Curriculum
POSIZIONE RICOPERTA
• Associate Professor MEDS-02/B (ex MED/05)-Full Time, University of Rome “Sapienza” Faculty of Pharmacy and Medicine, Department of Medical-Surgical Sciences and Biotechnologies, C.so della Repubblica 79, 04100 Latina, Italy
• From 01/11/2024: Head of Pathologist, Clinical Pathology Unit (UOC), Sapienza University of Rome, Istituto Chirurgico Ortopedico Traumatologico ICOT Latina, Italy.
WORK EXPERIENCE
June 2023: Expert for the European Commission Research Executive Agency N. EX2013D147179
16/12/2019-31/10/2024:First level Biologist-Pathologist, Clinical Pathology Unit (UOC), Sapienza University of Rome, Istituto Chirurgico Ortopedico Traumatologico ICOT Latina, Italy
2019-2023: Scientific Collaboration-Contract Mediterranea Cardiocentro, via Orazio, 2 – 80122 Naples, Italy
2018: Erasmus and International Credit Mobility at Department of Pharmacology and Toxicology Ernest Mario School of Pharmacy, Rutgers at Rutgers University, USA
30/12/2011-29/10/2015: Assistant Professor MED/50, Sapienza University of Rome
2009: Scientific Internship The Lancet/Elsevier, London, UK
2008-2011: Senior Associate-Healthcare Scientist (Grade 8), Gene Therapy Laboratory, Institute of Child Health (Great Ormond Street Hospital), University College of London, London, UK
2007-2008: Research Associate, King’s College University, Cardiovascular Department, Denmark Hill, James Black Centre, London, UK
2003-2007 Researcher (Co.Co.Co/Co.Co.Pro.), Vascular Pathology Laboratory, Istituto Dermopatico dell’Immacolata IDI, Rome, Italy
2002-2003 Researcher (Co.Co.Co), Centro Cardiologico Monzino, Milan, Italy
EDUCATION:
2021: Specialisation in Clinical Pathology and Biochemistry (4 years), University of Rome “Sapienza” (70/70 cum laude), University of Rome “Sapienza”, Rome, Italy
2006: PhD, Immunology (4 years), University of Rome “Sapienza”, Rome, Italy
2020: Biologist Board Certification, Elenco Speciale Sezione A, EA_020069
2001 Master Degree Biological Sciences (5 years) (110/110 cum laude), University of Rome “Sapienza”, Rome, Italy
PUBLICATIONS:
De Falco E, Porcelli D, Torella AR, Straino S, Iachininoto MG, Orlandi A, Truffa S, Biglioli P, Napolitano M, Capogrossi MC, Pesce M. SDF-1 involvement in endothelial phenotype and ischemia-induced recruitment of bone marrow progenitors cells. Blood 2004;104(12):3472-82. IMPACT FACTOR: 22.113
2. De Falco E, Iachininoto MG, Torella AR, Orlandi A, Porcelli D, Napolitano M, Pompilio G, Biglioli P, Capogrossi MC, Pesce M. Chemokine SDF-1 controls endothelial commitment of bone marrow progenitor cells. International Journal of Cardiology 01/2004; 95(Supplement 1):S68. IMPACT FACTOR: 2.095
3. De Falco E, Avitabile D, Totta P, Straino S, Spallotta F, Cencioni C, Torella AR, Rizzi R, Porcelli D, Zacheo A, Di Vito L, Pompilio G, Napolitano M, Melillo G, Capogrossi MC, Pesce M. Altered SDF-1 mediated differentiation of bone marrow-derived endothelial progenitor cells in diabetes mellitus. J Cell Mol Med. 2009 Sep;13(9B):3405-14. Doi: 10.1111/j.1582-4934.2009.00655.x IMPACT FACTOR: 5.31
4. Lagostena L, Avitabile D, De Falco E, Orlandi A, Grassi F, Iachininoto MG, Ragone G, Fucile S, Pompilio G, Eusebi F, Pesce M, Capogrossi MC. Electrophysiological properties of mouse bone marrow C-kit+ cells co-cultured onto neonatal cardiac myocytes. Cardiovasc Res. 2005 Jun 1;66(3):482-92. Doi: 10.1016/j.cardiores.2005.01.018. IMPACT FACTOR: 10.787
5. Zampetaki A, Zeng L, Margariti A, Xiao Q, Li H, Zhang Z, Pepe AE, Wang G, Habi O, De Falco E, Cockerill G, Mason JC, Hu Y, Xu Q. HDAC3 Is Critical in Endothelial Survival and Atherosclerosis Development in Response to Disturbed Flow. Circulation. 2010 Jan 5;121(1):132-42. Doi: 10.1161/CIRCULATIONAHA.109.890491. IMPACT FACTOR: 29.69
6. Margariti A, Zampetaki A, Xiao Q, Zhou B, Karamariti E, Martin D, Yin X, Mayr M, Li H, Zhang Z, De Falco E, Hu Y, Cockerill G, Xu Q, Zeng L. Histone Deacetylase 7 Controls Endothelial Cell Growth through Stabilization of β-Catenin. Circ Res. 2010 Apr 16;106(7):1202-11. Doi: 10.1161/CIRCRESAHA.109.213165. IMPACT FACTOR: 17.367
7. Riganò R. & Buttari B, De Falco E, Profumo E, Ortona E, Margutti P, Scottà C, Teggi A, Siracusano A. Echinococcus granulosus-specific T cell lines derived from patients at various clinical stages of cystic echinococcosis. Parasite Immunol. 2004, (1):45-52. Doi: 10.1111/j.0141-9838.2004.00682.x. IMPACT FACTOR: 2.28
8. Bouma G, Mendoza-Naranjo A, Blundell MP, De Falco E, Parsley K, Burns SO, Thrasher A. Cytoskeletal remodeling mediated by WASp in dendritic cells is necessary for normal immune synapse formation and T-cell priming. Blood. 2011;118(9):2492-501. Doi: 10.1182/blood-2011-03-340265. IMPACT FACTOR: 22.113
