GIOVANNI BERNARDINI

CURRICULUM DIDATTICO-SCIENTIFICO DEL PROF. GIOVANNI BERNARDINI

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DATI PERSONALI

Curriculum Vitae

First name(s) / Surname(s) Personal information

Giovanni Bernardini
Address(es) Department of Molecular Medicine,
Viale Regina Elena 291
00161-Rome
Italy
Telephone(s) +39 06 49255121
Fax(es) NONE
E-mail giovanni.bernardini@uniroma1.it

Nationality Italian
Gender
Male

Occupational field

Dates IMMUNOLOGY

Academic assignments and professional experience

Call 2021/2023
National Scientific qualification (abilitazione scientifica nazionale) as full professor for the disciplinary fields 06/N1 and 06/A2

Dates 3-1-2018
Occupation or position held Associate Professor
Main activities/ responsibilities

Dates
Scientific activity (2008-today): Giovanni Bernardini is mainly interested in the molecular mechanisms regulating mouse NK cell trafficking and differentiation in the bone marrow and in recruitment in tissues during pathological conditions.

2017-today

Member of the body responsible for animal wealfare (interdipartimental OPBA: Department of Molecular Medicine/Department of Experimental Medicine).

Teaching Experience:
Teaching and student training in Immunology courses (Biotechnology Inter-Faculty course, Bioinformatics, Medical Biotechnology, Nursing). Faculty of Medicine University of Rome “La Sapienza”
Lecturer in the immunology course. Faculty of Medicine University of Rome “La Sapienza”
Member of the teaching body for the evaluation of PhD students (PhD school in Immunological, Hematological and Rheumatological Sciences and since 2018 in “Innovation in immunomediated and hematological diseases”).
Name/address
of employer
University of Rome “La Sapienza”/Piazzale Aldo Moro 5-Rome
Sector

Dates
Occupation and position held
Main Activities and responsabilities General Pathology/Immunology

2002-2017

Assistant Professor

Scientific activity: He was responsible of several projects aimed at analyzing the role of chemokines in human glioma cell invasiveness, in NK cell trafficking in tumors and inflammation and NK cell-based tumor immunotherapy using mouse models.

Teaching Experience:
Teaching and student training in Immunology courses (Biotechnology Inter-Faculty course, Bioinformatics). Faculty of Medicine University of Rome “La Sapienza”
Lecturer in the immunology course. Faculty of Medicine University of Rome “La Sapienza”
Member of the teaching body for the evaluation of PhD students (PhD school in Immunological, Hematological and Rheumatological Sciences and since 2018 in “Innovation in immunomediated and hematological diseases”).

Dates 2000-2001
Occupation or position held Post-doctoral fellow
Main activities and
responsibilities Scientific activity: Visiting scholar in the Laboratory directed by Prof. Eugene C. Butcher at Stanford University. During this period, he was interested in the analysis of signal transduction pathway activated by chemokines leading to integrin activation.
Name/ address of employer Stanford University School of Medicine
Stanford, California 94305-5324
Sector
General Pathology
Dates 1995-1999
Occupation or position held PhD student in Immunology
Main activities /responsibilities Scientific activities: Involved in cloning of the human chemokine receptor CCR8 ORF and in the identification of its human and viral ligands and their pro-angiogenic role. In addition, he contributed to the cloning and functional characterization of the ORF of other GPCRs
Name/address of employer Sapienza University of Rome/ Istituto Dermopatico dell’Immacolata, Rome
Sector
PhD in Immunological Sciences
Education and training
Dates 2000-2002
Title of qualification awarded Post-doctoral fellow
Organisation providing education and training Laboratory of Immunology and Vascular Biology
Stanford University Medical School
Director: Prof. Eugene C. Butcher
Founded by: Italian Federation for Cancer Research Fellowship and The
Foundation Blanceflor Boncompagni-Ludovisi of Sweden
Dates 2000
Title of qualification awarded PhD in Immunological Sciences
organisation University of Rome “La Sapienza”.

Dates 1996
Title of qualification awarded National Board for Biologists
Dates 1994
Title of qualification awarded Graduated with honors in Biology
Organisation University of Rome “La Sapienza”.

