient population. J Negat Results Biomed. 2014 Jun 12;13(1):12. IF: 1.20

Zicari AM, Mora B, Lollobrigida V, Occasi F, Cesoni Marcelli A, Megiorni F, Pizzuti A, Nebbioso M, Duse M. Immunogenetic investigation in vernal keratoconjunctivitis. Pediatr Allergy Immunol. 2014 Aug;25(5):508-10. IF: 3.397

Conteduca G, Rossi A, Megiorni F, Parodi A, Ferrera F, Tardito S, Battaglia F, Kalli F, Negrini S, Pizzuti A, Rizza E, Indiveri F, Fenoglio D, Filaci G. Single nucleotide polymorphisms in the promoter regions of Foxp3 and ICOSLG genes are associated with Alopecia areata. Clin Exp Med. 2014 Feb;14(1):91-7. IF: 2.959

#Megiorni F, Cialfi S, Cimino G, De Biase RV, Dominici C, Quattrucci S, Pizzuti A. Elevated levels of miR-145 correlate with SMAD3 down-regulation in cystic fibrosis patients. J Cyst Fibros. 2013 Dec;12(6):797-802. IF: 3.82

#Megiorni F, Mora B, Maxia C, Gerardi M, Pizzuti A, Rossi A. Cytotoxic T-lymphocyte antigen 4 (CTLA4) +49AG and CT60 gene polymorphisms in Alopecia Areata: a case-control association study in the Italian population. Arch Dermatol Res. 2013 Sep;305(7):665-70. IF: 2.270

Ledda M, Megiorni F, Pozzi D, Giuliani L, D'Emilia E, Piccirillo S, Mattei C, Grimaldi S, Lisi A. Non ionising radiation as a non chemical strategy in regenerative medicine: Ca(2+)-ICR "In Vitro" effect on neuronal differentiation and tumorigenicity modulation in NT2 cells. PLoS One. 2013 Apr 9;8(4):e61535. IF: 3.534

Porpora MG, Resta S, Fuggetta E, Storelli P, Megiorni F, Manganaro L, De Felip E. Role of environmental organochlorinated pollutants in the development of endometriosis. Clin Exp Obstet Gynecol. 2013;40(4):565-7. Review. IF: 0.62

#Megiorni F, Pizzuti A. HLA-DQA1 and HLA-DQB1 in Celiac disease predisposition: practical implications of the HLA molecular typing. J Biomed Sci. 2012 Oct 11;19:88. Review. IF: 2.458

Colombrita C, Onesto E, Megiorni F, Pizzuti A, Baralle FE, Buratti E, Silani V, Ratti A. TDP-43 and FUS RNA-binding proteins bind distinct sets of cytoplasmic messenger RNAs and differently regulate their post-transcriptional fate in motoneuron-like cells. J Biol Chem. 2012 May 4;287(19):15635-47. IF: 4.651

#Megiorni F, Cialfi S, Dominici C, Quattrucci S, Pizzuti A. Synergistic post-transcriptional regulation of the Cystic Fibrosis Transmembrane conductance Regulator (CFTR) by miR-101 and miR-494 specific binding. PLoS One. 2011;6(10):e26601. IF: 4.092

#Megiorni F, Pizzuti A, Mora B, Rizzuti A, Garelli V, Maxia C, Carlesimo M, Fotruna MC, Delle Chiaie R, Cavaggioni G, Rossi A. Genetic association of HLA-DQB1 and HLA-DRB1 polymorphisms with alopecia areata in the Italian population. Br J Dermatol. 2011 Oct;165(4):823-7. IF: 3.666

Tomaselli S, Megiorni F, Lin L, Mazzilli MC, Gerrelli D, Majore S, Grammatico P, Achermann JC. Human RSPO1/R-spondin1 is expressed during early ovary development and augments β-catenin signaling. PLoS One. 2011 Jan 28;6(1):e16366. IF: 4.092

Nanni L, Quagliarini F, Megiorni F, Montali A, Minicocci I, Campagna F, Pizzuti A, Arca M. Genetic variants in adipose triglyceride lipase influence lipid levels in familial combined hyperlipidemia. Atherosclerosis. 2010 Nov;213(1):206-11. IF: 4.086

Megiorni F, Mora B, Bonamico M, Barbato M, Montuori M, Viola F, Trabace S, Mazzilli MC. Response to Dubois et al. Am J Gastroenterol. 2009;104(3):784-785. IF: 6.012