9. Siciliano C, Chimenti I, Ibrahim M, Napoletano C, Mangino G, Scafetta G, Zoccai GB, Rendina EA, Calogero A, Frati G, De Falco E. Cardiosphere conditioned media influence the plasticity of human mediastinal adipose tissue-derived mesenchymal stem cells. Cell Transplant. 2015, 24(11):2307-22. DOI: 10.3727/096368914X685771. IMPACT FACTOR: 4.064
10. Siciliano C, Ibrahim M, Scafetta G, Napolitano C, Mangino G., Pierelli L, Frati G, De Falco E. Optimization of the isolation and expansion method of human mediastinal mesenchymal stem cells with virally inactivated GMP-grade platelet lysate. Cytotechnology. 2015, 67(1):165-74. DOI: 10.1007/s10616-013-9667-y. IMPACT FACTOR: 1.95
11. Chimenti I, Gaetani R, Forte E, Angelini F, De Falco E, Messina E, Frati G, Giacomello A. Serum and supplement optimization for EU-GMP compliance in cardiospheres cell culture. J Cell Mol Med. 2014, 18(4):624-34. DOI: 10.1111/jcmm.12210. IMPACT FACTOR: 5.31
12. Bastianelli D, Siciliano C, Puca R, Coccia A, Murdoch C, Bordin A, Mangino G, Pompilio G, Calogero A, De Falco E. Influence of Egr-1 in cardiac tissue-derived mesenchymal stem cells in response to glucose variations. Biomed Res Int. 2014;2014:254793. DOI: 10.1155/2014/254793. IMPACT FACTOR: 3.411
13. De Falco E*, Biondi-Zoccai G*, Peruzzi M, Cavarretta E, Mancone M, Leoni O, Caristo ME, Lotrionte M, Marullo AGM, Amodeo A, Pacini L, Calogero A, Petrozza V, Chimenti I, D’Ascenzo F, and Frati G. *equal contribution. A Novel Closed-Chest Porcine Model of Chronic Ischemic Heart Failure Suitable for Experimental Research in Cardiovascular Disease. Biomed Res Int. 2013;2013:410631. DOI: IMPACT FACTOR: 3.411
14. Loffredo L, Perri L, Catasca E, Pignatelli P, Brancorsini M, Nocella C, De Falco E. Bartomoccia S, Frati G, Carnevale R, Violi F. Dark chocolate acutely improves walking autonomy in patients with peripheral artery disease. J Am Heart Assoc. 2014 Jul 2;3(4). Doi: 10.1161/JAHA.114.001072. IMPACT FACTOR: 5.501
15. Carnevale R, Loffredo L, Nocella C,Bartimoccia S, De Falco E, Peruzzi M,Chimenti I., Violi F, Frati G. Epicatechin and catechin modulate endothelial activation induced by platelets of patients with peripheral artery disease. Oxidative Medicine and Cellular Longevity. 2014;2014:691015. Doi: 10.1155/2014/691015 IMPACT FACTOR: 6.543
16. Carnevale R, Pastori D, Peruzzi M, De Falco E, Chimenti I, Biondi-Zoccai G, Greco E, Marullo AGM, Violi F, Pignatelli P, Calvieri C, Frati G. and Nocella C. Total adiponectin is inversely associated with platelet activation and CHA2DS2-VASc score in anticoagulated patients with atrial fibrillation. Mediators Inflamm. 2014;2014:908901. Doi: 10.1155/2014/908901. IMPACT FACTOR: 4.711
17. Carnevale R, Biondi-Zoccai G, Peruzzi M, De Falco E, Chimenti I, Venuta F, Anile M, Diso D, Cavarretta E, Marullo A, Sartini P, Pignatelli P, Violi F, Frati G. New insight into the steen solution properties: breakthrough in antioxidant effects via nox2 downregulation. Oxid Med Cell Longev. 2014;2014:242180. doi: 10.1155/2014/242180. IMPACT FACTOR: 6.543
18. Paone G, Conti V, Biondi-Zoccai G, De Falco E, Chimenti I, Peruzzi M, Mollica C, Giannunzio G, Brunetti G, Schmid G, Ranieri VM, Frati G. Mediators of inflammation. Long-term home non-invasive mechanical ventilation increases systemic inflammatory response in chronic obstructive pulmonary disease. Mediators Inflamm. 2014;2014:503145. Doi: 10.1155/2014/503145 IMPACT FACTOR: 4.711
19. Scafetta G, Tricoli E, Siciliano C, Napoletano C, Puca R, Vingolo EM, Cavallaro G, Polistena A, Frati G, De Falco E. Suitability of human Tenon’s fibroblasts as feeder cells for culturing human limbal epithelial stem cells. Stem Cell Rev. 2013;9(6):847-57. Doi: 10.1007/s12015-013-9451-6. IMPACT FACTOR: 4.81
20. De Falco E, Scafetta G, Napoletano C, Puca R, Vingolo EM, Ragona G, Iorio O, Frati G. A standardized laboratory and surgical method for in vitro culture isolation and expansion of primary human Tenon's fibroblasts. Cell Tissue Bank. 2013;14(2):277-87. Doi: 10.1007/s10561-012-9325-1. IMPACT FACTOR: 1.522
21. Scafetta G, Siciliano C, Frati G, De Falco E. Culture of Human Limbal Epithelial Stem Cells on Tenon's Fibroblast Feeder-Layers: A Translational Approach. Methods. Mol. Biol. 2015;1283:187-98. Doi: 10.1007/7651_2014_102. IMPACT FACTOR: 1.167
22. De Falco E*, Menna C*, Pacini L, Scafetta G, Ruggieri P, Puca R, Petrozza V, Ciccone AM, Rendina EA, Calogero A and Ibrahim M. *equal contribution. Axitinib affects cell viability and migration of a primary foetal lung adenocarcinoma culture. Cancer Invest. 2014;32(1):13-21. Doi: 10.3109/07357907.2013.861472. IMPACT FACTOR: 2.176
23. Raimondi C, Nicolazzo C, Gradilone A, Giannini G, De Falco E, Chimenti I, Varriale E, Hauch S, Plappert L, Cortesi E, Gazzaniga P. Circulating tumor cells: Exploring intratumor heterogeneity of colorectal cancer. Cancer Biol Ther. 2014;15(5):496-503. Doi: 10.4161/cbt.28020. IMPACT FACTOR: 4.742