Personal skills/ competences Dr. Bernardini has a high competence and experience in several techniques in cellular and molecular biology, as well as in immunology. Since 2003, he has been teaching Immunology at the Sapienza Università di Roma. He has experience in supervising students, postdocs and in leading small research groups as well as in writing grants.
Dr. Bernardini has a long-lasting experience in the study of the role of chemotactic molecules of the chemokine family in several aspects of physiological and pathological processes. His results have been published in highly qualified international journals, such as Blood journal, Cancer Research, Nature, Journal for Immunotherapy of Cancer, Journal of Immunology, etc. and presented in international congresses
Mother tongue(s) ITALIAN
Other language(s)
Self-assessment Understanding Speaking Writing
European level (*) Listening Reading Spoken interaction Spoken production
English C1 C1 C1 C1 C1
French A2 A2 A2 A1 A1
(*) Common European Framework of Reference for Languages

Annexes .
Publications 60 research articles; 2 textbook chapters; H index (Scopus): 32; total citations: 2800
Scientific Publications (selected from last 10 years)
1. Bernardini G, Sciumè G, Santoni A. Differential chemotactic receptor requirements for NK cell subset trafficking into bone marrow. Front Immunol. 2013
2. Ponzetta A, Sciumè G, Benigni G, Antonangeli F, Morrone S, Santoni A*, Bernardini G.* CX3CR1 regulates the maintenance of KLRG1+ NK cells into the bone marrow by promoting their entry into circulation. J Immunol. 2013;191(11):5684-94.
3. Paolini R, Bernardini G, Molfetta R, Santoni A. NK cells and interferons Cytokine Growth Factor Rev. 2015; 26(2):113-20
4. Garofalo S, D’Alessandro G, Chece G, Frederic Brau, Maggi L, Rosa A, Porzia A, Mainiero F, Esposito V, Lauro C, Benigni G, Bernardini G, Santoni A, Limatola C. Enriched environment reduces glioma growth through immune and non immune mechanisms in mice. Nat Commun. 2015;6:6623.
5. Ponzetta A, Benigni G, Antonangeli F, Sciumè G, Sanseviero E, Zingoni A, Ricciardi MR, Petrucci MT, Santoni A*, Bernardini G*. Multiple Myeloma Impairs Bone Marrow Localization of Effector Natural Killer Cells by Altering the Chemokine Microenvironment. Cancer Res. 2015;75(22):4766-77
6. Bernardini G, Antonangeli F, Bonanni V, Santoni A. Dysregulation of Chemokine/Chemokine Receptor Axes and NK Cell Tissue Localization during Diseases. Front Immunol. 2016; 7:402.
7. Benigni G, Dimitrova P, Antonangeli F, Sanseviero E, Milanova V, Blom A, van Lent P, Morrone S, Santoni A, Bernardini G. CXCR3/CXCL10 Axis Regulates Neutrophil-NK Cell Cross-Talk Determining the Severity of Experimental Osteoarthritis. J Immunol. 2017 Mar 1;198(5):2115-2124. doi: 10.4049/jimmunol.1601359.
8. Molgora M., Bonavita E, Ponzetta A, Riva F, Barbagallo M, Jaillon S, Popović B, Bernardini G, Elena Magrini E, Gianni F, Zelenay S, Jonjić S, Santoni A, Garlanda C and Mantovan A. IL-1R8 is a checkpoint in NK cells regulating anti-tumor and anti-viral activity. Nature; 551(7678):110-114
9. Ferrandino F, Bernardini G, Tsaouli G, Grazioli P, Campese AF, Noce C, Ciuffetta A, Vacca A, Besharat ZM, Bellavia D, Screpanti I, Felli MP. Intrathymic Notch3 and CXCR4 combinatorial interplay facilitates T-cell leukemia propagation. Oncogene. 2018 Dec;37(49):6285-6298. doi: 10.1038/s41388-018-0401-2.
10. Bonanni V, Antonangeli F, Santoni A, Bernardini G Targeting of CXCR3 improves anti-myeloma efficacy of adoptively transferred activated natural killer cells J IMMUNOTHER CANCER 2019 Nov; 7: 290
11. Garofalo S, Cocozza G, Porzia A, Inghilleri M, Raspa M, Scavizzi F, Aronica E, Bernardini G, Peng L, Ransohoff R, Santoni A, Limatola C. Natural killer cells modulate motor neuron-immune cell cross talk in models of Amyotrophic Lateral Sclerosis. NATURE COMMUNICATIONS. - 1:11(2020), pp. 1773-1788.