Megiorni F, Mora B, Bonamico M, Barbato M, Nenna R, Maiella G, Lulli P, Mazzilli MC. HLA-DQ and risk gradient for celiac disease. Hum Immunol. 2009 Jan;70(1):55-9. IF: 2.550

Nenna R, Mora B, Megiorni F, Mazzilli MC, Magliocca FM, Tiberti C, Bonamico M. HLA-DQB1*02 dose effect on RIA anti-tissue transglutaminase autoantibody levels and clinicopathological expressivity of celiac disease. J Pediatr Gastroenterol Nutr. 2008 Sep;47(3):288-92. IF: 2.132

Megiorni F, Mora B, Bonamico M, Barbato M, Montuori M, Viola F, Trabace S, Mazzilli MC. HLA-DQ and susceptibility to celiac disease: evidence for gender differences and parent-of-origin effects. Am J Gastroenterol. 2008 Apr;103(4):997-1003. IF: 6.444

Tomaselli S, Megiorni F, De Bernardo C, Felici A, Marrocco G, Maggiulli G, Grammatico B, Remotti D, Saccucci P, Valentini F, Mazzilli MC, Majore S, Grammatico P. Syndromic true hermaphroditism due to an R-spondin1 (RSPO1) homozygous mutation. Hum Mutat. 2008 Feb;29(2):220-6. IF: 7.033

Latiano A, Mora B, Bonamico M, Megiorni F, Mazzilli MC, Cucchiara S, Palmieri O, Valvano MR, Annese V. Analysis of candidate genes on chromosomes 5q and 19p in celiac disease. J Pediatr Gastroenterol Nutr. 2007 Aug;45(2):180-6. IF: 2.102

Bonamico M, Ferri M, Mariani P, Nenna R, Thanasi E, Luparia RP, Picarelli A, Magliocca FM, Mora B, Bardella MT, Verrienti A, Fiore B, Uccini S, Megiorni F, Mazzilli MC, Tiberti C. Serologic and genetic markers of celiac disease: a sequential study in the screening of first degree relatives. J Pediatr Gastroenterol Nutr. 2006 Feb;42(2):150-4. IF: 2.067

Megiorni F, Indovina P, Mora B, Mazzilli MC. Minor expression of fascin-1 gene (FSCN1) in NTera2 cells depleted of CREB-binding protein. Neurosci Lett. 2005 Jun 10-17;381(1-2):169-74. IF: 2.02

Mora B, Bonamico M, Ferri M, Megiorni F, Osborn J, Pizzuti A, Mazzilli MC. Association of the matrix metalloproteinase-3 (MMP-3) promoter polymorphism with celiac disease in male subjects. Hum Immunol. 2005 Jun;66(6):716-20. IF: 2.467

Megiorni F, Mora B, Indovina P, Mazzilli MC. Expression of neuronal markers during NTera2/cloneD1 differentiation by cell aggregation method. Neurosci Lett. 2005 Jan 10;373(2):105-9. IF: 2.02

Mora B, Bonamico M, Indovina P, Megiorni F, Ferri M, Carbone MC, Cipolletta E, Mazzilli MC. CTLA-4 +49 A/G dimorphism in Italian patients with celiac disease. Hum Immunol. 2003 Feb;64(2):297-301. IF: 2.619

Indovina P, Megiorni F, Fontemaggi G, Coni P, Mora B, Mazzilli MC. Absence of in vivo DNA-protein interactions in the DQA2 and DQB2 promoter regions. Hum Immunol. 2001 May;62(5):504-8. IF: 2.373

Indovina P, *Megiorni F, Ferrante P, Apollonio I, Petronzelli F, Mazzilli MC. Different binding of NF-Y transcriptional factor to DQA1 promoter variants. Hum Immunol. 1998 Dec;59(12):758-67. IF: 2.169

Megiorni F, Carlesimo M, Maxia C, Pizzuti A, Rossi A. The genetic basis of alopecia areata (Book chapter). Alopecia: Causes, Diagnosis and Treatment. 2012; pp. 85-96. ISBN: 978-162081804-6; Nova Science Publishers, Inc.

*co-first author / co-last author; #corresponding author

Autorizzo il trattamento dei dati personali contenuti nel mio curriculum vitae in base all’art. 13 del D. Lgs. 196/2003 e all’art. 13 GDPR 679/16.