24. Gazzaniga P, de Berandinis E, Raimondi C, Gradilone A, Busetto GM, De Falco E, Nicolazzo C, Giovannone R, Gentile V, Cortesi E, Pantel K, Circulating tumor cell detection has independent prognostic impact in high-risk non-muscle invasive bladder cancer. Int J Cancer. 2014;135(8):1978-82. Doi: 10.1002/ijc.28830. IMPACT FACTOR: 7.396
25. Pacini L, De Falco E, Di Bari M, Coccia A, Siciliano C, Ponti D, Pastore AL, Petrozza V, Carbone A, Tata AM, Calogero A. M2 muscarinic receptors inhibit cell proliferation and migration in urothelial bladder cancer cells. Cancer Biol Ther. 2014;15(11):1489-98. Doi: 10.4161/15384047.2014.955740. IMPACT FACTOR: 3.73
26. Murdoch CE, Broadway-Stringer SA, Bartkeviciute M, Siciliano C, Altobelli R, De Falco E. Stem cell therapies for ischemic cardiovascular diseases. Recent Patent on Reg. Medicine. 2014. 09/2014; 4(3). Doi: 10.2174/2210296504666141016214824. IMPACT FACTOR: 0
27. Peruzzi M, Colombo D, De Falco E, Chimenti I, Abbate A, Frati G, and Biondi-Zoccai G. Biologic Therapy for Psoriatic Arthritis or Moderate to Severe Plaque Psoriasis: Systematic Review with Pairwise and Network Meta-Analysis. International Journal of Statistics in Medical Research.2014;3:74-87. Doi: 10.6000/1929-6029.2014.03.02.1. IMPACT FACTOR: 0
28. Peruzzi M, Colombo D, Chimenti I, De Falco E, Abbate A, Frati G and Biondi-Zoccai G. Comparative Risk-Benefit Analysis of Different Classes of Biologic Agents in Patients with Psoriasis: A Case Study on the Pros and Cons of Mixed Treatment Comparison in Synthesizing Complex Evidence Networks. International Journal of Statistics in Medical Research. 2014; 3:231-247. Doi: 10.6000/1929-6029.2014.03.03.3. IMPACT FACTOR: 0
29. Peruzzi M, Biondi-Zoccai G, Frati L, De Falco E, Chimenti I, Greco E, Antonino G. M. Marullo, Vitulli P., Frati G., Bridging regenerative medicine-based therapies into the 21st Century: solo or symphony. Inter. Arch. Medicine 2015, (8) Vol. 81:1-7. Doi: 10.3823/1680. IMPACT FACTOR: 1.08
30. De Falco E*, Peruzzi M*, Abbate A, Biondi-Zoccai G, Chimenti I, Lotrionte M, Benedetto M, Delewi R, Marullo A and Frati G. *equal contribution. State of the art on the evidence base in cardiac regenerative therapy: overview of 41 systematic reviews. Biomed Res Inter. 2015;2015:613782. Doi: 10.1155/2015/613782. IMPACT FACTOR: 2.583
31. Biondi Zoccai G, Cerrato E, Peruzzi M, D’ Ascenzo F, De Falco E, Chimenti I, Sciarretta S, Marullo AGM, Cavarretta E, Greco E, Di Benedetto U, Pompilio G, Abbate A, Chachques J, Semino C, Frati G. An International survey, on taking up a career in cardiovascular research: opportunities and biases toward would-be physician-scientists. PlosOne, 2015, 10.1371/journal.pone.0131900. IMPACT FACTOR: 2.766
32. Siciliano C, Chimenti I, Bordin A, Ponti D, Iudicone P, Peruzzi M, Rendina EA, Calogero A, Pierelli L, Ibrahim M, De Falco E. The potential of GMP-compliant platelet lysate to induce a permissive state for cardiovascular transdifferention in human mediastinal adipose tissue-derived mesenchymal stem cells. Biomed Res Inter. 2015; doi: 10.1155/2015/162439 IMPACT FACTOR: 2.583
33. Carducci A, Scafetta G, Siciliano C, Carnevale R, Rosa P, Coccia A, Mangino G, Bordin A, Vingolo EM, Pierelli L, Lendaro E, Ragona G, Frati G, De Falco E. GMP-grade platelet lysate enhances proliferation and migration of Tenon fibroblasts. Front Biosci (Elite Ed). 2016 Jan 1;8:84-99. Doi: 10.2741/753. IMPACT FACTOR: 2.11
34. Spaltro G, Avitabile D, De Falco E, Gambini E. Physiological conditions influencing regenerative potential of stem cells. Frontiers in Bioscience (Landmark Ed.) 2016 Jun 1;21:1126-50. IMPACT FACTOR: 2.349
35. Bartimoccia S, Carnevale R, Sanguigni V, De Falco E, Frati G, Loffredo L, Plebani A, Soresina A, Pignatelli P, Violi F. NOX 5 is expressed in platelets from patients with chronic granulomatous disease. Thrombosis and Haemostasis. 2016;116(1). Doi: 10.1160/TH15-12-0999 IMPACT FACTOR: 4.952
36. Carnevale R, Sciarretta S, Violi F, Nocella C, Loffredo L, Perri L, Peruzzi M, Marullo AG, De Falco E, Chimenti I, Valenti V, Biondi-Zoccai G, Frati G. Acute impact of tobacco versus electronic cigarette smoking on oxidative stress and vascular function. Chest. 2016;150(3):606-12..doi: 10.1016/j.chest.2016.04.012 IMPACT FACTOR: 7.652
37. De Falco E, Carnevale R, Pagano F, Chimenti I, Fianchini L, Bordin A, Siciliano C, Monticolo R, Equitani F, Carrizzo A, Peruzzi M, Vecchione C, Rubattu S, Sciarretta S, Frati G. Role of NOX2 in mediating doxorubicin-induced senescence in human endothelial progenitor cells. Mech Ageing Dev. 2016 Oct;159:37-43. doi: 10.1016/j.mad.2016.05.004 IMPACT FACTOR: 3.739