12. Russo E, Santoni A, Bernardini G. Tumor inhibition or tumor promotion? The duplicity of CXCR3 in cancer. J Leukoc Biol. 2020 Aug;108(2):673-685. doi: 10.1002/JLB.5MR0320-205R. PMID: 32745326
13. Kveštak D, Juranić Lisnić V, Lisnić B, Tomac J, Golemac M, Brizić I, Indenbirken D, Cokarić Brdovčak M, Bernardini G, Krstanović F, Rožmanić C, Grundhoff A, Krmpotić A, Britt WJ, Jonjić S. NK/ILC1 cells mediate neuroinflammation and brain pathology following congenital CMV infection. J Exp Med. 2021 May 3;218(5):e20201503. doi: 10.1084/jem.20201503
14. Russo E, Laffranchi M, Tomaipitinca L, Del Prete A, Santoni A, Sozzani S, Bernardini G. NK Cell Anti-Tumor Surveillance in a Myeloid Cell-Shaped Environment. Front Immunol. 2021. 12:787116. doi:10.3389/fimmu.2021.787116. PMID: 34975880; PMCID: PMC8718597
15. Vulpis E, Loconte L, Peri A, Molfetta R, Caracciolo G, Masuelli L, Tomaipitinca L, Peruzzi G, Petillo S, Petrucci MT, Fazio F, Simonelli L, Fionda C, Soriani A, Cerboni C, Cippitelli M, Paolini R, Bernardini G, Palmieri G, Santoni A, Zingoni A. Impact on NK cell functions of acute versus chronic exposure to extracellular vesicle-associated MICA: Dual role in cancer immunosurveillance. J Extracell Vesicles. 2022 Jan;11(1):e12176. doi:10.1002/jev2.12176.
16. Garofalo S, Cocozza G, Mormino A, Bernardini G, Russo E, Ielpo D, Andolina D, Ventura R, Martinello K, Renzi M, Fucile S, Laffranchi M, Mortari EP, Carsetti R, Sciumè G, Sozzani S, Santoni A, Tremblay ME, Ransohoff RM, Limatola C. Natural killer cells and innate lymphoid cells 1 tune anxiety-like behavior and memory in mice via interferon-γ and acetylcholine. Nat Commun. 2023 May 29;14(1):3103. doi: 10.1038/s41467-023-38899-3.
17. Sozio F, Schioppa T, Laffranchi M, Salvi V, Tamassia N, Bianchetto-Aguilera, FM, Tiberio L, Bonecchi R, Bosisio D, Parmentier M, Bottazzi B, Leone R, Russo E, Bernardini G, Garofalo S, Limatola C, Gismondi A, Sciumè G, Mantovani A, Del Prete A, Sozzani S. CCRL2 Expression by Specialized Lung Capillary Endothelial
Cells Controls NK-cell Homing in Lung Cancer. Cancer Immunol Res. 2023 Sep 1;11(9):1280-1295. doi:
10.1158/2326-6066.CIR-22-0951
18. Molfetta R, Lecce M, Milito ND, Putro E, Pietropaolo G, Marangio C, Scarno G, Moretti M, De Smaele E,
Santini T, Bernardini G, Sciumè G, Santoni A, Paolini R. SCF and IL-33 regulate mouse mast cell phenotypic
and functional plasticity supporting a pro-inflammatory microenvironment. Cell Death Dis. 2023 Sep
20;14(9):616. doi: 10.1038/s41419-023-06139-7.
19. Scarno G, Mazej J, Laffranchi M, Di Censo C, Mattiola I, Candelotti AM, Pietropaolo G, Stabile H, Fionda C, Peruzzi G, Brooks SR, Tsai WL, Mikami Y,Bernardini G, Gismondi A, Sozzani S, Di Santo JP, Vosshenrich CAJ, Diefenbach A, Gadina M, Santoni A, Sciumè G. Divergent roles for STAT4 in shaping differentiation of cytotoxic ILC1 and NK cells during gut inflammation. Proc Natl Acad Sci U S A. 2023 Oct 3;120(40):e2306761120. doi: 10.1073/pnas.2306761120.
20. Sergio I, Varricchio C, Patel SK, Del Gaizo M, Russo E, Orlando A, Peruzzi G, Ferrandino F, Tsaouli G, Coni S, Peluso D, Besharat ZM, Campolo F, Venneri MA, Del Bufalo D, Lai S, Indraccolo S, Minuzzo S, La Starza R, Bernardini G, Screpanti I, Campese AF, Felli MP. Notch3-regulated microRNAs impair CXCR4-dependent maturation of thymocytes allowing maintenance and progression of T-ALL. Oncogene. 2024 Aug;43(34):2535-2547. doi: 10.1038/s41388-024-03079-0.
21. Russo E, D'Aquino C, Di Censo C, Laffranchi M, Tomaipitinca L, Licursi V, Garofalo S, Promeuschel J, Peruzzi G, Sozio F, Kaffke A, Garlanda C, Panzer U, Limatola C, Vosshenrich CAJ, Sozzani S, Sciumè G, Santoni A, Bernardini G. Cxcr3 promotes protection from colorectal cancer liver metastasis by driving NK cell infiltration and plasticity. J Clin Invest. 2025 Apr 1:e184036. doi: 10.1172/JCI184036. Epub ahead of print.