DANIELA DE BIASE

SEMESTRE I / SEMESTER I

Medicine and Surgery - Degree course "F"- International Medical School LM-41 a.y. 2024-2025

Biochemistry II (teaching code: 1038227) will be delivered in presence.

Classes: Daniela De Biase classes will take place from October 2 to November 14, 2024 and January 16 and 20, 2025.

Hours: Mon and Thu 11:00-13:00 / Wed 9:00-11:00

Communications as well as study material will be provided through E-learning "Biochemistry II" course (https://elearning.uniroma1.it/course/view.php?id=6377). Please make sure you are registered to stay updated!

OPIS code: T60EEKHK

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Dentistry and Dental prosthodontics - International Dentistry School LM-46 a.y. 2023-2024

Biochemistry II (teaching code: 10604486) will be delivered in presence in accordance with the COVID-19 regulation adopted by Sapienza.

Classes: Daniela De Biase classes will take place from October 2 to November 14, 2024.

Hours: Mon 11:00-13:00 / Wed 9:00-11:00

Communications as well as study material will be provided through E-learning "Biochemistry II" course (https://elearning.uniroma1.it/course/view.php?id=6377). Please make sure you are registered to stay updated!

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Ostetricia - Corso di laurea A - Roma Azienda Policlinico Umberto I L/SNT1 a.a. 2024-2025

Biochimica (codice insegnamento: 1034944) in "Basi Molecolari e Cellulari della Vita". La modalità di erogazione del corso è prevista in presenza in accordo con le linee guida Sapienza.

Lezioni: Il corso sarà svolto sempre di venerdì dal 18 ottobre 2024 al 24 gennaio 2025.

Orario: 11:00 alle 13:00 per tutta la durata del corso (alcune modifiche sono state comunicate in aula e sono disponibili nel file relativo alla prima lezione).

Comunicazioni e materiale di studio saranno forniti attraverso la piattaforma E-learning Biochimica(Ostetricia A) (https://elearning.uniroma1.it/course/view.php?id=8234). Gli studenti sono pregati di registrarsi al corso per rimanere costatentemente aggiornati e informati.

codice OPIS: XEY87G27

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Medicina e Chirurgia - Corso  di Laurea "E"- Polo Pontino LM-41 a.a. 2024-2025

Chimica e Propedeutica Biochimica (codice insegnamento: 1025530). La modalità di erogazione del corso modulo di Propedeutica Biochimica del corso è prevista in presenza in accordo con le linee guida Sapienza.

Lezioni: Il modulo sarà svolto nei giorni 5-9-10-11 Dicembre 2024

Orario: 14:30-17:30

Comunicazioni e materiale di studio saranno forniti attraverso la piattaforma E-learning Chimica e Propedeutica Biochimica (https://elearning.uniroma1.it/course/view.php?id=1249). Gli studenti sono pregati di registrarsi al corso per rimanere costatentemente aggiornati e informati.

codice OPIS: ML2RAYKJ

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Molecular Biology Medicinal Chemistry and Computer Science L-29 a.a. 2024-2025

Fundamentals of Chemical Biology (codice insegnamento: 10607290_2). Teaching will be delivered in presence in accordance with the COVID-19 regulation adopted by Sapienza.

Classes: Daniela De Biase classes will take place from November 20, 2024 to January 8, 2025

Hours: Wed 9:00-14:00

Communications as well as study material will be provided through E-learning "Fundamentals of Chemical Biology" course (). Please make sure you are registered to stay updated!

OPIS code: 7JTJKXRX

SEMESTRE II / SEMESTER II

Medicina e Chirurgia - Corso  di Laurea "E"- Polo Pontino LM-41 a.a. 2024-2025

- Biochimica I (codice insegnamento: 1026210) per Medicina e Chirurgia "E" Polo Pontino LM-41.

La modalità di erogazione del corso modulo di Biochimica del corso è prevista in presenza in accordo con le linee guida Sapienza.

Lezioni: Il modulo sarà svolto a partire dal 3 marzo e fino al 29 maggio 2025

Orario: 11:30-13:30/14:30-16:30 (lunedi)  e 14:30-16:30 (giovedì, tranne 3-10-17-24 aprile, 8,15 maggio)

Comunicazioni e materiale di studio saranno forniti attraverso la piattaforma E-learning Biochimica I (https://elearning.uniroma1.it/course/view.php?id=631). Gli studenti sono pregati di registrarsi al corso per rimanere costatentemente aggiornati e informati.

codice OPIS: Q6LL3262

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Medicine and Surgery - Degree course "F"- International Medical School LM-41 a.y. 2024-2025

- Biochemistry I (teaching code: 10604486) for Dentistry and Dental Prosthodontics - Odontoiatria e protesi dentaria LM-46. 