38. Businaro R, Di Raimo T, Corsi M, Siciliano C, Frati G, De Falco E. Multidisciplinary approaches to stimulate wound healing. Ann N Y Acad Sci. 2016;1378(1):137-142 doi: 10.1111/nyas.13158 IMPACT FACTOR: 4.277
39. Siciliano C, Bordin A, Ibrahim M, Chimenti I, Cassiano F, Gatto I, Mangino G, Coccia A, Miglietta S, Bastianelli D, Petrozza V, Calogero A, Frati G, De Falco E. The adipose tissue of origin influences the biological potential of human adipose stromal cells isolated from mediastinal and subcutaneous fat depots. Stem Cell Res. 2016;17(2):342-351. doi: 10.1016/j.scr.2016.07.010 IMPACT FACTOR: 3.902
40. Chimenti I, Pagano F, Cavarretta E, Angelini F, Peruzzi M, Barretta A, Greco E, De Falco E, Marullo AG, Sciarretta S, Biondi-Zoccai G, Frati G. Β-blockers treatment of cardiac surgery patients enhances isolation and improves phenotype of cardiosphere-derived cells. Sci Rep. 2016 Nov 14;6:36774. Doi: 10.1038/srep36774 IMPACT FACTOR: 4.122
41. Forte M, Nocella C, De Falco E, Palmerio S, Schirone L, Valenti V, Frati G, Carnevale R, Sciarretta S. The Pathophysiological Role of NOX2 in Hypertension and Organ Damage. High Blood Press Cardiovasc Prev. 2016 Dec;23(4):355-364. Doi: 10.1007/s40292-016-0175-y. IMPACT FACTOR: 1.27
42. Chimenti I, Pagano F, Angelini F, Siciliano C, Mangino G, Picchio V, De Falco E, Peruzzi M, Carnevale R, Ibrahim M, Biondi-Zoccai G, Messina E, Frati G. Human Lung Spheroids as In Vitro Niches of Lung Progenitor Cells With Distinctive Paracrine and Plasticity Properties. Stem Cells Transl Med. 2017 Mar;6(3):767-777. doi: 10.5966/sctm.2015-0374. IMPACT FACTOR: 5.61
43. Pagano F, Angelini F, Siciliano C, Tasciotti J, Mangino G, De Falco E, Carnevale R, Sciarretta S, Frati G, Chimenti I. Beta2-adrenergic signalling affects the phenotype of human cardiac progenitor cells through EMT modulation. Pharmacol Res. 2017 Jan 15. pii: S1043-6618(16)30624-7. DOI: 10.1016/j.phrs.2017.01.016. IMPACT FACTOR: 7.658
44. Sciarretta S, De Falco E, Frati G, Sadoshima J. How to be young at heart? miR-22 as a potential therapeutic target to boost autophagy and protect the old myocardium. Ann Transl Med. 2017 Feb;5(3):52. DOI: 10.21037/atm.2017.01.52. IMPACT FACTOR: 3.932
45. Pagano F, Nocella C, Sciarretta S, Fianchini L, Siciliano C, Mangino G, Ibrahim M, De Falco E, Carnevale R, Chimenti I, Frati G. Cytoprotective and antioxidant effects of Steen solution on human lung spheroids and human endothelial cells. Am J Transplant. 2017 Mar 20. doi: 10.1111/ajt.14278. IMPACT FACTOR: 8.086
46. Angelini F., Pagano F, Bordin A, Milan M, Chimenti I, Peruzzi M, Valenti V, Marullo A, Schirone L, Palmerio S, Sciarretta S, Murdoch CE, Frati G, De Falco E. The impact of environmental factors in influencing epigenetics related to oxidative states in the cardiovascular system. Oxid Med Cell Longev. 2017;2017:2712751. doi: 10.1155/2017/2712751. IMPACT FACTOR: 6.543
47. De Falco E, Bordin A, Scaccia E, Pagano F, Ibrahim M, Schirone L, Angelini F, Palmerio S, Madonna M, Fianchini L, Chimenti I, Sciarretta S, Frati G. Histone acetylation favours the cardiovascular commitment of adipose tissue-derived stromal cells. Int J Cardiol. 2017 Jun 2. pii: S0167-5273(17)31296-2. doi: 10.1016/j.ijcard.2017.05.112. IMPACT FACTOR: 4.164
48. Schirone L, Forte M, Palmerio S, Yee D, Nocella C, Angelini F, Pagano F, Schiavon S, Bordin A, Carrizzo A, Vecchione C, Valenti V, Chimenti I, De Falco E, Sciarretta S, Frati G. A review of the molecular mechanisms underlying the development and progression of cardiac remodelling. Oxid Med Cell Longev. Volume 2017 (2017), doi: 10.1155/2017/3920195. MPACT FACTOR: 6.543
49. Straface E, Gambardella L, Pagano F, Angelini F, Ascione B, Vona R, De Falco E, Cavarretta E, La Russa R, Malorni V, Frati G, Chimenti I. Sex differences of human cardiac progenitor cells in the biological response to TNF-α treatment. Stem Cells Int. 2017;2017:4790563. doi: 10.1155/2017/4790563. IMPACT FACTOR: 5.443
50. Carnevale R., Raparelli V, Nocella C, Bartimoccia S, Novo M, Severino A, De Falco E, Cammisotto V, Pasquale C, Sili Scavalli A, Riggio O, Basili S and Violi F. Gut-derived endotoxin enhances factor VIII secretion from endothelial cells implications for hypercoagulability in cirrhosis. J Hepatol. 2017 Nov;67(5):950-956. doi: 10.1016/j.jhep.2017.07.002. IMPACT FACTOR: 25.083
51. Angelini F, Pagano F, Bordin A, Picchio V, De Falco E, Chimenti I. Getting Old through the Blood: Circulating Molecules in Aging and Senescence of Cardiovascular Regenerative Cells. Front Cardiovasc Med. 2017 Oct 6;4:62. doi: 10.3389/fcvm.2017.00062. eCollection 2017. IMPACT FACTOR: 4.79
52. Ibrahim M, Scozzi D, Toth KA, Ponti D, Kreisel D, Menna C, De Falco E, D’Andrilli A, Rendina EA, Calogero A, Krupnick AS, Gelman AE. Naive CD4+ T Cells Carrying a TLR2 Agonist Overcome TGF-b–Mediated Tumor Immune Evasion. J Immunol. 2018 Jan 15;200(2):847-856. doi: 10.4049/jimmunol.1700396. IMPACT FACTOR: 4.539
53. Milan M, Pace V, Maiullari F, Chirivì M, Baci D, Maiullari S, Madaro L, Maccari S, Stati T, Marano G, Frati G, Puri PL, De Falco E, Bearzi C, Rizzi R. Givinostat reduces adverse cardiac remodeling regulating fibroblasts activation. Cell Death Dis. 2018 Jan 25;9(2):108. doi: 10.1038/s41419-017-0174-5. IMPACT FACTOR: 8.496
54. Mastrangeli S, Carnevale R, Cavarretta E, Sciarretta S, Peruzzi M, Marullo AGM, De Falco E, Chimenti E, Valenti V, Bullen C, Roever L, Frati G, Biondi-Zoccai G. Predictors of oxidative stress and vascular function in an experimental study of tobacco versus electronic cigarettes: A post hoc analysis of the SUR-VAPES 1 Study. Tob. Induc. Dis. 2018;16(May):18. Doi: 10.18332/tid/89975. IMPACT FACTOR: 2.6
55. Menna C, De Falco E, Teodonio L, Andreetti C, Maurizi G, Ciccone AM, D'Andrilli A, Cassiano F, Vanni C, Baccarini AE, Rendina EA, Ibrahim M. Surgical wound-site inflammation: video-assisted thoracic surgery versus thoracotomy. Interact Cardiovasc Thorac Surg. 2019 Jul 27. doi: 10.1093/icvts/ivy231. IMPACT FACTOR: 1.46
56. Pagano F, Picchio V, Angelini F, Iaccarino A, Peruzzi M, Cavarretta E, Biondi-Zoccai G, Sciarretta S, De Falco E, Chimenti I, Frati G. The Biological Mechanisms of Action of Cardiac Progenitor Cell Therapy. Curr Cardiol Rep. 2018 Aug 13;20(10):84. doi: 10.1007/s11886-018-1031-6. IMPACT FACTOR: 2.931
57. Poz D, De Falco E, Pisano C, Madonna R, Ferdinandy P, Balistreri CR. Diagnostic and prognostic relevance of Red blood cell distribution width for vascular aging and cardiovascular diseases. Rejuvenation Res. 2018 Aug 22. doi: 10.1089/rej.2018.2094. IMPACT FACTOR: 4.663
58. Businaro R, Scaccia E, Bordin A, Pagano F, Corsi M, Siciliano C, Capoano R, Procaccini E, Salvati B, Petrozza V, Totta P, Vietri MT, Frati G. De Falco E. Platelet Lysate-Derived Neuropeptide y Influences Migration and Angiogenesis of Human Adipose Tissue-Derived Stromal Cells. Scientific reports. 2018 25;8(1):14365. doi: 10.1038/s41598-018-32623-8 IMPACT FACTOR: 4.380
59. Cavarretta E, Peruzzi M, Del Vescovo R, Di Pilla R, Gobbi G, Serdoz A, Ferrara R, Schirone L, Sciarretta S, Nocella C, De Falco E, Schiavon S, Biondi-Zoccai G, Frati G and Carnevale R. Dark chocolate intake positively modulates redox status and markers of muscular damage in elite football athletes: a randomized controlled study". Oxidative Medicine and Cellular Longevity 2018 Nov 21; 2018:4061901, doi: 10.1155/2018/4061901 IMPACT FACTOR: 6.543
60. Bordin A, Pagano F, Scaccia E, Saccucci M, Vozza I, Incerti N, Polimeni A, Cavarretta E, Chimenti I, De Falco E. Oral Plaque from Type 2 Diabetic Patients Reduces Clonogenic Capacity of Dental Pulp-Derived Mesenchymal Stem Cells. Stem cells Int. 2018 10.1155/2019/1516746. IMPACT FACTOR: 5.443
61. Biondi-Zoccai G, Sciarretta S, Bullen C, Nocella C, Violi F, Loffredo L, Pignatelli P, Perri L, Peruzzi M, Marullo AGM, De Falco E, Chimenti I, Cammisotto V, Valenti V, Coluzzi F, Cavarretta E, Carrizzo A, Prati F, Carnevale R, Frati G. Acute effects of heat-not-burn, electronic vaping, and traditional tobacco combustion cigarettes: the Sapienza University of Rome-Vascular Assessment of Proatherosclerotic Effects of Smoking (SUR-VAPES) 2 randomized trial. J Am Heart Assoc. 2019 Mar 19;8(6):e010455. doi: 10.1161/JAHA.118.010455. IMPACT FACTOR: 5.117
62. E. Giordano, Griffoni C, G. Brodano, E. De Falco, H. AbdelRazik, A. Pelaga. Substantial Overview on Mesenchymal Stem Cell Biological and Physical Properties as an Opportunity in Translational Medicine. Int. J. Mol. S. 2019 Oct 29;20(21). pii: E5386. doi: 10.3390/ijms20215386. IMPACT FACTOR: 5.924
63. A. Vaiserman, E. De Falco, A. Koliada, O. Maslova, C.R. Balistreri. Anti-Ageing Gene Therapy: Not so Far Away? Ageing Research Reviews 2019 Dec;56: 100977. doi: 10.1016/j.arr.2019.100977. IMPACT FACTOR: 10.895
64. Pagano F, Picchio V, Chimenti I, Sordano A, De Falco E, Peruzzi M, Miraldi F, Cavarretta E, Zoccai GB, Sciarretta S, Frati G, Marullo AGM. On the Road to Regeneration: "Tools" and "Routes" Towards Efficient Cardiac Cell Therapy for Ischemic Cardiomyopathy. Curr Cardiol Rep. 2019 Oct 31;21(11):133. doi: 10.1007/s11886-019-1226-5. IMPACT FACTOR: 2.931
65. Forte M, Bianchi F, Cotugno M, Marchitti S, De Falco E, Raffa S, Stanzione R, Di Nonno F, Chimenti I, Palmerio S, Pagano F, Petrozza V, Micaloni A, Madonna M, Relucenti M, Torrisi MR, Frati G, Volpe M, Rubattu S, Sciarretta S. Pharmacological restoration of autophagy reduces hypertension-related stroke occurrence. Autophagy. 2020 Nov 12:1-14. doi: 10.1080/15548627.2019.1687215. IMPACT FACTOR: 16.016