(see below)

- Biochemistry I (teaching code: 1038227) for Medicine and Surgery "F"- Medicina e Chirurgia LM-41. 

Teaching will be delivered in presence in accordance with the COVID-19 regulation adopted by Sapienza.

Classes: Daniela De Biase classes will take place on 16-20-21-23-27-28 May 2025

Hours: Tue-Wed-Fri 14:30-16:30

Communications as well as study material will be provided through E-learning "Biochemistry I" course (https://elearning.uniroma1.it/course/view.php?id=421). Please make sure you are registered to stay updated!

OPIS code: 80BRCAJ3

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Prof. DANIELA DE BIASE (DDB) – Short CV
2021: Habilitation to Full Professor BIOS-07/A (Biochemistry)
2010: Visiting Professor (1 month) at Laboratoire de Biologie et Pharmacologie Appliquée - Ecole Normale Supérieure (ENS) de Cachan-France;
2001-to date: Associate Professor of Biochemistry (BIO/10 noe BIOS-07/A), Sapienza University of Rome, Dpt of Biochemical sciences "A. Rossi Fanelli (2001-2010) and then Dpt. of Medico-Surgical Sciences and Biotechnologies (Latina-Polo Pontino, 2010-present);
1991-2001: Assistant Professor/Researcher, Sapienza University of Rome, Dpt. of Biochemical Sciences.
1991: Ph.D in Biochemistry, awarded by University of Wales, College of Cardiff, Cardiff (UK; ranked as one of the world’s top 154 Universities by the QS World University Rankings 2024).
1987: Degree (summa cum laude) in Biological Sciences awarded by University La Sapienza, Rome - Italy
1983: Diploma (56/60) in classical studies Liceo “Giulio Cesare” Rome - Italy

Teaching activity in Sapienza (currently 15 CFU) in the following courses:
2022-to date: Fundamentals of Chemical Biology II; first cycle degree: Molecular Biology, Medicinal Chemistry and Computer Science in Pharmaceutical Applications (fully taught in english), Sapienza University of Rome (3 CFU)
2022-to date: Biochemistry I+II; Full cycle degree: Dentistry and Dental Prosthodontics (fully taught in english), Sapienza University of Rome (1+2 CFU)
2012-to date: Biochemistry I+II; Full cycle degree: Medicine and Surgery “F” (fully taught in english), Sapienza University of Rome (1+4 CFU);
2012-to date: Chemistry and Introduction to Biochemistry; Full cycle degree: Medicina e Chirurgia “E” (Latina-Polo Pontino), Sapienza University of Rome (1 CFU);
2000-to date: Biochemistry I; Full cycle degree: Medicina e Chirurgia “E” (Latina-Polo Pontino), Sapienza University of Rome (4 CFU);
2008-to date: Biochemistry; First cycle Degree in Midwifery (Roma-Policlinico Umberto I), University of Rome “La Sapienza” (2 CFU).

Institutional activities in Sapienza University of Rome:
2024- to date: Contact person for Sapienza in the AAHCI (by Rector decree)
2020-to date: Member and Focal point of Sapienza Working group in the World Health Summit Academic Alliance (by Rector decree)
2023- to date: Coordinator of the interfaculty Monitoring Committee (Pharmacy and Medicine – Medicine and Dentistry) monitoring the Quality of 90+ degree courses (first, second and full cycle)
2023- to date: Vice-president of the full cycle degree course in Medicina e Chirurgia “E” (Latina, Polo Pontino)
2012-to date: Member of the Teachers’ board of the PhD in "Life Sciences" (Sapienza).
2000-to date: Member of the Technical-Pedagogical Commission (CTP) for the degree course in Medicine and Surgery "E" (Latina);
2000-to date: Semester coordinator for I year-II semester, degree course in Medicine and Surgery "E" (Latina);
Coordinator and President of the exam commission "Basi Molecolari e cellulari della Vita", first degree course in Midwifery (Sapienza, sede Policlinico Umberto I) and of “Fundamentals of Chemical Biology”; first cycle degree: Molecular Biology, Medicinal
Chemistry and Computer Science in Pharmaceutical Applications
2017-2018: Member of the ad hoc University Commission "24-CFU" (BIO/10, Biochemistry) to certify CFUs of candidates for teaching in the secondary schools.