66. Balistrieri CR, De Falco E., Bordin A, Olga Maslovad O, Koliadae A, Vaiserman A. Stem Cell Therapy: Old Challenges and New Solutions. Mol Biol Rep. 2020 Mar 3. doi: 10.1007/s11033-020-05353-2. IMPACT FACTOR: 2.316
67. Frati G, Carnevale R, Nocella C, Peruzzi M, Marullo AGM, De Falco E, Chimenti I, Cammisotto V, Valenti V, Cavarretta E, Carrizzo A, Versaci F, Vitali M, Protano C, Roever L, Giordano A, Sciarretta S, Biondi-Zoccai G. Profiling the acute effects of modified risk products: evidence from the SUR-VAPES (Sapienza University of Rome-Vascular Assessment of Proatherosclerotic Effects of Smoking) Cluster Study. Curr Atheroscler Rep. 2020 Feb 7;22(2):8. doi: 10.1007/s11883-020-0824-4IMPACT FACTOR: 4.32
68. Murdoch CE, De Falco E. Antioxidant synthetic peptides counteracting hyperglycaemia induced endothelial cell dysfunction. Int. J. Cardiology 2020 Jun 1;308:82-83. doi: 10.1016/j.ijcard.2020.03.051. IMPACT FACTOR: 4.164
69. Caruso G, Pacini L, Iossa A, Di Cristofano C, Bastianelli D, Silecchia G, Mele M, Petrozza V, Calogero A, De Falco E. A rare case of extra gastrointestinal stromal tumour showing two coexisting mutations on exon 14 of the PDGFRA gene. Gastroenterol Rep (Oxf). 2021 Aug; 9(4): 377–379. doi: 10.1093/gastro/goaa086. IMOCAT FACTOR: 3.651
70. Frati G, Forte M, di Nonno F, Bordin A, Chimenti I, Picchio V, Cavarretta E, Stanzione R, Bianchi F, Carnevale R, Nocella C, Schiavon S, Vecchio D, Marchitti S, De Falco E, Rubattu S, Paneni F, Biondi-Zoccai G, Versaci F, Volpe M, Pagano F, Sciarretta S. Inhibition of miR-155 Attenuates Detrimental Vascular Effects of Tobacco Cigarette Smoking. J Am Heart Assoc. 2020 Dec 15;9(24):e017000. doi: 10.1161/JAHA.120.017000. IMPACT FACTOR: 5.501
71. A. Di Carlo, S. Beji, S. Palmerio, M. Picozza, M. D'Agostino, V. Petrozza, R. Melchionna, A. Germani, A. Magenta, E. De Falco*, D. Avitabile* (co-lasting authors). The nucleolar protein Nucleophosmin is physiologically secreted by endothelial cells in response to stress exerting proangiogenic activity both in vitro and in vivo. International J. Molecular Sciences. 2021 doi: 10.3390/ijms22073672. IMPACT FACTOR: 5.924
72. Concomitant mutations G12D and G13D on the exon 2 of the KRAS gene: two cases of women with colon adenocarcinoma. E. De Falco, L. Pacini, D. Bastianelli, GP Spinelli, C. Spoto, E. Veltri, A. Calogero. Diagnostics 2021 doi: 10.3390/diagnostics11040659 IMPACT FACTOR: 3.24
73. . Loffredo L, Carnevale R, Battaglia S, Marti R, Pizzolo S, Bartimoccia S, Nocella C, Cammisotto V, Sciarretta S, Chimenti I, De Falco E, Cavarretta E, Peruzzi M, Marullo A, Miraldi F, Violi F, Morelli A, Biondi-Zoccai G, Frati G. Impact of chronic use of heat-not-burn cigarettes on oxidative stress, endothelial dysfunction and platelet activation: the SUR-VAPES Chronic Study. Thorax. 2021 Jun;76(6):618-620. doi: 10.1136/thoraxjnl-2020-215900. IMPACT FACTOR: 9.139
74. Tito C. De Falco E., Fazi F. Rosa P., Iaiza A., Petrozza V., Calogero A. Circulating microRNAs from the molecular mechanisms to clinical biomarkers: a focus on the clear cell Renal Cell Carcinoma. Genes (Basel). 2021 Jul 28;12(8):1154. doi: 10.3390/genes12081154. IMPACT FACTOR: 3.886
75. Perrotta A., Biondi-Zoccai G, Saade W, Miraldi F, Morelli A, Marullo AG, Cavarretta E, Carnevale R, De Falco E, Chimenti I, Sciarretta S, Frati P, Mamas MA, Ciardi S, Frati L, Frati G, Peruzzi M. A snapshot global survey on side effects of COVID-19 vaccines among healthcare professionals and armed forces with a focus on headache. Panminerva Med. 2021 Sep;63(3):324-331. DOI: 10.23736/S0031-0808.21.04435-9. IMPACT FACTOR: 5.197
76. Annunziata C, Pirozzi C, Lama A, Senzacqua M, Comella F, Bordin A, Monnolo A, Pelagalli A, Ferrante MC, Mollica MP, Iossa A, De Falco E, Mattace Raso G, Cinti S, Giordano A, Meli R. Palmitoylethanolamide Promotes White-to-Beige Conversion and Metabolic Reprogramming of Adipocytes: Contribution of PPAR-α. Pharmaceutics 2022 Jan 31;14(2):338. doi: 10.3390/pharmaceutics14020338.. IMPACT FACTOR: 6.072
77. Picchio V, Bordin A, Floris E, Cozzolino C, Dhori X, Peruzzi M, Frati G, De Falco E, Pagano F, Chimenti I. The dynamic facets of the cardiac stroma: from classical markers to omics and translational perspectives. Am J Transl Res 2022 Feb 15;14(2):1172-1187. eCollection 2022. IMPACT FACTOR: 4.06
78. Chimenti I, Picchio V, Pagano F, Schirone L, Schiavon S, D'Ambrosio L, Valenti V, Forte M, Di Nonno F, Rubattu S, Peruzzi M, Versaci F, Greco E, Calogero, De Falco E, Frati G, Sciarretta S. The impact of autophagy modulation on phenotype and survival of cardiac stromal cells under metabolic stress. Cell Death Discov. 2022 Apr 1;8(1):149. doi: 10.1038/s41420-022-00924-7. IMPACT FACTOR: 4.53.
79. Pagano F, Picchio V, Bordin A, Cavarretta E, Nocella C, Cozzolino C, Floris E, Angelini F, Sordano A, Peruzzi M, Miraldi F, Biondi-Zoccai G, De Falco E, Carnevale R, Sciarretta S, Frati G, Chimenti I. Progressive stages of dysmetabolism are associated with impaired biological features of human cardiac stromal cells mediated by the oxidative state and autophagy. Journal of Pathology. 2022 Jun 25. doi: 10.1002/path.5985 IMPACT FACTOR: 7.996
80. Schirone L, Loffredo L, Carnevale R, Battaglia S, Marti R, Pizzolo S, Bartimoccia S, Nocella C, Cammisotto V, Saade W, Tanzilli A, Sciarretta S, Chimenti I, De Falco E, Cavarretta E, Picchio V, Peruzzi M, Marullo AGM, Miraldi F, Violi F, Morelli A, Biondi-Zoccai G, Frati G. Sex-related differences in oxidative, platelet and vascular function in chronic users of heat-not-burn vs. traditional combustion cigarettes. Antioxidants 2022, 11(7), 1237; https://doi.org/10.3390/antiox11071237. IMPACT FACTOR: 7.675
81. Bordin A, Chirivì M, Francesca Pagano F, Milan M, Iuliano M, Scaccia E, Fortunato O, Mangino G, Dhori X, De Marinis E, D’Amico A, Miglietta S, Picchio V, Rizzi R, Romeo G, Pulcinelli F, Chimenti I, Frati G, De Falco E. Human platelet lysate derived extracellular vesicles enhance angiogenesis through miR-126. Cell proliferation Cell Prolif. 2022 Aug 9:e13312. doi: 10.1111/cpr.13312. IMPACT FACTOR: 8.755
82. Biomimetic Keratin-Coated Gold Nanoparticles for Photo-Thermal Therapy in a 3D Bioprinted Glioblastoma Tumor Model. Chirivì M, Bearzi C, Rosa P, Miglietta S, Petronella F, De Falco E, Calogero A, Pani R, Petrozza V, Perotto G, Rizzi R, De Sio L. Int J Mol Sci. 2022 Aug 23;23(17):9528. doi: 10.3390/ijms23179528. IMPACT FACTOR: 6.208
83. Unusual Association of NF-κB Components in Tumor-Associated Macrophages (TAMs) Promotes HSPG2-Mediated Immune-Escaping Mechanism in Breast Cancer. De Paolis V, Maiullari F, Chirivì M, Milan M, Cordiglieri C, Pagano F, La Manna AR, De Falco E, Bearzi C, Rizzi R, Parisi C. Int J Mol Sci. 2022 Jul 18;23(14):7902. doi: 10.3390/ijms23147902. IMPACT FACTOR: 6.208.
84. Rosa P*, De Falco E*, Pacini L, Piazza A, Ciracì P, Ricciardi L, Fiorentino F, Trungu S, Miscusi M, Raco A, Calogero A. *co-autorship. Next-Generation Sequencing Comparative Analysis of DNA Mutations between Blood-Derived Extracellular Vesicles and Matched Cancer Tissue in Patients with Grade 4 Glioblastoma. Biomedicines. 2022 Oct 15;10(10):2590. doi: 10.3390/biomedicines10102590. IMPACT FACTOR: 4.757.
85. Remote adipose tissue-derived stromal cells of patients with lung adenocarcinoma generate a similar malignant microenvironment of the lung stromal counterpart. De Falco E., Bordin S., Menna C, Dhori X, Picchio V., Cozzolino C., De Marinis E, Floris E., Giorgiano NM, Rosa P., Rendina EA., Ibrahim M., Calogero A. Journal of Oncology vol. 2023, Article ID 1011063, 15 pages, 2023. doi.org/10.1155/2023/1011063. IMPACT FACTOR: 4.501
86. A Focus on the Synergy of Radiomics and RNA Sequencing in Breast Cancer. Bellini D. Milan M, Bordin A, Rizzi R, Rengo M, Vicini S, Onori A, Carbone I, E. De Falco. Int. J. Mol. Sci. 2023, 24, 7214. doi: 10.3390/ijms24087214. IMPACT FACTOR: 6.208.
87. Botticelli A, Galvano A, Iuliani M, Incorvaia L, Gristina V, Taffon C, Foderaro S, Paccagnella E, Simonetti S, Fazio F, Scagnoli S, Pomati S, Pantano F, Perrone G, De Falco E, Russo A, Spinelli GP, Santini D. Network approach in liquidomics landscape. J Exp Clin Cancer Res. 2023 Aug 4;42(1):193. doi: 10.1186/s13046-023-02743-9. IMPACT FACTOR: 12.658
88. Picchio V, Gaetani R, Pagano F, Derevyanchuk Y, Pagliarosi O, Floris E, Cozzolino C, Bernava G, Bordin A, Rocha F, Simões Pereira AR, Ministro A, Pinto AT, De Falco E, Serino G, Massai D, Tamarat N, Pesce M, Constantino Rosa Santos S, Messina E, Chimenti I. Early Impairment of Paracrine and Phenotypic Features in Resident Cardiac Mesenchymal Stromal Cells after Thoracic Radiotherapy. Int J Mol Sci. 2024 Mar 1;25(5):2873. doi: 10.3390/ijms25052873. IMPACT FACTOR: 5.6
89. Schirone L, Overi D, Carpino G, Carnevale R, De Falco E, Nocella C, D’Amico A, Bartimoccia S, Cammisotto V, Castellani V, Frati G, Sciarretta S, Gaudio E, Pignatelli P, Alvaro D, Violi F. Oleuropein, a component of extra virgin olive oil, improves liver steatosis and lobular inflammation by LPS-TLR4 axis downregulation. Int. J. Mol. Sci. 2024, 25(11), 5580; doi: 10.3390/ijms25115580. FACTOR: 5.6
90. Picchio V, Pagano F, Carnevale R, D'Amico A, Cozzolino C, Floris E, Bordin A, Schirone L, Vecchio D, Saade W, Miraldi F, De Falco E, Sciarretta S, Peruzzi M, Biondi-Zoccai G, Frati G, Chimenti I. Exposure to serum from exclusive heated tobacco product smokers induces mTOR activation and fibrotic features in human cardiac stromal cells. Biochim Biophys Acta Mol Basis Dis. 2024 Jul 11:167350. doi: 10.1016/j.bbadis.2024.167350. FACTOR: 4.2
91. Milani, I., Gaita C., Guarisco G., Chinucci,M., Parisella R., Piroli S., Bruno E., Martellucci, A., De Falco E., Ricci F., Calogero A., Leonetti F., Capoccia D. The intricate relationship between obesity, type 2 diabetes and female breast cancer: A retrospective study of 335 women. Obes Sci Pract. 2024 Aug 9;10(4):e786. doi: 10.1002/osp4.786. IMPACT FACTOR: 3.7
92. Milan M, Maiullari F, Chirivì M, Ceraolo MG, Zigiotto R, Soluri A, Maiullari S, Landoni E, Di Silvestre D, Brambilla F, Mauri P, De Paolis V, Fratini N, Crosti MC, Cordiglieri C, Parisi C, Calogero A, Seliktar D, Torrente Y, Lanzuolo C, Gianpietro G , Toccafondi M, Bombaci M , De Falco E, Bearzi C, Rizzi R. Macrophages producing Chondroitin Sulfate Proteoglycan-4 induce neuro-cardiac junction impairment in Duchenne Muscular Dystrophy. The J. of Pathol. 2024 doi: 10.1002/path.6362. IMPACT FACTOR: 5.6.