Erasmus and Internationalization (Cambridge English level: C1)
2023-to date: Coordinator of the Internationalization commission, Faculty of Pharmacy and Medicine, Sapienza
2022-to date: Sapienza Referent teacher and Work package Leader for Erasmus+ KA220 project “DOMINOS”
2019-to date: Academic Coordinator of Mobility (CAM) CIVIS Faculty of Pharmacy and Medicine (Medical area);
2017-to date: Academic Coordinator of Mobility (CAM) Faculty of Pharmacy and Medicine, Sapienza (Medical area);
2017-to date: Member of Erasmus Traineeship Commission, Sapienza (at central or faculty level);
2021-2022: Member of the CIVIS Council of the Hub on Health
2020-2022: Sapienza Working Group CIVIS Hub on Health
2019-2023: Sapienza Representative for CIVIS Task Force “Mobility”;
2018-2023: Member of Internationalization Commission, Faculty of Pharmacy and Medicine, Sapienza;
2017-2019: Member of the ad hoc University Commission Erasmus+ Unipharma-Graduates scholarships.
2017-2018: Member of the ad hoc University Commission "Don’t miss your chance" to award scholaships to both EU and Non-EU graduates who will enroll in a Master Degree Programme at Sapienza for academic year 2018-19.
2022: Member of the ad hoc University Commission for the competition to confer bursaries for “frequenza di corsi o attività di perfezionamento all’estero” (D.R. n. 1369 del 19/04/2022- Area CUN 6)
2021: Member of the ad hoc University Commission for the competition to confer bursaries for “frequenza di corsi o attività di perfezionamento all’estero” (D.R. n. 972/2021 del 02/04/2021 - Area CUN 6)
2020: Member of the ad hoc University Commission for the competition to confer bursaries for “frequenza di corsi o attività di perfezionamento all’estero” (D.R. 1256/2020 dell’11.05.2020 - Area CUN 6)
2018: Member of the ad hoc University Commission for the competition to confer bursaries of “frequenza di corsi o attività di perfezionamento all’estero” (D.R. 1076/2018 del 13.04.2018- Area CUN 5)

Agreement promoter of 40+ bilateral agreements with prestigious European and extra-european academic institutions

Research:
• Microbiology-Molecular Biology: working on the transcriptional regulation and the biochemistry of the glutamate and glutamine-dependent systems, the major acid resistance (AR) systems in Escherichia coli (commensal and pathogenic) and many other enteric bacteria. Several interconnections between different AR systems and other physiological and stress-related processes in E. coli and other bacteria are currently under investigation. Novel antimicrobials are studied to combat AMR. Human microbiome of skin and bladder are currently under study.
• Biochemistry: Expert on PLP-dependent enzymes, in particular glutamate decarboxylase (GAD) and GABA-transaminase (GABA-T) of mammalian and bacterial origin. The structural properties and the catalytic mechanism of GAD are investigated via site-directed mutagenesis, expression and purification of recombinant variants, kinetic and spectroscopic studies in combination with structural studies (the latter in collaboration).
• Biotechnology: Exploiting and engineering GAD for biotech applications, including the synthesis of bioactive molecules. In addition she is also studying the acid stress response in E. coli and other bacterial species for applications in the food and biotech sector (vice-chair and then chair of the COST Action CA18113 “Understanding and exploiting the impacts of low pH on micro-organisms”). Nanotechnologies to target skin infections and detection of water contaminations by bacterial pathogens are also currently under investigation