93. Schirone L, Di Paolo MC, Vecchio D, Nocella C, D'Amico A, Urgesi R, Pallotta L, Fanello G, Villotti G, Graziani MG, Peruzzi M, De Falco E, Carnevale R, Sciarretta S, Frati G, Pagnini C. Stenosing Crohn's disease patients display gut autophagy/oxidative stress imbalance. Sci Rep. 2024 Nov 9;14(1):27312. doi: 10.1038/s41598-024-79308-z. IMPACT FACTOR: 3.8.
94. De Falco E*, Proietti I*, Pacini L, Spagnoli A, Melone V, Petrozza V, Di Cristofano C, Mangino G, Romeo G, Rosa P, Calogero A, Potenza C. BRAF-mutant melanoma management: a single center retrospective analysis of patients treated with sequential therapy. *equal contribution. Melanoma Manag. 2024 Dec;11(1):2432826. doi: 10.1080/20450885.2024.2432826. IMPACT FACTOR: 1.9
95. Milan M, Maiullari F, Chirivì M, Ceraolo MG, Zigiotto R, Soluri A, Maiullari S, Landoni E, Silvestre DD, Brambilla F, Mauri P, De Paolis V, Fratini N, Crosti MC, Cordiglieri C, Parisi C, Calogero A, Seliktar D, Torrente Y, Lanzuolo C, Dotti G, Toccafondi M, Bombaci M, De Falco E, Bearzi C, Rizzi R. Macrophages producing chondroitin sulfate proteoglycan-4 induce neuro-cardiac junction impairment in Duchenne muscular dystrophyJ Pathol. 2025 Jan;265(1):1-13. doi: 10.1002/path.6362. IMPACT FACTOR: 5.6
96. Chirivì M, Maiullari F, Milan M, Ceraolo MG, Fratini N, Fasciani A, Bousselmi S, Stirm M, Scalera F, Gervaso F, Villa M, Viganò R, Brambilla F, Mauri P, Di Silvestre D, De Falco E, Costantini M, Wolf E, Bearzi C, Rizzi R. Mimicking the Dystrophic Cardiac Extracellular Environment through DystroGel. Advanced Healthcare Materials 2025. Doi: 10.1002/adhm.202404251. IMPACT FACTOR: 10.
97. Visco V, Forte M, Giallauria F, D'Ambrosio L, Piccoli M, Schiattarella GG, Mancusi C, Salerno N, Cesaro A, Perrone MA, Izzo C, Loffredo FS, Bellino M, Bertero E, De Luca N, Pilichou K, Calabrò P, Manno G, De Falco E, Carrizzo A, Valenti V, Castelletti S, Spadafora L, Tourkmani N, D'Andrea A, Pacileo M, Bernardi M, Maloberti A, Simeone B, Sarto G, Frati G, Perrino C, Pedrinelli R, Filardi PP, Vecchione C, Sciarretta S, Ciccarelli M. Epigenetic mechanisms underlying the beneficial effects of cardiac rehabilitation. An overview from the working groups of "cellular and molecular biology of the heart" and "cardiac rehabilitation and cardiovascular prevention" of the Italian Society of Cardiology (SIC). Int J Cardiol. 2025 Mar 13;429:133166. doi: 10.1016/j.ijcard.2025.133166.
98. Pontecorvi V, Angeli A, Cutarella L, Mori M, Secci D, Coluccia M, Carradori S, Spano M, Arrighi F, De Falco E, Bordin A, Berrino E, Granese A, Chimenti P, Guglielmi P, Supuran CT. Design, synthesis, molecular modelling investigation and biological studies of novel human carbonic anhydrase inhibitors based on coumalic acid. RCS Medicinal Chemistry. MD-RES-03-2025-000208. 2025 in press
Books
1. Scaccia E, Bordin A, Balistrieri CR, De Falco E. Part 1: EPIGENETICS, OXIDATIVE STATES AND DIABETES in: DIABETES: OXIDATIVE STRESS AND DIETARY ANTIOXIDANTS Edited by Victor R. Preedy. (Elsevier, 2020). ISBN: 9780128157763
2. E. De Falco, A. Bordin, E. Scaccia, C.R. Balistrieri. Stem cells therapy. Editor(s): Suresh I.S. Rattan, Encyclopedia of Biomedical Gerontology, Academic Press, 2020, Pages 262-270, ISBN 9780128160763, https://doi.org/10.1016/B978-0-12-801238-3.11323-6.
3. Chimenti I, Peruzzi M. E. De Falco. volume “Malattie cardiovascolari – Approccio clinico e scientifico. Torino: Edizioni Minerva Medica; 2021. ISBN: 978-88-5532-066-5