Editorial and Reviewing Activity:
1) 2023 – to date: in the Editorial Board of Molecular Microbiology (https://onlinelibrary.wiley.com/page/journal/13652958/homepage/editorial...)
2) 2017 – to date: in the Editorial Board (Associate Editor) of Frontiers in Microbiology - Section: Microbial Physiology and Metabolism (https://loop.frontiersin.org/people/426213/overview).
3) 2015 – to date: in the Editorial Board of AIMS Microbiology (https://www.aimspress.com/news/131.html)
4) 2020 – to date: in the Editorial Board of Folia Microbiologica (https://www.springer.com/journal/12223/editors)
5) 2020 – to date: in the Editorial Board of Minerva Biotecnologica (https://www.minervamedica.it/en/journals/minerva-biotecnologica/editoria...)
6) 2017-2019: Guest Associate Editor (Sept 2017-Febr 2019) of the Frontiers in Microbiology Research Topic “Microbial Stress: From Sensing to Intracellular and Population Responses” (to date >80,000 views and >14,000 downloads); https://www.frontiersin.org/research-topics/6690/microbial-stress-from-s...);
7) 2020: Guest Editor (Febr 2020-July 2020) of the Genes Special Issue “"Mechanisms of Microbial Adaptation to Low pH"; https://www.mdpi.com/journal/genes/special_issues/microbial_adaptation
8) 2021 – to date: Guest Associate Editor of the Frontiers in Microbiology Research Topic “Microbial Stress: From Model Organisms to Applications in Food, Microbiotechnology and Medicine” https://www.frontiersin.org/research-topics/21774/microbial-stress-from-...);
9) ad hoc reviewer for several indexed Journals, as certified by Clarivate.
10) She evaluated projects proposals for BBSRC (UK), ANR (France), Università Italo-Francese, ERC, ESF.

Conference organiser:
1) Co-chair 2018 EFB meeting “Microbial Stress: from System to Molecules and back” Kinsale, Ireland - 23-25 April 2018 (http://www.efb-central.org/index.php/microbial_stress/)
2) Co-chair and Local organizer 2019 Advanced Course “Trends in Enzymology and Biocatalysis” Rome, Italy - 27-31 May 2019 (https://teb2019.azuleon.org/) ;
3) Local organizer 2019 COST Action CA18113 Management Committee meeting, Sapienza, Rome, Italy – 22-23 October 2019 (https://euromicroph.eu/events/core-group-working-groups-meeting/);
4) Co-organizer 2020 COST Action CA18113 Global meeting, IST, Lisbon, Portugal – 12-14 February 2020 (https://euromicroph.eu/events/core-group-working-groups-meeting/);
5) Chair and Local organizer of the 2020 EFB meeting “Microbial Stress: from System to Molecules and back” Rome, Italy – 16-18 November 2020 online.
6) Local organizer 2020 COST Action CA18113 Working Groups meeting, Sapienza, Rome, Italy – 19 November 2020 (online)
7) In the Organizing Committee of the World Health Summit Regional Meeting – Europe, Sapienza University of Rome, 15-17 June 2022 (https://www.regionalmeetingwhs2022.com).
8) co-organizer of the 2023 EFB meeting “Microbial Stress Meeting” Vienna, Austria – 19-21 September 2023 (https://www.efbiotechnology.org/microbialstress/)
9) in the International Advisory Committee of the 2025 World Health Summit Regional Meeting – New Delhi 25-27 April 2025 (https://whsnewdelhi2025.com/international-advisory-committee.php)

Affiliation to Scientific societies and Federations:
1989 - to date: SIB (Italian Biochemistry and Molecular Biology Society)
2009 - to date: ASM (American Society for Microbiology)

Research funding as Principal Investigator (since 2019):
2019-2023 COST Action CA18113 “Understanding and exploiting the impacts of low pH on micro-organisms” Chair (until August 2022): Dr. Peter A. Lund (University of Birmingham (UK); chair (from august 2022) and Grant Holder Scientific Representative for the whole
duration of the project: Prof. Daniela De Biase. 4 years (https://www.cost.eu/actions/CA18113; https://euromicroph.eu/);
2019 “Investigation of the biological activities of carbon-phosphorus and carbon-sulfur containing amino acids and of their derivatives, obtained by chemical synthesis and biocatalysis” Sapienza-Progetto di Ricerca di Università RM118164308E05B2, 1 year.
2020 “Investigation of the biological activities of carbon-phosphorus and carbon-sulfur containing amino acids and of their derivatives, obtained by chemical synthesis and biocatalysis” Sapienza-Progetto di Ricerca di Università RM120172B6587496, 1 year.
2021 World Health Summit Regional Meeting - Europe Science - Innovation - Policies Rome, 2022 Sapienza- Congressi e Convegni CC22117A7A5C3127.
2022 “Metabolic derivatives of homocysteine and thiotaurine as potential antimicrobials, antioxidants and anti-inflammatory molecules” Sapienza-Progetto di Ricerca di Università RM1221816A4F3695, 1 year.
2023-2025 PRIN 2022 PNRR “Investigation on the nanoparticles-driven controlled delivery of antimicrobial peptides to treat dermatological infections”